The contribution of the lateral posterior and anteroventral thalamic nuclei on spontaneous recurrent seizures in the pilocarpine model of epilepsy

The pilocarpine model of epilepsy in rats is characterised by the occurrence of spontaneous seizures (SRSs) during the chronic period that recur 2-3 times per week during the whole animal life. In a previous study on brain metabolism during the chronic period of the pilocarpine model it was possible...
Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Fulvio Alexandre Scorza [verfasserIn] Ricardo Mario Arida [verfasserIn] Margareth Priel [verfasserIn] Lineu Calderazzo [verfasserIn] Esper Abrão Cavalheiro [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2002

Schlagwörter:	pilocarpine lateral posterior thalamic nuclei

Übergeordnetes Werk:	In: Arquivos de Neuro-Psiquiatria - Academia Brasileira de Neurologia (ABNEURO), 2004, 60(2002), 3A, Seite 572-575
Übergeordnetes Werk:	volume:60 ; year:2002 ; number:3A ; pages:572-575

Links:	Link aufrufen Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.1590/S0004-282X2002000400011

Katalog-ID:	DOAJ086318837

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allfields	10.1590/S0004-282X2002000400011 doi (DE-627)DOAJ086318837 (DE-599)DOAJ7779ff5d5d23401d896aca28331e3e30 DE-627 ger DE-627 rakwb eng RC321-571 Fulvio Alexandre Scorza verfasserin aut The contribution of the lateral posterior and anteroventral thalamic nuclei on spontaneous recurrent seizures in the pilocarpine model of epilepsy 2002 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The pilocarpine model of epilepsy in rats is characterised by the occurrence of spontaneous seizures (SRSs) during the chronic period that recur 2-3 times per week during the whole animal life. In a previous study on brain metabolism during the chronic period of the pilocarpine model it was possible to observe that, among several brain structures, the lateral posterior thalamic nuclei (LP) showed a strikingly increased metabolism. Some evidences suggest that the LP can participate in an inhibitory control system involved in the propagation of the seizures. The aim of the present study was to verify the role of LP in the expression and frequency of spontaneous seizures observed in the pilocarpine model. Ten adult male rats presenting SRSs were monitored for behavioural events by video system one month before and one month after LP ibotenic acid lesion. Another group of chronic epileptic rats (n=10) had the anteroventral thalamic nuclei (AV) lesioned by ibotenic acid. After the surgical procedure, the animals were sacrified and the brains were processed for histological analysis by the Nissl method. The LP group seizure frequency was 3.1±1.9 before ibotenic acid injection and showed an increase (16.3±7.2 per week) after LP lesion. No changes in SRSs frequency were observed in the AV group after ibotenic lesion in these nuclei. These results seem to suggest that LP play a role in the seizure circuitry inhibiting the expression of spontaneous seizures in the pilocarpine model. pilocarpine lateral posterior thalamic nuclei Neurosciences. Biological psychiatry. Neuropsychiatry Ricardo Mario Arida verfasserin aut Margareth Priel verfasserin aut Lineu Calderazzo verfasserin aut Esper Abrão Cavalheiro verfasserin aut In Arquivos de Neuro-Psiquiatria Academia Brasileira de Neurologia (ABNEURO), 2004 60(2002), 3A, Seite 572-575 (DE-627)331708310 (DE-600)2053072-9 16784227 nnns volume:60 year:2002 number:3A pages:572-575 https://doi.org/10.1590/S0004-282X2002000400011 kostenfrei https://doaj.org/article/7779ff5d5d23401d896aca28331e3e30 kostenfrei http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2002000400011&tlng=en kostenfrei http://www.scielo.br/pdf/anp/v60n3a/11128.pdf kostenfrei https://doaj.org/toc/1678-4227 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 60 2002 3A 572-575
spelling	10.1590/S0004-282X2002000400011 doi (DE-627)DOAJ086318837 (DE-599)DOAJ7779ff5d5d23401d896aca28331e3e30 DE-627 ger DE-627 rakwb eng RC321-571 Fulvio Alexandre Scorza verfasserin aut The contribution of the lateral posterior and anteroventral thalamic nuclei on spontaneous recurrent seizures in the pilocarpine model of epilepsy 2002 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The pilocarpine model of epilepsy in rats is characterised by the occurrence of spontaneous seizures (SRSs) during the chronic period that recur 2-3 times per week during the whole animal life. In a previous study on brain metabolism during the chronic period of the pilocarpine model it was possible to observe that, among several brain structures, the lateral posterior thalamic nuclei (LP) showed a strikingly increased metabolism. Some evidences suggest that the LP can participate in an inhibitory control system involved in the propagation of the seizures. The aim of the present study was to verify the role of LP in the expression and frequency of spontaneous seizures observed in the pilocarpine model. Ten adult male rats presenting SRSs were monitored for behavioural events by video system one month before and one month after LP ibotenic acid lesion. Another group of chronic epileptic rats (n=10) had the anteroventral thalamic nuclei (AV) lesioned by ibotenic acid. After the surgical procedure, the animals were sacrified and the brains were processed for histological analysis by the Nissl method. The LP group seizure frequency was 3.1±1.9 before ibotenic acid injection and showed an increase (16.3±7.2 per week) after LP lesion. No changes in SRSs frequency were observed in the AV group after ibotenic lesion in these nuclei. These results seem to suggest that LP play a role in the seizure circuitry inhibiting the expression of spontaneous seizures in the pilocarpine model. pilocarpine lateral posterior thalamic nuclei Neurosciences. Biological psychiatry. Neuropsychiatry Ricardo Mario Arida verfasserin aut Margareth Priel verfasserin aut Lineu Calderazzo verfasserin aut Esper Abrão Cavalheiro verfasserin aut In Arquivos de Neuro-Psiquiatria Academia Brasileira de Neurologia (ABNEURO), 2004 60(2002), 3A, Seite 572-575 (DE-627)331708310 (DE-600)2053072-9 16784227 nnns volume:60 year:2002 number:3A pages:572-575 https://doi.org/10.1590/S0004-282X2002000400011 kostenfrei https://doaj.org/article/7779ff5d5d23401d896aca28331e3e30 kostenfrei http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2002000400011&tlng=en kostenfrei http://www.scielo.br/pdf/anp/v60n3a/11128.pdf kostenfrei https://doaj.org/toc/1678-4227 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 60 2002 3A 572-575
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allfieldsGer	10.1590/S0004-282X2002000400011 doi (DE-627)DOAJ086318837 (DE-599)DOAJ7779ff5d5d23401d896aca28331e3e30 DE-627 ger DE-627 rakwb eng RC321-571 Fulvio Alexandre Scorza verfasserin aut The contribution of the lateral posterior and anteroventral thalamic nuclei on spontaneous recurrent seizures in the pilocarpine model of epilepsy 2002 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The pilocarpine model of epilepsy in rats is characterised by the occurrence of spontaneous seizures (SRSs) during the chronic period that recur 2-3 times per week during the whole animal life. In a previous study on brain metabolism during the chronic period of the pilocarpine model it was possible to observe that, among several brain structures, the lateral posterior thalamic nuclei (LP) showed a strikingly increased metabolism. Some evidences suggest that the LP can participate in an inhibitory control system involved in the propagation of the seizures. The aim of the present study was to verify the role of LP in the expression and frequency of spontaneous seizures observed in the pilocarpine model. Ten adult male rats presenting SRSs were monitored for behavioural events by video system one month before and one month after LP ibotenic acid lesion. Another group of chronic epileptic rats (n=10) had the anteroventral thalamic nuclei (AV) lesioned by ibotenic acid. After the surgical procedure, the animals were sacrified and the brains were processed for histological analysis by the Nissl method. The LP group seizure frequency was 3.1±1.9 before ibotenic acid injection and showed an increase (16.3±7.2 per week) after LP lesion. No changes in SRSs frequency were observed in the AV group after ibotenic lesion in these nuclei. These results seem to suggest that LP play a role in the seizure circuitry inhibiting the expression of spontaneous seizures in the pilocarpine model. pilocarpine lateral posterior thalamic nuclei Neurosciences. Biological psychiatry. Neuropsychiatry Ricardo Mario Arida verfasserin aut Margareth Priel verfasserin aut Lineu Calderazzo verfasserin aut Esper Abrão Cavalheiro verfasserin aut In Arquivos de Neuro-Psiquiatria Academia Brasileira de Neurologia (ABNEURO), 2004 60(2002), 3A, Seite 572-575 (DE-627)331708310 (DE-600)2053072-9 16784227 nnns volume:60 year:2002 number:3A pages:572-575 https://doi.org/10.1590/S0004-282X2002000400011 kostenfrei https://doaj.org/article/7779ff5d5d23401d896aca28331e3e30 kostenfrei http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2002000400011&tlng=en kostenfrei http://www.scielo.br/pdf/anp/v60n3a/11128.pdf kostenfrei https://doaj.org/toc/1678-4227 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 60 2002 3A 572-575
allfieldsSound	10.1590/S0004-282X2002000400011 doi (DE-627)DOAJ086318837 (DE-599)DOAJ7779ff5d5d23401d896aca28331e3e30 DE-627 ger DE-627 rakwb eng RC321-571 Fulvio Alexandre Scorza verfasserin aut The contribution of the lateral posterior and anteroventral thalamic nuclei on spontaneous recurrent seizures in the pilocarpine model of epilepsy 2002 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The pilocarpine model of epilepsy in rats is characterised by the occurrence of spontaneous seizures (SRSs) during the chronic period that recur 2-3 times per week during the whole animal life. In a previous study on brain metabolism during the chronic period of the pilocarpine model it was possible to observe that, among several brain structures, the lateral posterior thalamic nuclei (LP) showed a strikingly increased metabolism. Some evidences suggest that the LP can participate in an inhibitory control system involved in the propagation of the seizures. The aim of the present study was to verify the role of LP in the expression and frequency of spontaneous seizures observed in the pilocarpine model. Ten adult male rats presenting SRSs were monitored for behavioural events by video system one month before and one month after LP ibotenic acid lesion. Another group of chronic epileptic rats (n=10) had the anteroventral thalamic nuclei (AV) lesioned by ibotenic acid. After the surgical procedure, the animals were sacrified and the brains were processed for histological analysis by the Nissl method. The LP group seizure frequency was 3.1±1.9 before ibotenic acid injection and showed an increase (16.3±7.2 per week) after LP lesion. No changes in SRSs frequency were observed in the AV group after ibotenic lesion in these nuclei. These results seem to suggest that LP play a role in the seizure circuitry inhibiting the expression of spontaneous seizures in the pilocarpine model. pilocarpine lateral posterior thalamic nuclei Neurosciences. Biological psychiatry. Neuropsychiatry Ricardo Mario Arida verfasserin aut Margareth Priel verfasserin aut Lineu Calderazzo verfasserin aut Esper Abrão Cavalheiro verfasserin aut In Arquivos de Neuro-Psiquiatria Academia Brasileira de Neurologia (ABNEURO), 2004 60(2002), 3A, Seite 572-575 (DE-627)331708310 (DE-600)2053072-9 16784227 nnns volume:60 year:2002 number:3A pages:572-575 https://doi.org/10.1590/S0004-282X2002000400011 kostenfrei https://doaj.org/article/7779ff5d5d23401d896aca28331e3e30 kostenfrei http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2002000400011&tlng=en kostenfrei http://www.scielo.br/pdf/anp/v60n3a/11128.pdf kostenfrei https://doaj.org/toc/1678-4227 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 60 2002 3A 572-575
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source	In Arquivos de Neuro-Psiquiatria 60(2002), 3A, Seite 572-575 volume:60 year:2002 number:3A pages:572-575
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callnumber-first	R - Medicine
author	Fulvio Alexandre Scorza
spellingShingle	Fulvio Alexandre Scorza misc RC321-571 misc pilocarpine misc lateral posterior thalamic nuclei misc Neurosciences. Biological psychiatry. Neuropsychiatry The contribution of the lateral posterior and anteroventral thalamic nuclei on spontaneous recurrent seizures in the pilocarpine model of epilepsy
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topic_title	RC321-571 The contribution of the lateral posterior and anteroventral thalamic nuclei on spontaneous recurrent seizures in the pilocarpine model of epilepsy pilocarpine lateral posterior thalamic nuclei
topic	misc RC321-571 misc pilocarpine misc lateral posterior thalamic nuclei misc Neurosciences. Biological psychiatry. Neuropsychiatry
topic_unstemmed	misc RC321-571 misc pilocarpine misc lateral posterior thalamic nuclei misc Neurosciences. Biological psychiatry. Neuropsychiatry
topic_browse	misc RC321-571 misc pilocarpine misc lateral posterior thalamic nuclei misc Neurosciences. Biological psychiatry. Neuropsychiatry
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title	The contribution of the lateral posterior and anteroventral thalamic nuclei on spontaneous recurrent seizures in the pilocarpine model of epilepsy
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title_full	The contribution of the lateral posterior and anteroventral thalamic nuclei on spontaneous recurrent seizures in the pilocarpine model of epilepsy
author_sort	Fulvio Alexandre Scorza
journal	Arquivos de Neuro-Psiquiatria
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title_sort	contribution of the lateral posterior and anteroventral thalamic nuclei on spontaneous recurrent seizures in the pilocarpine model of epilepsy
callnumber	RC321-571
title_auth	The contribution of the lateral posterior and anteroventral thalamic nuclei on spontaneous recurrent seizures in the pilocarpine model of epilepsy
abstract	The pilocarpine model of epilepsy in rats is characterised by the occurrence of spontaneous seizures (SRSs) during the chronic period that recur 2-3 times per week during the whole animal life. In a previous study on brain metabolism during the chronic period of the pilocarpine model it was possible to observe that, among several brain structures, the lateral posterior thalamic nuclei (LP) showed a strikingly increased metabolism. Some evidences suggest that the LP can participate in an inhibitory control system involved in the propagation of the seizures. The aim of the present study was to verify the role of LP in the expression and frequency of spontaneous seizures observed in the pilocarpine model. Ten adult male rats presenting SRSs were monitored for behavioural events by video system one month before and one month after LP ibotenic acid lesion. Another group of chronic epileptic rats (n=10) had the anteroventral thalamic nuclei (AV) lesioned by ibotenic acid. After the surgical procedure, the animals were sacrified and the brains were processed for histological analysis by the Nissl method. The LP group seizure frequency was 3.1±1.9 before ibotenic acid injection and showed an increase (16.3±7.2 per week) after LP lesion. No changes in SRSs frequency were observed in the AV group after ibotenic lesion in these nuclei. These results seem to suggest that LP play a role in the seizure circuitry inhibiting the expression of spontaneous seizures in the pilocarpine model.
abstractGer	The pilocarpine model of epilepsy in rats is characterised by the occurrence of spontaneous seizures (SRSs) during the chronic period that recur 2-3 times per week during the whole animal life. In a previous study on brain metabolism during the chronic period of the pilocarpine model it was possible to observe that, among several brain structures, the lateral posterior thalamic nuclei (LP) showed a strikingly increased metabolism. Some evidences suggest that the LP can participate in an inhibitory control system involved in the propagation of the seizures. The aim of the present study was to verify the role of LP in the expression and frequency of spontaneous seizures observed in the pilocarpine model. Ten adult male rats presenting SRSs were monitored for behavioural events by video system one month before and one month after LP ibotenic acid lesion. Another group of chronic epileptic rats (n=10) had the anteroventral thalamic nuclei (AV) lesioned by ibotenic acid. After the surgical procedure, the animals were sacrified and the brains were processed for histological analysis by the Nissl method. The LP group seizure frequency was 3.1±1.9 before ibotenic acid injection and showed an increase (16.3±7.2 per week) after LP lesion. No changes in SRSs frequency were observed in the AV group after ibotenic lesion in these nuclei. These results seem to suggest that LP play a role in the seizure circuitry inhibiting the expression of spontaneous seizures in the pilocarpine model.
abstract_unstemmed	The pilocarpine model of epilepsy in rats is characterised by the occurrence of spontaneous seizures (SRSs) during the chronic period that recur 2-3 times per week during the whole animal life. In a previous study on brain metabolism during the chronic period of the pilocarpine model it was possible to observe that, among several brain structures, the lateral posterior thalamic nuclei (LP) showed a strikingly increased metabolism. Some evidences suggest that the LP can participate in an inhibitory control system involved in the propagation of the seizures. The aim of the present study was to verify the role of LP in the expression and frequency of spontaneous seizures observed in the pilocarpine model. Ten adult male rats presenting SRSs were monitored for behavioural events by video system one month before and one month after LP ibotenic acid lesion. Another group of chronic epileptic rats (n=10) had the anteroventral thalamic nuclei (AV) lesioned by ibotenic acid. After the surgical procedure, the animals were sacrified and the brains were processed for histological analysis by the Nissl method. The LP group seizure frequency was 3.1±1.9 before ibotenic acid injection and showed an increase (16.3±7.2 per week) after LP lesion. No changes in SRSs frequency were observed in the AV group after ibotenic lesion in these nuclei. These results seem to suggest that LP play a role in the seizure circuitry inhibiting the expression of spontaneous seizures in the pilocarpine model.
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title_short	The contribution of the lateral posterior and anteroventral thalamic nuclei on spontaneous recurrent seizures in the pilocarpine model of epilepsy
url	https://doi.org/10.1590/S0004-282X2002000400011 https://doaj.org/article/7779ff5d5d23401d896aca28331e3e30 http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2002000400011&tlng=en http://www.scielo.br/pdf/anp/v60n3a/11128.pdf https://doaj.org/toc/1678-4227
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up_date	2024-07-03T19:56:56.602Z
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The contribution of the lateral posterior and anteroventral thalamic nuclei on spontaneous recurrent seizures in the pilocarpine model of epilepsy

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