Structure and Anticoagulant Activity of a Galactofuranose-Containing Sulfated Polysaccharide from the Green Seaweed, <i<Codium isthmocladum</i<

A water-soluble sulfated polysaccharide, F2-1, was obtained from the marine green alga, <i<Codium isthmocladum</i<, using ion-exchange and size-exclusion chromatography. Structure analysis showed that the F2-1 was a sulfated arabinan comprising Ara, Rha, Man, Gal, and Xyl with an 18% sul...
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Autor*in:	Peipei Li [verfasserIn] Junlu Bai [verfasserIn] XiaoJun Zhang [verfasserIn] Zhongyong Yan [verfasserIn] Pengfei He [verfasserIn] Yin Chen [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2022

Schlagwörter:	marine green alga polysaccharide galactofuranose anticoagulant activity

Übergeordnetes Werk:	In: Molecules - MDPI AG, 2003, 27(2022), 22, p 8012
Übergeordnetes Werk:	volume:27 ; year:2022 ; number:22, p 8012

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3390/molecules27228012

Katalog-ID:	DOAJ085788643

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520			\|a A water-soluble sulfated polysaccharide, F2-1, was obtained from the marine green alga, <i<Codium isthmocladum</i<, using ion-exchange and size-exclusion chromatography. Structure analysis showed that the F2-1 was a sulfated arabinan comprising Ara, Rha, Man, Gal, and Xyl with an 18% sulfate content and a molecular weight of 100 kDa. Methylation analysis combined with desulfation, GC-MS, IR, and NMR spectroscopy showed that the backbone of F2-1 was →4)-β-L-Ara<i<p</i<(1→ residue. Its 2-<i<O</i< and/or 3-<i<O</i< positions showed sulfate modification; additionally, the 2-<i<O</i< or 3-<i<O</i< position showed branch points. The side chains were composed of →5)-β-D-Gal<i<f</i<, (1→2,6)-β-D-Gal<i<f</i<(1→, (1→2)-β-L-Rha<i<p</i<4S, →4)-α-D-Glc<i<p</i<(1→, and terminal α-D-Gal<i<p</i<(1→ and β-D-Xyl<i<p</i<(1→. Polysaccharides containing β-D-galactofuranose are rarely found in seaweed. F2-1 exhibited significant anticoagulant activity in vitro. Our findings suggested that the green-tide alga, <i<Codium isthmocladum</i<, can be considered as a useful resource for bioactive polysaccharides.
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653		0	\|a Organic chemistry
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700	0		\|a Yin Chen \|e verfasserin \|4 aut
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allfields	10.3390/molecules27228012 doi (DE-627)DOAJ085788643 (DE-599)DOAJ9801e82b24c44b69994ae55c674134ce DE-627 ger DE-627 rakwb eng QD241-441 Peipei Li verfasserin aut Structure and Anticoagulant Activity of a Galactofuranose-Containing Sulfated Polysaccharide from the Green Seaweed, <i<Codium isthmocladum</i< 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier A water-soluble sulfated polysaccharide, F2-1, was obtained from the marine green alga, <i<Codium isthmocladum</i<, using ion-exchange and size-exclusion chromatography. Structure analysis showed that the F2-1 was a sulfated arabinan comprising Ara, Rha, Man, Gal, and Xyl with an 18% sulfate content and a molecular weight of 100 kDa. Methylation analysis combined with desulfation, GC-MS, IR, and NMR spectroscopy showed that the backbone of F2-1 was →4)-β-L-Ara<i<p</i<(1→ residue. Its 2-<i<O</i< and/or 3-<i<O</i< positions showed sulfate modification; additionally, the 2-<i<O</i< or 3-<i<O</i< position showed branch points. The side chains were composed of →5)-β-D-Gal<i<f</i<, (1→2,6)-β-D-Gal<i<f</i<(1→, (1→2)-β-L-Rha<i<p</i<4S, →4)-α-D-Glc<i<p</i<(1→, and terminal α-D-Gal<i<p</i<(1→ and β-D-Xyl<i<p</i<(1→. Polysaccharides containing β-D-galactofuranose are rarely found in seaweed. F2-1 exhibited significant anticoagulant activity in vitro. Our findings suggested that the green-tide alga, <i<Codium isthmocladum</i<, can be considered as a useful resource for bioactive polysaccharides. marine green alga polysaccharide galactofuranose anticoagulant activity Organic chemistry Junlu Bai verfasserin aut XiaoJun Zhang verfasserin aut Zhongyong Yan verfasserin aut Pengfei He verfasserin aut Yin Chen verfasserin aut In Molecules MDPI AG, 2003 27(2022), 22, p 8012 (DE-627)311313132 (DE-600)2008644-1 14203049 nnns volume:27 year:2022 number:22, p 8012 https://doi.org/10.3390/molecules27228012 kostenfrei https://doaj.org/article/9801e82b24c44b69994ae55c674134ce kostenfrei https://www.mdpi.com/1420-3049/27/22/8012 kostenfrei https://doaj.org/toc/1420-3049 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 27 2022 22, p 8012
spelling	10.3390/molecules27228012 doi (DE-627)DOAJ085788643 (DE-599)DOAJ9801e82b24c44b69994ae55c674134ce DE-627 ger DE-627 rakwb eng QD241-441 Peipei Li verfasserin aut Structure and Anticoagulant Activity of a Galactofuranose-Containing Sulfated Polysaccharide from the Green Seaweed, <i<Codium isthmocladum</i< 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier A water-soluble sulfated polysaccharide, F2-1, was obtained from the marine green alga, <i<Codium isthmocladum</i<, using ion-exchange and size-exclusion chromatography. Structure analysis showed that the F2-1 was a sulfated arabinan comprising Ara, Rha, Man, Gal, and Xyl with an 18% sulfate content and a molecular weight of 100 kDa. Methylation analysis combined with desulfation, GC-MS, IR, and NMR spectroscopy showed that the backbone of F2-1 was →4)-β-L-Ara<i<p</i<(1→ residue. Its 2-<i<O</i< and/or 3-<i<O</i< positions showed sulfate modification; additionally, the 2-<i<O</i< or 3-<i<O</i< position showed branch points. The side chains were composed of →5)-β-D-Gal<i<f</i<, (1→2,6)-β-D-Gal<i<f</i<(1→, (1→2)-β-L-Rha<i<p</i<4S, →4)-α-D-Glc<i<p</i<(1→, and terminal α-D-Gal<i<p</i<(1→ and β-D-Xyl<i<p</i<(1→. Polysaccharides containing β-D-galactofuranose are rarely found in seaweed. F2-1 exhibited significant anticoagulant activity in vitro. Our findings suggested that the green-tide alga, <i<Codium isthmocladum</i<, can be considered as a useful resource for bioactive polysaccharides. marine green alga polysaccharide galactofuranose anticoagulant activity Organic chemistry Junlu Bai verfasserin aut XiaoJun Zhang verfasserin aut Zhongyong Yan verfasserin aut Pengfei He verfasserin aut Yin Chen verfasserin aut In Molecules MDPI AG, 2003 27(2022), 22, p 8012 (DE-627)311313132 (DE-600)2008644-1 14203049 nnns volume:27 year:2022 number:22, p 8012 https://doi.org/10.3390/molecules27228012 kostenfrei https://doaj.org/article/9801e82b24c44b69994ae55c674134ce kostenfrei https://www.mdpi.com/1420-3049/27/22/8012 kostenfrei https://doaj.org/toc/1420-3049 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 27 2022 22, p 8012
allfields_unstemmed	10.3390/molecules27228012 doi (DE-627)DOAJ085788643 (DE-599)DOAJ9801e82b24c44b69994ae55c674134ce DE-627 ger DE-627 rakwb eng QD241-441 Peipei Li verfasserin aut Structure and Anticoagulant Activity of a Galactofuranose-Containing Sulfated Polysaccharide from the Green Seaweed, <i<Codium isthmocladum</i< 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier A water-soluble sulfated polysaccharide, F2-1, was obtained from the marine green alga, <i<Codium isthmocladum</i<, using ion-exchange and size-exclusion chromatography. Structure analysis showed that the F2-1 was a sulfated arabinan comprising Ara, Rha, Man, Gal, and Xyl with an 18% sulfate content and a molecular weight of 100 kDa. Methylation analysis combined with desulfation, GC-MS, IR, and NMR spectroscopy showed that the backbone of F2-1 was →4)-β-L-Ara<i<p</i<(1→ residue. Its 2-<i<O</i< and/or 3-<i<O</i< positions showed sulfate modification; additionally, the 2-<i<O</i< or 3-<i<O</i< position showed branch points. The side chains were composed of →5)-β-D-Gal<i<f</i<, (1→2,6)-β-D-Gal<i<f</i<(1→, (1→2)-β-L-Rha<i<p</i<4S, →4)-α-D-Glc<i<p</i<(1→, and terminal α-D-Gal<i<p</i<(1→ and β-D-Xyl<i<p</i<(1→. Polysaccharides containing β-D-galactofuranose are rarely found in seaweed. F2-1 exhibited significant anticoagulant activity in vitro. Our findings suggested that the green-tide alga, <i<Codium isthmocladum</i<, can be considered as a useful resource for bioactive polysaccharides. marine green alga polysaccharide galactofuranose anticoagulant activity Organic chemistry Junlu Bai verfasserin aut XiaoJun Zhang verfasserin aut Zhongyong Yan verfasserin aut Pengfei He verfasserin aut Yin Chen verfasserin aut In Molecules MDPI AG, 2003 27(2022), 22, p 8012 (DE-627)311313132 (DE-600)2008644-1 14203049 nnns volume:27 year:2022 number:22, p 8012 https://doi.org/10.3390/molecules27228012 kostenfrei https://doaj.org/article/9801e82b24c44b69994ae55c674134ce kostenfrei https://www.mdpi.com/1420-3049/27/22/8012 kostenfrei https://doaj.org/toc/1420-3049 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 27 2022 22, p 8012
allfieldsGer	10.3390/molecules27228012 doi (DE-627)DOAJ085788643 (DE-599)DOAJ9801e82b24c44b69994ae55c674134ce DE-627 ger DE-627 rakwb eng QD241-441 Peipei Li verfasserin aut Structure and Anticoagulant Activity of a Galactofuranose-Containing Sulfated Polysaccharide from the Green Seaweed, <i<Codium isthmocladum</i< 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier A water-soluble sulfated polysaccharide, F2-1, was obtained from the marine green alga, <i<Codium isthmocladum</i<, using ion-exchange and size-exclusion chromatography. Structure analysis showed that the F2-1 was a sulfated arabinan comprising Ara, Rha, Man, Gal, and Xyl with an 18% sulfate content and a molecular weight of 100 kDa. Methylation analysis combined with desulfation, GC-MS, IR, and NMR spectroscopy showed that the backbone of F2-1 was →4)-β-L-Ara<i<p</i<(1→ residue. Its 2-<i<O</i< and/or 3-<i<O</i< positions showed sulfate modification; additionally, the 2-<i<O</i< or 3-<i<O</i< position showed branch points. The side chains were composed of →5)-β-D-Gal<i<f</i<, (1→2,6)-β-D-Gal<i<f</i<(1→, (1→2)-β-L-Rha<i<p</i<4S, →4)-α-D-Glc<i<p</i<(1→, and terminal α-D-Gal<i<p</i<(1→ and β-D-Xyl<i<p</i<(1→. Polysaccharides containing β-D-galactofuranose are rarely found in seaweed. F2-1 exhibited significant anticoagulant activity in vitro. Our findings suggested that the green-tide alga, <i<Codium isthmocladum</i<, can be considered as a useful resource for bioactive polysaccharides. marine green alga polysaccharide galactofuranose anticoagulant activity Organic chemistry Junlu Bai verfasserin aut XiaoJun Zhang verfasserin aut Zhongyong Yan verfasserin aut Pengfei He verfasserin aut Yin Chen verfasserin aut In Molecules MDPI AG, 2003 27(2022), 22, p 8012 (DE-627)311313132 (DE-600)2008644-1 14203049 nnns volume:27 year:2022 number:22, p 8012 https://doi.org/10.3390/molecules27228012 kostenfrei https://doaj.org/article/9801e82b24c44b69994ae55c674134ce kostenfrei https://www.mdpi.com/1420-3049/27/22/8012 kostenfrei https://doaj.org/toc/1420-3049 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 27 2022 22, p 8012
allfieldsSound	10.3390/molecules27228012 doi (DE-627)DOAJ085788643 (DE-599)DOAJ9801e82b24c44b69994ae55c674134ce DE-627 ger DE-627 rakwb eng QD241-441 Peipei Li verfasserin aut Structure and Anticoagulant Activity of a Galactofuranose-Containing Sulfated Polysaccharide from the Green Seaweed, <i<Codium isthmocladum</i< 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier A water-soluble sulfated polysaccharide, F2-1, was obtained from the marine green alga, <i<Codium isthmocladum</i<, using ion-exchange and size-exclusion chromatography. Structure analysis showed that the F2-1 was a sulfated arabinan comprising Ara, Rha, Man, Gal, and Xyl with an 18% sulfate content and a molecular weight of 100 kDa. Methylation analysis combined with desulfation, GC-MS, IR, and NMR spectroscopy showed that the backbone of F2-1 was →4)-β-L-Ara<i<p</i<(1→ residue. Its 2-<i<O</i< and/or 3-<i<O</i< positions showed sulfate modification; additionally, the 2-<i<O</i< or 3-<i<O</i< position showed branch points. The side chains were composed of →5)-β-D-Gal<i<f</i<, (1→2,6)-β-D-Gal<i<f</i<(1→, (1→2)-β-L-Rha<i<p</i<4S, →4)-α-D-Glc<i<p</i<(1→, and terminal α-D-Gal<i<p</i<(1→ and β-D-Xyl<i<p</i<(1→. Polysaccharides containing β-D-galactofuranose are rarely found in seaweed. F2-1 exhibited significant anticoagulant activity in vitro. Our findings suggested that the green-tide alga, <i<Codium isthmocladum</i<, can be considered as a useful resource for bioactive polysaccharides. marine green alga polysaccharide galactofuranose anticoagulant activity Organic chemistry Junlu Bai verfasserin aut XiaoJun Zhang verfasserin aut Zhongyong Yan verfasserin aut Pengfei He verfasserin aut Yin Chen verfasserin aut In Molecules MDPI AG, 2003 27(2022), 22, p 8012 (DE-627)311313132 (DE-600)2008644-1 14203049 nnns volume:27 year:2022 number:22, p 8012 https://doi.org/10.3390/molecules27228012 kostenfrei https://doaj.org/article/9801e82b24c44b69994ae55c674134ce kostenfrei https://www.mdpi.com/1420-3049/27/22/8012 kostenfrei https://doaj.org/toc/1420-3049 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 27 2022 22, p 8012
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callnumber-first	Q - Science
author	Peipei Li
spellingShingle	Peipei Li misc QD241-441 misc marine green alga misc polysaccharide misc galactofuranose misc anticoagulant activity misc Organic chemistry Structure and Anticoagulant Activity of a Galactofuranose-Containing Sulfated Polysaccharide from the Green Seaweed, <i<Codium isthmocladum</i<
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topic_title	QD241-441 Structure and Anticoagulant Activity of a Galactofuranose-Containing Sulfated Polysaccharide from the Green Seaweed, <i<Codium isthmocladum</i< marine green alga polysaccharide galactofuranose anticoagulant activity
topic	misc QD241-441 misc marine green alga misc polysaccharide misc galactofuranose misc anticoagulant activity misc Organic chemistry
topic_unstemmed	misc QD241-441 misc marine green alga misc polysaccharide misc galactofuranose misc anticoagulant activity misc Organic chemistry
topic_browse	misc QD241-441 misc marine green alga misc polysaccharide misc galactofuranose misc anticoagulant activity misc Organic chemistry
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title	Structure and Anticoagulant Activity of a Galactofuranose-Containing Sulfated Polysaccharide from the Green Seaweed, <i<Codium isthmocladum</i<
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title_full	Structure and Anticoagulant Activity of a Galactofuranose-Containing Sulfated Polysaccharide from the Green Seaweed, <i<Codium isthmocladum</i<
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author_browse	Peipei Li Junlu Bai XiaoJun Zhang Zhongyong Yan Pengfei He Yin Chen
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title_sort	structure and anticoagulant activity of a galactofuranose-containing sulfated polysaccharide from the green seaweed, <i<codium isthmocladum</i<
callnumber	QD241-441
title_auth	Structure and Anticoagulant Activity of a Galactofuranose-Containing Sulfated Polysaccharide from the Green Seaweed, <i<Codium isthmocladum</i<
abstract	A water-soluble sulfated polysaccharide, F2-1, was obtained from the marine green alga, <i<Codium isthmocladum</i<, using ion-exchange and size-exclusion chromatography. Structure analysis showed that the F2-1 was a sulfated arabinan comprising Ara, Rha, Man, Gal, and Xyl with an 18% sulfate content and a molecular weight of 100 kDa. Methylation analysis combined with desulfation, GC-MS, IR, and NMR spectroscopy showed that the backbone of F2-1 was →4)-β-L-Ara<i<p</i<(1→ residue. Its 2-<i<O</i< and/or 3-<i<O</i< positions showed sulfate modification; additionally, the 2-<i<O</i< or 3-<i<O</i< position showed branch points. The side chains were composed of →5)-β-D-Gal<i<f</i<, (1→2,6)-β-D-Gal<i<f</i<(1→, (1→2)-β-L-Rha<i<p</i<4S, →4)-α-D-Glc<i<p</i<(1→, and terminal α-D-Gal<i<p</i<(1→ and β-D-Xyl<i<p</i<(1→. Polysaccharides containing β-D-galactofuranose are rarely found in seaweed. F2-1 exhibited significant anticoagulant activity in vitro. Our findings suggested that the green-tide alga, <i<Codium isthmocladum</i<, can be considered as a useful resource for bioactive polysaccharides.
abstractGer	A water-soluble sulfated polysaccharide, F2-1, was obtained from the marine green alga, <i<Codium isthmocladum</i<, using ion-exchange and size-exclusion chromatography. Structure analysis showed that the F2-1 was a sulfated arabinan comprising Ara, Rha, Man, Gal, and Xyl with an 18% sulfate content and a molecular weight of 100 kDa. Methylation analysis combined with desulfation, GC-MS, IR, and NMR spectroscopy showed that the backbone of F2-1 was →4)-β-L-Ara<i<p</i<(1→ residue. Its 2-<i<O</i< and/or 3-<i<O</i< positions showed sulfate modification; additionally, the 2-<i<O</i< or 3-<i<O</i< position showed branch points. The side chains were composed of →5)-β-D-Gal<i<f</i<, (1→2,6)-β-D-Gal<i<f</i<(1→, (1→2)-β-L-Rha<i<p</i<4S, →4)-α-D-Glc<i<p</i<(1→, and terminal α-D-Gal<i<p</i<(1→ and β-D-Xyl<i<p</i<(1→. Polysaccharides containing β-D-galactofuranose are rarely found in seaweed. F2-1 exhibited significant anticoagulant activity in vitro. Our findings suggested that the green-tide alga, <i<Codium isthmocladum</i<, can be considered as a useful resource for bioactive polysaccharides.
abstract_unstemmed	A water-soluble sulfated polysaccharide, F2-1, was obtained from the marine green alga, <i<Codium isthmocladum</i<, using ion-exchange and size-exclusion chromatography. Structure analysis showed that the F2-1 was a sulfated arabinan comprising Ara, Rha, Man, Gal, and Xyl with an 18% sulfate content and a molecular weight of 100 kDa. Methylation analysis combined with desulfation, GC-MS, IR, and NMR spectroscopy showed that the backbone of F2-1 was →4)-β-L-Ara<i<p</i<(1→ residue. Its 2-<i<O</i< and/or 3-<i<O</i< positions showed sulfate modification; additionally, the 2-<i<O</i< or 3-<i<O</i< position showed branch points. The side chains were composed of →5)-β-D-Gal<i<f</i<, (1→2,6)-β-D-Gal<i<f</i<(1→, (1→2)-β-L-Rha<i<p</i<4S, →4)-α-D-Glc<i<p</i<(1→, and terminal α-D-Gal<i<p</i<(1→ and β-D-Xyl<i<p</i<(1→. Polysaccharides containing β-D-galactofuranose are rarely found in seaweed. F2-1 exhibited significant anticoagulant activity in vitro. Our findings suggested that the green-tide alga, <i<Codium isthmocladum</i<, can be considered as a useful resource for bioactive polysaccharides.
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container_issue	22, p 8012
title_short	Structure and Anticoagulant Activity of a Galactofuranose-Containing Sulfated Polysaccharide from the Green Seaweed, <i<Codium isthmocladum</i<
url	https://doi.org/10.3390/molecules27228012 https://doaj.org/article/9801e82b24c44b69994ae55c674134ce https://www.mdpi.com/1420-3049/27/22/8012 https://doaj.org/toc/1420-3049
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Structure and Anticoagulant Activity of a Galactofuranose-Containing Sulfated Polysaccharide from the Green Seaweed, <i<Codium isthmocladum</i<

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