Effects of <i<Colocasia antiquorum</i< var. <i<Esculenta</i< Extract In Vitro and In Vivo against Periodontal Disease

<i<Background and Objectives</i<: Periodontal disease is a chronic inflammatory disease in which gradual destruction of tissues around teeth is caused by plaque formed by pathogenic bacteria. The purpose of this study was to evaluate the potential of 75% ethanol extract of <i<Coloc...
Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Seong-Hee Moon [verfasserIn] Seong-Jin Shin [verfasserIn] Hyun-Jin Tae [verfasserIn] Seung-Han Oh [verfasserIn] Ji-Myung Bae [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2021

Schlagwörter:	oral infection periodontal diseases oral microbiome

Übergeordnetes Werk:	In: Medicina - MDPI AG, 2016, 57(2021), 10, p 1054
Übergeordnetes Werk:	volume:57 ; year:2021 ; number:10, p 1054

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc Journal toc

DOI / URN:	10.3390/medicina57101054

Katalog-ID:	DOAJ086184628

Internformat


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520			\|a <i<Background and Objectives</i<: Periodontal disease is a chronic inflammatory disease in which gradual destruction of tissues around teeth is caused by plaque formed by pathogenic bacteria. The purpose of this study was to evaluate the potential of 75% ethanol extract of <i<Colocasia antiquorum</i< var. <i<esculenta</i< (CA) as a prophylactic and improvement agent for periodontal disease in vitro and in vivo. <i<Materials and Methods</i<: The antimicrobial efficacy of CA against <i<Porphyromonas gingivalis</i< (<i<P. gingivalis</i<, ATCC 33277) was evaluated using minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) test, and cytotoxicity was confirmed by CCK-8 assay. For the in vivo study, <i<P. gingivalis</i< was applied by oral gavage to BALB/c mice. Forty-two days after the first inoculation of <i<P. gingivalis</i<, intraoral swabs were taken for microbiome analysis, and the mice were sacrificed to evaluate the alveolar bone loss. <i<Results</i<: The MIC of CA against <i<P. gingivalis</i< was 31.3 μg/mL, the MBC was 62.5 μg/mL, with no cytotoxicity. The diversity of the oral microbiome decreased in the positive control group, while those of the VA (varnish) and VCA (varnish added with CA) groups increased as much as in the negative control group, although the alveolar bone loss was not induced in the mouse model. <i<Conclusions</i<: CA showed antibacterial effects in vitro, and the VA and VCA groups exhibited increased diversity in the oral microbiome, suggesting that CA has potential for improving periodontal disease.
650		4	\|a <i<Porphyromonas gingivalis</i<
650		4	\|a oral infection
650		4	\|a periodontal diseases
650		4	\|a oral microbiome
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allfields	10.3390/medicina57101054 doi (DE-627)DOAJ086184628 (DE-599)DOAJ99bcc872f28b4402ba001269fa1701ca DE-627 ger DE-627 rakwb eng R5-920 Seong-Hee Moon verfasserin aut Effects of <i<Colocasia antiquorum</i< var. <i<Esculenta</i< Extract In Vitro and In Vivo against Periodontal Disease 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier <i<Background and Objectives</i<: Periodontal disease is a chronic inflammatory disease in which gradual destruction of tissues around teeth is caused by plaque formed by pathogenic bacteria. The purpose of this study was to evaluate the potential of 75% ethanol extract of <i<Colocasia antiquorum</i< var. <i<esculenta</i< (CA) as a prophylactic and improvement agent for periodontal disease in vitro and in vivo. <i<Materials and Methods</i<: The antimicrobial efficacy of CA against <i<Porphyromonas gingivalis</i< (<i<P. gingivalis</i<, ATCC 33277) was evaluated using minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) test, and cytotoxicity was confirmed by CCK-8 assay. For the in vivo study, <i<P. gingivalis</i< was applied by oral gavage to BALB/c mice. Forty-two days after the first inoculation of <i<P. gingivalis</i<, intraoral swabs were taken for microbiome analysis, and the mice were sacrificed to evaluate the alveolar bone loss. <i<Results</i<: The MIC of CA against <i<P. gingivalis</i< was 31.3 μg/mL, the MBC was 62.5 μg/mL, with no cytotoxicity. The diversity of the oral microbiome decreased in the positive control group, while those of the VA (varnish) and VCA (varnish added with CA) groups increased as much as in the negative control group, although the alveolar bone loss was not induced in the mouse model. <i<Conclusions</i<: CA showed antibacterial effects in vitro, and the VA and VCA groups exhibited increased diversity in the oral microbiome, suggesting that CA has potential for improving periodontal disease. <i<Porphyromonas gingivalis</i< oral infection periodontal diseases oral microbiome <i<Colocasia antiquorum</i< Medicine (General) Seong-Jin Shin verfasserin aut Hyun-Jin Tae verfasserin aut Seung-Han Oh verfasserin aut Ji-Myung Bae verfasserin aut In Medicina MDPI AG, 2016 57(2021), 10, p 1054 (DE-627)354543296 (DE-600)2088820-X 16489144 nnns volume:57 year:2021 number:10, p 1054 https://doi.org/10.3390/medicina57101054 kostenfrei https://doaj.org/article/99bcc872f28b4402ba001269fa1701ca kostenfrei https://www.mdpi.com/1648-9144/57/10/1054 kostenfrei https://doaj.org/toc/1010-660X Journal toc kostenfrei https://doaj.org/toc/1648-9144 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 57 2021 10, p 1054
spelling	10.3390/medicina57101054 doi (DE-627)DOAJ086184628 (DE-599)DOAJ99bcc872f28b4402ba001269fa1701ca DE-627 ger DE-627 rakwb eng R5-920 Seong-Hee Moon verfasserin aut Effects of <i<Colocasia antiquorum</i< var. <i<Esculenta</i< Extract In Vitro and In Vivo against Periodontal Disease 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier <i<Background and Objectives</i<: Periodontal disease is a chronic inflammatory disease in which gradual destruction of tissues around teeth is caused by plaque formed by pathogenic bacteria. The purpose of this study was to evaluate the potential of 75% ethanol extract of <i<Colocasia antiquorum</i< var. <i<esculenta</i< (CA) as a prophylactic and improvement agent for periodontal disease in vitro and in vivo. <i<Materials and Methods</i<: The antimicrobial efficacy of CA against <i<Porphyromonas gingivalis</i< (<i<P. gingivalis</i<, ATCC 33277) was evaluated using minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) test, and cytotoxicity was confirmed by CCK-8 assay. For the in vivo study, <i<P. gingivalis</i< was applied by oral gavage to BALB/c mice. Forty-two days after the first inoculation of <i<P. gingivalis</i<, intraoral swabs were taken for microbiome analysis, and the mice were sacrificed to evaluate the alveolar bone loss. <i<Results</i<: The MIC of CA against <i<P. gingivalis</i< was 31.3 μg/mL, the MBC was 62.5 μg/mL, with no cytotoxicity. The diversity of the oral microbiome decreased in the positive control group, while those of the VA (varnish) and VCA (varnish added with CA) groups increased as much as in the negative control group, although the alveolar bone loss was not induced in the mouse model. <i<Conclusions</i<: CA showed antibacterial effects in vitro, and the VA and VCA groups exhibited increased diversity in the oral microbiome, suggesting that CA has potential for improving periodontal disease. <i<Porphyromonas gingivalis</i< oral infection periodontal diseases oral microbiome <i<Colocasia antiquorum</i< Medicine (General) Seong-Jin Shin verfasserin aut Hyun-Jin Tae verfasserin aut Seung-Han Oh verfasserin aut Ji-Myung Bae verfasserin aut In Medicina MDPI AG, 2016 57(2021), 10, p 1054 (DE-627)354543296 (DE-600)2088820-X 16489144 nnns volume:57 year:2021 number:10, p 1054 https://doi.org/10.3390/medicina57101054 kostenfrei https://doaj.org/article/99bcc872f28b4402ba001269fa1701ca kostenfrei https://www.mdpi.com/1648-9144/57/10/1054 kostenfrei https://doaj.org/toc/1010-660X Journal toc kostenfrei https://doaj.org/toc/1648-9144 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 57 2021 10, p 1054
allfields_unstemmed	10.3390/medicina57101054 doi (DE-627)DOAJ086184628 (DE-599)DOAJ99bcc872f28b4402ba001269fa1701ca DE-627 ger DE-627 rakwb eng R5-920 Seong-Hee Moon verfasserin aut Effects of <i<Colocasia antiquorum</i< var. <i<Esculenta</i< Extract In Vitro and In Vivo against Periodontal Disease 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier <i<Background and Objectives</i<: Periodontal disease is a chronic inflammatory disease in which gradual destruction of tissues around teeth is caused by plaque formed by pathogenic bacteria. The purpose of this study was to evaluate the potential of 75% ethanol extract of <i<Colocasia antiquorum</i< var. <i<esculenta</i< (CA) as a prophylactic and improvement agent for periodontal disease in vitro and in vivo. <i<Materials and Methods</i<: The antimicrobial efficacy of CA against <i<Porphyromonas gingivalis</i< (<i<P. gingivalis</i<, ATCC 33277) was evaluated using minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) test, and cytotoxicity was confirmed by CCK-8 assay. For the in vivo study, <i<P. gingivalis</i< was applied by oral gavage to BALB/c mice. Forty-two days after the first inoculation of <i<P. gingivalis</i<, intraoral swabs were taken for microbiome analysis, and the mice were sacrificed to evaluate the alveolar bone loss. <i<Results</i<: The MIC of CA against <i<P. gingivalis</i< was 31.3 μg/mL, the MBC was 62.5 μg/mL, with no cytotoxicity. The diversity of the oral microbiome decreased in the positive control group, while those of the VA (varnish) and VCA (varnish added with CA) groups increased as much as in the negative control group, although the alveolar bone loss was not induced in the mouse model. <i<Conclusions</i<: CA showed antibacterial effects in vitro, and the VA and VCA groups exhibited increased diversity in the oral microbiome, suggesting that CA has potential for improving periodontal disease. <i<Porphyromonas gingivalis</i< oral infection periodontal diseases oral microbiome <i<Colocasia antiquorum</i< Medicine (General) Seong-Jin Shin verfasserin aut Hyun-Jin Tae verfasserin aut Seung-Han Oh verfasserin aut Ji-Myung Bae verfasserin aut In Medicina MDPI AG, 2016 57(2021), 10, p 1054 (DE-627)354543296 (DE-600)2088820-X 16489144 nnns volume:57 year:2021 number:10, p 1054 https://doi.org/10.3390/medicina57101054 kostenfrei https://doaj.org/article/99bcc872f28b4402ba001269fa1701ca kostenfrei https://www.mdpi.com/1648-9144/57/10/1054 kostenfrei https://doaj.org/toc/1010-660X Journal toc kostenfrei https://doaj.org/toc/1648-9144 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 57 2021 10, p 1054
allfieldsGer	10.3390/medicina57101054 doi (DE-627)DOAJ086184628 (DE-599)DOAJ99bcc872f28b4402ba001269fa1701ca DE-627 ger DE-627 rakwb eng R5-920 Seong-Hee Moon verfasserin aut Effects of <i<Colocasia antiquorum</i< var. <i<Esculenta</i< Extract In Vitro and In Vivo against Periodontal Disease 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier <i<Background and Objectives</i<: Periodontal disease is a chronic inflammatory disease in which gradual destruction of tissues around teeth is caused by plaque formed by pathogenic bacteria. The purpose of this study was to evaluate the potential of 75% ethanol extract of <i<Colocasia antiquorum</i< var. <i<esculenta</i< (CA) as a prophylactic and improvement agent for periodontal disease in vitro and in vivo. <i<Materials and Methods</i<: The antimicrobial efficacy of CA against <i<Porphyromonas gingivalis</i< (<i<P. gingivalis</i<, ATCC 33277) was evaluated using minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) test, and cytotoxicity was confirmed by CCK-8 assay. For the in vivo study, <i<P. gingivalis</i< was applied by oral gavage to BALB/c mice. Forty-two days after the first inoculation of <i<P. gingivalis</i<, intraoral swabs were taken for microbiome analysis, and the mice were sacrificed to evaluate the alveolar bone loss. <i<Results</i<: The MIC of CA against <i<P. gingivalis</i< was 31.3 μg/mL, the MBC was 62.5 μg/mL, with no cytotoxicity. The diversity of the oral microbiome decreased in the positive control group, while those of the VA (varnish) and VCA (varnish added with CA) groups increased as much as in the negative control group, although the alveolar bone loss was not induced in the mouse model. <i<Conclusions</i<: CA showed antibacterial effects in vitro, and the VA and VCA groups exhibited increased diversity in the oral microbiome, suggesting that CA has potential for improving periodontal disease. <i<Porphyromonas gingivalis</i< oral infection periodontal diseases oral microbiome <i<Colocasia antiquorum</i< Medicine (General) Seong-Jin Shin verfasserin aut Hyun-Jin Tae verfasserin aut Seung-Han Oh verfasserin aut Ji-Myung Bae verfasserin aut In Medicina MDPI AG, 2016 57(2021), 10, p 1054 (DE-627)354543296 (DE-600)2088820-X 16489144 nnns volume:57 year:2021 number:10, p 1054 https://doi.org/10.3390/medicina57101054 kostenfrei https://doaj.org/article/99bcc872f28b4402ba001269fa1701ca kostenfrei https://www.mdpi.com/1648-9144/57/10/1054 kostenfrei https://doaj.org/toc/1010-660X Journal toc kostenfrei https://doaj.org/toc/1648-9144 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 57 2021 10, p 1054
allfieldsSound	10.3390/medicina57101054 doi (DE-627)DOAJ086184628 (DE-599)DOAJ99bcc872f28b4402ba001269fa1701ca DE-627 ger DE-627 rakwb eng R5-920 Seong-Hee Moon verfasserin aut Effects of <i<Colocasia antiquorum</i< var. <i<Esculenta</i< Extract In Vitro and In Vivo against Periodontal Disease 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier <i<Background and Objectives</i<: Periodontal disease is a chronic inflammatory disease in which gradual destruction of tissues around teeth is caused by plaque formed by pathogenic bacteria. The purpose of this study was to evaluate the potential of 75% ethanol extract of <i<Colocasia antiquorum</i< var. <i<esculenta</i< (CA) as a prophylactic and improvement agent for periodontal disease in vitro and in vivo. <i<Materials and Methods</i<: The antimicrobial efficacy of CA against <i<Porphyromonas gingivalis</i< (<i<P. gingivalis</i<, ATCC 33277) was evaluated using minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) test, and cytotoxicity was confirmed by CCK-8 assay. For the in vivo study, <i<P. gingivalis</i< was applied by oral gavage to BALB/c mice. Forty-two days after the first inoculation of <i<P. gingivalis</i<, intraoral swabs were taken for microbiome analysis, and the mice were sacrificed to evaluate the alveolar bone loss. <i<Results</i<: The MIC of CA against <i<P. gingivalis</i< was 31.3 μg/mL, the MBC was 62.5 μg/mL, with no cytotoxicity. The diversity of the oral microbiome decreased in the positive control group, while those of the VA (varnish) and VCA (varnish added with CA) groups increased as much as in the negative control group, although the alveolar bone loss was not induced in the mouse model. <i<Conclusions</i<: CA showed antibacterial effects in vitro, and the VA and VCA groups exhibited increased diversity in the oral microbiome, suggesting that CA has potential for improving periodontal disease. <i<Porphyromonas gingivalis</i< oral infection periodontal diseases oral microbiome <i<Colocasia antiquorum</i< Medicine (General) Seong-Jin Shin verfasserin aut Hyun-Jin Tae verfasserin aut Seung-Han Oh verfasserin aut Ji-Myung Bae verfasserin aut In Medicina MDPI AG, 2016 57(2021), 10, p 1054 (DE-627)354543296 (DE-600)2088820-X 16489144 nnns volume:57 year:2021 number:10, p 1054 https://doi.org/10.3390/medicina57101054 kostenfrei https://doaj.org/article/99bcc872f28b4402ba001269fa1701ca kostenfrei https://www.mdpi.com/1648-9144/57/10/1054 kostenfrei https://doaj.org/toc/1010-660X Journal toc kostenfrei https://doaj.org/toc/1648-9144 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 57 2021 10, p 1054
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callnumber-first	R - Medicine
author	Seong-Hee Moon
spellingShingle	Seong-Hee Moon misc R5-920 misc <i<Porphyromonas gingivalis</i< misc oral infection misc periodontal diseases misc oral microbiome misc <i<Colocasia antiquorum</i< misc Medicine (General) Effects of <i<Colocasia antiquorum</i< var. <i<Esculenta</i< Extract In Vitro and In Vivo against Periodontal Disease
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topic_title	R5-920 Effects of <i<Colocasia antiquorum</i< var. <i<Esculenta</i< Extract In Vitro and In Vivo against Periodontal Disease <i<Porphyromonas gingivalis</i< oral infection periodontal diseases oral microbiome <i<Colocasia antiquorum</i<
topic	misc R5-920 misc <i<Porphyromonas gingivalis</i< misc oral infection misc periodontal diseases misc oral microbiome misc <i<Colocasia antiquorum</i< misc Medicine (General)
topic_unstemmed	misc R5-920 misc <i<Porphyromonas gingivalis</i< misc oral infection misc periodontal diseases misc oral microbiome misc <i<Colocasia antiquorum</i< misc Medicine (General)
topic_browse	misc R5-920 misc <i<Porphyromonas gingivalis</i< misc oral infection misc periodontal diseases misc oral microbiome misc <i<Colocasia antiquorum</i< misc Medicine (General)
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title	Effects of <i<Colocasia antiquorum</i< var. <i<Esculenta</i< Extract In Vitro and In Vivo against Periodontal Disease
ctrlnum	(DE-627)DOAJ086184628 (DE-599)DOAJ99bcc872f28b4402ba001269fa1701ca
title_full	Effects of <i<Colocasia antiquorum</i< var. <i<Esculenta</i< Extract In Vitro and In Vivo against Periodontal Disease
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title_sort	effects of <i<colocasia antiquorum</i< var. <i<esculenta</i< extract in vitro and in vivo against periodontal disease
callnumber	R5-920
title_auth	Effects of <i<Colocasia antiquorum</i< var. <i<Esculenta</i< Extract In Vitro and In Vivo against Periodontal Disease
abstract	<i<Background and Objectives</i<: Periodontal disease is a chronic inflammatory disease in which gradual destruction of tissues around teeth is caused by plaque formed by pathogenic bacteria. The purpose of this study was to evaluate the potential of 75% ethanol extract of <i<Colocasia antiquorum</i< var. <i<esculenta</i< (CA) as a prophylactic and improvement agent for periodontal disease in vitro and in vivo. <i<Materials and Methods</i<: The antimicrobial efficacy of CA against <i<Porphyromonas gingivalis</i< (<i<P. gingivalis</i<, ATCC 33277) was evaluated using minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) test, and cytotoxicity was confirmed by CCK-8 assay. For the in vivo study, <i<P. gingivalis</i< was applied by oral gavage to BALB/c mice. Forty-two days after the first inoculation of <i<P. gingivalis</i<, intraoral swabs were taken for microbiome analysis, and the mice were sacrificed to evaluate the alveolar bone loss. <i<Results</i<: The MIC of CA against <i<P. gingivalis</i< was 31.3 μg/mL, the MBC was 62.5 μg/mL, with no cytotoxicity. The diversity of the oral microbiome decreased in the positive control group, while those of the VA (varnish) and VCA (varnish added with CA) groups increased as much as in the negative control group, although the alveolar bone loss was not induced in the mouse model. <i<Conclusions</i<: CA showed antibacterial effects in vitro, and the VA and VCA groups exhibited increased diversity in the oral microbiome, suggesting that CA has potential for improving periodontal disease.
abstractGer	<i<Background and Objectives</i<: Periodontal disease is a chronic inflammatory disease in which gradual destruction of tissues around teeth is caused by plaque formed by pathogenic bacteria. The purpose of this study was to evaluate the potential of 75% ethanol extract of <i<Colocasia antiquorum</i< var. <i<esculenta</i< (CA) as a prophylactic and improvement agent for periodontal disease in vitro and in vivo. <i<Materials and Methods</i<: The antimicrobial efficacy of CA against <i<Porphyromonas gingivalis</i< (<i<P. gingivalis</i<, ATCC 33277) was evaluated using minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) test, and cytotoxicity was confirmed by CCK-8 assay. For the in vivo study, <i<P. gingivalis</i< was applied by oral gavage to BALB/c mice. Forty-two days after the first inoculation of <i<P. gingivalis</i<, intraoral swabs were taken for microbiome analysis, and the mice were sacrificed to evaluate the alveolar bone loss. <i<Results</i<: The MIC of CA against <i<P. gingivalis</i< was 31.3 μg/mL, the MBC was 62.5 μg/mL, with no cytotoxicity. The diversity of the oral microbiome decreased in the positive control group, while those of the VA (varnish) and VCA (varnish added with CA) groups increased as much as in the negative control group, although the alveolar bone loss was not induced in the mouse model. <i<Conclusions</i<: CA showed antibacterial effects in vitro, and the VA and VCA groups exhibited increased diversity in the oral microbiome, suggesting that CA has potential for improving periodontal disease.
abstract_unstemmed	<i<Background and Objectives</i<: Periodontal disease is a chronic inflammatory disease in which gradual destruction of tissues around teeth is caused by plaque formed by pathogenic bacteria. The purpose of this study was to evaluate the potential of 75% ethanol extract of <i<Colocasia antiquorum</i< var. <i<esculenta</i< (CA) as a prophylactic and improvement agent for periodontal disease in vitro and in vivo. <i<Materials and Methods</i<: The antimicrobial efficacy of CA against <i<Porphyromonas gingivalis</i< (<i<P. gingivalis</i<, ATCC 33277) was evaluated using minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) test, and cytotoxicity was confirmed by CCK-8 assay. For the in vivo study, <i<P. gingivalis</i< was applied by oral gavage to BALB/c mice. Forty-two days after the first inoculation of <i<P. gingivalis</i<, intraoral swabs were taken for microbiome analysis, and the mice were sacrificed to evaluate the alveolar bone loss. <i<Results</i<: The MIC of CA against <i<P. gingivalis</i< was 31.3 μg/mL, the MBC was 62.5 μg/mL, with no cytotoxicity. The diversity of the oral microbiome decreased in the positive control group, while those of the VA (varnish) and VCA (varnish added with CA) groups increased as much as in the negative control group, although the alveolar bone loss was not induced in the mouse model. <i<Conclusions</i<: CA showed antibacterial effects in vitro, and the VA and VCA groups exhibited increased diversity in the oral microbiome, suggesting that CA has potential for improving periodontal disease.
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title_short	Effects of <i<Colocasia antiquorum</i< var. <i<Esculenta</i< Extract In Vitro and In Vivo against Periodontal Disease
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The purpose of this study was to evaluate the potential of 75% ethanol extract of <i<Colocasia antiquorum</i< var. <i<esculenta</i< (CA) as a prophylactic and improvement agent for periodontal disease in vitro and in vivo. <i<Materials and Methods</i<: The antimicrobial efficacy of CA against <i<Porphyromonas gingivalis</i< (<i<P. gingivalis</i<, ATCC 33277) was evaluated using minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) test, and cytotoxicity was confirmed by CCK-8 assay. For the in vivo study, <i<P. gingivalis</i< was applied by oral gavage to BALB/c mice. Forty-two days after the first inoculation of <i<P. gingivalis</i<, intraoral swabs were taken for microbiome analysis, and the mice were sacrificed to evaluate the alveolar bone loss. <i<Results</i<: The MIC of CA against <i<P. gingivalis</i< was 31.3 μg/mL, the MBC was 62.5 μg/mL, with no cytotoxicity. 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Effects of <i<Colocasia antiquorum</i< var. <i<Esculenta</i< Extract In Vitro and In Vivo against Periodontal Disease

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