Investigating neuroprotective roles of Bacopa monnieri extracts: Mechanistic insights and therapeutic implications

Bacopa monnieri (Brahmi) is a well-known perennial, creeping herb of the Indian Ayurveda system; it contains numerous bioactive phytoconstituents implicated in the therapeutic management of several life-threatening diseases. This herb was used by Ancient Vedic scholars due to its pharmacological eff...
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Autor*in:	Urooj Fatima [verfasserIn] Sonam Roy [verfasserIn] Shahnawaz Ahmad [verfasserIn] Lamya Ahmed Al-Keridis [verfasserIn] Nawaf Alshammari [verfasserIn] Mohd Adnan [verfasserIn] Asimul Islam [verfasserIn] Md. Imtaiyaz Hassan [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2022

Schlagwörter:	Neuroprotection Tau aggregates Bacopa monnieri Alzheimer's disease Reactive Oxygen Species Bacosides

Übergeordnetes Werk:	In: Biomedicine & Pharmacotherapy - Elsevier, 2021, 153(2022), Seite 113469-
Übergeordnetes Werk:	volume:153 ; year:2022 ; pages:113469-

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.1016/j.biopha.2022.113469

Katalog-ID:	DOAJ085668907

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allfields_unstemmed	10.1016/j.biopha.2022.113469 doi (DE-627)DOAJ085668907 (DE-599)DOAJd4aea4341d3b4f2d947cce4ecb1b2e83 DE-627 ger DE-627 rakwb eng RM1-950 Urooj Fatima verfasserin aut Investigating neuroprotective roles of Bacopa monnieri extracts: Mechanistic insights and therapeutic implications 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Bacopa monnieri (Brahmi) is a well-known perennial, creeping herb of the Indian Ayurveda system; it contains numerous bioactive phytoconstituents implicated in the therapeutic management of several life-threatening diseases. This herb was used by Ancient Vedic scholars due to its pharmacological effect, especially as a nerve tonic and nootropic booster. However, to better understand the roles of Bacopa monnieri extract (BME) in neurological disorders and memory-related diseases, it is necessary to understand its active phytochemical constituents and their molecular mechanisms. Several clinical studies suggested that BME have neuroprotective effects, making it worth revising a notable herb. Here we investigated the contours of BME's phytochemistry and pharmacological features, focusing on neuronal disorders. We further analyzed the underlying molecular mechanisms in therapeutic intervention. Various clinical concerns and synergistic potential of BME were explored for their effective use in cognition and neuroprotection. The generation of reactive oxygen species increases neuroinflammation and neurotoxicity and is associated with Tau and amyloid-beta (Aβ) aggregation, leading to a neurological disorder. Our findings provide deeper mechanistic insights into the neuroprotective roles of BME, which can be further implicated in the therapeutic management of neurological disorders and exerting cognitive-enhancing effects. Neuroprotection Tau aggregates Bacopa monnieri Alzheimer's disease Reactive Oxygen Species Bacosides Therapeutics. Pharmacology Sonam Roy verfasserin aut Shahnawaz Ahmad verfasserin aut Lamya Ahmed Al-Keridis verfasserin aut Nawaf Alshammari verfasserin aut Mohd Adnan verfasserin aut Asimul Islam verfasserin aut Md. Imtaiyaz Hassan verfasserin aut In Biomedicine & Pharmacotherapy Elsevier, 2021 153(2022), Seite 113469- (DE-627)306717565 (DE-600)1501510-5 19506007 nnns volume:153 year:2022 pages:113469- https://doi.org/10.1016/j.biopha.2022.113469 kostenfrei https://doaj.org/article/d4aea4341d3b4f2d947cce4ecb1b2e83 kostenfrei http://www.sciencedirect.com/science/article/pii/S0753332222008587 kostenfrei https://doaj.org/toc/0753-3322 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_165 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2008 GBV_ILN_2014 GBV_ILN_2025 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2064 GBV_ILN_2106 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 153 2022 113469-
allfieldsGer	10.1016/j.biopha.2022.113469 doi (DE-627)DOAJ085668907 (DE-599)DOAJd4aea4341d3b4f2d947cce4ecb1b2e83 DE-627 ger DE-627 rakwb eng RM1-950 Urooj Fatima verfasserin aut Investigating neuroprotective roles of Bacopa monnieri extracts: Mechanistic insights and therapeutic implications 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Bacopa monnieri (Brahmi) is a well-known perennial, creeping herb of the Indian Ayurveda system; it contains numerous bioactive phytoconstituents implicated in the therapeutic management of several life-threatening diseases. This herb was used by Ancient Vedic scholars due to its pharmacological effect, especially as a nerve tonic and nootropic booster. However, to better understand the roles of Bacopa monnieri extract (BME) in neurological disorders and memory-related diseases, it is necessary to understand its active phytochemical constituents and their molecular mechanisms. Several clinical studies suggested that BME have neuroprotective effects, making it worth revising a notable herb. Here we investigated the contours of BME's phytochemistry and pharmacological features, focusing on neuronal disorders. We further analyzed the underlying molecular mechanisms in therapeutic intervention. Various clinical concerns and synergistic potential of BME were explored for their effective use in cognition and neuroprotection. The generation of reactive oxygen species increases neuroinflammation and neurotoxicity and is associated with Tau and amyloid-beta (Aβ) aggregation, leading to a neurological disorder. Our findings provide deeper mechanistic insights into the neuroprotective roles of BME, which can be further implicated in the therapeutic management of neurological disorders and exerting cognitive-enhancing effects. Neuroprotection Tau aggregates Bacopa monnieri Alzheimer's disease Reactive Oxygen Species Bacosides Therapeutics. Pharmacology Sonam Roy verfasserin aut Shahnawaz Ahmad verfasserin aut Lamya Ahmed Al-Keridis verfasserin aut Nawaf Alshammari verfasserin aut Mohd Adnan verfasserin aut Asimul Islam verfasserin aut Md. Imtaiyaz Hassan verfasserin aut In Biomedicine & Pharmacotherapy Elsevier, 2021 153(2022), Seite 113469- (DE-627)306717565 (DE-600)1501510-5 19506007 nnns volume:153 year:2022 pages:113469- https://doi.org/10.1016/j.biopha.2022.113469 kostenfrei https://doaj.org/article/d4aea4341d3b4f2d947cce4ecb1b2e83 kostenfrei http://www.sciencedirect.com/science/article/pii/S0753332222008587 kostenfrei https://doaj.org/toc/0753-3322 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_165 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2008 GBV_ILN_2014 GBV_ILN_2025 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2064 GBV_ILN_2106 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 153 2022 113469-
allfieldsSound	10.1016/j.biopha.2022.113469 doi (DE-627)DOAJ085668907 (DE-599)DOAJd4aea4341d3b4f2d947cce4ecb1b2e83 DE-627 ger DE-627 rakwb eng RM1-950 Urooj Fatima verfasserin aut Investigating neuroprotective roles of Bacopa monnieri extracts: Mechanistic insights and therapeutic implications 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Bacopa monnieri (Brahmi) is a well-known perennial, creeping herb of the Indian Ayurveda system; it contains numerous bioactive phytoconstituents implicated in the therapeutic management of several life-threatening diseases. This herb was used by Ancient Vedic scholars due to its pharmacological effect, especially as a nerve tonic and nootropic booster. However, to better understand the roles of Bacopa monnieri extract (BME) in neurological disorders and memory-related diseases, it is necessary to understand its active phytochemical constituents and their molecular mechanisms. Several clinical studies suggested that BME have neuroprotective effects, making it worth revising a notable herb. Here we investigated the contours of BME's phytochemistry and pharmacological features, focusing on neuronal disorders. We further analyzed the underlying molecular mechanisms in therapeutic intervention. Various clinical concerns and synergistic potential of BME were explored for their effective use in cognition and neuroprotection. The generation of reactive oxygen species increases neuroinflammation and neurotoxicity and is associated with Tau and amyloid-beta (Aβ) aggregation, leading to a neurological disorder. Our findings provide deeper mechanistic insights into the neuroprotective roles of BME, which can be further implicated in the therapeutic management of neurological disorders and exerting cognitive-enhancing effects. Neuroprotection Tau aggregates Bacopa monnieri Alzheimer's disease Reactive Oxygen Species Bacosides Therapeutics. Pharmacology Sonam Roy verfasserin aut Shahnawaz Ahmad verfasserin aut Lamya Ahmed Al-Keridis verfasserin aut Nawaf Alshammari verfasserin aut Mohd Adnan verfasserin aut Asimul Islam verfasserin aut Md. Imtaiyaz Hassan verfasserin aut In Biomedicine & Pharmacotherapy Elsevier, 2021 153(2022), Seite 113469- (DE-627)306717565 (DE-600)1501510-5 19506007 nnns volume:153 year:2022 pages:113469- https://doi.org/10.1016/j.biopha.2022.113469 kostenfrei https://doaj.org/article/d4aea4341d3b4f2d947cce4ecb1b2e83 kostenfrei http://www.sciencedirect.com/science/article/pii/S0753332222008587 kostenfrei https://doaj.org/toc/0753-3322 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_165 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2008 GBV_ILN_2014 GBV_ILN_2025 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2064 GBV_ILN_2106 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 153 2022 113469-
language	English
source	In Biomedicine & Pharmacotherapy 153(2022), Seite 113469- volume:153 year:2022 pages:113469-
sourceStr	In Biomedicine & Pharmacotherapy 153(2022), Seite 113469- volume:153 year:2022 pages:113469-
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	Neuroprotection Tau aggregates Bacopa monnieri Alzheimer's disease Reactive Oxygen Species Bacosides Therapeutics. Pharmacology
isfreeaccess_bool	true
container_title	Biomedicine & Pharmacotherapy
authorswithroles_txt_mv	Urooj Fatima @@aut@@ Sonam Roy @@aut@@ Shahnawaz Ahmad @@aut@@ Lamya Ahmed Al-Keridis @@aut@@ Nawaf Alshammari @@aut@@ Mohd Adnan @@aut@@ Asimul Islam @@aut@@ Md. Imtaiyaz Hassan @@aut@@
publishDateDaySort_date	2022-01-01T00:00:00Z
hierarchy_top_id	306717565
id	DOAJ085668907
language_de	englisch
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callnumber-first	R - Medicine
author	Urooj Fatima
spellingShingle	Urooj Fatima misc RM1-950 misc Neuroprotection misc Tau aggregates misc Bacopa monnieri misc Alzheimer's disease misc Reactive Oxygen Species misc Bacosides misc Therapeutics. Pharmacology Investigating neuroprotective roles of Bacopa monnieri extracts: Mechanistic insights and therapeutic implications
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topic_title	RM1-950 Investigating neuroprotective roles of Bacopa monnieri extracts: Mechanistic insights and therapeutic implications Neuroprotection Tau aggregates Bacopa monnieri Alzheimer's disease Reactive Oxygen Species Bacosides
topic	misc RM1-950 misc Neuroprotection misc Tau aggregates misc Bacopa monnieri misc Alzheimer's disease misc Reactive Oxygen Species misc Bacosides misc Therapeutics. Pharmacology
topic_unstemmed	misc RM1-950 misc Neuroprotection misc Tau aggregates misc Bacopa monnieri misc Alzheimer's disease misc Reactive Oxygen Species misc Bacosides misc Therapeutics. Pharmacology
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title	Investigating neuroprotective roles of Bacopa monnieri extracts: Mechanistic insights and therapeutic implications
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title_full	Investigating neuroprotective roles of Bacopa monnieri extracts: Mechanistic insights and therapeutic implications
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title_sort	investigating neuroprotective roles of bacopa monnieri extracts: mechanistic insights and therapeutic implications
callnumber	RM1-950
title_auth	Investigating neuroprotective roles of Bacopa monnieri extracts: Mechanistic insights and therapeutic implications
abstract	Bacopa monnieri (Brahmi) is a well-known perennial, creeping herb of the Indian Ayurveda system; it contains numerous bioactive phytoconstituents implicated in the therapeutic management of several life-threatening diseases. This herb was used by Ancient Vedic scholars due to its pharmacological effect, especially as a nerve tonic and nootropic booster. However, to better understand the roles of Bacopa monnieri extract (BME) in neurological disorders and memory-related diseases, it is necessary to understand its active phytochemical constituents and their molecular mechanisms. Several clinical studies suggested that BME have neuroprotective effects, making it worth revising a notable herb. Here we investigated the contours of BME's phytochemistry and pharmacological features, focusing on neuronal disorders. We further analyzed the underlying molecular mechanisms in therapeutic intervention. Various clinical concerns and synergistic potential of BME were explored for their effective use in cognition and neuroprotection. The generation of reactive oxygen species increases neuroinflammation and neurotoxicity and is associated with Tau and amyloid-beta (Aβ) aggregation, leading to a neurological disorder. Our findings provide deeper mechanistic insights into the neuroprotective roles of BME, which can be further implicated in the therapeutic management of neurological disorders and exerting cognitive-enhancing effects.
abstractGer	Bacopa monnieri (Brahmi) is a well-known perennial, creeping herb of the Indian Ayurveda system; it contains numerous bioactive phytoconstituents implicated in the therapeutic management of several life-threatening diseases. This herb was used by Ancient Vedic scholars due to its pharmacological effect, especially as a nerve tonic and nootropic booster. However, to better understand the roles of Bacopa monnieri extract (BME) in neurological disorders and memory-related diseases, it is necessary to understand its active phytochemical constituents and their molecular mechanisms. Several clinical studies suggested that BME have neuroprotective effects, making it worth revising a notable herb. Here we investigated the contours of BME's phytochemistry and pharmacological features, focusing on neuronal disorders. We further analyzed the underlying molecular mechanisms in therapeutic intervention. Various clinical concerns and synergistic potential of BME were explored for their effective use in cognition and neuroprotection. The generation of reactive oxygen species increases neuroinflammation and neurotoxicity and is associated with Tau and amyloid-beta (Aβ) aggregation, leading to a neurological disorder. Our findings provide deeper mechanistic insights into the neuroprotective roles of BME, which can be further implicated in the therapeutic management of neurological disorders and exerting cognitive-enhancing effects.
abstract_unstemmed	Bacopa monnieri (Brahmi) is a well-known perennial, creeping herb of the Indian Ayurveda system; it contains numerous bioactive phytoconstituents implicated in the therapeutic management of several life-threatening diseases. This herb was used by Ancient Vedic scholars due to its pharmacological effect, especially as a nerve tonic and nootropic booster. However, to better understand the roles of Bacopa monnieri extract (BME) in neurological disorders and memory-related diseases, it is necessary to understand its active phytochemical constituents and their molecular mechanisms. Several clinical studies suggested that BME have neuroprotective effects, making it worth revising a notable herb. Here we investigated the contours of BME's phytochemistry and pharmacological features, focusing on neuronal disorders. We further analyzed the underlying molecular mechanisms in therapeutic intervention. Various clinical concerns and synergistic potential of BME were explored for their effective use in cognition and neuroprotection. The generation of reactive oxygen species increases neuroinflammation and neurotoxicity and is associated with Tau and amyloid-beta (Aβ) aggregation, leading to a neurological disorder. Our findings provide deeper mechanistic insights into the neuroprotective roles of BME, which can be further implicated in the therapeutic management of neurological disorders and exerting cognitive-enhancing effects.
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title_short	Investigating neuroprotective roles of Bacopa monnieri extracts: Mechanistic insights and therapeutic implications
url	https://doi.org/10.1016/j.biopha.2022.113469 https://doaj.org/article/d4aea4341d3b4f2d947cce4ecb1b2e83 http://www.sciencedirect.com/science/article/pii/S0753332222008587 https://doaj.org/toc/0753-3322
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