Analytical study of RUNX1-RUNXT1, PML-RARA, CBFB-MYH11, BCR-ABL1p210, and KMT2-MLLT3 in Mexican children with acute myeloid leukemia: A multicenter study of the Mexican interinstitutional group for the identification of the causes of childhood leukemia (MIGICCL)

BackgroundThe distribution of RUNX1-RUNXT1, PML-RARA, CBFB-MYH11, BCR-ABL1p210, and KMT2A-MLLT3 in the pediatric population with acute myeloid leukemia (AML) in many countries of Latin America is largely unknown. Therefore, we aimed to investigate the frequency of these fusion genes in children with...
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Autor*in:	Omar Sepúlveda-Robles [verfasserIn] Elva Jiménez-Hernández [verfasserIn] Victoria Domínguez-Catzín [verfasserIn] Eber Gómez-Flores [verfasserIn] Jorge Alfonso Martín-Trejo [verfasserIn] Janet Flores-Lujano [verfasserIn] José Refugio Torres-Nava [verfasserIn] Juan Carlos Núñez-Enríquez [verfasserIn] Marlon De Ita [verfasserIn] Aurora Medina-Sanson [verfasserIn] Minerva Mata-Rocha [verfasserIn] Blanca Angelica Morales-Castillo [verfasserIn] Juan Carlos Bravata-Alcántara [verfasserIn] Alan Steve Nájera-Cortés [verfasserIn] Norberto Sánchez-Escobar [verfasserIn] José Gabriel Peñaloza-Gonzalez [verfasserIn] Rosa Martha Espinosa-Elizondo [verfasserIn] Luz Victoria Flores-Villegas [verfasserIn] Raquel Amador-Sanchez [verfasserIn] Darío Orozco-Ruiz [verfasserIn] Maria Luisa Pérez-Saldívar [verfasserIn] Martha Margarita Velázquez-Aviña [verfasserIn] Laura Elizabeth Merino-Pasaye [verfasserIn] Karina Anastacia Solís-Labastida [verfasserIn] Ana Itamar González-Ávila [verfasserIn] Jessica Denisse Santillán-Juárez [verfasserIn] Vilma Carolina Bekker-Méndez [verfasserIn] Silvia Jiménez-Morales [verfasserIn] Angélica Rangel-López [verfasserIn] Haydeé Rosas-Vargas [verfasserIn] Juan Manuel Mejía-Aranguré [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2022

Schlagwörter:	AML – acute myeloid leukaemia fusion genes translocation pediatric population Mexican population

Übergeordnetes Werk:	In: Frontiers in Pediatrics - Frontiers Media S.A., 2013, 10(2022)
Übergeordnetes Werk:	volume:10 ; year:2022

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3389/fped.2022.946690

Katalog-ID:	DOAJ085966630

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245	1	0	\|a Analytical study of RUNX1-RUNXT1, PML-RARA, CBFB-MYH11, BCR-ABL1p210, and KMT2-MLLT3 in Mexican children with acute myeloid leukemia: A multicenter study of the Mexican interinstitutional group for the identification of the causes of childhood leukemia (MIGICCL)
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520			\|a BackgroundThe distribution of RUNX1-RUNXT1, PML-RARA, CBFB-MYH11, BCR-ABL1p210, and KMT2A-MLLT3 in the pediatric population with acute myeloid leukemia (AML) in many countries of Latin America is largely unknown. Therefore, we aimed to investigate the frequency of these fusion genes in children with de novo AML from Mexico City, which has one of the highest incidence rates of acute leukemia in the world. Additionally, we explored their impact in mortality during the first year of treatment.MethodsWe retrospectively analyzed the presence of RUNX1-RUNXT1, PML-RARA, CBFB-MYH11, BCR-ABL1p210, and KMT2A-MLLT3 by RT-PCR among 77 patients (<18 years) diagnosed with de novo AML between 2019 and 2021 in nine Mexico City hospitals.ResultsThe overall frequency of the fusion genes was 50.7%; RUNX1-RUNXT1 (22.1%) and PML-RARA (20.8%) were the most prevalent, followed by CBFB-MYH11 (5.2%) and BCR-ABL1p210 (2.4%). KMT2A-MLLT3 was not detected. Patients with PML-RARA showed the lowest survival with high early mortality events. However, more studies are required to evaluate the impact of analyzed fusion genes on the overall survival of the Mexican child population with AML.ConclusionThe pediatric population of Mexico City with AML had frequencies of AML1-ETO, PML-RARA, CBFB-MYH11, and BCR-ABL1p210 similar to those of other populations around the world. Patients with BCR-ABL1p210and CBFB-MYH11 were few or did not die, while those with MLL-AF9 was not detected. Although patients with PML-RARA had a low survival and a high early mortality rate, further studies are needed to determine the long-term impacts of these fusion genes on this Latino population.
650		4	\|a AML – acute myeloid leukaemia
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650		4	\|a translocation
650		4	\|a pediatric population
650		4	\|a Mexican population
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700	0		\|a Jorge Alfonso Martín-Trejo \|e verfasserin \|4 aut
700	0		\|a Janet Flores-Lujano \|e verfasserin \|4 aut
700	0		\|a José Refugio Torres-Nava \|e verfasserin \|4 aut
700	0		\|a Juan Carlos Núñez-Enríquez \|e verfasserin \|4 aut
700	0		\|a Marlon De Ita \|e verfasserin \|4 aut
700	0		\|a Aurora Medina-Sanson \|e verfasserin \|4 aut
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700	0		\|a Luz Victoria Flores-Villegas \|e verfasserin \|4 aut
700	0		\|a Raquel Amador-Sanchez \|e verfasserin \|4 aut
700	0		\|a Darío Orozco-Ruiz \|e verfasserin \|4 aut
700	0		\|a Maria Luisa Pérez-Saldívar \|e verfasserin \|4 aut
700	0		\|a Martha Margarita Velázquez-Aviña \|e verfasserin \|4 aut
700	0		\|a Laura Elizabeth Merino-Pasaye \|e verfasserin \|4 aut
700	0		\|a Karina Anastacia Solís-Labastida \|e verfasserin \|4 aut
700	0		\|a Ana Itamar González-Ávila \|e verfasserin \|4 aut
700	0		\|a Jessica Denisse Santillán-Juárez \|e verfasserin \|4 aut
700	0		\|a Vilma Carolina Bekker-Méndez \|e verfasserin \|4 aut
700	0		\|a Silvia Jiménez-Morales \|e verfasserin \|4 aut
700	0		\|a Angélica Rangel-López \|e verfasserin \|4 aut
700	0		\|a Haydeé Rosas-Vargas \|e verfasserin \|4 aut
700	0		\|a Juan Manuel Mejía-Aranguré \|e verfasserin \|4 aut
700	0		\|a Juan Manuel Mejía-Aranguré \|e verfasserin \|4 aut
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allfields	10.3389/fped.2022.946690 doi (DE-627)DOAJ085966630 (DE-599)DOAJ79fe7748d1694d3491bbe6908fc9722d DE-627 ger DE-627 rakwb eng RJ1-570 Omar Sepúlveda-Robles verfasserin aut Analytical study of RUNX1-RUNXT1, PML-RARA, CBFB-MYH11, BCR-ABL1p210, and KMT2-MLLT3 in Mexican children with acute myeloid leukemia: A multicenter study of the Mexican interinstitutional group for the identification of the causes of childhood leukemia (MIGICCL) 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier BackgroundThe distribution of RUNX1-RUNXT1, PML-RARA, CBFB-MYH11, BCR-ABL1p210, and KMT2A-MLLT3 in the pediatric population with acute myeloid leukemia (AML) in many countries of Latin America is largely unknown. Therefore, we aimed to investigate the frequency of these fusion genes in children with de novo AML from Mexico City, which has one of the highest incidence rates of acute leukemia in the world. Additionally, we explored their impact in mortality during the first year of treatment.MethodsWe retrospectively analyzed the presence of RUNX1-RUNXT1, PML-RARA, CBFB-MYH11, BCR-ABL1p210, and KMT2A-MLLT3 by RT-PCR among 77 patients (<18 years) diagnosed with de novo AML between 2019 and 2021 in nine Mexico City hospitals.ResultsThe overall frequency of the fusion genes was 50.7%; RUNX1-RUNXT1 (22.1%) and PML-RARA (20.8%) were the most prevalent, followed by CBFB-MYH11 (5.2%) and BCR-ABL1p210 (2.4%). KMT2A-MLLT3 was not detected. Patients with PML-RARA showed the lowest survival with high early mortality events. However, more studies are required to evaluate the impact of analyzed fusion genes on the overall survival of the Mexican child population with AML.ConclusionThe pediatric population of Mexico City with AML had frequencies of AML1-ETO, PML-RARA, CBFB-MYH11, and BCR-ABL1p210 similar to those of other populations around the world. Patients with BCR-ABL1p210and CBFB-MYH11 were few or did not die, while those with MLL-AF9 was not detected. Although patients with PML-RARA had a low survival and a high early mortality rate, further studies are needed to determine the long-term impacts of these fusion genes on this Latino population. AML – acute myeloid leukaemia fusion genes translocation pediatric population Mexican population Pediatrics Elva Jiménez-Hernández verfasserin aut Victoria Domínguez-Catzín verfasserin aut Eber Gómez-Flores verfasserin aut Jorge Alfonso Martín-Trejo verfasserin aut Janet Flores-Lujano verfasserin aut José Refugio Torres-Nava verfasserin aut Juan Carlos Núñez-Enríquez verfasserin aut Marlon De Ita verfasserin aut Aurora Medina-Sanson verfasserin aut Minerva Mata-Rocha verfasserin aut Blanca Angelica Morales-Castillo verfasserin aut Juan Carlos Bravata-Alcántara verfasserin aut Alan Steve Nájera-Cortés verfasserin aut Norberto Sánchez-Escobar verfasserin aut José Gabriel Peñaloza-Gonzalez verfasserin aut Rosa Martha Espinosa-Elizondo verfasserin aut Luz Victoria Flores-Villegas verfasserin aut Raquel Amador-Sanchez verfasserin aut Darío Orozco-Ruiz verfasserin aut Maria Luisa Pérez-Saldívar verfasserin aut Martha Margarita Velázquez-Aviña verfasserin aut Laura Elizabeth Merino-Pasaye verfasserin aut Karina Anastacia Solís-Labastida verfasserin aut Ana Itamar González-Ávila verfasserin aut Jessica Denisse Santillán-Juárez verfasserin aut Vilma Carolina Bekker-Méndez verfasserin aut Silvia Jiménez-Morales verfasserin aut Angélica Rangel-López verfasserin aut Haydeé Rosas-Vargas verfasserin aut Juan Manuel Mejía-Aranguré verfasserin aut Juan Manuel Mejía-Aranguré verfasserin aut Juan Manuel Mejía-Aranguré verfasserin aut In Frontiers in Pediatrics Frontiers Media S.A., 2013 10(2022) (DE-627)742738744 (DE-600)2711999-3 22962360 nnns volume:10 year:2022 https://doi.org/10.3389/fped.2022.946690 kostenfrei https://doaj.org/article/79fe7748d1694d3491bbe6908fc9722d kostenfrei https://www.frontiersin.org/articles/10.3389/fped.2022.946690/full kostenfrei https://doaj.org/toc/2296-2360 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 10 2022
spelling	10.3389/fped.2022.946690 doi (DE-627)DOAJ085966630 (DE-599)DOAJ79fe7748d1694d3491bbe6908fc9722d DE-627 ger DE-627 rakwb eng RJ1-570 Omar Sepúlveda-Robles verfasserin aut Analytical study of RUNX1-RUNXT1, PML-RARA, CBFB-MYH11, BCR-ABL1p210, and KMT2-MLLT3 in Mexican children with acute myeloid leukemia: A multicenter study of the Mexican interinstitutional group for the identification of the causes of childhood leukemia (MIGICCL) 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier BackgroundThe distribution of RUNX1-RUNXT1, PML-RARA, CBFB-MYH11, BCR-ABL1p210, and KMT2A-MLLT3 in the pediatric population with acute myeloid leukemia (AML) in many countries of Latin America is largely unknown. Therefore, we aimed to investigate the frequency of these fusion genes in children with de novo AML from Mexico City, which has one of the highest incidence rates of acute leukemia in the world. Additionally, we explored their impact in mortality during the first year of treatment.MethodsWe retrospectively analyzed the presence of RUNX1-RUNXT1, PML-RARA, CBFB-MYH11, BCR-ABL1p210, and KMT2A-MLLT3 by RT-PCR among 77 patients (<18 years) diagnosed with de novo AML between 2019 and 2021 in nine Mexico City hospitals.ResultsThe overall frequency of the fusion genes was 50.7%; RUNX1-RUNXT1 (22.1%) and PML-RARA (20.8%) were the most prevalent, followed by CBFB-MYH11 (5.2%) and BCR-ABL1p210 (2.4%). KMT2A-MLLT3 was not detected. Patients with PML-RARA showed the lowest survival with high early mortality events. However, more studies are required to evaluate the impact of analyzed fusion genes on the overall survival of the Mexican child population with AML.ConclusionThe pediatric population of Mexico City with AML had frequencies of AML1-ETO, PML-RARA, CBFB-MYH11, and BCR-ABL1p210 similar to those of other populations around the world. Patients with BCR-ABL1p210and CBFB-MYH11 were few or did not die, while those with MLL-AF9 was not detected. Although patients with PML-RARA had a low survival and a high early mortality rate, further studies are needed to determine the long-term impacts of these fusion genes on this Latino population. AML – acute myeloid leukaemia fusion genes translocation pediatric population Mexican population Pediatrics Elva Jiménez-Hernández verfasserin aut Victoria Domínguez-Catzín verfasserin aut Eber Gómez-Flores verfasserin aut Jorge Alfonso Martín-Trejo verfasserin aut Janet Flores-Lujano verfasserin aut José Refugio Torres-Nava verfasserin aut Juan Carlos Núñez-Enríquez verfasserin aut Marlon De Ita verfasserin aut Aurora Medina-Sanson verfasserin aut Minerva Mata-Rocha verfasserin aut Blanca Angelica Morales-Castillo verfasserin aut Juan Carlos Bravata-Alcántara verfasserin aut Alan Steve Nájera-Cortés verfasserin aut Norberto Sánchez-Escobar verfasserin aut José Gabriel Peñaloza-Gonzalez verfasserin aut Rosa Martha Espinosa-Elizondo verfasserin aut Luz Victoria Flores-Villegas verfasserin aut Raquel Amador-Sanchez verfasserin aut Darío Orozco-Ruiz verfasserin aut Maria Luisa Pérez-Saldívar verfasserin aut Martha Margarita Velázquez-Aviña verfasserin aut Laura Elizabeth Merino-Pasaye verfasserin aut Karina Anastacia Solís-Labastida verfasserin aut Ana Itamar González-Ávila verfasserin aut Jessica Denisse Santillán-Juárez verfasserin aut Vilma Carolina Bekker-Méndez verfasserin aut Silvia Jiménez-Morales verfasserin aut Angélica Rangel-López verfasserin aut Haydeé Rosas-Vargas verfasserin aut Juan Manuel Mejía-Aranguré verfasserin aut Juan Manuel Mejía-Aranguré verfasserin aut Juan Manuel Mejía-Aranguré verfasserin aut In Frontiers in Pediatrics Frontiers Media S.A., 2013 10(2022) (DE-627)742738744 (DE-600)2711999-3 22962360 nnns volume:10 year:2022 https://doi.org/10.3389/fped.2022.946690 kostenfrei https://doaj.org/article/79fe7748d1694d3491bbe6908fc9722d kostenfrei https://www.frontiersin.org/articles/10.3389/fped.2022.946690/full kostenfrei https://doaj.org/toc/2296-2360 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 10 2022
allfields_unstemmed	10.3389/fped.2022.946690 doi (DE-627)DOAJ085966630 (DE-599)DOAJ79fe7748d1694d3491bbe6908fc9722d DE-627 ger DE-627 rakwb eng RJ1-570 Omar Sepúlveda-Robles verfasserin aut Analytical study of RUNX1-RUNXT1, PML-RARA, CBFB-MYH11, BCR-ABL1p210, and KMT2-MLLT3 in Mexican children with acute myeloid leukemia: A multicenter study of the Mexican interinstitutional group for the identification of the causes of childhood leukemia (MIGICCL) 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier BackgroundThe distribution of RUNX1-RUNXT1, PML-RARA, CBFB-MYH11, BCR-ABL1p210, and KMT2A-MLLT3 in the pediatric population with acute myeloid leukemia (AML) in many countries of Latin America is largely unknown. Therefore, we aimed to investigate the frequency of these fusion genes in children with de novo AML from Mexico City, which has one of the highest incidence rates of acute leukemia in the world. Additionally, we explored their impact in mortality during the first year of treatment.MethodsWe retrospectively analyzed the presence of RUNX1-RUNXT1, PML-RARA, CBFB-MYH11, BCR-ABL1p210, and KMT2A-MLLT3 by RT-PCR among 77 patients (<18 years) diagnosed with de novo AML between 2019 and 2021 in nine Mexico City hospitals.ResultsThe overall frequency of the fusion genes was 50.7%; RUNX1-RUNXT1 (22.1%) and PML-RARA (20.8%) were the most prevalent, followed by CBFB-MYH11 (5.2%) and BCR-ABL1p210 (2.4%). KMT2A-MLLT3 was not detected. Patients with PML-RARA showed the lowest survival with high early mortality events. However, more studies are required to evaluate the impact of analyzed fusion genes on the overall survival of the Mexican child population with AML.ConclusionThe pediatric population of Mexico City with AML had frequencies of AML1-ETO, PML-RARA, CBFB-MYH11, and BCR-ABL1p210 similar to those of other populations around the world. Patients with BCR-ABL1p210and CBFB-MYH11 were few or did not die, while those with MLL-AF9 was not detected. Although patients with PML-RARA had a low survival and a high early mortality rate, further studies are needed to determine the long-term impacts of these fusion genes on this Latino population. AML – acute myeloid leukaemia fusion genes translocation pediatric population Mexican population Pediatrics Elva Jiménez-Hernández verfasserin aut Victoria Domínguez-Catzín verfasserin aut Eber Gómez-Flores verfasserin aut Jorge Alfonso Martín-Trejo verfasserin aut Janet Flores-Lujano verfasserin aut José Refugio Torres-Nava verfasserin aut Juan Carlos Núñez-Enríquez verfasserin aut Marlon De Ita verfasserin aut Aurora Medina-Sanson verfasserin aut Minerva Mata-Rocha verfasserin aut Blanca Angelica Morales-Castillo verfasserin aut Juan Carlos Bravata-Alcántara verfasserin aut Alan Steve Nájera-Cortés verfasserin aut Norberto Sánchez-Escobar verfasserin aut José Gabriel Peñaloza-Gonzalez verfasserin aut Rosa Martha Espinosa-Elizondo verfasserin aut Luz Victoria Flores-Villegas verfasserin aut Raquel Amador-Sanchez verfasserin aut Darío Orozco-Ruiz verfasserin aut Maria Luisa Pérez-Saldívar verfasserin aut Martha Margarita Velázquez-Aviña verfasserin aut Laura Elizabeth Merino-Pasaye verfasserin aut Karina Anastacia Solís-Labastida verfasserin aut Ana Itamar González-Ávila verfasserin aut Jessica Denisse Santillán-Juárez verfasserin aut Vilma Carolina Bekker-Méndez verfasserin aut Silvia Jiménez-Morales verfasserin aut Angélica Rangel-López verfasserin aut Haydeé Rosas-Vargas verfasserin aut Juan Manuel Mejía-Aranguré verfasserin aut Juan Manuel Mejía-Aranguré verfasserin aut Juan Manuel Mejía-Aranguré verfasserin aut In Frontiers in Pediatrics Frontiers Media S.A., 2013 10(2022) (DE-627)742738744 (DE-600)2711999-3 22962360 nnns volume:10 year:2022 https://doi.org/10.3389/fped.2022.946690 kostenfrei https://doaj.org/article/79fe7748d1694d3491bbe6908fc9722d kostenfrei https://www.frontiersin.org/articles/10.3389/fped.2022.946690/full kostenfrei https://doaj.org/toc/2296-2360 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 10 2022
allfieldsGer	10.3389/fped.2022.946690 doi (DE-627)DOAJ085966630 (DE-599)DOAJ79fe7748d1694d3491bbe6908fc9722d DE-627 ger DE-627 rakwb eng RJ1-570 Omar Sepúlveda-Robles verfasserin aut Analytical study of RUNX1-RUNXT1, PML-RARA, CBFB-MYH11, BCR-ABL1p210, and KMT2-MLLT3 in Mexican children with acute myeloid leukemia: A multicenter study of the Mexican interinstitutional group for the identification of the causes of childhood leukemia (MIGICCL) 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier BackgroundThe distribution of RUNX1-RUNXT1, PML-RARA, CBFB-MYH11, BCR-ABL1p210, and KMT2A-MLLT3 in the pediatric population with acute myeloid leukemia (AML) in many countries of Latin America is largely unknown. Therefore, we aimed to investigate the frequency of these fusion genes in children with de novo AML from Mexico City, which has one of the highest incidence rates of acute leukemia in the world. Additionally, we explored their impact in mortality during the first year of treatment.MethodsWe retrospectively analyzed the presence of RUNX1-RUNXT1, PML-RARA, CBFB-MYH11, BCR-ABL1p210, and KMT2A-MLLT3 by RT-PCR among 77 patients (<18 years) diagnosed with de novo AML between 2019 and 2021 in nine Mexico City hospitals.ResultsThe overall frequency of the fusion genes was 50.7%; RUNX1-RUNXT1 (22.1%) and PML-RARA (20.8%) were the most prevalent, followed by CBFB-MYH11 (5.2%) and BCR-ABL1p210 (2.4%). KMT2A-MLLT3 was not detected. Patients with PML-RARA showed the lowest survival with high early mortality events. However, more studies are required to evaluate the impact of analyzed fusion genes on the overall survival of the Mexican child population with AML.ConclusionThe pediatric population of Mexico City with AML had frequencies of AML1-ETO, PML-RARA, CBFB-MYH11, and BCR-ABL1p210 similar to those of other populations around the world. Patients with BCR-ABL1p210and CBFB-MYH11 were few or did not die, while those with MLL-AF9 was not detected. Although patients with PML-RARA had a low survival and a high early mortality rate, further studies are needed to determine the long-term impacts of these fusion genes on this Latino population. AML – acute myeloid leukaemia fusion genes translocation pediatric population Mexican population Pediatrics Elva Jiménez-Hernández verfasserin aut Victoria Domínguez-Catzín verfasserin aut Eber Gómez-Flores verfasserin aut Jorge Alfonso Martín-Trejo verfasserin aut Janet Flores-Lujano verfasserin aut José Refugio Torres-Nava verfasserin aut Juan Carlos Núñez-Enríquez verfasserin aut Marlon De Ita verfasserin aut Aurora Medina-Sanson verfasserin aut Minerva Mata-Rocha verfasserin aut Blanca Angelica Morales-Castillo verfasserin aut Juan Carlos Bravata-Alcántara verfasserin aut Alan Steve Nájera-Cortés verfasserin aut Norberto Sánchez-Escobar verfasserin aut José Gabriel Peñaloza-Gonzalez verfasserin aut Rosa Martha Espinosa-Elizondo verfasserin aut Luz Victoria Flores-Villegas verfasserin aut Raquel Amador-Sanchez verfasserin aut Darío Orozco-Ruiz verfasserin aut Maria Luisa Pérez-Saldívar verfasserin aut Martha Margarita Velázquez-Aviña verfasserin aut Laura Elizabeth Merino-Pasaye verfasserin aut Karina Anastacia Solís-Labastida verfasserin aut Ana Itamar González-Ávila verfasserin aut Jessica Denisse Santillán-Juárez verfasserin aut Vilma Carolina Bekker-Méndez verfasserin aut Silvia Jiménez-Morales verfasserin aut Angélica Rangel-López verfasserin aut Haydeé Rosas-Vargas verfasserin aut Juan Manuel Mejía-Aranguré verfasserin aut Juan Manuel Mejía-Aranguré verfasserin aut Juan Manuel Mejía-Aranguré verfasserin aut In Frontiers in Pediatrics Frontiers Media S.A., 2013 10(2022) (DE-627)742738744 (DE-600)2711999-3 22962360 nnns volume:10 year:2022 https://doi.org/10.3389/fped.2022.946690 kostenfrei https://doaj.org/article/79fe7748d1694d3491bbe6908fc9722d kostenfrei https://www.frontiersin.org/articles/10.3389/fped.2022.946690/full kostenfrei https://doaj.org/toc/2296-2360 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 10 2022
allfieldsSound	10.3389/fped.2022.946690 doi (DE-627)DOAJ085966630 (DE-599)DOAJ79fe7748d1694d3491bbe6908fc9722d DE-627 ger DE-627 rakwb eng RJ1-570 Omar Sepúlveda-Robles verfasserin aut Analytical study of RUNX1-RUNXT1, PML-RARA, CBFB-MYH11, BCR-ABL1p210, and KMT2-MLLT3 in Mexican children with acute myeloid leukemia: A multicenter study of the Mexican interinstitutional group for the identification of the causes of childhood leukemia (MIGICCL) 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier BackgroundThe distribution of RUNX1-RUNXT1, PML-RARA, CBFB-MYH11, BCR-ABL1p210, and KMT2A-MLLT3 in the pediatric population with acute myeloid leukemia (AML) in many countries of Latin America is largely unknown. Therefore, we aimed to investigate the frequency of these fusion genes in children with de novo AML from Mexico City, which has one of the highest incidence rates of acute leukemia in the world. Additionally, we explored their impact in mortality during the first year of treatment.MethodsWe retrospectively analyzed the presence of RUNX1-RUNXT1, PML-RARA, CBFB-MYH11, BCR-ABL1p210, and KMT2A-MLLT3 by RT-PCR among 77 patients (<18 years) diagnosed with de novo AML between 2019 and 2021 in nine Mexico City hospitals.ResultsThe overall frequency of the fusion genes was 50.7%; RUNX1-RUNXT1 (22.1%) and PML-RARA (20.8%) were the most prevalent, followed by CBFB-MYH11 (5.2%) and BCR-ABL1p210 (2.4%). KMT2A-MLLT3 was not detected. Patients with PML-RARA showed the lowest survival with high early mortality events. However, more studies are required to evaluate the impact of analyzed fusion genes on the overall survival of the Mexican child population with AML.ConclusionThe pediatric population of Mexico City with AML had frequencies of AML1-ETO, PML-RARA, CBFB-MYH11, and BCR-ABL1p210 similar to those of other populations around the world. Patients with BCR-ABL1p210and CBFB-MYH11 were few or did not die, while those with MLL-AF9 was not detected. Although patients with PML-RARA had a low survival and a high early mortality rate, further studies are needed to determine the long-term impacts of these fusion genes on this Latino population. AML – acute myeloid leukaemia fusion genes translocation pediatric population Mexican population Pediatrics Elva Jiménez-Hernández verfasserin aut Victoria Domínguez-Catzín verfasserin aut Eber Gómez-Flores verfasserin aut Jorge Alfonso Martín-Trejo verfasserin aut Janet Flores-Lujano verfasserin aut José Refugio Torres-Nava verfasserin aut Juan Carlos Núñez-Enríquez verfasserin aut Marlon De Ita verfasserin aut Aurora Medina-Sanson verfasserin aut Minerva Mata-Rocha verfasserin aut Blanca Angelica Morales-Castillo verfasserin aut Juan Carlos Bravata-Alcántara verfasserin aut Alan Steve Nájera-Cortés verfasserin aut Norberto Sánchez-Escobar verfasserin aut José Gabriel Peñaloza-Gonzalez verfasserin aut Rosa Martha Espinosa-Elizondo verfasserin aut Luz Victoria Flores-Villegas verfasserin aut Raquel Amador-Sanchez verfasserin aut Darío Orozco-Ruiz verfasserin aut Maria Luisa Pérez-Saldívar verfasserin aut Martha Margarita Velázquez-Aviña verfasserin aut Laura Elizabeth Merino-Pasaye verfasserin aut Karina Anastacia Solís-Labastida verfasserin aut Ana Itamar González-Ávila verfasserin aut Jessica Denisse Santillán-Juárez verfasserin aut Vilma Carolina Bekker-Méndez verfasserin aut Silvia Jiménez-Morales verfasserin aut Angélica Rangel-López verfasserin aut Haydeé Rosas-Vargas verfasserin aut Juan Manuel Mejía-Aranguré verfasserin aut Juan Manuel Mejía-Aranguré verfasserin aut Juan Manuel Mejía-Aranguré verfasserin aut In Frontiers in Pediatrics Frontiers Media S.A., 2013 10(2022) (DE-627)742738744 (DE-600)2711999-3 22962360 nnns volume:10 year:2022 https://doi.org/10.3389/fped.2022.946690 kostenfrei https://doaj.org/article/79fe7748d1694d3491bbe6908fc9722d kostenfrei https://www.frontiersin.org/articles/10.3389/fped.2022.946690/full kostenfrei https://doaj.org/toc/2296-2360 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 10 2022
language	English
source	In Frontiers in Pediatrics 10(2022) volume:10 year:2022
sourceStr	In Frontiers in Pediatrics 10(2022) volume:10 year:2022
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	AML – acute myeloid leukaemia fusion genes translocation pediatric population Mexican population Pediatrics
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container_title	Frontiers in Pediatrics
authorswithroles_txt_mv	Omar Sepúlveda-Robles @@aut@@ Elva Jiménez-Hernández @@aut@@ Victoria Domínguez-Catzín @@aut@@ Eber Gómez-Flores @@aut@@ Jorge Alfonso Martín-Trejo @@aut@@ Janet Flores-Lujano @@aut@@ José Refugio Torres-Nava @@aut@@ Juan Carlos Núñez-Enríquez @@aut@@ Marlon De Ita @@aut@@ Aurora Medina-Sanson @@aut@@ Minerva Mata-Rocha @@aut@@ Blanca Angelica Morales-Castillo @@aut@@ Juan Carlos Bravata-Alcántara @@aut@@ Alan Steve Nájera-Cortés @@aut@@ Norberto Sánchez-Escobar @@aut@@ José Gabriel Peñaloza-Gonzalez @@aut@@ Rosa Martha Espinosa-Elizondo @@aut@@ Luz Victoria Flores-Villegas @@aut@@ Raquel Amador-Sanchez @@aut@@ Darío Orozco-Ruiz @@aut@@ Maria Luisa Pérez-Saldívar @@aut@@ Martha Margarita Velázquez-Aviña @@aut@@ Laura Elizabeth Merino-Pasaye @@aut@@ Karina Anastacia Solís-Labastida @@aut@@ Ana Itamar González-Ávila @@aut@@ Jessica Denisse Santillán-Juárez @@aut@@ Vilma Carolina Bekker-Méndez @@aut@@ Silvia Jiménez-Morales @@aut@@ Angélica Rangel-López @@aut@@ Haydeé Rosas-Vargas @@aut@@ Juan Manuel Mejía-Aranguré @@aut@@
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Therefore, we aimed to investigate the frequency of these fusion genes in children with de novo AML from Mexico City, which has one of the highest incidence rates of acute leukemia in the world. Additionally, we explored their impact in mortality during the first year of treatment.MethodsWe retrospectively analyzed the presence of RUNX1-RUNXT1, PML-RARA, CBFB-MYH11, BCR-ABL1p210, and KMT2A-MLLT3 by RT-PCR among 77 patients (&lt;18 years) diagnosed with de novo AML between 2019 and 2021 in nine Mexico City hospitals.ResultsThe overall frequency of the fusion genes was 50.7%; RUNX1-RUNXT1 (22.1%) and PML-RARA (20.8%) were the most prevalent, followed by CBFB-MYH11 (5.2%) and BCR-ABL1p210 (2.4%). KMT2A-MLLT3 was not detected. Patients with PML-RARA showed the lowest survival with high early mortality events. However, more studies are required to evaluate the impact of analyzed fusion genes on the overall survival of the Mexican child population with AML.ConclusionThe pediatric population of Mexico City with AML had frequencies of AML1-ETO, PML-RARA, CBFB-MYH11, and BCR-ABL1p210 similar to those of other populations around the world. Patients with BCR-ABL1p210and CBFB-MYH11 were few or did not die, while those with MLL-AF9 was not detected. 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callnumber-first	R - Medicine
author	Omar Sepúlveda-Robles
spellingShingle	Omar Sepúlveda-Robles misc RJ1-570 misc AML – acute myeloid leukaemia misc fusion genes misc translocation misc pediatric population misc Mexican population misc Pediatrics Analytical study of RUNX1-RUNXT1, PML-RARA, CBFB-MYH11, BCR-ABL1p210, and KMT2-MLLT3 in Mexican children with acute myeloid leukemia: A multicenter study of the Mexican interinstitutional group for the identification of the causes of childhood leukemia (MIGICCL)
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topic_title	RJ1-570 Analytical study of RUNX1-RUNXT1, PML-RARA, CBFB-MYH11, BCR-ABL1p210, and KMT2-MLLT3 in Mexican children with acute myeloid leukemia: A multicenter study of the Mexican interinstitutional group for the identification of the causes of childhood leukemia (MIGICCL) AML – acute myeloid leukaemia fusion genes translocation pediatric population Mexican population
topic	misc RJ1-570 misc AML – acute myeloid leukaemia misc fusion genes misc translocation misc pediatric population misc Mexican population misc Pediatrics
topic_unstemmed	misc RJ1-570 misc AML – acute myeloid leukaemia misc fusion genes misc translocation misc pediatric population misc Mexican population misc Pediatrics
topic_browse	misc RJ1-570 misc AML – acute myeloid leukaemia misc fusion genes misc translocation misc pediatric population misc Mexican population misc Pediatrics
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title	Analytical study of RUNX1-RUNXT1, PML-RARA, CBFB-MYH11, BCR-ABL1p210, and KMT2-MLLT3 in Mexican children with acute myeloid leukemia: A multicenter study of the Mexican interinstitutional group for the identification of the causes of childhood leukemia (MIGICCL)
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title_full	Analytical study of RUNX1-RUNXT1, PML-RARA, CBFB-MYH11, BCR-ABL1p210, and KMT2-MLLT3 in Mexican children with acute myeloid leukemia: A multicenter study of the Mexican interinstitutional group for the identification of the causes of childhood leukemia (MIGICCL)
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author_browse	Omar Sepúlveda-Robles Elva Jiménez-Hernández Victoria Domínguez-Catzín Eber Gómez-Flores Jorge Alfonso Martín-Trejo Janet Flores-Lujano José Refugio Torres-Nava Juan Carlos Núñez-Enríquez Marlon De Ita Aurora Medina-Sanson Minerva Mata-Rocha Blanca Angelica Morales-Castillo Juan Carlos Bravata-Alcántara Alan Steve Nájera-Cortés Norberto Sánchez-Escobar José Gabriel Peñaloza-Gonzalez Rosa Martha Espinosa-Elizondo Luz Victoria Flores-Villegas Raquel Amador-Sanchez Darío Orozco-Ruiz Maria Luisa Pérez-Saldívar Martha Margarita Velázquez-Aviña Laura Elizabeth Merino-Pasaye Karina Anastacia Solís-Labastida Ana Itamar González-Ávila Jessica Denisse Santillán-Juárez Vilma Carolina Bekker-Méndez Silvia Jiménez-Morales Angélica Rangel-López Haydeé Rosas-Vargas Juan Manuel Mejía-Aranguré
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author-letter	Omar Sepúlveda-Robles
doi_str_mv	10.3389/fped.2022.946690
author2-role	verfasserin
title_sort	analytical study of runx1-runxt1, pml-rara, cbfb-myh11, bcr-abl1p210, and kmt2-mllt3 in mexican children with acute myeloid leukemia: a multicenter study of the mexican interinstitutional group for the identification of the causes of childhood leukemia (migiccl)
callnumber	RJ1-570
title_auth	Analytical study of RUNX1-RUNXT1, PML-RARA, CBFB-MYH11, BCR-ABL1p210, and KMT2-MLLT3 in Mexican children with acute myeloid leukemia: A multicenter study of the Mexican interinstitutional group for the identification of the causes of childhood leukemia (MIGICCL)
abstract	BackgroundThe distribution of RUNX1-RUNXT1, PML-RARA, CBFB-MYH11, BCR-ABL1p210, and KMT2A-MLLT3 in the pediatric population with acute myeloid leukemia (AML) in many countries of Latin America is largely unknown. Therefore, we aimed to investigate the frequency of these fusion genes in children with de novo AML from Mexico City, which has one of the highest incidence rates of acute leukemia in the world. Additionally, we explored their impact in mortality during the first year of treatment.MethodsWe retrospectively analyzed the presence of RUNX1-RUNXT1, PML-RARA, CBFB-MYH11, BCR-ABL1p210, and KMT2A-MLLT3 by RT-PCR among 77 patients (<18 years) diagnosed with de novo AML between 2019 and 2021 in nine Mexico City hospitals.ResultsThe overall frequency of the fusion genes was 50.7%; RUNX1-RUNXT1 (22.1%) and PML-RARA (20.8%) were the most prevalent, followed by CBFB-MYH11 (5.2%) and BCR-ABL1p210 (2.4%). KMT2A-MLLT3 was not detected. Patients with PML-RARA showed the lowest survival with high early mortality events. However, more studies are required to evaluate the impact of analyzed fusion genes on the overall survival of the Mexican child population with AML.ConclusionThe pediatric population of Mexico City with AML had frequencies of AML1-ETO, PML-RARA, CBFB-MYH11, and BCR-ABL1p210 similar to those of other populations around the world. Patients with BCR-ABL1p210and CBFB-MYH11 were few or did not die, while those with MLL-AF9 was not detected. Although patients with PML-RARA had a low survival and a high early mortality rate, further studies are needed to determine the long-term impacts of these fusion genes on this Latino population.
abstractGer	BackgroundThe distribution of RUNX1-RUNXT1, PML-RARA, CBFB-MYH11, BCR-ABL1p210, and KMT2A-MLLT3 in the pediatric population with acute myeloid leukemia (AML) in many countries of Latin America is largely unknown. Therefore, we aimed to investigate the frequency of these fusion genes in children with de novo AML from Mexico City, which has one of the highest incidence rates of acute leukemia in the world. Additionally, we explored their impact in mortality during the first year of treatment.MethodsWe retrospectively analyzed the presence of RUNX1-RUNXT1, PML-RARA, CBFB-MYH11, BCR-ABL1p210, and KMT2A-MLLT3 by RT-PCR among 77 patients (<18 years) diagnosed with de novo AML between 2019 and 2021 in nine Mexico City hospitals.ResultsThe overall frequency of the fusion genes was 50.7%; RUNX1-RUNXT1 (22.1%) and PML-RARA (20.8%) were the most prevalent, followed by CBFB-MYH11 (5.2%) and BCR-ABL1p210 (2.4%). KMT2A-MLLT3 was not detected. Patients with PML-RARA showed the lowest survival with high early mortality events. However, more studies are required to evaluate the impact of analyzed fusion genes on the overall survival of the Mexican child population with AML.ConclusionThe pediatric population of Mexico City with AML had frequencies of AML1-ETO, PML-RARA, CBFB-MYH11, and BCR-ABL1p210 similar to those of other populations around the world. Patients with BCR-ABL1p210and CBFB-MYH11 were few or did not die, while those with MLL-AF9 was not detected. Although patients with PML-RARA had a low survival and a high early mortality rate, further studies are needed to determine the long-term impacts of these fusion genes on this Latino population.
abstract_unstemmed	BackgroundThe distribution of RUNX1-RUNXT1, PML-RARA, CBFB-MYH11, BCR-ABL1p210, and KMT2A-MLLT3 in the pediatric population with acute myeloid leukemia (AML) in many countries of Latin America is largely unknown. Therefore, we aimed to investigate the frequency of these fusion genes in children with de novo AML from Mexico City, which has one of the highest incidence rates of acute leukemia in the world. Additionally, we explored their impact in mortality during the first year of treatment.MethodsWe retrospectively analyzed the presence of RUNX1-RUNXT1, PML-RARA, CBFB-MYH11, BCR-ABL1p210, and KMT2A-MLLT3 by RT-PCR among 77 patients (<18 years) diagnosed with de novo AML between 2019 and 2021 in nine Mexico City hospitals.ResultsThe overall frequency of the fusion genes was 50.7%; RUNX1-RUNXT1 (22.1%) and PML-RARA (20.8%) were the most prevalent, followed by CBFB-MYH11 (5.2%) and BCR-ABL1p210 (2.4%). KMT2A-MLLT3 was not detected. Patients with PML-RARA showed the lowest survival with high early mortality events. However, more studies are required to evaluate the impact of analyzed fusion genes on the overall survival of the Mexican child population with AML.ConclusionThe pediatric population of Mexico City with AML had frequencies of AML1-ETO, PML-RARA, CBFB-MYH11, and BCR-ABL1p210 similar to those of other populations around the world. Patients with BCR-ABL1p210and CBFB-MYH11 were few or did not die, while those with MLL-AF9 was not detected. Although patients with PML-RARA had a low survival and a high early mortality rate, further studies are needed to determine the long-term impacts of these fusion genes on this Latino population.
collection_details	GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700
title_short	Analytical study of RUNX1-RUNXT1, PML-RARA, CBFB-MYH11, BCR-ABL1p210, and KMT2-MLLT3 in Mexican children with acute myeloid leukemia: A multicenter study of the Mexican interinstitutional group for the identification of the causes of childhood leukemia (MIGICCL)
url	https://doi.org/10.3389/fped.2022.946690 https://doaj.org/article/79fe7748d1694d3491bbe6908fc9722d https://www.frontiersin.org/articles/10.3389/fped.2022.946690/full https://doaj.org/toc/2296-2360
remote_bool	true
author2	Elva Jiménez-Hernández Victoria Domínguez-Catzín Eber Gómez-Flores Jorge Alfonso Martín-Trejo Janet Flores-Lujano José Refugio Torres-Nava Juan Carlos Núñez-Enríquez Marlon De Ita Aurora Medina-Sanson Minerva Mata-Rocha Blanca Angelica Morales-Castillo Juan Carlos Bravata-Alcántara Alan Steve Nájera-Cortés Norberto Sánchez-Escobar José Gabriel Peñaloza-Gonzalez Rosa Martha Espinosa-Elizondo Luz Victoria Flores-Villegas Raquel Amador-Sanchez Darío Orozco-Ruiz Maria Luisa Pérez-Saldívar Martha Margarita Velázquez-Aviña Laura Elizabeth Merino-Pasaye Karina Anastacia Solís-Labastida Ana Itamar González-Ávila Jessica Denisse Santillán-Juárez Vilma Carolina Bekker-Méndez Silvia Jiménez-Morales Angélica Rangel-López Haydeé Rosas-Vargas Juan Manuel Mejía-Aranguré
author2Str	Elva Jiménez-Hernández Victoria Domínguez-Catzín Eber Gómez-Flores Jorge Alfonso Martín-Trejo Janet Flores-Lujano José Refugio Torres-Nava Juan Carlos Núñez-Enríquez Marlon De Ita Aurora Medina-Sanson Minerva Mata-Rocha Blanca Angelica Morales-Castillo Juan Carlos Bravata-Alcántara Alan Steve Nájera-Cortés Norberto Sánchez-Escobar José Gabriel Peñaloza-Gonzalez Rosa Martha Espinosa-Elizondo Luz Victoria Flores-Villegas Raquel Amador-Sanchez Darío Orozco-Ruiz Maria Luisa Pérez-Saldívar Martha Margarita Velázquez-Aviña Laura Elizabeth Merino-Pasaye Karina Anastacia Solís-Labastida Ana Itamar González-Ávila Jessica Denisse Santillán-Juárez Vilma Carolina Bekker-Méndez Silvia Jiménez-Morales Angélica Rangel-López Haydeé Rosas-Vargas Juan Manuel Mejía-Aranguré
ppnlink	742738744
callnumber-subject	RJ - Pediatrics
mediatype_str_mv	c
isOA_txt	true
hochschulschrift_bool	false
doi_str	10.3389/fped.2022.946690
callnumber-a	RJ1-570
up_date	2024-07-03T17:54:28.459Z
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Therefore, we aimed to investigate the frequency of these fusion genes in children with de novo AML from Mexico City, which has one of the highest incidence rates of acute leukemia in the world. Additionally, we explored their impact in mortality during the first year of treatment.MethodsWe retrospectively analyzed the presence of RUNX1-RUNXT1, PML-RARA, CBFB-MYH11, BCR-ABL1p210, and KMT2A-MLLT3 by RT-PCR among 77 patients (&lt;18 years) diagnosed with de novo AML between 2019 and 2021 in nine Mexico City hospitals.ResultsThe overall frequency of the fusion genes was 50.7%; RUNX1-RUNXT1 (22.1%) and PML-RARA (20.8%) were the most prevalent, followed by CBFB-MYH11 (5.2%) and BCR-ABL1p210 (2.4%). KMT2A-MLLT3 was not detected. Patients with PML-RARA showed the lowest survival with high early mortality events. However, more studies are required to evaluate the impact of analyzed fusion genes on the overall survival of the Mexican child population with AML.ConclusionThe pediatric population of Mexico City with AML had frequencies of AML1-ETO, PML-RARA, CBFB-MYH11, and BCR-ABL1p210 similar to those of other populations around the world. Patients with BCR-ABL1p210and CBFB-MYH11 were few or did not die, while those with MLL-AF9 was not detected. 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Analytical study of RUNX1-RUNXT1, PML-RARA, CBFB-MYH11, BCR-ABL1p210, and KMT2-MLLT3 in Mexican children with acute myeloid leukemia: A multicenter study of the Mexican interinstitutional group for the identification of the causes of childhood leukemia (MIGICCL)

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