Study protocol of Branch Atheromatous Disease-related stroke (BAD-study): a multicenter prospective cohort study

Abstract Background As a meaningful subtype of ischemic stroke in Asians, Branch atheromatous disease (BAD)-related stroke is associated with high early neurological deterioration (END) and disability, but is understudied and without recommended therapy. The mechanism of END still remains unclear. B...
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Autor*in:	Shengde Li [verfasserIn] Jun Ni [verfasserIn] Xiaoyuan Fan [verfasserIn] Ming Yao [verfasserIn] Feng Feng [verfasserIn] Dongxue Li [verfasserIn] Jianxun Qu [verfasserIn] Yicheng Zhu [verfasserIn] Lixin Zhou [verfasserIn] Bin Peng [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2022

Schlagwörter:	Branch atheromatous disease Stroke Prospective cohort Risk factors Early neurological deterioration High-resolution magnetic resonance imaging

Übergeordnetes Werk:	In: BMC Neurology - BMC, 2003, 22(2022), 1, Seite 9
Übergeordnetes Werk:	volume:22 ; year:2022 ; number:1 ; pages:9

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.1186/s12883-022-02976-9

Katalog-ID:	DOAJ08574221X

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520			\|a Abstract Background As a meaningful subtype of ischemic stroke in Asians, Branch atheromatous disease (BAD)-related stroke is associated with high early neurological deterioration (END) and disability, but is understudied and without recommended therapy. The mechanism of END still remains unclear. Branch atheromatous disease-related stroke study (BAD-study) therefore aims to investigate demographic, clinical and radiological features, and prognosis of BAD-related stroke in Chinese patients. Methods/design BAD-study is a nationwide, multicenter, consecutive, prospective, observational cohort study enrolling patients aged 18–80 years with BAD-related stroke within 72 h after symptom onset. Initial clinical data, laboratory tests, and imaging data are collected via structured case report form, and follow-ups will be performed at 7 days, 30 days, 90 days, 6 months and 12 months after enrollment. The primary outcome is the score on modified Rankin Scale at 90-day follow-up with single-blinded assessment. Secondary outcomes include END within 7 days, and National institute of health stroke scale score, Barthel index, cerebrovascular events, major bleeding complications, and all-cause mortality during 90-day follow-up. Characteristics of penetrating and parent artery will be assessed by high-resolution magnetic resonance imaging combined with other imaging techniques. Discussion BAD-study can provide demographic, clinical, radiological, and prognostic characteristics of BAD-related stroke, and thereby potentially figure out the vascular mechanism of early neurological deterioration and optimize therapy strategy with the aid of advanced imaging technique. Baseline data and evidence will also be generated for randomized controlled trials on BAD-related stroke in the future.
650		4	\|a Branch atheromatous disease
650		4	\|a Stroke
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650		4	\|a Early neurological deterioration
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allfields	10.1186/s12883-022-02976-9 doi (DE-627)DOAJ08574221X (DE-599)DOAJ16c7662a4d654bc9b0528879492a3d66 DE-627 ger DE-627 rakwb eng RC346-429 Shengde Li verfasserin aut Study protocol of Branch Atheromatous Disease-related stroke (BAD-study): a multicenter prospective cohort study 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Background As a meaningful subtype of ischemic stroke in Asians, Branch atheromatous disease (BAD)-related stroke is associated with high early neurological deterioration (END) and disability, but is understudied and without recommended therapy. The mechanism of END still remains unclear. Branch atheromatous disease-related stroke study (BAD-study) therefore aims to investigate demographic, clinical and radiological features, and prognosis of BAD-related stroke in Chinese patients. Methods/design BAD-study is a nationwide, multicenter, consecutive, prospective, observational cohort study enrolling patients aged 18–80 years with BAD-related stroke within 72 h after symptom onset. Initial clinical data, laboratory tests, and imaging data are collected via structured case report form, and follow-ups will be performed at 7 days, 30 days, 90 days, 6 months and 12 months after enrollment. The primary outcome is the score on modified Rankin Scale at 90-day follow-up with single-blinded assessment. Secondary outcomes include END within 7 days, and National institute of health stroke scale score, Barthel index, cerebrovascular events, major bleeding complications, and all-cause mortality during 90-day follow-up. Characteristics of penetrating and parent artery will be assessed by high-resolution magnetic resonance imaging combined with other imaging techniques. Discussion BAD-study can provide demographic, clinical, radiological, and prognostic characteristics of BAD-related stroke, and thereby potentially figure out the vascular mechanism of early neurological deterioration and optimize therapy strategy with the aid of advanced imaging technique. Baseline data and evidence will also be generated for randomized controlled trials on BAD-related stroke in the future. Branch atheromatous disease Stroke Prospective cohort Risk factors Early neurological deterioration High-resolution magnetic resonance imaging Neurology. Diseases of the nervous system Jun Ni verfasserin aut Xiaoyuan Fan verfasserin aut Ming Yao verfasserin aut Feng Feng verfasserin aut Dongxue Li verfasserin aut Jianxun Qu verfasserin aut Yicheng Zhu verfasserin aut Lixin Zhou verfasserin aut Bin Peng verfasserin aut In BMC Neurology BMC, 2003 22(2022), 1, Seite 9 (DE-627)326643664 (DE-600)2041347-6 14712377 nnns volume:22 year:2022 number:1 pages:9 https://doi.org/10.1186/s12883-022-02976-9 kostenfrei https://doaj.org/article/16c7662a4d654bc9b0528879492a3d66 kostenfrei https://doi.org/10.1186/s12883-022-02976-9 kostenfrei https://doaj.org/toc/1471-2377 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 22 2022 1 9
spelling	10.1186/s12883-022-02976-9 doi (DE-627)DOAJ08574221X (DE-599)DOAJ16c7662a4d654bc9b0528879492a3d66 DE-627 ger DE-627 rakwb eng RC346-429 Shengde Li verfasserin aut Study protocol of Branch Atheromatous Disease-related stroke (BAD-study): a multicenter prospective cohort study 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Background As a meaningful subtype of ischemic stroke in Asians, Branch atheromatous disease (BAD)-related stroke is associated with high early neurological deterioration (END) and disability, but is understudied and without recommended therapy. The mechanism of END still remains unclear. Branch atheromatous disease-related stroke study (BAD-study) therefore aims to investigate demographic, clinical and radiological features, and prognosis of BAD-related stroke in Chinese patients. Methods/design BAD-study is a nationwide, multicenter, consecutive, prospective, observational cohort study enrolling patients aged 18–80 years with BAD-related stroke within 72 h after symptom onset. Initial clinical data, laboratory tests, and imaging data are collected via structured case report form, and follow-ups will be performed at 7 days, 30 days, 90 days, 6 months and 12 months after enrollment. The primary outcome is the score on modified Rankin Scale at 90-day follow-up with single-blinded assessment. Secondary outcomes include END within 7 days, and National institute of health stroke scale score, Barthel index, cerebrovascular events, major bleeding complications, and all-cause mortality during 90-day follow-up. Characteristics of penetrating and parent artery will be assessed by high-resolution magnetic resonance imaging combined with other imaging techniques. Discussion BAD-study can provide demographic, clinical, radiological, and prognostic characteristics of BAD-related stroke, and thereby potentially figure out the vascular mechanism of early neurological deterioration and optimize therapy strategy with the aid of advanced imaging technique. Baseline data and evidence will also be generated for randomized controlled trials on BAD-related stroke in the future. Branch atheromatous disease Stroke Prospective cohort Risk factors Early neurological deterioration High-resolution magnetic resonance imaging Neurology. Diseases of the nervous system Jun Ni verfasserin aut Xiaoyuan Fan verfasserin aut Ming Yao verfasserin aut Feng Feng verfasserin aut Dongxue Li verfasserin aut Jianxun Qu verfasserin aut Yicheng Zhu verfasserin aut Lixin Zhou verfasserin aut Bin Peng verfasserin aut In BMC Neurology BMC, 2003 22(2022), 1, Seite 9 (DE-627)326643664 (DE-600)2041347-6 14712377 nnns volume:22 year:2022 number:1 pages:9 https://doi.org/10.1186/s12883-022-02976-9 kostenfrei https://doaj.org/article/16c7662a4d654bc9b0528879492a3d66 kostenfrei https://doi.org/10.1186/s12883-022-02976-9 kostenfrei https://doaj.org/toc/1471-2377 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 22 2022 1 9
allfields_unstemmed	10.1186/s12883-022-02976-9 doi (DE-627)DOAJ08574221X (DE-599)DOAJ16c7662a4d654bc9b0528879492a3d66 DE-627 ger DE-627 rakwb eng RC346-429 Shengde Li verfasserin aut Study protocol of Branch Atheromatous Disease-related stroke (BAD-study): a multicenter prospective cohort study 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Background As a meaningful subtype of ischemic stroke in Asians, Branch atheromatous disease (BAD)-related stroke is associated with high early neurological deterioration (END) and disability, but is understudied and without recommended therapy. The mechanism of END still remains unclear. Branch atheromatous disease-related stroke study (BAD-study) therefore aims to investigate demographic, clinical and radiological features, and prognosis of BAD-related stroke in Chinese patients. Methods/design BAD-study is a nationwide, multicenter, consecutive, prospective, observational cohort study enrolling patients aged 18–80 years with BAD-related stroke within 72 h after symptom onset. Initial clinical data, laboratory tests, and imaging data are collected via structured case report form, and follow-ups will be performed at 7 days, 30 days, 90 days, 6 months and 12 months after enrollment. The primary outcome is the score on modified Rankin Scale at 90-day follow-up with single-blinded assessment. Secondary outcomes include END within 7 days, and National institute of health stroke scale score, Barthel index, cerebrovascular events, major bleeding complications, and all-cause mortality during 90-day follow-up. Characteristics of penetrating and parent artery will be assessed by high-resolution magnetic resonance imaging combined with other imaging techniques. Discussion BAD-study can provide demographic, clinical, radiological, and prognostic characteristics of BAD-related stroke, and thereby potentially figure out the vascular mechanism of early neurological deterioration and optimize therapy strategy with the aid of advanced imaging technique. Baseline data and evidence will also be generated for randomized controlled trials on BAD-related stroke in the future. Branch atheromatous disease Stroke Prospective cohort Risk factors Early neurological deterioration High-resolution magnetic resonance imaging Neurology. Diseases of the nervous system Jun Ni verfasserin aut Xiaoyuan Fan verfasserin aut Ming Yao verfasserin aut Feng Feng verfasserin aut Dongxue Li verfasserin aut Jianxun Qu verfasserin aut Yicheng Zhu verfasserin aut Lixin Zhou verfasserin aut Bin Peng verfasserin aut In BMC Neurology BMC, 2003 22(2022), 1, Seite 9 (DE-627)326643664 (DE-600)2041347-6 14712377 nnns volume:22 year:2022 number:1 pages:9 https://doi.org/10.1186/s12883-022-02976-9 kostenfrei https://doaj.org/article/16c7662a4d654bc9b0528879492a3d66 kostenfrei https://doi.org/10.1186/s12883-022-02976-9 kostenfrei https://doaj.org/toc/1471-2377 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 22 2022 1 9
allfieldsGer	10.1186/s12883-022-02976-9 doi (DE-627)DOAJ08574221X (DE-599)DOAJ16c7662a4d654bc9b0528879492a3d66 DE-627 ger DE-627 rakwb eng RC346-429 Shengde Li verfasserin aut Study protocol of Branch Atheromatous Disease-related stroke (BAD-study): a multicenter prospective cohort study 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Background As a meaningful subtype of ischemic stroke in Asians, Branch atheromatous disease (BAD)-related stroke is associated with high early neurological deterioration (END) and disability, but is understudied and without recommended therapy. The mechanism of END still remains unclear. Branch atheromatous disease-related stroke study (BAD-study) therefore aims to investigate demographic, clinical and radiological features, and prognosis of BAD-related stroke in Chinese patients. Methods/design BAD-study is a nationwide, multicenter, consecutive, prospective, observational cohort study enrolling patients aged 18–80 years with BAD-related stroke within 72 h after symptom onset. Initial clinical data, laboratory tests, and imaging data are collected via structured case report form, and follow-ups will be performed at 7 days, 30 days, 90 days, 6 months and 12 months after enrollment. The primary outcome is the score on modified Rankin Scale at 90-day follow-up with single-blinded assessment. Secondary outcomes include END within 7 days, and National institute of health stroke scale score, Barthel index, cerebrovascular events, major bleeding complications, and all-cause mortality during 90-day follow-up. Characteristics of penetrating and parent artery will be assessed by high-resolution magnetic resonance imaging combined with other imaging techniques. Discussion BAD-study can provide demographic, clinical, radiological, and prognostic characteristics of BAD-related stroke, and thereby potentially figure out the vascular mechanism of early neurological deterioration and optimize therapy strategy with the aid of advanced imaging technique. Baseline data and evidence will also be generated for randomized controlled trials on BAD-related stroke in the future. Branch atheromatous disease Stroke Prospective cohort Risk factors Early neurological deterioration High-resolution magnetic resonance imaging Neurology. Diseases of the nervous system Jun Ni verfasserin aut Xiaoyuan Fan verfasserin aut Ming Yao verfasserin aut Feng Feng verfasserin aut Dongxue Li verfasserin aut Jianxun Qu verfasserin aut Yicheng Zhu verfasserin aut Lixin Zhou verfasserin aut Bin Peng verfasserin aut In BMC Neurology BMC, 2003 22(2022), 1, Seite 9 (DE-627)326643664 (DE-600)2041347-6 14712377 nnns volume:22 year:2022 number:1 pages:9 https://doi.org/10.1186/s12883-022-02976-9 kostenfrei https://doaj.org/article/16c7662a4d654bc9b0528879492a3d66 kostenfrei https://doi.org/10.1186/s12883-022-02976-9 kostenfrei https://doaj.org/toc/1471-2377 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 22 2022 1 9
allfieldsSound	10.1186/s12883-022-02976-9 doi (DE-627)DOAJ08574221X (DE-599)DOAJ16c7662a4d654bc9b0528879492a3d66 DE-627 ger DE-627 rakwb eng RC346-429 Shengde Li verfasserin aut Study protocol of Branch Atheromatous Disease-related stroke (BAD-study): a multicenter prospective cohort study 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Background As a meaningful subtype of ischemic stroke in Asians, Branch atheromatous disease (BAD)-related stroke is associated with high early neurological deterioration (END) and disability, but is understudied and without recommended therapy. The mechanism of END still remains unclear. Branch atheromatous disease-related stroke study (BAD-study) therefore aims to investigate demographic, clinical and radiological features, and prognosis of BAD-related stroke in Chinese patients. Methods/design BAD-study is a nationwide, multicenter, consecutive, prospective, observational cohort study enrolling patients aged 18–80 years with BAD-related stroke within 72 h after symptom onset. Initial clinical data, laboratory tests, and imaging data are collected via structured case report form, and follow-ups will be performed at 7 days, 30 days, 90 days, 6 months and 12 months after enrollment. The primary outcome is the score on modified Rankin Scale at 90-day follow-up with single-blinded assessment. Secondary outcomes include END within 7 days, and National institute of health stroke scale score, Barthel index, cerebrovascular events, major bleeding complications, and all-cause mortality during 90-day follow-up. Characteristics of penetrating and parent artery will be assessed by high-resolution magnetic resonance imaging combined with other imaging techniques. Discussion BAD-study can provide demographic, clinical, radiological, and prognostic characteristics of BAD-related stroke, and thereby potentially figure out the vascular mechanism of early neurological deterioration and optimize therapy strategy with the aid of advanced imaging technique. Baseline data and evidence will also be generated for randomized controlled trials on BAD-related stroke in the future. Branch atheromatous disease Stroke Prospective cohort Risk factors Early neurological deterioration High-resolution magnetic resonance imaging Neurology. Diseases of the nervous system Jun Ni verfasserin aut Xiaoyuan Fan verfasserin aut Ming Yao verfasserin aut Feng Feng verfasserin aut Dongxue Li verfasserin aut Jianxun Qu verfasserin aut Yicheng Zhu verfasserin aut Lixin Zhou verfasserin aut Bin Peng verfasserin aut In BMC Neurology BMC, 2003 22(2022), 1, Seite 9 (DE-627)326643664 (DE-600)2041347-6 14712377 nnns volume:22 year:2022 number:1 pages:9 https://doi.org/10.1186/s12883-022-02976-9 kostenfrei https://doaj.org/article/16c7662a4d654bc9b0528879492a3d66 kostenfrei https://doi.org/10.1186/s12883-022-02976-9 kostenfrei https://doaj.org/toc/1471-2377 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 22 2022 1 9
language	English
source	In BMC Neurology 22(2022), 1, Seite 9 volume:22 year:2022 number:1 pages:9
sourceStr	In BMC Neurology 22(2022), 1, Seite 9 volume:22 year:2022 number:1 pages:9
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	Branch atheromatous disease Stroke Prospective cohort Risk factors Early neurological deterioration High-resolution magnetic resonance imaging Neurology. Diseases of the nervous system
isfreeaccess_bool	true
container_title	BMC Neurology
authorswithroles_txt_mv	Shengde Li @@aut@@ Jun Ni @@aut@@ Xiaoyuan Fan @@aut@@ Ming Yao @@aut@@ Feng Feng @@aut@@ Dongxue Li @@aut@@ Jianxun Qu @@aut@@ Yicheng Zhu @@aut@@ Lixin Zhou @@aut@@ Bin Peng @@aut@@
publishDateDaySort_date	2022-01-01T00:00:00Z
hierarchy_top_id	326643664
id	DOAJ08574221X
language_de	englisch
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The mechanism of END still remains unclear. Branch atheromatous disease-related stroke study (BAD-study) therefore aims to investigate demographic, clinical and radiological features, and prognosis of BAD-related stroke in Chinese patients. Methods/design BAD-study is a nationwide, multicenter, consecutive, prospective, observational cohort study enrolling patients aged 18–80 years with BAD-related stroke within 72 h after symptom onset. Initial clinical data, laboratory tests, and imaging data are collected via structured case report form, and follow-ups will be performed at 7 days, 30 days, 90 days, 6 months and 12 months after enrollment. The primary outcome is the score on modified Rankin Scale at 90-day follow-up with single-blinded assessment. Secondary outcomes include END within 7 days, and National institute of health stroke scale score, Barthel index, cerebrovascular events, major bleeding complications, and all-cause mortality during 90-day follow-up. 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callnumber-first	R - Medicine
author	Shengde Li
spellingShingle	Shengde Li misc RC346-429 misc Branch atheromatous disease misc Stroke misc Prospective cohort misc Risk factors misc Early neurological deterioration misc High-resolution magnetic resonance imaging misc Neurology. Diseases of the nervous system Study protocol of Branch Atheromatous Disease-related stroke (BAD-study): a multicenter prospective cohort study
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topic_title	RC346-429 Study protocol of Branch Atheromatous Disease-related stroke (BAD-study): a multicenter prospective cohort study Branch atheromatous disease Stroke Prospective cohort Risk factors Early neurological deterioration High-resolution magnetic resonance imaging
topic	misc RC346-429 misc Branch atheromatous disease misc Stroke misc Prospective cohort misc Risk factors misc Early neurological deterioration misc High-resolution magnetic resonance imaging misc Neurology. Diseases of the nervous system
topic_unstemmed	misc RC346-429 misc Branch atheromatous disease misc Stroke misc Prospective cohort misc Risk factors misc Early neurological deterioration misc High-resolution magnetic resonance imaging misc Neurology. Diseases of the nervous system
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title	Study protocol of Branch Atheromatous Disease-related stroke (BAD-study): a multicenter prospective cohort study
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title_full	Study protocol of Branch Atheromatous Disease-related stroke (BAD-study): a multicenter prospective cohort study
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author_browse	Shengde Li Jun Ni Xiaoyuan Fan Ming Yao Feng Feng Dongxue Li Jianxun Qu Yicheng Zhu Lixin Zhou Bin Peng
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title_sort	study protocol of branch atheromatous disease-related stroke (bad-study): a multicenter prospective cohort study
callnumber	RC346-429
title_auth	Study protocol of Branch Atheromatous Disease-related stroke (BAD-study): a multicenter prospective cohort study
abstract	Abstract Background As a meaningful subtype of ischemic stroke in Asians, Branch atheromatous disease (BAD)-related stroke is associated with high early neurological deterioration (END) and disability, but is understudied and without recommended therapy. The mechanism of END still remains unclear. Branch atheromatous disease-related stroke study (BAD-study) therefore aims to investigate demographic, clinical and radiological features, and prognosis of BAD-related stroke in Chinese patients. Methods/design BAD-study is a nationwide, multicenter, consecutive, prospective, observational cohort study enrolling patients aged 18–80 years with BAD-related stroke within 72 h after symptom onset. Initial clinical data, laboratory tests, and imaging data are collected via structured case report form, and follow-ups will be performed at 7 days, 30 days, 90 days, 6 months and 12 months after enrollment. The primary outcome is the score on modified Rankin Scale at 90-day follow-up with single-blinded assessment. Secondary outcomes include END within 7 days, and National institute of health stroke scale score, Barthel index, cerebrovascular events, major bleeding complications, and all-cause mortality during 90-day follow-up. Characteristics of penetrating and parent artery will be assessed by high-resolution magnetic resonance imaging combined with other imaging techniques. Discussion BAD-study can provide demographic, clinical, radiological, and prognostic characteristics of BAD-related stroke, and thereby potentially figure out the vascular mechanism of early neurological deterioration and optimize therapy strategy with the aid of advanced imaging technique. Baseline data and evidence will also be generated for randomized controlled trials on BAD-related stroke in the future.
abstractGer	Abstract Background As a meaningful subtype of ischemic stroke in Asians, Branch atheromatous disease (BAD)-related stroke is associated with high early neurological deterioration (END) and disability, but is understudied and without recommended therapy. The mechanism of END still remains unclear. Branch atheromatous disease-related stroke study (BAD-study) therefore aims to investigate demographic, clinical and radiological features, and prognosis of BAD-related stroke in Chinese patients. Methods/design BAD-study is a nationwide, multicenter, consecutive, prospective, observational cohort study enrolling patients aged 18–80 years with BAD-related stroke within 72 h after symptom onset. Initial clinical data, laboratory tests, and imaging data are collected via structured case report form, and follow-ups will be performed at 7 days, 30 days, 90 days, 6 months and 12 months after enrollment. The primary outcome is the score on modified Rankin Scale at 90-day follow-up with single-blinded assessment. Secondary outcomes include END within 7 days, and National institute of health stroke scale score, Barthel index, cerebrovascular events, major bleeding complications, and all-cause mortality during 90-day follow-up. Characteristics of penetrating and parent artery will be assessed by high-resolution magnetic resonance imaging combined with other imaging techniques. Discussion BAD-study can provide demographic, clinical, radiological, and prognostic characteristics of BAD-related stroke, and thereby potentially figure out the vascular mechanism of early neurological deterioration and optimize therapy strategy with the aid of advanced imaging technique. Baseline data and evidence will also be generated for randomized controlled trials on BAD-related stroke in the future.
abstract_unstemmed	Abstract Background As a meaningful subtype of ischemic stroke in Asians, Branch atheromatous disease (BAD)-related stroke is associated with high early neurological deterioration (END) and disability, but is understudied and without recommended therapy. The mechanism of END still remains unclear. Branch atheromatous disease-related stroke study (BAD-study) therefore aims to investigate demographic, clinical and radiological features, and prognosis of BAD-related stroke in Chinese patients. Methods/design BAD-study is a nationwide, multicenter, consecutive, prospective, observational cohort study enrolling patients aged 18–80 years with BAD-related stroke within 72 h after symptom onset. Initial clinical data, laboratory tests, and imaging data are collected via structured case report form, and follow-ups will be performed at 7 days, 30 days, 90 days, 6 months and 12 months after enrollment. The primary outcome is the score on modified Rankin Scale at 90-day follow-up with single-blinded assessment. Secondary outcomes include END within 7 days, and National institute of health stroke scale score, Barthel index, cerebrovascular events, major bleeding complications, and all-cause mortality during 90-day follow-up. Characteristics of penetrating and parent artery will be assessed by high-resolution magnetic resonance imaging combined with other imaging techniques. Discussion BAD-study can provide demographic, clinical, radiological, and prognostic characteristics of BAD-related stroke, and thereby potentially figure out the vascular mechanism of early neurological deterioration and optimize therapy strategy with the aid of advanced imaging technique. Baseline data and evidence will also be generated for randomized controlled trials on BAD-related stroke in the future.
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title_short	Study protocol of Branch Atheromatous Disease-related stroke (BAD-study): a multicenter prospective cohort study
url	https://doi.org/10.1186/s12883-022-02976-9 https://doaj.org/article/16c7662a4d654bc9b0528879492a3d66 https://doaj.org/toc/1471-2377
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