Association between age at diabetes onset or diabetes duration and subsequent risk of pancreatic cancer: Results from a longitudinal cohort and mendelian randomization study
Summary: Background: The aim of the study is to estimate the incidence of pancreatic cancer among individuals with new-onset type 2 Diabetes (T2DM) and evaluate the relationship of pancreatic cancer risk with age at diabetes onset and diabetes duration. Methods: This longitudinal cohort study inclu...
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| Autor*in: |
Baiyong Shen [verfasserIn] Yanyun Li [verfasserIn] Chang-Sheng Sheng [verfasserIn] Lili Liu [verfasserIn] Tianzhichao Hou [verfasserIn] Nan Xia [verfasserIn] Siming Sun [verfasserIn] Ya Miao [verfasserIn] Yi Pang [verfasserIn] Kai Gu [verfasserIn] Xiongxiong Lu [verfasserIn] Chenlei Wen [verfasserIn] Yi Cheng [verfasserIn] Yulin Yang [verfasserIn] Dan Wang [verfasserIn] Yijie Zhu [verfasserIn] Minna Cheng [verfasserIn] Katie Harris [verfasserIn] Zachary T. Bloomgarden [verfasserIn] Jingyan Tian [verfasserIn] John Chalmers [verfasserIn] Yan Shi [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2023 |
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| Schlagwörter: |
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| Übergeordnetes Werk: |
In: The Lancet Regional Health. Western Pacific - Elsevier, 2021, 30(2023), Seite 100596- |
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| Übergeordnetes Werk: |
volume:30 ; year:2023 ; pages:100596- |
| Links: |
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| DOI / URN: |
10.1016/j.lanwpc.2022.100596 |
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| Katalog-ID: |
DOAJ085769932 |
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| 520 | |a Summary: Background: The aim of the study is to estimate the incidence of pancreatic cancer among individuals with new-onset type 2 Diabetes (T2DM) and evaluate the relationship of pancreatic cancer risk with age at diabetes onset and diabetes duration. Methods: This longitudinal cohort study included 428,362 new-onset T2DM patients in Shanghai and Mendelian randomization (MR) in the east-Asian population were used to investigate the association. Incidence rates of pancreatic cancer in all patients and by subgroups were calculated and compared to the general population. Findings: A total of 1056 incident pancreatic cancer cases were identified during eight consecutive years of follow-up. The overall pancreatic cancer annual incidence rate was 55·28/100,000 person years in T2DM patients, higher than that in the general population, with a standardized incidence ratio (SIR) of 1·54 (95% confidence interval [CI], 1·45–1·64). The incidence of pancreatic cancer increased with age and a significantly higher incidence was observed in the older groups with T2DM. However, the relative pancreatic cancer risk was inversely related to age of T2DM onset, and a higher SIR of 5·73 (95%CI, 4·49–7·22) was observed in the 20–54 years old group. The risk of pancreatic cancer was elevated at any diabetes duration. Fasting blood glucose ≥10·0 mmol/L was associated with increased risk of pancreatic cancer. MR analysis indicated a positive association between T2DM and pancreatic cancer risk. Interpretation: Efforts toward early and close follow-up programs, especially in individuals with young-onset T2DM, and the improvement of glucose control might represent effective strategies for improving the detection and results of treatment of pancreatic cancer. Funding: Chinese National Natural Science Foundation. | ||
| 650 | 4 | |a Type 2 diabetes mellitus | |
| 650 | 4 | |a Pancreatic cancer | |
| 650 | 4 | |a Onset age | |
| 650 | 4 | |a Diabetes duration | |
| 650 | 4 | |a Mendelian randomization | |
| 653 | 0 | |a Public aspects of medicine | |
| 700 | 0 | |a Yanyun Li |e verfasserin |4 aut | |
| 700 | 0 | |a Chang-Sheng Sheng |e verfasserin |4 aut | |
| 700 | 0 | |a Lili Liu |e verfasserin |4 aut | |
| 700 | 0 | |a Tianzhichao Hou |e verfasserin |4 aut | |
| 700 | 0 | |a Nan Xia |e verfasserin |4 aut | |
| 700 | 0 | |a Siming Sun |e verfasserin |4 aut | |
| 700 | 0 | |a Ya Miao |e verfasserin |4 aut | |
| 700 | 0 | |a Yi Pang |e verfasserin |4 aut | |
| 700 | 0 | |a Kai Gu |e verfasserin |4 aut | |
| 700 | 0 | |a Xiongxiong Lu |e verfasserin |4 aut | |
| 700 | 0 | |a Chenlei Wen |e verfasserin |4 aut | |
| 700 | 0 | |a Yi Cheng |e verfasserin |4 aut | |
| 700 | 0 | |a Yulin Yang |e verfasserin |4 aut | |
| 700 | 0 | |a Dan Wang |e verfasserin |4 aut | |
| 700 | 0 | |a Yijie Zhu |e verfasserin |4 aut | |
| 700 | 0 | |a Minna Cheng |e verfasserin |4 aut | |
| 700 | 0 | |a Katie Harris |e verfasserin |4 aut | |
| 700 | 0 | |a Zachary T. Bloomgarden |e verfasserin |4 aut | |
| 700 | 0 | |a Jingyan Tian |e verfasserin |4 aut | |
| 700 | 0 | |a John Chalmers |e verfasserin |4 aut | |
| 700 | 0 | |a Yan Shi |e verfasserin |4 aut | |
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10.1016/j.lanwpc.2022.100596 doi (DE-627)DOAJ085769932 (DE-599)DOAJ8db08795b5bd46b9b91deb7bf6481b5e DE-627 ger DE-627 rakwb eng RA1-1270 Baiyong Shen verfasserin aut Association between age at diabetes onset or diabetes duration and subsequent risk of pancreatic cancer: Results from a longitudinal cohort and mendelian randomization study 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Summary: Background: The aim of the study is to estimate the incidence of pancreatic cancer among individuals with new-onset type 2 Diabetes (T2DM) and evaluate the relationship of pancreatic cancer risk with age at diabetes onset and diabetes duration. Methods: This longitudinal cohort study included 428,362 new-onset T2DM patients in Shanghai and Mendelian randomization (MR) in the east-Asian population were used to investigate the association. Incidence rates of pancreatic cancer in all patients and by subgroups were calculated and compared to the general population. Findings: A total of 1056 incident pancreatic cancer cases were identified during eight consecutive years of follow-up. The overall pancreatic cancer annual incidence rate was 55·28/100,000 person years in T2DM patients, higher than that in the general population, with a standardized incidence ratio (SIR) of 1·54 (95% confidence interval [CI], 1·45–1·64). The incidence of pancreatic cancer increased with age and a significantly higher incidence was observed in the older groups with T2DM. However, the relative pancreatic cancer risk was inversely related to age of T2DM onset, and a higher SIR of 5·73 (95%CI, 4·49–7·22) was observed in the 20–54 years old group. The risk of pancreatic cancer was elevated at any diabetes duration. Fasting blood glucose ≥10·0 mmol/L was associated with increased risk of pancreatic cancer. MR analysis indicated a positive association between T2DM and pancreatic cancer risk. Interpretation: Efforts toward early and close follow-up programs, especially in individuals with young-onset T2DM, and the improvement of glucose control might represent effective strategies for improving the detection and results of treatment of pancreatic cancer. Funding: Chinese National Natural Science Foundation. Type 2 diabetes mellitus Pancreatic cancer Onset age Diabetes duration Mendelian randomization Public aspects of medicine Yanyun Li verfasserin aut Chang-Sheng Sheng verfasserin aut Lili Liu verfasserin aut Tianzhichao Hou verfasserin aut Nan Xia verfasserin aut Siming Sun verfasserin aut Ya Miao verfasserin aut Yi Pang verfasserin aut Kai Gu verfasserin aut Xiongxiong Lu verfasserin aut Chenlei Wen verfasserin aut Yi Cheng verfasserin aut Yulin Yang verfasserin aut Dan Wang verfasserin aut Yijie Zhu verfasserin aut Minna Cheng verfasserin aut Katie Harris verfasserin aut Zachary T. Bloomgarden verfasserin aut Jingyan Tian verfasserin aut John Chalmers verfasserin aut Yan Shi verfasserin aut In The Lancet Regional Health. Western Pacific Elsevier, 2021 30(2023), Seite 100596- (DE-627)1746678372 26666065 nnns volume:30 year:2023 pages:100596- https://doi.org/10.1016/j.lanwpc.2022.100596 kostenfrei https://doaj.org/article/8db08795b5bd46b9b91deb7bf6481b5e kostenfrei http://www.sciencedirect.com/science/article/pii/S2666606522002115 kostenfrei https://doaj.org/toc/2666-6065 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 30 2023 100596- |
| spelling |
10.1016/j.lanwpc.2022.100596 doi (DE-627)DOAJ085769932 (DE-599)DOAJ8db08795b5bd46b9b91deb7bf6481b5e DE-627 ger DE-627 rakwb eng RA1-1270 Baiyong Shen verfasserin aut Association between age at diabetes onset or diabetes duration and subsequent risk of pancreatic cancer: Results from a longitudinal cohort and mendelian randomization study 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Summary: Background: The aim of the study is to estimate the incidence of pancreatic cancer among individuals with new-onset type 2 Diabetes (T2DM) and evaluate the relationship of pancreatic cancer risk with age at diabetes onset and diabetes duration. Methods: This longitudinal cohort study included 428,362 new-onset T2DM patients in Shanghai and Mendelian randomization (MR) in the east-Asian population were used to investigate the association. Incidence rates of pancreatic cancer in all patients and by subgroups were calculated and compared to the general population. Findings: A total of 1056 incident pancreatic cancer cases were identified during eight consecutive years of follow-up. The overall pancreatic cancer annual incidence rate was 55·28/100,000 person years in T2DM patients, higher than that in the general population, with a standardized incidence ratio (SIR) of 1·54 (95% confidence interval [CI], 1·45–1·64). The incidence of pancreatic cancer increased with age and a significantly higher incidence was observed in the older groups with T2DM. However, the relative pancreatic cancer risk was inversely related to age of T2DM onset, and a higher SIR of 5·73 (95%CI, 4·49–7·22) was observed in the 20–54 years old group. The risk of pancreatic cancer was elevated at any diabetes duration. Fasting blood glucose ≥10·0 mmol/L was associated with increased risk of pancreatic cancer. MR analysis indicated a positive association between T2DM and pancreatic cancer risk. Interpretation: Efforts toward early and close follow-up programs, especially in individuals with young-onset T2DM, and the improvement of glucose control might represent effective strategies for improving the detection and results of treatment of pancreatic cancer. Funding: Chinese National Natural Science Foundation. Type 2 diabetes mellitus Pancreatic cancer Onset age Diabetes duration Mendelian randomization Public aspects of medicine Yanyun Li verfasserin aut Chang-Sheng Sheng verfasserin aut Lili Liu verfasserin aut Tianzhichao Hou verfasserin aut Nan Xia verfasserin aut Siming Sun verfasserin aut Ya Miao verfasserin aut Yi Pang verfasserin aut Kai Gu verfasserin aut Xiongxiong Lu verfasserin aut Chenlei Wen verfasserin aut Yi Cheng verfasserin aut Yulin Yang verfasserin aut Dan Wang verfasserin aut Yijie Zhu verfasserin aut Minna Cheng verfasserin aut Katie Harris verfasserin aut Zachary T. Bloomgarden verfasserin aut Jingyan Tian verfasserin aut John Chalmers verfasserin aut Yan Shi verfasserin aut In The Lancet Regional Health. Western Pacific Elsevier, 2021 30(2023), Seite 100596- (DE-627)1746678372 26666065 nnns volume:30 year:2023 pages:100596- https://doi.org/10.1016/j.lanwpc.2022.100596 kostenfrei https://doaj.org/article/8db08795b5bd46b9b91deb7bf6481b5e kostenfrei http://www.sciencedirect.com/science/article/pii/S2666606522002115 kostenfrei https://doaj.org/toc/2666-6065 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 30 2023 100596- |
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10.1016/j.lanwpc.2022.100596 doi (DE-627)DOAJ085769932 (DE-599)DOAJ8db08795b5bd46b9b91deb7bf6481b5e DE-627 ger DE-627 rakwb eng RA1-1270 Baiyong Shen verfasserin aut Association between age at diabetes onset or diabetes duration and subsequent risk of pancreatic cancer: Results from a longitudinal cohort and mendelian randomization study 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Summary: Background: The aim of the study is to estimate the incidence of pancreatic cancer among individuals with new-onset type 2 Diabetes (T2DM) and evaluate the relationship of pancreatic cancer risk with age at diabetes onset and diabetes duration. Methods: This longitudinal cohort study included 428,362 new-onset T2DM patients in Shanghai and Mendelian randomization (MR) in the east-Asian population were used to investigate the association. Incidence rates of pancreatic cancer in all patients and by subgroups were calculated and compared to the general population. Findings: A total of 1056 incident pancreatic cancer cases were identified during eight consecutive years of follow-up. The overall pancreatic cancer annual incidence rate was 55·28/100,000 person years in T2DM patients, higher than that in the general population, with a standardized incidence ratio (SIR) of 1·54 (95% confidence interval [CI], 1·45–1·64). The incidence of pancreatic cancer increased with age and a significantly higher incidence was observed in the older groups with T2DM. However, the relative pancreatic cancer risk was inversely related to age of T2DM onset, and a higher SIR of 5·73 (95%CI, 4·49–7·22) was observed in the 20–54 years old group. The risk of pancreatic cancer was elevated at any diabetes duration. Fasting blood glucose ≥10·0 mmol/L was associated with increased risk of pancreatic cancer. MR analysis indicated a positive association between T2DM and pancreatic cancer risk. Interpretation: Efforts toward early and close follow-up programs, especially in individuals with young-onset T2DM, and the improvement of glucose control might represent effective strategies for improving the detection and results of treatment of pancreatic cancer. Funding: Chinese National Natural Science Foundation. Type 2 diabetes mellitus Pancreatic cancer Onset age Diabetes duration Mendelian randomization Public aspects of medicine Yanyun Li verfasserin aut Chang-Sheng Sheng verfasserin aut Lili Liu verfasserin aut Tianzhichao Hou verfasserin aut Nan Xia verfasserin aut Siming Sun verfasserin aut Ya Miao verfasserin aut Yi Pang verfasserin aut Kai Gu verfasserin aut Xiongxiong Lu verfasserin aut Chenlei Wen verfasserin aut Yi Cheng verfasserin aut Yulin Yang verfasserin aut Dan Wang verfasserin aut Yijie Zhu verfasserin aut Minna Cheng verfasserin aut Katie Harris verfasserin aut Zachary T. Bloomgarden verfasserin aut Jingyan Tian verfasserin aut John Chalmers verfasserin aut Yan Shi verfasserin aut In The Lancet Regional Health. Western Pacific Elsevier, 2021 30(2023), Seite 100596- (DE-627)1746678372 26666065 nnns volume:30 year:2023 pages:100596- https://doi.org/10.1016/j.lanwpc.2022.100596 kostenfrei https://doaj.org/article/8db08795b5bd46b9b91deb7bf6481b5e kostenfrei http://www.sciencedirect.com/science/article/pii/S2666606522002115 kostenfrei https://doaj.org/toc/2666-6065 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 30 2023 100596- |
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10.1016/j.lanwpc.2022.100596 doi (DE-627)DOAJ085769932 (DE-599)DOAJ8db08795b5bd46b9b91deb7bf6481b5e DE-627 ger DE-627 rakwb eng RA1-1270 Baiyong Shen verfasserin aut Association between age at diabetes onset or diabetes duration and subsequent risk of pancreatic cancer: Results from a longitudinal cohort and mendelian randomization study 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Summary: Background: The aim of the study is to estimate the incidence of pancreatic cancer among individuals with new-onset type 2 Diabetes (T2DM) and evaluate the relationship of pancreatic cancer risk with age at diabetes onset and diabetes duration. Methods: This longitudinal cohort study included 428,362 new-onset T2DM patients in Shanghai and Mendelian randomization (MR) in the east-Asian population were used to investigate the association. Incidence rates of pancreatic cancer in all patients and by subgroups were calculated and compared to the general population. Findings: A total of 1056 incident pancreatic cancer cases were identified during eight consecutive years of follow-up. The overall pancreatic cancer annual incidence rate was 55·28/100,000 person years in T2DM patients, higher than that in the general population, with a standardized incidence ratio (SIR) of 1·54 (95% confidence interval [CI], 1·45–1·64). The incidence of pancreatic cancer increased with age and a significantly higher incidence was observed in the older groups with T2DM. However, the relative pancreatic cancer risk was inversely related to age of T2DM onset, and a higher SIR of 5·73 (95%CI, 4·49–7·22) was observed in the 20–54 years old group. The risk of pancreatic cancer was elevated at any diabetes duration. Fasting blood glucose ≥10·0 mmol/L was associated with increased risk of pancreatic cancer. MR analysis indicated a positive association between T2DM and pancreatic cancer risk. Interpretation: Efforts toward early and close follow-up programs, especially in individuals with young-onset T2DM, and the improvement of glucose control might represent effective strategies for improving the detection and results of treatment of pancreatic cancer. Funding: Chinese National Natural Science Foundation. Type 2 diabetes mellitus Pancreatic cancer Onset age Diabetes duration Mendelian randomization Public aspects of medicine Yanyun Li verfasserin aut Chang-Sheng Sheng verfasserin aut Lili Liu verfasserin aut Tianzhichao Hou verfasserin aut Nan Xia verfasserin aut Siming Sun verfasserin aut Ya Miao verfasserin aut Yi Pang verfasserin aut Kai Gu verfasserin aut Xiongxiong Lu verfasserin aut Chenlei Wen verfasserin aut Yi Cheng verfasserin aut Yulin Yang verfasserin aut Dan Wang verfasserin aut Yijie Zhu verfasserin aut Minna Cheng verfasserin aut Katie Harris verfasserin aut Zachary T. Bloomgarden verfasserin aut Jingyan Tian verfasserin aut John Chalmers verfasserin aut Yan Shi verfasserin aut In The Lancet Regional Health. Western Pacific Elsevier, 2021 30(2023), Seite 100596- (DE-627)1746678372 26666065 nnns volume:30 year:2023 pages:100596- https://doi.org/10.1016/j.lanwpc.2022.100596 kostenfrei https://doaj.org/article/8db08795b5bd46b9b91deb7bf6481b5e kostenfrei http://www.sciencedirect.com/science/article/pii/S2666606522002115 kostenfrei https://doaj.org/toc/2666-6065 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 30 2023 100596- |
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10.1016/j.lanwpc.2022.100596 doi (DE-627)DOAJ085769932 (DE-599)DOAJ8db08795b5bd46b9b91deb7bf6481b5e DE-627 ger DE-627 rakwb eng RA1-1270 Baiyong Shen verfasserin aut Association between age at diabetes onset or diabetes duration and subsequent risk of pancreatic cancer: Results from a longitudinal cohort and mendelian randomization study 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Summary: Background: The aim of the study is to estimate the incidence of pancreatic cancer among individuals with new-onset type 2 Diabetes (T2DM) and evaluate the relationship of pancreatic cancer risk with age at diabetes onset and diabetes duration. Methods: This longitudinal cohort study included 428,362 new-onset T2DM patients in Shanghai and Mendelian randomization (MR) in the east-Asian population were used to investigate the association. Incidence rates of pancreatic cancer in all patients and by subgroups were calculated and compared to the general population. Findings: A total of 1056 incident pancreatic cancer cases were identified during eight consecutive years of follow-up. The overall pancreatic cancer annual incidence rate was 55·28/100,000 person years in T2DM patients, higher than that in the general population, with a standardized incidence ratio (SIR) of 1·54 (95% confidence interval [CI], 1·45–1·64). The incidence of pancreatic cancer increased with age and a significantly higher incidence was observed in the older groups with T2DM. However, the relative pancreatic cancer risk was inversely related to age of T2DM onset, and a higher SIR of 5·73 (95%CI, 4·49–7·22) was observed in the 20–54 years old group. The risk of pancreatic cancer was elevated at any diabetes duration. Fasting blood glucose ≥10·0 mmol/L was associated with increased risk of pancreatic cancer. MR analysis indicated a positive association between T2DM and pancreatic cancer risk. Interpretation: Efforts toward early and close follow-up programs, especially in individuals with young-onset T2DM, and the improvement of glucose control might represent effective strategies for improving the detection and results of treatment of pancreatic cancer. Funding: Chinese National Natural Science Foundation. Type 2 diabetes mellitus Pancreatic cancer Onset age Diabetes duration Mendelian randomization Public aspects of medicine Yanyun Li verfasserin aut Chang-Sheng Sheng verfasserin aut Lili Liu verfasserin aut Tianzhichao Hou verfasserin aut Nan Xia verfasserin aut Siming Sun verfasserin aut Ya Miao verfasserin aut Yi Pang verfasserin aut Kai Gu verfasserin aut Xiongxiong Lu verfasserin aut Chenlei Wen verfasserin aut Yi Cheng verfasserin aut Yulin Yang verfasserin aut Dan Wang verfasserin aut Yijie Zhu verfasserin aut Minna Cheng verfasserin aut Katie Harris verfasserin aut Zachary T. Bloomgarden verfasserin aut Jingyan Tian verfasserin aut John Chalmers verfasserin aut Yan Shi verfasserin aut In The Lancet Regional Health. Western Pacific Elsevier, 2021 30(2023), Seite 100596- (DE-627)1746678372 26666065 nnns volume:30 year:2023 pages:100596- https://doi.org/10.1016/j.lanwpc.2022.100596 kostenfrei https://doaj.org/article/8db08795b5bd46b9b91deb7bf6481b5e kostenfrei http://www.sciencedirect.com/science/article/pii/S2666606522002115 kostenfrei https://doaj.org/toc/2666-6065 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 30 2023 100596- |
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Baiyong Shen @@aut@@ Yanyun Li @@aut@@ Chang-Sheng Sheng @@aut@@ Lili Liu @@aut@@ Tianzhichao Hou @@aut@@ Nan Xia @@aut@@ Siming Sun @@aut@@ Ya Miao @@aut@@ Yi Pang @@aut@@ Kai Gu @@aut@@ Xiongxiong Lu @@aut@@ Chenlei Wen @@aut@@ Yi Cheng @@aut@@ Yulin Yang @@aut@@ Dan Wang @@aut@@ Yijie Zhu @@aut@@ Minna Cheng @@aut@@ Katie Harris @@aut@@ Zachary T. Bloomgarden @@aut@@ Jingyan Tian @@aut@@ John Chalmers @@aut@@ Yan Shi @@aut@@ |
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<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000naa a22002652 4500</leader><controlfield tag="001">DOAJ085769932</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20230311041324.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">230311s2023 xx |||||o 00| ||eng c</controlfield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.1016/j.lanwpc.2022.100596</subfield><subfield code="2">doi</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)DOAJ085769932</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-599)DOAJ8db08795b5bd46b9b91deb7bf6481b5e</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="050" ind1=" " ind2="0"><subfield code="a">RA1-1270</subfield></datafield><datafield tag="100" ind1="0" ind2=" "><subfield code="a">Baiyong Shen</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Association between age at diabetes onset or diabetes duration and subsequent risk of pancreatic cancer: Results from a longitudinal cohort and mendelian randomization study</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2023</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">Text</subfield><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">Computermedien</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Summary: Background: The aim of the study is to estimate the incidence of pancreatic cancer among individuals with new-onset type 2 Diabetes (T2DM) and evaluate the relationship of pancreatic cancer risk with age at diabetes onset and diabetes duration. Methods: This longitudinal cohort study included 428,362 new-onset T2DM patients in Shanghai and Mendelian randomization (MR) in the east-Asian population were used to investigate the association. Incidence rates of pancreatic cancer in all patients and by subgroups were calculated and compared to the general population. Findings: A total of 1056 incident pancreatic cancer cases were identified during eight consecutive years of follow-up. The overall pancreatic cancer annual incidence rate was 55·28/100,000 person years in T2DM patients, higher than that in the general population, with a standardized incidence ratio (SIR) of 1·54 (95% confidence interval [CI], 1·45–1·64). The incidence of pancreatic cancer increased with age and a significantly higher incidence was observed in the older groups with T2DM. However, the relative pancreatic cancer risk was inversely related to age of T2DM onset, and a higher SIR of 5·73 (95%CI, 4·49–7·22) was observed in the 20–54 years old group. The risk of pancreatic cancer was elevated at any diabetes duration. Fasting blood glucose ≥10·0 mmol/L was associated with increased risk of pancreatic cancer. MR analysis indicated a positive association between T2DM and pancreatic cancer risk. Interpretation: Efforts toward early and close follow-up programs, especially in individuals with young-onset T2DM, and the improvement of glucose control might represent effective strategies for improving the detection and results of treatment of pancreatic cancer. 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RA1-1270 Association between age at diabetes onset or diabetes duration and subsequent risk of pancreatic cancer: Results from a longitudinal cohort and mendelian randomization study Type 2 diabetes mellitus Pancreatic cancer Onset age Diabetes duration Mendelian randomization |
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Baiyong Shen Yanyun Li Chang-Sheng Sheng Lili Liu Tianzhichao Hou Nan Xia Siming Sun Ya Miao Yi Pang Kai Gu Xiongxiong Lu Chenlei Wen Yi Cheng Yulin Yang Dan Wang Yijie Zhu Minna Cheng Katie Harris Zachary T. Bloomgarden Jingyan Tian John Chalmers Yan Shi |
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Association between age at diabetes onset or diabetes duration and subsequent risk of pancreatic cancer: Results from a longitudinal cohort and mendelian randomization study |
| abstract |
Summary: Background: The aim of the study is to estimate the incidence of pancreatic cancer among individuals with new-onset type 2 Diabetes (T2DM) and evaluate the relationship of pancreatic cancer risk with age at diabetes onset and diabetes duration. Methods: This longitudinal cohort study included 428,362 new-onset T2DM patients in Shanghai and Mendelian randomization (MR) in the east-Asian population were used to investigate the association. Incidence rates of pancreatic cancer in all patients and by subgroups were calculated and compared to the general population. Findings: A total of 1056 incident pancreatic cancer cases were identified during eight consecutive years of follow-up. The overall pancreatic cancer annual incidence rate was 55·28/100,000 person years in T2DM patients, higher than that in the general population, with a standardized incidence ratio (SIR) of 1·54 (95% confidence interval [CI], 1·45–1·64). The incidence of pancreatic cancer increased with age and a significantly higher incidence was observed in the older groups with T2DM. However, the relative pancreatic cancer risk was inversely related to age of T2DM onset, and a higher SIR of 5·73 (95%CI, 4·49–7·22) was observed in the 20–54 years old group. The risk of pancreatic cancer was elevated at any diabetes duration. Fasting blood glucose ≥10·0 mmol/L was associated with increased risk of pancreatic cancer. MR analysis indicated a positive association between T2DM and pancreatic cancer risk. Interpretation: Efforts toward early and close follow-up programs, especially in individuals with young-onset T2DM, and the improvement of glucose control might represent effective strategies for improving the detection and results of treatment of pancreatic cancer. Funding: Chinese National Natural Science Foundation. |
| abstractGer |
Summary: Background: The aim of the study is to estimate the incidence of pancreatic cancer among individuals with new-onset type 2 Diabetes (T2DM) and evaluate the relationship of pancreatic cancer risk with age at diabetes onset and diabetes duration. Methods: This longitudinal cohort study included 428,362 new-onset T2DM patients in Shanghai and Mendelian randomization (MR) in the east-Asian population were used to investigate the association. Incidence rates of pancreatic cancer in all patients and by subgroups were calculated and compared to the general population. Findings: A total of 1056 incident pancreatic cancer cases were identified during eight consecutive years of follow-up. The overall pancreatic cancer annual incidence rate was 55·28/100,000 person years in T2DM patients, higher than that in the general population, with a standardized incidence ratio (SIR) of 1·54 (95% confidence interval [CI], 1·45–1·64). The incidence of pancreatic cancer increased with age and a significantly higher incidence was observed in the older groups with T2DM. However, the relative pancreatic cancer risk was inversely related to age of T2DM onset, and a higher SIR of 5·73 (95%CI, 4·49–7·22) was observed in the 20–54 years old group. The risk of pancreatic cancer was elevated at any diabetes duration. Fasting blood glucose ≥10·0 mmol/L was associated with increased risk of pancreatic cancer. MR analysis indicated a positive association between T2DM and pancreatic cancer risk. Interpretation: Efforts toward early and close follow-up programs, especially in individuals with young-onset T2DM, and the improvement of glucose control might represent effective strategies for improving the detection and results of treatment of pancreatic cancer. Funding: Chinese National Natural Science Foundation. |
| abstract_unstemmed |
Summary: Background: The aim of the study is to estimate the incidence of pancreatic cancer among individuals with new-onset type 2 Diabetes (T2DM) and evaluate the relationship of pancreatic cancer risk with age at diabetes onset and diabetes duration. Methods: This longitudinal cohort study included 428,362 new-onset T2DM patients in Shanghai and Mendelian randomization (MR) in the east-Asian population were used to investigate the association. Incidence rates of pancreatic cancer in all patients and by subgroups were calculated and compared to the general population. Findings: A total of 1056 incident pancreatic cancer cases were identified during eight consecutive years of follow-up. The overall pancreatic cancer annual incidence rate was 55·28/100,000 person years in T2DM patients, higher than that in the general population, with a standardized incidence ratio (SIR) of 1·54 (95% confidence interval [CI], 1·45–1·64). The incidence of pancreatic cancer increased with age and a significantly higher incidence was observed in the older groups with T2DM. However, the relative pancreatic cancer risk was inversely related to age of T2DM onset, and a higher SIR of 5·73 (95%CI, 4·49–7·22) was observed in the 20–54 years old group. The risk of pancreatic cancer was elevated at any diabetes duration. Fasting blood glucose ≥10·0 mmol/L was associated with increased risk of pancreatic cancer. MR analysis indicated a positive association between T2DM and pancreatic cancer risk. Interpretation: Efforts toward early and close follow-up programs, especially in individuals with young-onset T2DM, and the improvement of glucose control might represent effective strategies for improving the detection and results of treatment of pancreatic cancer. Funding: Chinese National Natural Science Foundation. |
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Association between age at diabetes onset or diabetes duration and subsequent risk of pancreatic cancer: Results from a longitudinal cohort and mendelian randomization study |
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https://doi.org/10.1016/j.lanwpc.2022.100596 https://doaj.org/article/8db08795b5bd46b9b91deb7bf6481b5e http://www.sciencedirect.com/science/article/pii/S2666606522002115 https://doaj.org/toc/2666-6065 |
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Yanyun Li Chang-Sheng Sheng Lili Liu Tianzhichao Hou Nan Xia Siming Sun Ya Miao Yi Pang Kai Gu Xiongxiong Lu Chenlei Wen Yi Cheng Yulin Yang Dan Wang Yijie Zhu Minna Cheng Katie Harris Zachary T. Bloomgarden Jingyan Tian John Chalmers Yan Shi |
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Yanyun Li Chang-Sheng Sheng Lili Liu Tianzhichao Hou Nan Xia Siming Sun Ya Miao Yi Pang Kai Gu Xiongxiong Lu Chenlei Wen Yi Cheng Yulin Yang Dan Wang Yijie Zhu Minna Cheng Katie Harris Zachary T. Bloomgarden Jingyan Tian John Chalmers Yan Shi |
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10.1016/j.lanwpc.2022.100596 |
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RA1-1270 |
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2024-07-03T16:45:03.136Z |
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