Synthesis and Herbicidal Activity of Phenylpyridines – A New Lead

Novel phenylpyridines were synthesized based on molecular modeling oriented design by superposition of herbicidal phenyl-uracils, -indazoles, and diphenylethers. Their preparation follows Suzuki-type coupling conditions of reactive 2-chloro-pyridines with appropriate 2,5-substituted 4-chloro-phenyl...
Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Peter Schäfer [verfasserIn] Gerhard Hamprecht [verfasserIn] Michael Puhl [verfasserIn] Karl-Otto Westphalen [verfasserIn] Cyrill Zagar [verfasserIn]

Format:	E-Artikel
Sprache:	Deutsch ; Englisch ; Französisch

Erschienen:	2003

Schlagwörter:	Phenylpyridines Protoporphyrinogen-ix-oxidase inhibitors Sar Suzuki-coupling

Übergeordnetes Werk:	In: CHIMIA - Swiss Chemical Society, 2020, 57(2003), 11
Übergeordnetes Werk:	volume:57 ; year:2003 ; number:11

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc Journal toc

DOI / URN:	10.2533/000942903777678650

Katalog-ID:	DOAJ085900915

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authorswithroles_txt_mv	Peter Schäfer @@aut@@ Gerhard Hamprecht @@aut@@ Michael Puhl @@aut@@ Karl-Otto Westphalen @@aut@@ Cyrill Zagar @@aut@@
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author	Peter Schäfer
spellingShingle	Peter Schäfer misc QD1-999 misc Phenylpyridines misc Protoporphyrinogen-ix-oxidase inhibitors misc Sar misc Suzuki-coupling misc Chemistry Synthesis and Herbicidal Activity of Phenylpyridines – A New Lead
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topic_title	QD1-999 Synthesis and Herbicidal Activity of Phenylpyridines – A New Lead Phenylpyridines Protoporphyrinogen-ix-oxidase inhibitors Sar Suzuki-coupling
topic	misc QD1-999 misc Phenylpyridines misc Protoporphyrinogen-ix-oxidase inhibitors misc Sar misc Suzuki-coupling misc Chemistry
topic_unstemmed	misc QD1-999 misc Phenylpyridines misc Protoporphyrinogen-ix-oxidase inhibitors misc Sar misc Suzuki-coupling misc Chemistry
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title	Synthesis and Herbicidal Activity of Phenylpyridines – A New Lead
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title_full	Synthesis and Herbicidal Activity of Phenylpyridines – A New Lead
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title_sort	synthesis and herbicidal activity of phenylpyridines – a new lead
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title_auth	Synthesis and Herbicidal Activity of Phenylpyridines – A New Lead
abstract	Novel phenylpyridines were synthesized based on molecular modeling oriented design by superposition of herbicidal phenyl-uracils, -indazoles, and diphenylethers. Their preparation follows Suzuki-type coupling conditions of reactive 2-chloro-pyridines with appropriate 2,5-substituted 4-chloro-phenyl boronic acids. Depending on the nature of substituents in the pyridine, and in particular the phenyl group, a large number of derivatives are readily accessible. Besides open-chain phenylpyridines also anellated compounds, such as pyridine-substituted 2H-1,4-benzothiazin-3(4H)-one or 3,4-dihydro-1H-quinolin-2-one, were prepared. Phenylpyridines act by inhibition of protoporphyrinogen-IX-oxidase. Their synthesis will be described in conjunction with structure–activity relationships. Phenylpyridines are highly active against many important broadleaf and grass weed species under pre- and – in particular – post-emergent conditions.
abstractGer	Novel phenylpyridines were synthesized based on molecular modeling oriented design by superposition of herbicidal phenyl-uracils, -indazoles, and diphenylethers. Their preparation follows Suzuki-type coupling conditions of reactive 2-chloro-pyridines with appropriate 2,5-substituted 4-chloro-phenyl boronic acids. Depending on the nature of substituents in the pyridine, and in particular the phenyl group, a large number of derivatives are readily accessible. Besides open-chain phenylpyridines also anellated compounds, such as pyridine-substituted 2H-1,4-benzothiazin-3(4H)-one or 3,4-dihydro-1H-quinolin-2-one, were prepared. Phenylpyridines act by inhibition of protoporphyrinogen-IX-oxidase. Their synthesis will be described in conjunction with structure–activity relationships. Phenylpyridines are highly active against many important broadleaf and grass weed species under pre- and – in particular – post-emergent conditions.
abstract_unstemmed	Novel phenylpyridines were synthesized based on molecular modeling oriented design by superposition of herbicidal phenyl-uracils, -indazoles, and diphenylethers. Their preparation follows Suzuki-type coupling conditions of reactive 2-chloro-pyridines with appropriate 2,5-substituted 4-chloro-phenyl boronic acids. Depending on the nature of substituents in the pyridine, and in particular the phenyl group, a large number of derivatives are readily accessible. Besides open-chain phenylpyridines also anellated compounds, such as pyridine-substituted 2H-1,4-benzothiazin-3(4H)-one or 3,4-dihydro-1H-quinolin-2-one, were prepared. Phenylpyridines act by inhibition of protoporphyrinogen-IX-oxidase. Their synthesis will be described in conjunction with structure–activity relationships. Phenylpyridines are highly active against many important broadleaf and grass weed species under pre- and – in particular – post-emergent conditions.
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title_short	Synthesis and Herbicidal Activity of Phenylpyridines – A New Lead
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