Determination of Nine Polypeptide Antibiotics Residues in Animal Tissue Food by Ultra-high Performance Liquid Chromatography-tandem Mass Spectrometry
A method combining SPE and Ultra-high performance liquid chromatography tandem mass spectrometry (UPLC-MS-MS) was developed for the simultaneous determination of nine polypeptide antibiotics in animal tissues. The samples were extracted by methanol and 0.1 mol/L hydrochloric acid (7:3, v/v), then cl...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Lianwei LI [verfasserIn] Xiaocong YANG [verfasserIn] Minna YAO [verfasserIn] Zhengcai LIU [verfasserIn] Xiaojing LI [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Chinesisch |
| Erschienen: |
2022 |
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| Schlagwörter: |
ultra-high performance liquid chromatography tandem mass spectrometry (uplc-ms/ms) |
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| Übergeordnetes Werk: |
In: Shipin gongye ke-ji - The editorial department of Science and Technology of Food Industry, 2022, 43(2022), 17, Seite 330-337 |
|---|---|
| Übergeordnetes Werk: |
volume:43 ; year:2022 ; number:17 ; pages:330-337 |
| Links: |
|---|
| DOI / URN: |
10.13386/j.issn1002-0306.2021120013 |
|---|
| Katalog-ID: |
DOAJ086109928 |
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| 520 | |a A method combining SPE and Ultra-high performance liquid chromatography tandem mass spectrometry (UPLC-MS-MS) was developed for the simultaneous determination of nine polypeptide antibiotics in animal tissues. The samples were extracted by methanol and 0.1 mol/L hydrochloric acid (7:3, v/v), then cleaned with Alumina-A and n-hexane, and finally purified by hydrophilic-lipophilic balance (hydrophilic-lipophilic balance, HLB) cartridge. The separations were performed on a C8 column (100A, 150 mm×2 mm, 3 µm) using a mobile phase gradient with 0.2% formic acid and acetonitrile. Electrospray positive ionization and multi-reaction monitoring (MRM) mode were used for detection. The calibration curves for vancomycin, norvancomycin, enramycin A, enramycin B, and teicoplanin, (concentration range 2~200 μg/L), colistin A, colistin B and bacitracin A (concentration range 5~500 μg/L), virginiamycin M1 (concentration range 0.1~20 μg/L) were linear with correlation coefficients more than 0.99. The limits of quantification (LOQ, S/N=10) of 9 kinds of polypeptide antibiotics were varied from 1 µg/kg to 20 µg/kg, the detection limit of the method was 0.3 µg/kg to 6 µg/kg. The recovery experiments were performed with chicken, pork, liver and kidney samples spiked in the range of 1~200 μg/kg. The average recoveries ranged from 74.2% and 96.3% with the relative standard deviations (RSDs) of 4.3%~14.6% (n=6). The method is simple and rapid with high sensitivity and good reproducibility. Furthermore, this method is effective for the safety monitoring of polypeptide antibiotic residues in animal tissues. | ||
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10.13386/j.issn1002-0306.2021120013 doi (DE-627)DOAJ086109928 (DE-599)DOAJacdb1bca394f4aae9f25793357a282e7 DE-627 ger DE-627 rakwb chi TP368-456 Lianwei LI verfasserin aut Determination of Nine Polypeptide Antibiotics Residues in Animal Tissue Food by Ultra-high Performance Liquid Chromatography-tandem Mass Spectrometry 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier A method combining SPE and Ultra-high performance liquid chromatography tandem mass spectrometry (UPLC-MS-MS) was developed for the simultaneous determination of nine polypeptide antibiotics in animal tissues. The samples were extracted by methanol and 0.1 mol/L hydrochloric acid (7:3, v/v), then cleaned with Alumina-A and n-hexane, and finally purified by hydrophilic-lipophilic balance (hydrophilic-lipophilic balance, HLB) cartridge. The separations were performed on a C8 column (100A, 150 mm×2 mm, 3 µm) using a mobile phase gradient with 0.2% formic acid and acetonitrile. Electrospray positive ionization and multi-reaction monitoring (MRM) mode were used for detection. The calibration curves for vancomycin, norvancomycin, enramycin A, enramycin B, and teicoplanin, (concentration range 2~200 μg/L), colistin A, colistin B and bacitracin A (concentration range 5~500 μg/L), virginiamycin M1 (concentration range 0.1~20 μg/L) were linear with correlation coefficients more than 0.99. The limits of quantification (LOQ, S/N=10) of 9 kinds of polypeptide antibiotics were varied from 1 µg/kg to 20 µg/kg, the detection limit of the method was 0.3 µg/kg to 6 µg/kg. The recovery experiments were performed with chicken, pork, liver and kidney samples spiked in the range of 1~200 μg/kg. The average recoveries ranged from 74.2% and 96.3% with the relative standard deviations (RSDs) of 4.3%~14.6% (n=6). The method is simple and rapid with high sensitivity and good reproducibility. Furthermore, this method is effective for the safety monitoring of polypeptide antibiotic residues in animal tissues. polypeptide antibiotic animal tissue solid-phase extraction ultra-high performance liquid chromatography tandem mass spectrometry (uplc-ms/ms) Food processing and manufacture Xiaocong YANG verfasserin aut Minna YAO verfasserin aut Zhengcai LIU verfasserin aut Xiaojing LI verfasserin aut In Shipin gongye ke-ji The editorial department of Science and Technology of Food Industry, 2022 43(2022), 17, Seite 330-337 (DE-627)DOAJ000150428 10020306 nnns volume:43 year:2022 number:17 pages:330-337 https://doi.org/10.13386/j.issn1002-0306.2021120013 kostenfrei https://doaj.org/article/acdb1bca394f4aae9f25793357a282e7 kostenfrei http://www.spgykj.com/cn/article/doi/10.13386/j.issn1002-0306.2021120013 kostenfrei https://doaj.org/toc/1002-0306 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ AR 43 2022 17 330-337 |
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10.13386/j.issn1002-0306.2021120013 doi (DE-627)DOAJ086109928 (DE-599)DOAJacdb1bca394f4aae9f25793357a282e7 DE-627 ger DE-627 rakwb chi TP368-456 Lianwei LI verfasserin aut Determination of Nine Polypeptide Antibiotics Residues in Animal Tissue Food by Ultra-high Performance Liquid Chromatography-tandem Mass Spectrometry 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier A method combining SPE and Ultra-high performance liquid chromatography tandem mass spectrometry (UPLC-MS-MS) was developed for the simultaneous determination of nine polypeptide antibiotics in animal tissues. The samples were extracted by methanol and 0.1 mol/L hydrochloric acid (7:3, v/v), then cleaned with Alumina-A and n-hexane, and finally purified by hydrophilic-lipophilic balance (hydrophilic-lipophilic balance, HLB) cartridge. The separations were performed on a C8 column (100A, 150 mm×2 mm, 3 µm) using a mobile phase gradient with 0.2% formic acid and acetonitrile. Electrospray positive ionization and multi-reaction monitoring (MRM) mode were used for detection. The calibration curves for vancomycin, norvancomycin, enramycin A, enramycin B, and teicoplanin, (concentration range 2~200 μg/L), colistin A, colistin B and bacitracin A (concentration range 5~500 μg/L), virginiamycin M1 (concentration range 0.1~20 μg/L) were linear with correlation coefficients more than 0.99. The limits of quantification (LOQ, S/N=10) of 9 kinds of polypeptide antibiotics were varied from 1 µg/kg to 20 µg/kg, the detection limit of the method was 0.3 µg/kg to 6 µg/kg. The recovery experiments were performed with chicken, pork, liver and kidney samples spiked in the range of 1~200 μg/kg. The average recoveries ranged from 74.2% and 96.3% with the relative standard deviations (RSDs) of 4.3%~14.6% (n=6). The method is simple and rapid with high sensitivity and good reproducibility. Furthermore, this method is effective for the safety monitoring of polypeptide antibiotic residues in animal tissues. polypeptide antibiotic animal tissue solid-phase extraction ultra-high performance liquid chromatography tandem mass spectrometry (uplc-ms/ms) Food processing and manufacture Xiaocong YANG verfasserin aut Minna YAO verfasserin aut Zhengcai LIU verfasserin aut Xiaojing LI verfasserin aut In Shipin gongye ke-ji The editorial department of Science and Technology of Food Industry, 2022 43(2022), 17, Seite 330-337 (DE-627)DOAJ000150428 10020306 nnns volume:43 year:2022 number:17 pages:330-337 https://doi.org/10.13386/j.issn1002-0306.2021120013 kostenfrei https://doaj.org/article/acdb1bca394f4aae9f25793357a282e7 kostenfrei http://www.spgykj.com/cn/article/doi/10.13386/j.issn1002-0306.2021120013 kostenfrei https://doaj.org/toc/1002-0306 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ AR 43 2022 17 330-337 |
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10.13386/j.issn1002-0306.2021120013 doi (DE-627)DOAJ086109928 (DE-599)DOAJacdb1bca394f4aae9f25793357a282e7 DE-627 ger DE-627 rakwb chi TP368-456 Lianwei LI verfasserin aut Determination of Nine Polypeptide Antibiotics Residues in Animal Tissue Food by Ultra-high Performance Liquid Chromatography-tandem Mass Spectrometry 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier A method combining SPE and Ultra-high performance liquid chromatography tandem mass spectrometry (UPLC-MS-MS) was developed for the simultaneous determination of nine polypeptide antibiotics in animal tissues. The samples were extracted by methanol and 0.1 mol/L hydrochloric acid (7:3, v/v), then cleaned with Alumina-A and n-hexane, and finally purified by hydrophilic-lipophilic balance (hydrophilic-lipophilic balance, HLB) cartridge. The separations were performed on a C8 column (100A, 150 mm×2 mm, 3 µm) using a mobile phase gradient with 0.2% formic acid and acetonitrile. Electrospray positive ionization and multi-reaction monitoring (MRM) mode were used for detection. The calibration curves for vancomycin, norvancomycin, enramycin A, enramycin B, and teicoplanin, (concentration range 2~200 μg/L), colistin A, colistin B and bacitracin A (concentration range 5~500 μg/L), virginiamycin M1 (concentration range 0.1~20 μg/L) were linear with correlation coefficients more than 0.99. The limits of quantification (LOQ, S/N=10) of 9 kinds of polypeptide antibiotics were varied from 1 µg/kg to 20 µg/kg, the detection limit of the method was 0.3 µg/kg to 6 µg/kg. The recovery experiments were performed with chicken, pork, liver and kidney samples spiked in the range of 1~200 μg/kg. The average recoveries ranged from 74.2% and 96.3% with the relative standard deviations (RSDs) of 4.3%~14.6% (n=6). The method is simple and rapid with high sensitivity and good reproducibility. Furthermore, this method is effective for the safety monitoring of polypeptide antibiotic residues in animal tissues. polypeptide antibiotic animal tissue solid-phase extraction ultra-high performance liquid chromatography tandem mass spectrometry (uplc-ms/ms) Food processing and manufacture Xiaocong YANG verfasserin aut Minna YAO verfasserin aut Zhengcai LIU verfasserin aut Xiaojing LI verfasserin aut In Shipin gongye ke-ji The editorial department of Science and Technology of Food Industry, 2022 43(2022), 17, Seite 330-337 (DE-627)DOAJ000150428 10020306 nnns volume:43 year:2022 number:17 pages:330-337 https://doi.org/10.13386/j.issn1002-0306.2021120013 kostenfrei https://doaj.org/article/acdb1bca394f4aae9f25793357a282e7 kostenfrei http://www.spgykj.com/cn/article/doi/10.13386/j.issn1002-0306.2021120013 kostenfrei https://doaj.org/toc/1002-0306 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ AR 43 2022 17 330-337 |
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10.13386/j.issn1002-0306.2021120013 doi (DE-627)DOAJ086109928 (DE-599)DOAJacdb1bca394f4aae9f25793357a282e7 DE-627 ger DE-627 rakwb chi TP368-456 Lianwei LI verfasserin aut Determination of Nine Polypeptide Antibiotics Residues in Animal Tissue Food by Ultra-high Performance Liquid Chromatography-tandem Mass Spectrometry 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier A method combining SPE and Ultra-high performance liquid chromatography tandem mass spectrometry (UPLC-MS-MS) was developed for the simultaneous determination of nine polypeptide antibiotics in animal tissues. The samples were extracted by methanol and 0.1 mol/L hydrochloric acid (7:3, v/v), then cleaned with Alumina-A and n-hexane, and finally purified by hydrophilic-lipophilic balance (hydrophilic-lipophilic balance, HLB) cartridge. The separations were performed on a C8 column (100A, 150 mm×2 mm, 3 µm) using a mobile phase gradient with 0.2% formic acid and acetonitrile. Electrospray positive ionization and multi-reaction monitoring (MRM) mode were used for detection. The calibration curves for vancomycin, norvancomycin, enramycin A, enramycin B, and teicoplanin, (concentration range 2~200 μg/L), colistin A, colistin B and bacitracin A (concentration range 5~500 μg/L), virginiamycin M1 (concentration range 0.1~20 μg/L) were linear with correlation coefficients more than 0.99. The limits of quantification (LOQ, S/N=10) of 9 kinds of polypeptide antibiotics were varied from 1 µg/kg to 20 µg/kg, the detection limit of the method was 0.3 µg/kg to 6 µg/kg. The recovery experiments were performed with chicken, pork, liver and kidney samples spiked in the range of 1~200 μg/kg. The average recoveries ranged from 74.2% and 96.3% with the relative standard deviations (RSDs) of 4.3%~14.6% (n=6). The method is simple and rapid with high sensitivity and good reproducibility. Furthermore, this method is effective for the safety monitoring of polypeptide antibiotic residues in animal tissues. polypeptide antibiotic animal tissue solid-phase extraction ultra-high performance liquid chromatography tandem mass spectrometry (uplc-ms/ms) Food processing and manufacture Xiaocong YANG verfasserin aut Minna YAO verfasserin aut Zhengcai LIU verfasserin aut Xiaojing LI verfasserin aut In Shipin gongye ke-ji The editorial department of Science and Technology of Food Industry, 2022 43(2022), 17, Seite 330-337 (DE-627)DOAJ000150428 10020306 nnns volume:43 year:2022 number:17 pages:330-337 https://doi.org/10.13386/j.issn1002-0306.2021120013 kostenfrei https://doaj.org/article/acdb1bca394f4aae9f25793357a282e7 kostenfrei http://www.spgykj.com/cn/article/doi/10.13386/j.issn1002-0306.2021120013 kostenfrei https://doaj.org/toc/1002-0306 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ AR 43 2022 17 330-337 |
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10.13386/j.issn1002-0306.2021120013 doi (DE-627)DOAJ086109928 (DE-599)DOAJacdb1bca394f4aae9f25793357a282e7 DE-627 ger DE-627 rakwb chi TP368-456 Lianwei LI verfasserin aut Determination of Nine Polypeptide Antibiotics Residues in Animal Tissue Food by Ultra-high Performance Liquid Chromatography-tandem Mass Spectrometry 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier A method combining SPE and Ultra-high performance liquid chromatography tandem mass spectrometry (UPLC-MS-MS) was developed for the simultaneous determination of nine polypeptide antibiotics in animal tissues. The samples were extracted by methanol and 0.1 mol/L hydrochloric acid (7:3, v/v), then cleaned with Alumina-A and n-hexane, and finally purified by hydrophilic-lipophilic balance (hydrophilic-lipophilic balance, HLB) cartridge. The separations were performed on a C8 column (100A, 150 mm×2 mm, 3 µm) using a mobile phase gradient with 0.2% formic acid and acetonitrile. Electrospray positive ionization and multi-reaction monitoring (MRM) mode were used for detection. The calibration curves for vancomycin, norvancomycin, enramycin A, enramycin B, and teicoplanin, (concentration range 2~200 μg/L), colistin A, colistin B and bacitracin A (concentration range 5~500 μg/L), virginiamycin M1 (concentration range 0.1~20 μg/L) were linear with correlation coefficients more than 0.99. The limits of quantification (LOQ, S/N=10) of 9 kinds of polypeptide antibiotics were varied from 1 µg/kg to 20 µg/kg, the detection limit of the method was 0.3 µg/kg to 6 µg/kg. The recovery experiments were performed with chicken, pork, liver and kidney samples spiked in the range of 1~200 μg/kg. The average recoveries ranged from 74.2% and 96.3% with the relative standard deviations (RSDs) of 4.3%~14.6% (n=6). The method is simple and rapid with high sensitivity and good reproducibility. Furthermore, this method is effective for the safety monitoring of polypeptide antibiotic residues in animal tissues. polypeptide antibiotic animal tissue solid-phase extraction ultra-high performance liquid chromatography tandem mass spectrometry (uplc-ms/ms) Food processing and manufacture Xiaocong YANG verfasserin aut Minna YAO verfasserin aut Zhengcai LIU verfasserin aut Xiaojing LI verfasserin aut In Shipin gongye ke-ji The editorial department of Science and Technology of Food Industry, 2022 43(2022), 17, Seite 330-337 (DE-627)DOAJ000150428 10020306 nnns volume:43 year:2022 number:17 pages:330-337 https://doi.org/10.13386/j.issn1002-0306.2021120013 kostenfrei https://doaj.org/article/acdb1bca394f4aae9f25793357a282e7 kostenfrei http://www.spgykj.com/cn/article/doi/10.13386/j.issn1002-0306.2021120013 kostenfrei https://doaj.org/toc/1002-0306 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ AR 43 2022 17 330-337 |
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The samples were extracted by methanol and 0.1 mol/L hydrochloric acid (7:3, v/v), then cleaned with Alumina-A and n-hexane, and finally purified by hydrophilic-lipophilic balance (hydrophilic-lipophilic balance, HLB) cartridge. The separations were performed on a C8 column (100A, 150 mm×2 mm, 3 µm) using a mobile phase gradient with 0.2% formic acid and acetonitrile. Electrospray positive ionization and multi-reaction monitoring (MRM) mode were used for detection. The calibration curves for vancomycin, norvancomycin, enramycin A, enramycin B, and teicoplanin, (concentration range 2~200 μg/L), colistin A, colistin B and bacitracin A (concentration range 5~500 μg/L), virginiamycin M1 (concentration range 0.1~20 μg/L) were linear with correlation coefficients more than 0.99. The limits of quantification (LOQ, S/N=10) of 9 kinds of polypeptide antibiotics were varied from 1 µg/kg to 20 µg/kg, the detection limit of the method was 0.3 µg/kg to 6 µg/kg. 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TP368-456 Determination of Nine Polypeptide Antibiotics Residues in Animal Tissue Food by Ultra-high Performance Liquid Chromatography-tandem Mass Spectrometry polypeptide antibiotic animal tissue solid-phase extraction ultra-high performance liquid chromatography tandem mass spectrometry (uplc-ms/ms) |
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Determination of Nine Polypeptide Antibiotics Residues in Animal Tissue Food by Ultra-high Performance Liquid Chromatography-tandem Mass Spectrometry |
| abstract |
A method combining SPE and Ultra-high performance liquid chromatography tandem mass spectrometry (UPLC-MS-MS) was developed for the simultaneous determination of nine polypeptide antibiotics in animal tissues. The samples were extracted by methanol and 0.1 mol/L hydrochloric acid (7:3, v/v), then cleaned with Alumina-A and n-hexane, and finally purified by hydrophilic-lipophilic balance (hydrophilic-lipophilic balance, HLB) cartridge. The separations were performed on a C8 column (100A, 150 mm×2 mm, 3 µm) using a mobile phase gradient with 0.2% formic acid and acetonitrile. Electrospray positive ionization and multi-reaction monitoring (MRM) mode were used for detection. The calibration curves for vancomycin, norvancomycin, enramycin A, enramycin B, and teicoplanin, (concentration range 2~200 μg/L), colistin A, colistin B and bacitracin A (concentration range 5~500 μg/L), virginiamycin M1 (concentration range 0.1~20 μg/L) were linear with correlation coefficients more than 0.99. The limits of quantification (LOQ, S/N=10) of 9 kinds of polypeptide antibiotics were varied from 1 µg/kg to 20 µg/kg, the detection limit of the method was 0.3 µg/kg to 6 µg/kg. The recovery experiments were performed with chicken, pork, liver and kidney samples spiked in the range of 1~200 μg/kg. The average recoveries ranged from 74.2% and 96.3% with the relative standard deviations (RSDs) of 4.3%~14.6% (n=6). The method is simple and rapid with high sensitivity and good reproducibility. Furthermore, this method is effective for the safety monitoring of polypeptide antibiotic residues in animal tissues. |
| abstractGer |
A method combining SPE and Ultra-high performance liquid chromatography tandem mass spectrometry (UPLC-MS-MS) was developed for the simultaneous determination of nine polypeptide antibiotics in animal tissues. The samples were extracted by methanol and 0.1 mol/L hydrochloric acid (7:3, v/v), then cleaned with Alumina-A and n-hexane, and finally purified by hydrophilic-lipophilic balance (hydrophilic-lipophilic balance, HLB) cartridge. The separations were performed on a C8 column (100A, 150 mm×2 mm, 3 µm) using a mobile phase gradient with 0.2% formic acid and acetonitrile. Electrospray positive ionization and multi-reaction monitoring (MRM) mode were used for detection. The calibration curves for vancomycin, norvancomycin, enramycin A, enramycin B, and teicoplanin, (concentration range 2~200 μg/L), colistin A, colistin B and bacitracin A (concentration range 5~500 μg/L), virginiamycin M1 (concentration range 0.1~20 μg/L) were linear with correlation coefficients more than 0.99. The limits of quantification (LOQ, S/N=10) of 9 kinds of polypeptide antibiotics were varied from 1 µg/kg to 20 µg/kg, the detection limit of the method was 0.3 µg/kg to 6 µg/kg. The recovery experiments were performed with chicken, pork, liver and kidney samples spiked in the range of 1~200 μg/kg. The average recoveries ranged from 74.2% and 96.3% with the relative standard deviations (RSDs) of 4.3%~14.6% (n=6). The method is simple and rapid with high sensitivity and good reproducibility. Furthermore, this method is effective for the safety monitoring of polypeptide antibiotic residues in animal tissues. |
| abstract_unstemmed |
A method combining SPE and Ultra-high performance liquid chromatography tandem mass spectrometry (UPLC-MS-MS) was developed for the simultaneous determination of nine polypeptide antibiotics in animal tissues. The samples were extracted by methanol and 0.1 mol/L hydrochloric acid (7:3, v/v), then cleaned with Alumina-A and n-hexane, and finally purified by hydrophilic-lipophilic balance (hydrophilic-lipophilic balance, HLB) cartridge. The separations were performed on a C8 column (100A, 150 mm×2 mm, 3 µm) using a mobile phase gradient with 0.2% formic acid and acetonitrile. Electrospray positive ionization and multi-reaction monitoring (MRM) mode were used for detection. The calibration curves for vancomycin, norvancomycin, enramycin A, enramycin B, and teicoplanin, (concentration range 2~200 μg/L), colistin A, colistin B and bacitracin A (concentration range 5~500 μg/L), virginiamycin M1 (concentration range 0.1~20 μg/L) were linear with correlation coefficients more than 0.99. The limits of quantification (LOQ, S/N=10) of 9 kinds of polypeptide antibiotics were varied from 1 µg/kg to 20 µg/kg, the detection limit of the method was 0.3 µg/kg to 6 µg/kg. The recovery experiments were performed with chicken, pork, liver and kidney samples spiked in the range of 1~200 μg/kg. The average recoveries ranged from 74.2% and 96.3% with the relative standard deviations (RSDs) of 4.3%~14.6% (n=6). The method is simple and rapid with high sensitivity and good reproducibility. Furthermore, this method is effective for the safety monitoring of polypeptide antibiotic residues in animal tissues. |
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Determination of Nine Polypeptide Antibiotics Residues in Animal Tissue Food by Ultra-high Performance Liquid Chromatography-tandem Mass Spectrometry |
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