THE STUDY OF LYMPHOCYTE APOPTOSIS INDUCED BY VIBRIO CHOLERAE ANTIGENS IN THE FORMATION OF IMMUNODEFICIENCY AND THE POSSIBILITY OF ITS CORRECTION

Purpose: To study the role of lymphocyte apoptosis induced by Vibrio cholerae microbial cells and cholera toxin in the formation of the postvaccinal apoptotic immunodeficiency, as well as the possibility of its correction with the use of immunomodulator imunofan.Materials and methods: The apoptosis...
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Autor*in:	I. A. Ivanova [verfasserIn] N. D. Omelchenko [verfasserIn] N. R. Telesmanich [verfasserIn] G. I. Vasilyeva [verfasserIn] Ye. P. Doroshenko [verfasserIn] I. A. Bespalova [verfasserIn] A. K. Kiselyova [verfasserIn] A. V. Filippenko [verfasserIn] L. V. Sudyina [verfasserIn] B. N. Mishankin [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch ; Russisch

Erschienen:	2013

Schlagwörter:	vibrio cholerae antigens lymphocytes apoptosis immunodeficiency imunophan immunomodulator

Übergeordnetes Werk:	In: Медицинский вестник Юга России - State Budget Educational Institute of Higher Professional Education, Rostov State Medical University, Ministry Health of Russian Federation, 2022, (2013), 1, Seite 24-27
Übergeordnetes Werk:	year:2013 ; number:1 ; pages:24-27

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc Journal toc

DOI / URN:	10.21886/2219-8075-2013-1-24-27

Katalog-ID:	DOAJ085756261

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allfields	10.21886/2219-8075-2013-1-24-27 doi (DE-627)DOAJ085756261 (DE-599)DOAJf62416aebfbf418a85e0c2f1dc2030dd DE-627 ger DE-627 rakwb eng rus R5-920 I. A. Ivanova verfasserin aut THE STUDY OF LYMPHOCYTE APOPTOSIS INDUCED BY VIBRIO CHOLERAE ANTIGENS IN THE FORMATION OF IMMUNODEFICIENCY AND THE POSSIBILITY OF ITS CORRECTION 2013 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Purpose: To study the role of lymphocyte apoptosis induced by Vibrio cholerae microbial cells and cholera toxin in the formation of the postvaccinal apoptotic immunodeficiency, as well as the possibility of its correction with the use of immunomodulator imunofan.Materials and methods: The apoptosis has been evaluated on the base of characteristic morphological changes of cells in preparations stained by histological stains, as well as by the method of flow cytofluorometry with propidium iodide staining on the cytofluorometer “NaviosТМ”.Results: It has been found that the etiological agent of cholera and its cholera toxin possess the apoptogenic activity towards murine T-lymphocytes. It has been shown that CD4+ T-cells are preferentially involved in the apoptosis. The role of scheduled cell death of immunocompetent cells in the formation of postvaccinal immunodeficiency in case of cholera is demonstrated. The preparation for immunocorrection of these changes is proposed.Summary: These findings confirm the usefulness of immunomodulator imunofan in vaccination against cholera and also open new perspectives for the improvement of cholera infection prophylaxis. vibrio cholerae antigens lymphocytes apoptosis immunodeficiency imunophan immunomodulator Medicine (General) N. D. Omelchenko verfasserin aut N. R. Telesmanich verfasserin aut G. I. Vasilyeva verfasserin aut Ye. P. Doroshenko verfasserin aut I. A. Bespalova verfasserin aut A. K. Kiselyova verfasserin aut A. V. Filippenko verfasserin aut L. V. Sudyina verfasserin aut B. N. Mishankin verfasserin aut In Медицинский вестник Юга России State Budget Educational Institute of Higher Professional Education, Rostov State Medical University, Ministry Health of Russian Federation, 2022 (2013), 1, Seite 24-27 (DE-627)DOAJ000152226 26187876 nnns year:2013 number:1 pages:24-27 https://doi.org/10.21886/2219-8075-2013-1-24-27 kostenfrei https://doaj.org/article/f62416aebfbf418a85e0c2f1dc2030dd kostenfrei https://www.medicalherald.ru/jour/article/view/62 kostenfrei https://doaj.org/toc/2219-8075 Journal toc kostenfrei https://doaj.org/toc/2618-7876 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ AR 2013 1 24-27
spelling	10.21886/2219-8075-2013-1-24-27 doi (DE-627)DOAJ085756261 (DE-599)DOAJf62416aebfbf418a85e0c2f1dc2030dd DE-627 ger DE-627 rakwb eng rus R5-920 I. A. Ivanova verfasserin aut THE STUDY OF LYMPHOCYTE APOPTOSIS INDUCED BY VIBRIO CHOLERAE ANTIGENS IN THE FORMATION OF IMMUNODEFICIENCY AND THE POSSIBILITY OF ITS CORRECTION 2013 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Purpose: To study the role of lymphocyte apoptosis induced by Vibrio cholerae microbial cells and cholera toxin in the formation of the postvaccinal apoptotic immunodeficiency, as well as the possibility of its correction with the use of immunomodulator imunofan.Materials and methods: The apoptosis has been evaluated on the base of characteristic morphological changes of cells in preparations stained by histological stains, as well as by the method of flow cytofluorometry with propidium iodide staining on the cytofluorometer “NaviosТМ”.Results: It has been found that the etiological agent of cholera and its cholera toxin possess the apoptogenic activity towards murine T-lymphocytes. It has been shown that CD4+ T-cells are preferentially involved in the apoptosis. The role of scheduled cell death of immunocompetent cells in the formation of postvaccinal immunodeficiency in case of cholera is demonstrated. The preparation for immunocorrection of these changes is proposed.Summary: These findings confirm the usefulness of immunomodulator imunofan in vaccination against cholera and also open new perspectives for the improvement of cholera infection prophylaxis. vibrio cholerae antigens lymphocytes apoptosis immunodeficiency imunophan immunomodulator Medicine (General) N. D. Omelchenko verfasserin aut N. R. Telesmanich verfasserin aut G. I. Vasilyeva verfasserin aut Ye. P. Doroshenko verfasserin aut I. A. Bespalova verfasserin aut A. K. Kiselyova verfasserin aut A. V. Filippenko verfasserin aut L. V. Sudyina verfasserin aut B. N. Mishankin verfasserin aut In Медицинский вестник Юга России State Budget Educational Institute of Higher Professional Education, Rostov State Medical University, Ministry Health of Russian Federation, 2022 (2013), 1, Seite 24-27 (DE-627)DOAJ000152226 26187876 nnns year:2013 number:1 pages:24-27 https://doi.org/10.21886/2219-8075-2013-1-24-27 kostenfrei https://doaj.org/article/f62416aebfbf418a85e0c2f1dc2030dd kostenfrei https://www.medicalherald.ru/jour/article/view/62 kostenfrei https://doaj.org/toc/2219-8075 Journal toc kostenfrei https://doaj.org/toc/2618-7876 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ AR 2013 1 24-27
allfields_unstemmed	10.21886/2219-8075-2013-1-24-27 doi (DE-627)DOAJ085756261 (DE-599)DOAJf62416aebfbf418a85e0c2f1dc2030dd DE-627 ger DE-627 rakwb eng rus R5-920 I. A. Ivanova verfasserin aut THE STUDY OF LYMPHOCYTE APOPTOSIS INDUCED BY VIBRIO CHOLERAE ANTIGENS IN THE FORMATION OF IMMUNODEFICIENCY AND THE POSSIBILITY OF ITS CORRECTION 2013 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Purpose: To study the role of lymphocyte apoptosis induced by Vibrio cholerae microbial cells and cholera toxin in the formation of the postvaccinal apoptotic immunodeficiency, as well as the possibility of its correction with the use of immunomodulator imunofan.Materials and methods: The apoptosis has been evaluated on the base of characteristic morphological changes of cells in preparations stained by histological stains, as well as by the method of flow cytofluorometry with propidium iodide staining on the cytofluorometer “NaviosТМ”.Results: It has been found that the etiological agent of cholera and its cholera toxin possess the apoptogenic activity towards murine T-lymphocytes. It has been shown that CD4+ T-cells are preferentially involved in the apoptosis. The role of scheduled cell death of immunocompetent cells in the formation of postvaccinal immunodeficiency in case of cholera is demonstrated. The preparation for immunocorrection of these changes is proposed.Summary: These findings confirm the usefulness of immunomodulator imunofan in vaccination against cholera and also open new perspectives for the improvement of cholera infection prophylaxis. vibrio cholerae antigens lymphocytes apoptosis immunodeficiency imunophan immunomodulator Medicine (General) N. D. Omelchenko verfasserin aut N. R. Telesmanich verfasserin aut G. I. Vasilyeva verfasserin aut Ye. P. Doroshenko verfasserin aut I. A. Bespalova verfasserin aut A. K. Kiselyova verfasserin aut A. V. Filippenko verfasserin aut L. V. Sudyina verfasserin aut B. N. Mishankin verfasserin aut In Медицинский вестник Юга России State Budget Educational Institute of Higher Professional Education, Rostov State Medical University, Ministry Health of Russian Federation, 2022 (2013), 1, Seite 24-27 (DE-627)DOAJ000152226 26187876 nnns year:2013 number:1 pages:24-27 https://doi.org/10.21886/2219-8075-2013-1-24-27 kostenfrei https://doaj.org/article/f62416aebfbf418a85e0c2f1dc2030dd kostenfrei https://www.medicalherald.ru/jour/article/view/62 kostenfrei https://doaj.org/toc/2219-8075 Journal toc kostenfrei https://doaj.org/toc/2618-7876 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ AR 2013 1 24-27
allfieldsGer	10.21886/2219-8075-2013-1-24-27 doi (DE-627)DOAJ085756261 (DE-599)DOAJf62416aebfbf418a85e0c2f1dc2030dd DE-627 ger DE-627 rakwb eng rus R5-920 I. A. Ivanova verfasserin aut THE STUDY OF LYMPHOCYTE APOPTOSIS INDUCED BY VIBRIO CHOLERAE ANTIGENS IN THE FORMATION OF IMMUNODEFICIENCY AND THE POSSIBILITY OF ITS CORRECTION 2013 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Purpose: To study the role of lymphocyte apoptosis induced by Vibrio cholerae microbial cells and cholera toxin in the formation of the postvaccinal apoptotic immunodeficiency, as well as the possibility of its correction with the use of immunomodulator imunofan.Materials and methods: The apoptosis has been evaluated on the base of characteristic morphological changes of cells in preparations stained by histological stains, as well as by the method of flow cytofluorometry with propidium iodide staining on the cytofluorometer “NaviosТМ”.Results: It has been found that the etiological agent of cholera and its cholera toxin possess the apoptogenic activity towards murine T-lymphocytes. It has been shown that CD4+ T-cells are preferentially involved in the apoptosis. The role of scheduled cell death of immunocompetent cells in the formation of postvaccinal immunodeficiency in case of cholera is demonstrated. The preparation for immunocorrection of these changes is proposed.Summary: These findings confirm the usefulness of immunomodulator imunofan in vaccination against cholera and also open new perspectives for the improvement of cholera infection prophylaxis. vibrio cholerae antigens lymphocytes apoptosis immunodeficiency imunophan immunomodulator Medicine (General) N. D. Omelchenko verfasserin aut N. R. Telesmanich verfasserin aut G. I. Vasilyeva verfasserin aut Ye. P. Doroshenko verfasserin aut I. A. Bespalova verfasserin aut A. K. Kiselyova verfasserin aut A. V. Filippenko verfasserin aut L. V. Sudyina verfasserin aut B. N. Mishankin verfasserin aut In Медицинский вестник Юга России State Budget Educational Institute of Higher Professional Education, Rostov State Medical University, Ministry Health of Russian Federation, 2022 (2013), 1, Seite 24-27 (DE-627)DOAJ000152226 26187876 nnns year:2013 number:1 pages:24-27 https://doi.org/10.21886/2219-8075-2013-1-24-27 kostenfrei https://doaj.org/article/f62416aebfbf418a85e0c2f1dc2030dd kostenfrei https://www.medicalherald.ru/jour/article/view/62 kostenfrei https://doaj.org/toc/2219-8075 Journal toc kostenfrei https://doaj.org/toc/2618-7876 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ AR 2013 1 24-27
allfieldsSound	10.21886/2219-8075-2013-1-24-27 doi (DE-627)DOAJ085756261 (DE-599)DOAJf62416aebfbf418a85e0c2f1dc2030dd DE-627 ger DE-627 rakwb eng rus R5-920 I. A. Ivanova verfasserin aut THE STUDY OF LYMPHOCYTE APOPTOSIS INDUCED BY VIBRIO CHOLERAE ANTIGENS IN THE FORMATION OF IMMUNODEFICIENCY AND THE POSSIBILITY OF ITS CORRECTION 2013 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Purpose: To study the role of lymphocyte apoptosis induced by Vibrio cholerae microbial cells and cholera toxin in the formation of the postvaccinal apoptotic immunodeficiency, as well as the possibility of its correction with the use of immunomodulator imunofan.Materials and methods: The apoptosis has been evaluated on the base of characteristic morphological changes of cells in preparations stained by histological stains, as well as by the method of flow cytofluorometry with propidium iodide staining on the cytofluorometer “NaviosТМ”.Results: It has been found that the etiological agent of cholera and its cholera toxin possess the apoptogenic activity towards murine T-lymphocytes. It has been shown that CD4+ T-cells are preferentially involved in the apoptosis. The role of scheduled cell death of immunocompetent cells in the formation of postvaccinal immunodeficiency in case of cholera is demonstrated. The preparation for immunocorrection of these changes is proposed.Summary: These findings confirm the usefulness of immunomodulator imunofan in vaccination against cholera and also open new perspectives for the improvement of cholera infection prophylaxis. vibrio cholerae antigens lymphocytes apoptosis immunodeficiency imunophan immunomodulator Medicine (General) N. D. Omelchenko verfasserin aut N. R. Telesmanich verfasserin aut G. I. Vasilyeva verfasserin aut Ye. P. Doroshenko verfasserin aut I. A. Bespalova verfasserin aut A. K. Kiselyova verfasserin aut A. V. Filippenko verfasserin aut L. V. Sudyina verfasserin aut B. N. Mishankin verfasserin aut In Медицинский вестник Юга России State Budget Educational Institute of Higher Professional Education, Rostov State Medical University, Ministry Health of Russian Federation, 2022 (2013), 1, Seite 24-27 (DE-627)DOAJ000152226 26187876 nnns year:2013 number:1 pages:24-27 https://doi.org/10.21886/2219-8075-2013-1-24-27 kostenfrei https://doaj.org/article/f62416aebfbf418a85e0c2f1dc2030dd kostenfrei https://www.medicalherald.ru/jour/article/view/62 kostenfrei https://doaj.org/toc/2219-8075 Journal toc kostenfrei https://doaj.org/toc/2618-7876 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ AR 2013 1 24-27
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authorswithroles_txt_mv	I. A. Ivanova @@aut@@ N. D. Omelchenko @@aut@@ N. R. Telesmanich @@aut@@ G. I. Vasilyeva @@aut@@ Ye. P. Doroshenko @@aut@@ I. A. Bespalova @@aut@@ A. K. Kiselyova @@aut@@ A. V. Filippenko @@aut@@ L. V. Sudyina @@aut@@ B. N. Mishankin @@aut@@
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callnumber-first	R - Medicine
author	I. A. Ivanova
spellingShingle	I. A. Ivanova misc R5-920 misc vibrio cholerae antigens misc lymphocytes misc apoptosis misc immunodeficiency misc imunophan immunomodulator misc Medicine (General) THE STUDY OF LYMPHOCYTE APOPTOSIS INDUCED BY VIBRIO CHOLERAE ANTIGENS IN THE FORMATION OF IMMUNODEFICIENCY AND THE POSSIBILITY OF ITS CORRECTION
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topic_title	R5-920 THE STUDY OF LYMPHOCYTE APOPTOSIS INDUCED BY VIBRIO CHOLERAE ANTIGENS IN THE FORMATION OF IMMUNODEFICIENCY AND THE POSSIBILITY OF ITS CORRECTION vibrio cholerae antigens lymphocytes apoptosis immunodeficiency imunophan immunomodulator
topic	misc R5-920 misc vibrio cholerae antigens misc lymphocytes misc apoptosis misc immunodeficiency misc imunophan immunomodulator misc Medicine (General)
topic_unstemmed	misc R5-920 misc vibrio cholerae antigens misc lymphocytes misc apoptosis misc immunodeficiency misc imunophan immunomodulator misc Medicine (General)
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title	THE STUDY OF LYMPHOCYTE APOPTOSIS INDUCED BY VIBRIO CHOLERAE ANTIGENS IN THE FORMATION OF IMMUNODEFICIENCY AND THE POSSIBILITY OF ITS CORRECTION
ctrlnum	(DE-627)DOAJ085756261 (DE-599)DOAJf62416aebfbf418a85e0c2f1dc2030dd
title_full	THE STUDY OF LYMPHOCYTE APOPTOSIS INDUCED BY VIBRIO CHOLERAE ANTIGENS IN THE FORMATION OF IMMUNODEFICIENCY AND THE POSSIBILITY OF ITS CORRECTION
author_sort	I. A. Ivanova
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author_browse	I. A. Ivanova N. D. Omelchenko N. R. Telesmanich G. I. Vasilyeva Ye. P. Doroshenko I. A. Bespalova A. K. Kiselyova A. V. Filippenko L. V. Sudyina B. N. Mishankin
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title_sort	study of lymphocyte apoptosis induced by vibrio cholerae antigens in the formation of immunodeficiency and the possibility of its correction
callnumber	R5-920
title_auth	THE STUDY OF LYMPHOCYTE APOPTOSIS INDUCED BY VIBRIO CHOLERAE ANTIGENS IN THE FORMATION OF IMMUNODEFICIENCY AND THE POSSIBILITY OF ITS CORRECTION
abstract	Purpose: To study the role of lymphocyte apoptosis induced by Vibrio cholerae microbial cells and cholera toxin in the formation of the postvaccinal apoptotic immunodeficiency, as well as the possibility of its correction with the use of immunomodulator imunofan.Materials and methods: The apoptosis has been evaluated on the base of characteristic morphological changes of cells in preparations stained by histological stains, as well as by the method of flow cytofluorometry with propidium iodide staining on the cytofluorometer “NaviosТМ”.Results: It has been found that the etiological agent of cholera and its cholera toxin possess the apoptogenic activity towards murine T-lymphocytes. It has been shown that CD4+ T-cells are preferentially involved in the apoptosis. The role of scheduled cell death of immunocompetent cells in the formation of postvaccinal immunodeficiency in case of cholera is demonstrated. The preparation for immunocorrection of these changes is proposed.Summary: These findings confirm the usefulness of immunomodulator imunofan in vaccination against cholera and also open new perspectives for the improvement of cholera infection prophylaxis.
abstractGer	Purpose: To study the role of lymphocyte apoptosis induced by Vibrio cholerae microbial cells and cholera toxin in the formation of the postvaccinal apoptotic immunodeficiency, as well as the possibility of its correction with the use of immunomodulator imunofan.Materials and methods: The apoptosis has been evaluated on the base of characteristic morphological changes of cells in preparations stained by histological stains, as well as by the method of flow cytofluorometry with propidium iodide staining on the cytofluorometer “NaviosТМ”.Results: It has been found that the etiological agent of cholera and its cholera toxin possess the apoptogenic activity towards murine T-lymphocytes. It has been shown that CD4+ T-cells are preferentially involved in the apoptosis. The role of scheduled cell death of immunocompetent cells in the formation of postvaccinal immunodeficiency in case of cholera is demonstrated. The preparation for immunocorrection of these changes is proposed.Summary: These findings confirm the usefulness of immunomodulator imunofan in vaccination against cholera and also open new perspectives for the improvement of cholera infection prophylaxis.
abstract_unstemmed	Purpose: To study the role of lymphocyte apoptosis induced by Vibrio cholerae microbial cells and cholera toxin in the formation of the postvaccinal apoptotic immunodeficiency, as well as the possibility of its correction with the use of immunomodulator imunofan.Materials and methods: The apoptosis has been evaluated on the base of characteristic morphological changes of cells in preparations stained by histological stains, as well as by the method of flow cytofluorometry with propidium iodide staining on the cytofluorometer “NaviosТМ”.Results: It has been found that the etiological agent of cholera and its cholera toxin possess the apoptogenic activity towards murine T-lymphocytes. It has been shown that CD4+ T-cells are preferentially involved in the apoptosis. The role of scheduled cell death of immunocompetent cells in the formation of postvaccinal immunodeficiency in case of cholera is demonstrated. The preparation for immunocorrection of these changes is proposed.Summary: These findings confirm the usefulness of immunomodulator imunofan in vaccination against cholera and also open new perspectives for the improvement of cholera infection prophylaxis.
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title_short	THE STUDY OF LYMPHOCYTE APOPTOSIS INDUCED BY VIBRIO CHOLERAE ANTIGENS IN THE FORMATION OF IMMUNODEFICIENCY AND THE POSSIBILITY OF ITS CORRECTION
url	https://doi.org/10.21886/2219-8075-2013-1-24-27 https://doaj.org/article/f62416aebfbf418a85e0c2f1dc2030dd https://www.medicalherald.ru/jour/article/view/62 https://doaj.org/toc/2219-8075 https://doaj.org/toc/2618-7876
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