Development of dietary fibers moringa-sterculia gum hydrogel for drug delivery applications

Introduction: Keeping in view the role of polysaccharide gums in pharmaceutical applications. Herein this research, Moringa gum (MOG) and Sterculia gum (SG) polysaccharides have been explored to design the network structure in the form of hydrogels which can act as a wound dressing for better wound...
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Autor*in:	Baljit Singh [verfasserIn] Vikrant Sharma [verfasserIn] Rajneesh [verfasserIn] Ajay Kumar [verfasserIn] Rohit [verfasserIn] Man Mohan [verfasserIn] Rajender Kumar [verfasserIn] Ankita Kumari [verfasserIn] Prerna Sharma [verfasserIn] Kaka Ram [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2022

Schlagwörter:	Moringa gum Sterculia gum Co-polymeric hydrogels Levofloxacin Wound dressings

Übergeordnetes Werk:	In: Food Hydrocolloids for Health - Elsevier, 2021, 2(2022), Seite 100095-
Übergeordnetes Werk:	volume:2 ; year:2022 ; pages:100095-

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.1016/j.fhfh.2022.100095

Katalog-ID:	DOAJ085842281

Internformat


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520			\|a Introduction: Keeping in view the role of polysaccharide gums in pharmaceutical applications. Herein this research, Moringa gum (MOG) and Sterculia gum (SG) polysaccharides have been explored to design the network structure in the form of hydrogels which can act as a wound dressing for better wound healing. Both gums are hydrophilic stem exudate and their anti-fungal and antioxidant activities have been reported for wound healing which can help the increase in wound healing potential of the antibiotic drug encapsulated hydrogel dressings. Objectives: To design the moringa gum, sterculia gum and polyacrylic acid based hydrogel wound dressings by graft copolymerization method impregnated with antibiotic drug levofloxacin for better wound care. Methodology: The co-polymers were prepared by grafting and crosslinking of the polyacrylic acid onto MOG and SG. The copolymers were characterized by cryo-SEM, AFM, FTIR, 13C NMR and swelling studies along with the evaluation of blood compatibility, wound fluid absorption, antioxidant activity, permeability (O2, H2O and, microbial), mucoadhesion, mechanical and in vitro release dynamics of antibiotic drug levofloxacin. Results and conclusion: The Cryo-SEM and AFM images of the hydrogels showed the porous nature and rough surface morphology of the hydrogels. The porosity in the hydrogel controlled the wound fluid absorption and drug diffusion from dressing. The release of the levofloxacin from MOG-cl-SG-co-poly(AAc) hydrogel occurred by the non-Fickian diffusion mechanism and release profile was best fitted in the Korsmeyer-Peppas kinetic model of drug release in the simulated wound fluid . The gum-based dressings were found permeable and antioxidant in nature. Overall, these hydrogels could be proposed as suitable materials for biomedical applications including drug delivery and wound dressing for better wound care.
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650		4	\|a Sterculia gum
650		4	\|a Co-polymeric hydrogels
650		4	\|a Levofloxacin
650		4	\|a Wound dressings
653		0	\|a Nutrition. Foods and food supply
653		0	\|a Nutritional diseases. Deficiency diseases
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700	0		\|a Prerna Sharma \|e verfasserin \|4 aut
700	0		\|a Kaka Ram \|e verfasserin \|4 aut
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allfields	10.1016/j.fhfh.2022.100095 doi (DE-627)DOAJ085842281 (DE-599)DOAJe79a3321eea040a383e1b14b3dc85eee DE-627 ger DE-627 rakwb eng TX341-641 RC620-627 Baljit Singh verfasserin aut Development of dietary fibers moringa-sterculia gum hydrogel for drug delivery applications 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Introduction: Keeping in view the role of polysaccharide gums in pharmaceutical applications. Herein this research, Moringa gum (MOG) and Sterculia gum (SG) polysaccharides have been explored to design the network structure in the form of hydrogels which can act as a wound dressing for better wound healing. Both gums are hydrophilic stem exudate and their anti-fungal and antioxidant activities have been reported for wound healing which can help the increase in wound healing potential of the antibiotic drug encapsulated hydrogel dressings. Objectives: To design the moringa gum, sterculia gum and polyacrylic acid based hydrogel wound dressings by graft copolymerization method impregnated with antibiotic drug levofloxacin for better wound care. Methodology: The co-polymers were prepared by grafting and crosslinking of the polyacrylic acid onto MOG and SG. The copolymers were characterized by cryo-SEM, AFM, FTIR, 13C NMR and swelling studies along with the evaluation of blood compatibility, wound fluid absorption, antioxidant activity, permeability (O2, H2O and, microbial), mucoadhesion, mechanical and in vitro release dynamics of antibiotic drug levofloxacin. Results and conclusion: The Cryo-SEM and AFM images of the hydrogels showed the porous nature and rough surface morphology of the hydrogels. The porosity in the hydrogel controlled the wound fluid absorption and drug diffusion from dressing. The release of the levofloxacin from MOG-cl-SG-co-poly(AAc) hydrogel occurred by the non-Fickian diffusion mechanism and release profile was best fitted in the Korsmeyer-Peppas kinetic model of drug release in the simulated wound fluid . The gum-based dressings were found permeable and antioxidant in nature. Overall, these hydrogels could be proposed as suitable materials for biomedical applications including drug delivery and wound dressing for better wound care. Moringa gum Sterculia gum Co-polymeric hydrogels Levofloxacin Wound dressings Nutrition. Foods and food supply Nutritional diseases. Deficiency diseases Vikrant Sharma verfasserin aut Rajneesh verfasserin aut Ajay Kumar verfasserin aut Rohit verfasserin aut Man Mohan verfasserin aut Rajender Kumar verfasserin aut Ankita Kumari verfasserin aut Prerna Sharma verfasserin aut Kaka Ram verfasserin aut In Food Hydrocolloids for Health Elsevier, 2021 2(2022), Seite 100095- (DE-627)1765892678 26670259 nnns volume:2 year:2022 pages:100095- https://doi.org/10.1016/j.fhfh.2022.100095 kostenfrei https://doaj.org/article/e79a3321eea040a383e1b14b3dc85eee kostenfrei http://www.sciencedirect.com/science/article/pii/S2667025922000425 kostenfrei https://doaj.org/toc/2667-0259 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 2 2022 100095-
spelling	10.1016/j.fhfh.2022.100095 doi (DE-627)DOAJ085842281 (DE-599)DOAJe79a3321eea040a383e1b14b3dc85eee DE-627 ger DE-627 rakwb eng TX341-641 RC620-627 Baljit Singh verfasserin aut Development of dietary fibers moringa-sterculia gum hydrogel for drug delivery applications 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Introduction: Keeping in view the role of polysaccharide gums in pharmaceutical applications. Herein this research, Moringa gum (MOG) and Sterculia gum (SG) polysaccharides have been explored to design the network structure in the form of hydrogels which can act as a wound dressing for better wound healing. Both gums are hydrophilic stem exudate and their anti-fungal and antioxidant activities have been reported for wound healing which can help the increase in wound healing potential of the antibiotic drug encapsulated hydrogel dressings. Objectives: To design the moringa gum, sterculia gum and polyacrylic acid based hydrogel wound dressings by graft copolymerization method impregnated with antibiotic drug levofloxacin for better wound care. Methodology: The co-polymers were prepared by grafting and crosslinking of the polyacrylic acid onto MOG and SG. The copolymers were characterized by cryo-SEM, AFM, FTIR, 13C NMR and swelling studies along with the evaluation of blood compatibility, wound fluid absorption, antioxidant activity, permeability (O2, H2O and, microbial), mucoadhesion, mechanical and in vitro release dynamics of antibiotic drug levofloxacin. Results and conclusion: The Cryo-SEM and AFM images of the hydrogels showed the porous nature and rough surface morphology of the hydrogels. The porosity in the hydrogel controlled the wound fluid absorption and drug diffusion from dressing. The release of the levofloxacin from MOG-cl-SG-co-poly(AAc) hydrogel occurred by the non-Fickian diffusion mechanism and release profile was best fitted in the Korsmeyer-Peppas kinetic model of drug release in the simulated wound fluid . The gum-based dressings were found permeable and antioxidant in nature. Overall, these hydrogels could be proposed as suitable materials for biomedical applications including drug delivery and wound dressing for better wound care. Moringa gum Sterculia gum Co-polymeric hydrogels Levofloxacin Wound dressings Nutrition. Foods and food supply Nutritional diseases. Deficiency diseases Vikrant Sharma verfasserin aut Rajneesh verfasserin aut Ajay Kumar verfasserin aut Rohit verfasserin aut Man Mohan verfasserin aut Rajender Kumar verfasserin aut Ankita Kumari verfasserin aut Prerna Sharma verfasserin aut Kaka Ram verfasserin aut In Food Hydrocolloids for Health Elsevier, 2021 2(2022), Seite 100095- (DE-627)1765892678 26670259 nnns volume:2 year:2022 pages:100095- https://doi.org/10.1016/j.fhfh.2022.100095 kostenfrei https://doaj.org/article/e79a3321eea040a383e1b14b3dc85eee kostenfrei http://www.sciencedirect.com/science/article/pii/S2667025922000425 kostenfrei https://doaj.org/toc/2667-0259 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 2 2022 100095-
allfields_unstemmed	10.1016/j.fhfh.2022.100095 doi (DE-627)DOAJ085842281 (DE-599)DOAJe79a3321eea040a383e1b14b3dc85eee DE-627 ger DE-627 rakwb eng TX341-641 RC620-627 Baljit Singh verfasserin aut Development of dietary fibers moringa-sterculia gum hydrogel for drug delivery applications 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Introduction: Keeping in view the role of polysaccharide gums in pharmaceutical applications. Herein this research, Moringa gum (MOG) and Sterculia gum (SG) polysaccharides have been explored to design the network structure in the form of hydrogels which can act as a wound dressing for better wound healing. Both gums are hydrophilic stem exudate and their anti-fungal and antioxidant activities have been reported for wound healing which can help the increase in wound healing potential of the antibiotic drug encapsulated hydrogel dressings. Objectives: To design the moringa gum, sterculia gum and polyacrylic acid based hydrogel wound dressings by graft copolymerization method impregnated with antibiotic drug levofloxacin for better wound care. Methodology: The co-polymers were prepared by grafting and crosslinking of the polyacrylic acid onto MOG and SG. The copolymers were characterized by cryo-SEM, AFM, FTIR, 13C NMR and swelling studies along with the evaluation of blood compatibility, wound fluid absorption, antioxidant activity, permeability (O2, H2O and, microbial), mucoadhesion, mechanical and in vitro release dynamics of antibiotic drug levofloxacin. Results and conclusion: The Cryo-SEM and AFM images of the hydrogels showed the porous nature and rough surface morphology of the hydrogels. The porosity in the hydrogel controlled the wound fluid absorption and drug diffusion from dressing. The release of the levofloxacin from MOG-cl-SG-co-poly(AAc) hydrogel occurred by the non-Fickian diffusion mechanism and release profile was best fitted in the Korsmeyer-Peppas kinetic model of drug release in the simulated wound fluid . The gum-based dressings were found permeable and antioxidant in nature. Overall, these hydrogels could be proposed as suitable materials for biomedical applications including drug delivery and wound dressing for better wound care. Moringa gum Sterculia gum Co-polymeric hydrogels Levofloxacin Wound dressings Nutrition. Foods and food supply Nutritional diseases. Deficiency diseases Vikrant Sharma verfasserin aut Rajneesh verfasserin aut Ajay Kumar verfasserin aut Rohit verfasserin aut Man Mohan verfasserin aut Rajender Kumar verfasserin aut Ankita Kumari verfasserin aut Prerna Sharma verfasserin aut Kaka Ram verfasserin aut In Food Hydrocolloids for Health Elsevier, 2021 2(2022), Seite 100095- (DE-627)1765892678 26670259 nnns volume:2 year:2022 pages:100095- https://doi.org/10.1016/j.fhfh.2022.100095 kostenfrei https://doaj.org/article/e79a3321eea040a383e1b14b3dc85eee kostenfrei http://www.sciencedirect.com/science/article/pii/S2667025922000425 kostenfrei https://doaj.org/toc/2667-0259 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 2 2022 100095-
allfieldsGer	10.1016/j.fhfh.2022.100095 doi (DE-627)DOAJ085842281 (DE-599)DOAJe79a3321eea040a383e1b14b3dc85eee DE-627 ger DE-627 rakwb eng TX341-641 RC620-627 Baljit Singh verfasserin aut Development of dietary fibers moringa-sterculia gum hydrogel for drug delivery applications 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Introduction: Keeping in view the role of polysaccharide gums in pharmaceutical applications. Herein this research, Moringa gum (MOG) and Sterculia gum (SG) polysaccharides have been explored to design the network structure in the form of hydrogels which can act as a wound dressing for better wound healing. Both gums are hydrophilic stem exudate and their anti-fungal and antioxidant activities have been reported for wound healing which can help the increase in wound healing potential of the antibiotic drug encapsulated hydrogel dressings. Objectives: To design the moringa gum, sterculia gum and polyacrylic acid based hydrogel wound dressings by graft copolymerization method impregnated with antibiotic drug levofloxacin for better wound care. Methodology: The co-polymers were prepared by grafting and crosslinking of the polyacrylic acid onto MOG and SG. The copolymers were characterized by cryo-SEM, AFM, FTIR, 13C NMR and swelling studies along with the evaluation of blood compatibility, wound fluid absorption, antioxidant activity, permeability (O2, H2O and, microbial), mucoadhesion, mechanical and in vitro release dynamics of antibiotic drug levofloxacin. Results and conclusion: The Cryo-SEM and AFM images of the hydrogels showed the porous nature and rough surface morphology of the hydrogels. The porosity in the hydrogel controlled the wound fluid absorption and drug diffusion from dressing. The release of the levofloxacin from MOG-cl-SG-co-poly(AAc) hydrogel occurred by the non-Fickian diffusion mechanism and release profile was best fitted in the Korsmeyer-Peppas kinetic model of drug release in the simulated wound fluid . The gum-based dressings were found permeable and antioxidant in nature. Overall, these hydrogels could be proposed as suitable materials for biomedical applications including drug delivery and wound dressing for better wound care. Moringa gum Sterculia gum Co-polymeric hydrogels Levofloxacin Wound dressings Nutrition. Foods and food supply Nutritional diseases. Deficiency diseases Vikrant Sharma verfasserin aut Rajneesh verfasserin aut Ajay Kumar verfasserin aut Rohit verfasserin aut Man Mohan verfasserin aut Rajender Kumar verfasserin aut Ankita Kumari verfasserin aut Prerna Sharma verfasserin aut Kaka Ram verfasserin aut In Food Hydrocolloids for Health Elsevier, 2021 2(2022), Seite 100095- (DE-627)1765892678 26670259 nnns volume:2 year:2022 pages:100095- https://doi.org/10.1016/j.fhfh.2022.100095 kostenfrei https://doaj.org/article/e79a3321eea040a383e1b14b3dc85eee kostenfrei http://www.sciencedirect.com/science/article/pii/S2667025922000425 kostenfrei https://doaj.org/toc/2667-0259 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 2 2022 100095-
allfieldsSound	10.1016/j.fhfh.2022.100095 doi (DE-627)DOAJ085842281 (DE-599)DOAJe79a3321eea040a383e1b14b3dc85eee DE-627 ger DE-627 rakwb eng TX341-641 RC620-627 Baljit Singh verfasserin aut Development of dietary fibers moringa-sterculia gum hydrogel for drug delivery applications 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Introduction: Keeping in view the role of polysaccharide gums in pharmaceutical applications. Herein this research, Moringa gum (MOG) and Sterculia gum (SG) polysaccharides have been explored to design the network structure in the form of hydrogels which can act as a wound dressing for better wound healing. Both gums are hydrophilic stem exudate and their anti-fungal and antioxidant activities have been reported for wound healing which can help the increase in wound healing potential of the antibiotic drug encapsulated hydrogel dressings. Objectives: To design the moringa gum, sterculia gum and polyacrylic acid based hydrogel wound dressings by graft copolymerization method impregnated with antibiotic drug levofloxacin for better wound care. Methodology: The co-polymers were prepared by grafting and crosslinking of the polyacrylic acid onto MOG and SG. The copolymers were characterized by cryo-SEM, AFM, FTIR, 13C NMR and swelling studies along with the evaluation of blood compatibility, wound fluid absorption, antioxidant activity, permeability (O2, H2O and, microbial), mucoadhesion, mechanical and in vitro release dynamics of antibiotic drug levofloxacin. Results and conclusion: The Cryo-SEM and AFM images of the hydrogels showed the porous nature and rough surface morphology of the hydrogels. The porosity in the hydrogel controlled the wound fluid absorption and drug diffusion from dressing. The release of the levofloxacin from MOG-cl-SG-co-poly(AAc) hydrogel occurred by the non-Fickian diffusion mechanism and release profile was best fitted in the Korsmeyer-Peppas kinetic model of drug release in the simulated wound fluid . The gum-based dressings were found permeable and antioxidant in nature. Overall, these hydrogels could be proposed as suitable materials for biomedical applications including drug delivery and wound dressing for better wound care. Moringa gum Sterculia gum Co-polymeric hydrogels Levofloxacin Wound dressings Nutrition. Foods and food supply Nutritional diseases. Deficiency diseases Vikrant Sharma verfasserin aut Rajneesh verfasserin aut Ajay Kumar verfasserin aut Rohit verfasserin aut Man Mohan verfasserin aut Rajender Kumar verfasserin aut Ankita Kumari verfasserin aut Prerna Sharma verfasserin aut Kaka Ram verfasserin aut In Food Hydrocolloids for Health Elsevier, 2021 2(2022), Seite 100095- (DE-627)1765892678 26670259 nnns volume:2 year:2022 pages:100095- https://doi.org/10.1016/j.fhfh.2022.100095 kostenfrei https://doaj.org/article/e79a3321eea040a383e1b14b3dc85eee kostenfrei http://www.sciencedirect.com/science/article/pii/S2667025922000425 kostenfrei https://doaj.org/toc/2667-0259 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 2 2022 100095-
language	English
source	In Food Hydrocolloids for Health 2(2022), Seite 100095- volume:2 year:2022 pages:100095-
sourceStr	In Food Hydrocolloids for Health 2(2022), Seite 100095- volume:2 year:2022 pages:100095-
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	Moringa gum Sterculia gum Co-polymeric hydrogels Levofloxacin Wound dressings Nutrition. Foods and food supply Nutritional diseases. Deficiency diseases
isfreeaccess_bool	true
container_title	Food Hydrocolloids for Health
authorswithroles_txt_mv	Baljit Singh @@aut@@ Vikrant Sharma @@aut@@ Rajneesh @@aut@@ Ajay Kumar @@aut@@ Rohit @@aut@@ Man Mohan @@aut@@ Rajender Kumar @@aut@@ Ankita Kumari @@aut@@ Prerna Sharma @@aut@@ Kaka Ram @@aut@@
publishDateDaySort_date	2022-01-01T00:00:00Z
hierarchy_top_id	1765892678
id	DOAJ085842281
language_de	englisch
fullrecord	<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000naa a22002652 4500</leader><controlfield tag="001">DOAJ085842281</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20230311041911.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">230311s2022 xx \|\|\|\|\|o 00\| \|\|eng c</controlfield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.1016/j.fhfh.2022.100095</subfield><subfield code="2">doi</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)DOAJ085842281</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-599)DOAJe79a3321eea040a383e1b14b3dc85eee</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="050" ind1=" " ind2="0"><subfield code="a">TX341-641</subfield></datafield><datafield tag="050" ind1=" " ind2="0"><subfield code="a">RC620-627</subfield></datafield><datafield tag="100" ind1="0" ind2=" "><subfield code="a">Baljit Singh</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Development of dietary fibers moringa-sterculia gum hydrogel for drug delivery applications</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2022</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">Text</subfield><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">Computermedien</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Introduction: Keeping in view the role of polysaccharide gums in pharmaceutical applications. Herein this research, Moringa gum (MOG) and Sterculia gum (SG) polysaccharides have been explored to design the network structure in the form of hydrogels which can act as a wound dressing for better wound healing. Both gums are hydrophilic stem exudate and their anti-fungal and antioxidant activities have been reported for wound healing which can help the increase in wound healing potential of the antibiotic drug encapsulated hydrogel dressings. Objectives: To design the moringa gum, sterculia gum and polyacrylic acid based hydrogel wound dressings by graft copolymerization method impregnated with antibiotic drug levofloxacin for better wound care. Methodology: The co-polymers were prepared by grafting and crosslinking of the polyacrylic acid onto MOG and SG. The copolymers were characterized by cryo-SEM, AFM, FTIR, 13C NMR and swelling studies along with the evaluation of blood compatibility, wound fluid absorption, antioxidant activity, permeability (O2, H2O and, microbial), mucoadhesion, mechanical and in vitro release dynamics of antibiotic drug levofloxacin. Results and conclusion: The Cryo-SEM and AFM images of the hydrogels showed the porous nature and rough surface morphology of the hydrogels. The porosity in the hydrogel controlled the wound fluid absorption and drug diffusion from dressing. The release of the levofloxacin from MOG-cl-SG-co-poly(AAc) hydrogel occurred by the non-Fickian diffusion mechanism and release profile was best fitted in the Korsmeyer-Peppas kinetic model of drug release in the simulated wound fluid . The gum-based dressings were found permeable and antioxidant in nature. 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callnumber-first	T - Technology
author	Baljit Singh
spellingShingle	Baljit Singh misc TX341-641 misc RC620-627 misc Moringa gum misc Sterculia gum misc Co-polymeric hydrogels misc Levofloxacin misc Wound dressings misc Nutrition. Foods and food supply misc Nutritional diseases. Deficiency diseases Development of dietary fibers moringa-sterculia gum hydrogel for drug delivery applications
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topic_title	TX341-641 RC620-627 Development of dietary fibers moringa-sterculia gum hydrogel for drug delivery applications Moringa gum Sterculia gum Co-polymeric hydrogels Levofloxacin Wound dressings
topic	misc TX341-641 misc RC620-627 misc Moringa gum misc Sterculia gum misc Co-polymeric hydrogels misc Levofloxacin misc Wound dressings misc Nutrition. Foods and food supply misc Nutritional diseases. Deficiency diseases
topic_unstemmed	misc TX341-641 misc RC620-627 misc Moringa gum misc Sterculia gum misc Co-polymeric hydrogels misc Levofloxacin misc Wound dressings misc Nutrition. Foods and food supply misc Nutritional diseases. Deficiency diseases
topic_browse	misc TX341-641 misc RC620-627 misc Moringa gum misc Sterculia gum misc Co-polymeric hydrogels misc Levofloxacin misc Wound dressings misc Nutrition. Foods and food supply misc Nutritional diseases. Deficiency diseases
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title	Development of dietary fibers moringa-sterculia gum hydrogel for drug delivery applications
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title_full	Development of dietary fibers moringa-sterculia gum hydrogel for drug delivery applications
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author_browse	Baljit Singh Vikrant Sharma Rajneesh Ajay Kumar Rohit Man Mohan Rajender Kumar Ankita Kumari Prerna Sharma Kaka Ram
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doi_str_mv	10.1016/j.fhfh.2022.100095
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title_sort	development of dietary fibers moringa-sterculia gum hydrogel for drug delivery applications
callnumber	TX341-641
title_auth	Development of dietary fibers moringa-sterculia gum hydrogel for drug delivery applications
abstract	Introduction: Keeping in view the role of polysaccharide gums in pharmaceutical applications. Herein this research, Moringa gum (MOG) and Sterculia gum (SG) polysaccharides have been explored to design the network structure in the form of hydrogels which can act as a wound dressing for better wound healing. Both gums are hydrophilic stem exudate and their anti-fungal and antioxidant activities have been reported for wound healing which can help the increase in wound healing potential of the antibiotic drug encapsulated hydrogel dressings. Objectives: To design the moringa gum, sterculia gum and polyacrylic acid based hydrogel wound dressings by graft copolymerization method impregnated with antibiotic drug levofloxacin for better wound care. Methodology: The co-polymers were prepared by grafting and crosslinking of the polyacrylic acid onto MOG and SG. The copolymers were characterized by cryo-SEM, AFM, FTIR, 13C NMR and swelling studies along with the evaluation of blood compatibility, wound fluid absorption, antioxidant activity, permeability (O2, H2O and, microbial), mucoadhesion, mechanical and in vitro release dynamics of antibiotic drug levofloxacin. Results and conclusion: The Cryo-SEM and AFM images of the hydrogels showed the porous nature and rough surface morphology of the hydrogels. The porosity in the hydrogel controlled the wound fluid absorption and drug diffusion from dressing. The release of the levofloxacin from MOG-cl-SG-co-poly(AAc) hydrogel occurred by the non-Fickian diffusion mechanism and release profile was best fitted in the Korsmeyer-Peppas kinetic model of drug release in the simulated wound fluid . The gum-based dressings were found permeable and antioxidant in nature. Overall, these hydrogels could be proposed as suitable materials for biomedical applications including drug delivery and wound dressing for better wound care.
abstractGer	Introduction: Keeping in view the role of polysaccharide gums in pharmaceutical applications. Herein this research, Moringa gum (MOG) and Sterculia gum (SG) polysaccharides have been explored to design the network structure in the form of hydrogels which can act as a wound dressing for better wound healing. Both gums are hydrophilic stem exudate and their anti-fungal and antioxidant activities have been reported for wound healing which can help the increase in wound healing potential of the antibiotic drug encapsulated hydrogel dressings. Objectives: To design the moringa gum, sterculia gum and polyacrylic acid based hydrogel wound dressings by graft copolymerization method impregnated with antibiotic drug levofloxacin for better wound care. Methodology: The co-polymers were prepared by grafting and crosslinking of the polyacrylic acid onto MOG and SG. The copolymers were characterized by cryo-SEM, AFM, FTIR, 13C NMR and swelling studies along with the evaluation of blood compatibility, wound fluid absorption, antioxidant activity, permeability (O2, H2O and, microbial), mucoadhesion, mechanical and in vitro release dynamics of antibiotic drug levofloxacin. Results and conclusion: The Cryo-SEM and AFM images of the hydrogels showed the porous nature and rough surface morphology of the hydrogels. The porosity in the hydrogel controlled the wound fluid absorption and drug diffusion from dressing. The release of the levofloxacin from MOG-cl-SG-co-poly(AAc) hydrogel occurred by the non-Fickian diffusion mechanism and release profile was best fitted in the Korsmeyer-Peppas kinetic model of drug release in the simulated wound fluid . The gum-based dressings were found permeable and antioxidant in nature. Overall, these hydrogels could be proposed as suitable materials for biomedical applications including drug delivery and wound dressing for better wound care.
abstract_unstemmed	Introduction: Keeping in view the role of polysaccharide gums in pharmaceutical applications. Herein this research, Moringa gum (MOG) and Sterculia gum (SG) polysaccharides have been explored to design the network structure in the form of hydrogels which can act as a wound dressing for better wound healing. Both gums are hydrophilic stem exudate and their anti-fungal and antioxidant activities have been reported for wound healing which can help the increase in wound healing potential of the antibiotic drug encapsulated hydrogel dressings. Objectives: To design the moringa gum, sterculia gum and polyacrylic acid based hydrogel wound dressings by graft copolymerization method impregnated with antibiotic drug levofloxacin for better wound care. Methodology: The co-polymers were prepared by grafting and crosslinking of the polyacrylic acid onto MOG and SG. The copolymers were characterized by cryo-SEM, AFM, FTIR, 13C NMR and swelling studies along with the evaluation of blood compatibility, wound fluid absorption, antioxidant activity, permeability (O2, H2O and, microbial), mucoadhesion, mechanical and in vitro release dynamics of antibiotic drug levofloxacin. Results and conclusion: The Cryo-SEM and AFM images of the hydrogels showed the porous nature and rough surface morphology of the hydrogels. The porosity in the hydrogel controlled the wound fluid absorption and drug diffusion from dressing. The release of the levofloxacin from MOG-cl-SG-co-poly(AAc) hydrogel occurred by the non-Fickian diffusion mechanism and release profile was best fitted in the Korsmeyer-Peppas kinetic model of drug release in the simulated wound fluid . The gum-based dressings were found permeable and antioxidant in nature. Overall, these hydrogels could be proposed as suitable materials for biomedical applications including drug delivery and wound dressing for better wound care.
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title_short	Development of dietary fibers moringa-sterculia gum hydrogel for drug delivery applications
url	https://doi.org/10.1016/j.fhfh.2022.100095 https://doaj.org/article/e79a3321eea040a383e1b14b3dc85eee http://www.sciencedirect.com/science/article/pii/S2667025922000425 https://doaj.org/toc/2667-0259
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up_date	2024-07-03T17:11:03.958Z
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fullrecord_marcxml	<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000naa a22002652 4500</leader><controlfield tag="001">DOAJ085842281</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20230311041911.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">230311s2022 xx \|\|\|\|\|o 00\| \|\|eng c</controlfield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.1016/j.fhfh.2022.100095</subfield><subfield code="2">doi</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)DOAJ085842281</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-599)DOAJe79a3321eea040a383e1b14b3dc85eee</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="050" ind1=" " ind2="0"><subfield code="a">TX341-641</subfield></datafield><datafield tag="050" ind1=" " ind2="0"><subfield code="a">RC620-627</subfield></datafield><datafield tag="100" ind1="0" ind2=" "><subfield code="a">Baljit Singh</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Development of dietary fibers moringa-sterculia gum hydrogel for drug delivery applications</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2022</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">Text</subfield><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">Computermedien</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Introduction: Keeping in view the role of polysaccharide gums in pharmaceutical applications. Herein this research, Moringa gum (MOG) and Sterculia gum (SG) polysaccharides have been explored to design the network structure in the form of hydrogels which can act as a wound dressing for better wound healing. Both gums are hydrophilic stem exudate and their anti-fungal and antioxidant activities have been reported for wound healing which can help the increase in wound healing potential of the antibiotic drug encapsulated hydrogel dressings. Objectives: To design the moringa gum, sterculia gum and polyacrylic acid based hydrogel wound dressings by graft copolymerization method impregnated with antibiotic drug levofloxacin for better wound care. Methodology: The co-polymers were prepared by grafting and crosslinking of the polyacrylic acid onto MOG and SG. The copolymers were characterized by cryo-SEM, AFM, FTIR, 13C NMR and swelling studies along with the evaluation of blood compatibility, wound fluid absorption, antioxidant activity, permeability (O2, H2O and, microbial), mucoadhesion, mechanical and in vitro release dynamics of antibiotic drug levofloxacin. Results and conclusion: The Cryo-SEM and AFM images of the hydrogels showed the porous nature and rough surface morphology of the hydrogels. The porosity in the hydrogel controlled the wound fluid absorption and drug diffusion from dressing. The release of the levofloxacin from MOG-cl-SG-co-poly(AAc) hydrogel occurred by the non-Fickian diffusion mechanism and release profile was best fitted in the Korsmeyer-Peppas kinetic model of drug release in the simulated wound fluid . The gum-based dressings were found permeable and antioxidant in nature. 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Development of dietary fibers moringa-sterculia gum hydrogel for drug delivery applications

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