Treatment of Indolent Cutaneous B-Cell Lymphoma with Intralesional or Intravenous Rituximab

Indolent cutaneous B-cell lymphomas (CBCL) are a rare disease for which the therapeutic recommendations are based on clinical reports. Recommendations for solitary lesions include surgery or irradiation. However, the high relapse rates may require less invasive repeatable therapy. This study seeks t...
Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Christian Menzer [verfasserIn] Adriana Rendon [verfasserIn] Jessica C. Hassel [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2022

Schlagwörter:	indolent cutaneous B-cell lymphoma (CBCL) primary cutaneous follicle center lymphoma (PCFCL) primary cutaneous marginal zone lymphoma (PCMZL) intralesional rituximab (ILR) intravenous rituximab (IVR) therapy recommendations

Übergeordnetes Werk:	In: Cancers - MDPI AG, 2010, 14(2022), 19, p 4787
Übergeordnetes Werk:	volume:14 ; year:2022 ; number:19, p 4787

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3390/cancers14194787

Katalog-ID:	DOAJ086428578

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allfieldsSound	10.3390/cancers14194787 doi (DE-627)DOAJ086428578 (DE-599)DOAJ7a4fb2b4a4b746488ae1d121cf602986 DE-627 ger DE-627 rakwb eng RC254-282 Christian Menzer verfasserin aut Treatment of Indolent Cutaneous B-Cell Lymphoma with Intralesional or Intravenous Rituximab 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Indolent cutaneous B-cell lymphomas (CBCL) are a rare disease for which the therapeutic recommendations are based on clinical reports. Recommendations for solitary lesions include surgery or irradiation. However, the high relapse rates may require less invasive repeatable therapy. This study seeks to retrospectively assess the efficacy of intralesional rituximab (ILR) for indolent CBCL when compared with intravenous rituximab (IVR). Patients treated for indolent CBCL with ILR or IVR at the Division of DermatoOncology of the University Hospital Heidelberg were eligible for this study. Characteristics of lymphoma, treatment response, and adverse events were assessed. Twenty-one patients, 67% male at a median age of 52 (range 17–80), were included. Nineteen (90%) had only localized lymphoma (stage T1 and T2). Complete response was achieved in 92% (11/12) of ILR after a median of one cycle (three injections) and 78% (7/8) of IVR patients after a median of six cycles. Half of ILR patients and 78% of IVR patients showed relapse after a median of 15 and 23 months, respectively. Adverse reactions were usually mild and were limited to the first injection of ILR. One patient with IVR contracted a pulmonary infection. ILR may be an alternative to the intravenous administration of rituximab for localized indolent CBCL. indolent cutaneous B-cell lymphoma (CBCL) primary cutaneous follicle center lymphoma (PCFCL) primary cutaneous marginal zone lymphoma (PCMZL) intralesional rituximab (ILR) intravenous rituximab (IVR) therapy recommendations Neoplasms. Tumors. Oncology. Including cancer and carcinogens Adriana Rendon verfasserin aut Jessica C. Hassel verfasserin aut In Cancers MDPI AG, 2010 14(2022), 19, p 4787 (DE-627)614095670 (DE-600)2527080-1 20726694 nnns volume:14 year:2022 number:19, p 4787 https://doi.org/10.3390/cancers14194787 kostenfrei https://doaj.org/article/7a4fb2b4a4b746488ae1d121cf602986 kostenfrei https://www.mdpi.com/2072-6694/14/19/4787 kostenfrei https://doaj.org/toc/2072-6694 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 14 2022 19, p 4787
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source	In Cancers 14(2022), 19, p 4787 volume:14 year:2022 number:19, p 4787
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topic_facet	indolent cutaneous B-cell lymphoma (CBCL) primary cutaneous follicle center lymphoma (PCFCL) primary cutaneous marginal zone lymphoma (PCMZL) intralesional rituximab (ILR) intravenous rituximab (IVR) therapy recommendations Neoplasms. Tumors. Oncology. Including cancer and carcinogens
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callnumber-first	R - Medicine
author	Christian Menzer
spellingShingle	Christian Menzer misc RC254-282 misc indolent cutaneous B-cell lymphoma (CBCL) misc primary cutaneous follicle center lymphoma (PCFCL) misc primary cutaneous marginal zone lymphoma (PCMZL) misc intralesional rituximab (ILR) misc intravenous rituximab (IVR) misc therapy recommendations misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens Treatment of Indolent Cutaneous B-Cell Lymphoma with Intralesional or Intravenous Rituximab
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topic_title	RC254-282 Treatment of Indolent Cutaneous B-Cell Lymphoma with Intralesional or Intravenous Rituximab indolent cutaneous B-cell lymphoma (CBCL) primary cutaneous follicle center lymphoma (PCFCL) primary cutaneous marginal zone lymphoma (PCMZL) intralesional rituximab (ILR) intravenous rituximab (IVR) therapy recommendations
topic	misc RC254-282 misc indolent cutaneous B-cell lymphoma (CBCL) misc primary cutaneous follicle center lymphoma (PCFCL) misc primary cutaneous marginal zone lymphoma (PCMZL) misc intralesional rituximab (ILR) misc intravenous rituximab (IVR) misc therapy recommendations misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens
topic_unstemmed	misc RC254-282 misc indolent cutaneous B-cell lymphoma (CBCL) misc primary cutaneous follicle center lymphoma (PCFCL) misc primary cutaneous marginal zone lymphoma (PCMZL) misc intralesional rituximab (ILR) misc intravenous rituximab (IVR) misc therapy recommendations misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens
topic_browse	misc RC254-282 misc indolent cutaneous B-cell lymphoma (CBCL) misc primary cutaneous follicle center lymphoma (PCFCL) misc primary cutaneous marginal zone lymphoma (PCMZL) misc intralesional rituximab (ILR) misc intravenous rituximab (IVR) misc therapy recommendations misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens
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title	Treatment of Indolent Cutaneous B-Cell Lymphoma with Intralesional or Intravenous Rituximab
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title_full	Treatment of Indolent Cutaneous B-Cell Lymphoma with Intralesional or Intravenous Rituximab
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title_sort	treatment of indolent cutaneous b-cell lymphoma with intralesional or intravenous rituximab
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title_auth	Treatment of Indolent Cutaneous B-Cell Lymphoma with Intralesional or Intravenous Rituximab
abstract	Indolent cutaneous B-cell lymphomas (CBCL) are a rare disease for which the therapeutic recommendations are based on clinical reports. Recommendations for solitary lesions include surgery or irradiation. However, the high relapse rates may require less invasive repeatable therapy. This study seeks to retrospectively assess the efficacy of intralesional rituximab (ILR) for indolent CBCL when compared with intravenous rituximab (IVR). Patients treated for indolent CBCL with ILR or IVR at the Division of DermatoOncology of the University Hospital Heidelberg were eligible for this study. Characteristics of lymphoma, treatment response, and adverse events were assessed. Twenty-one patients, 67% male at a median age of 52 (range 17–80), were included. Nineteen (90%) had only localized lymphoma (stage T1 and T2). Complete response was achieved in 92% (11/12) of ILR after a median of one cycle (three injections) and 78% (7/8) of IVR patients after a median of six cycles. Half of ILR patients and 78% of IVR patients showed relapse after a median of 15 and 23 months, respectively. Adverse reactions were usually mild and were limited to the first injection of ILR. One patient with IVR contracted a pulmonary infection. ILR may be an alternative to the intravenous administration of rituximab for localized indolent CBCL.
abstractGer	Indolent cutaneous B-cell lymphomas (CBCL) are a rare disease for which the therapeutic recommendations are based on clinical reports. Recommendations for solitary lesions include surgery or irradiation. However, the high relapse rates may require less invasive repeatable therapy. This study seeks to retrospectively assess the efficacy of intralesional rituximab (ILR) for indolent CBCL when compared with intravenous rituximab (IVR). Patients treated for indolent CBCL with ILR or IVR at the Division of DermatoOncology of the University Hospital Heidelberg were eligible for this study. Characteristics of lymphoma, treatment response, and adverse events were assessed. Twenty-one patients, 67% male at a median age of 52 (range 17–80), were included. Nineteen (90%) had only localized lymphoma (stage T1 and T2). Complete response was achieved in 92% (11/12) of ILR after a median of one cycle (three injections) and 78% (7/8) of IVR patients after a median of six cycles. Half of ILR patients and 78% of IVR patients showed relapse after a median of 15 and 23 months, respectively. Adverse reactions were usually mild and were limited to the first injection of ILR. One patient with IVR contracted a pulmonary infection. ILR may be an alternative to the intravenous administration of rituximab for localized indolent CBCL.
abstract_unstemmed	Indolent cutaneous B-cell lymphomas (CBCL) are a rare disease for which the therapeutic recommendations are based on clinical reports. Recommendations for solitary lesions include surgery or irradiation. However, the high relapse rates may require less invasive repeatable therapy. This study seeks to retrospectively assess the efficacy of intralesional rituximab (ILR) for indolent CBCL when compared with intravenous rituximab (IVR). Patients treated for indolent CBCL with ILR or IVR at the Division of DermatoOncology of the University Hospital Heidelberg were eligible for this study. Characteristics of lymphoma, treatment response, and adverse events were assessed. Twenty-one patients, 67% male at a median age of 52 (range 17–80), were included. Nineteen (90%) had only localized lymphoma (stage T1 and T2). Complete response was achieved in 92% (11/12) of ILR after a median of one cycle (three injections) and 78% (7/8) of IVR patients after a median of six cycles. Half of ILR patients and 78% of IVR patients showed relapse after a median of 15 and 23 months, respectively. Adverse reactions were usually mild and were limited to the first injection of ILR. One patient with IVR contracted a pulmonary infection. ILR may be an alternative to the intravenous administration of rituximab for localized indolent CBCL.
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title_short	Treatment of Indolent Cutaneous B-Cell Lymphoma with Intralesional or Intravenous Rituximab
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