Dynamical Mechanism Analysis of Three Neuroregulatory Strategies on the Modulation of Seizures

This paper attempts to explore and compare the regulatory mechanisms of optogenetic stimulation (OS), deep brain stimulation (DBS) and electromagnetic induction on epilepsy. Based on the Wilson–Cowan model, we first demonstrate that the external input received by excitatory and inhibitory neural pop...
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Autor*in:	Honghui Zhang [verfasserIn] Zhuan Shen [verfasserIn] Yuzhi Zhao [verfasserIn] Lin Du [verfasserIn] Zichen Deng [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2022

Schlagwörter:	Wilson–Cowan model optogenetic stimulation deep brain stimulation electromagnetic induction epilepsy

Übergeordnetes Werk:	In: International Journal of Molecular Sciences - MDPI AG, 2003, 23(2022), 21, p 13652
Übergeordnetes Werk:	volume:23 ; year:2022 ; number:21, p 13652

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc Journal toc

DOI / URN:	10.3390/ijms232113652

Katalog-ID:	DOAJ086458949

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spelling	10.3390/ijms232113652 doi (DE-627)DOAJ086458949 (DE-599)DOAJ4d85a499328f47858ecc24ec3dab70a1 DE-627 ger DE-627 rakwb eng QH301-705.5 QD1-999 Honghui Zhang verfasserin aut Dynamical Mechanism Analysis of Three Neuroregulatory Strategies on the Modulation of Seizures 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier This paper attempts to explore and compare the regulatory mechanisms of optogenetic stimulation (OS), deep brain stimulation (DBS) and electromagnetic induction on epilepsy. Based on the Wilson–Cowan model, we first demonstrate that the external input received by excitatory and inhibitory neural populations can induce rich dynamic bifurcation behaviors such as Hopf bifurcation, and make the system exhibit epileptic and normal states. Then, both OS and DBS are shown to be effective in controlling the epileptic state to a normal low-level state, and the stimulus parameters have a broad effective range. However, electromagnetic induction cannot directly control epilepsy to this desired state, even if it can significantly reduce the oscillation frequency of neural populations. One main difference worth noting is that the high spatiotemporal specificity of OS allows it to target inhibitory neuronal populations, whereas DBS and electromagnetic induction can only stimulate excitatory as well as inhibitory neuronal populations together. Next, the propagation behavior of epilepsy is explored under a typical three-node feedback loop structure. An increase in coupling strength accelerates and exacerbates epileptic activity in other brain regions. Finally, OS and DBS applied to the epileptic focus play similar positive roles in controlling the behavior of the area of seizure propagation, while electromagnetic induction still only achieves unsatisfactory effects. It is hoped that these dynamical results can provide insights into the treatment of epilepsy as well as other neurological disorders. Wilson–Cowan model optogenetic stimulation deep brain stimulation electromagnetic induction epilepsy Biology (General) Chemistry Zhuan Shen verfasserin aut Yuzhi Zhao verfasserin aut Lin Du verfasserin aut Zichen Deng verfasserin aut In International Journal of Molecular Sciences MDPI AG, 2003 23(2022), 21, p 13652 (DE-627)316340715 (DE-600)2019364-6 14220067 nnns volume:23 year:2022 number:21, p 13652 https://doi.org/10.3390/ijms232113652 kostenfrei https://doaj.org/article/4d85a499328f47858ecc24ec3dab70a1 kostenfrei https://www.mdpi.com/1422-0067/23/21/13652 kostenfrei https://doaj.org/toc/1661-6596 Journal toc kostenfrei https://doaj.org/toc/1422-0067 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 23 2022 21, p 13652
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callnumber-first	Q - Science
author	Honghui Zhang
spellingShingle	Honghui Zhang misc QH301-705.5 misc QD1-999 misc Wilson–Cowan model misc optogenetic stimulation misc deep brain stimulation misc electromagnetic induction misc epilepsy misc Biology (General) misc Chemistry Dynamical Mechanism Analysis of Three Neuroregulatory Strategies on the Modulation of Seizures
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topic_title	QH301-705.5 QD1-999 Dynamical Mechanism Analysis of Three Neuroregulatory Strategies on the Modulation of Seizures Wilson–Cowan model optogenetic stimulation deep brain stimulation electromagnetic induction epilepsy
topic	misc QH301-705.5 misc QD1-999 misc Wilson–Cowan model misc optogenetic stimulation misc deep brain stimulation misc electromagnetic induction misc epilepsy misc Biology (General) misc Chemistry
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title	Dynamical Mechanism Analysis of Three Neuroregulatory Strategies on the Modulation of Seizures
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title_sort	dynamical mechanism analysis of three neuroregulatory strategies on the modulation of seizures
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title_auth	Dynamical Mechanism Analysis of Three Neuroregulatory Strategies on the Modulation of Seizures
abstract	This paper attempts to explore and compare the regulatory mechanisms of optogenetic stimulation (OS), deep brain stimulation (DBS) and electromagnetic induction on epilepsy. Based on the Wilson–Cowan model, we first demonstrate that the external input received by excitatory and inhibitory neural populations can induce rich dynamic bifurcation behaviors such as Hopf bifurcation, and make the system exhibit epileptic and normal states. Then, both OS and DBS are shown to be effective in controlling the epileptic state to a normal low-level state, and the stimulus parameters have a broad effective range. However, electromagnetic induction cannot directly control epilepsy to this desired state, even if it can significantly reduce the oscillation frequency of neural populations. One main difference worth noting is that the high spatiotemporal specificity of OS allows it to target inhibitory neuronal populations, whereas DBS and electromagnetic induction can only stimulate excitatory as well as inhibitory neuronal populations together. Next, the propagation behavior of epilepsy is explored under a typical three-node feedback loop structure. An increase in coupling strength accelerates and exacerbates epileptic activity in other brain regions. Finally, OS and DBS applied to the epileptic focus play similar positive roles in controlling the behavior of the area of seizure propagation, while electromagnetic induction still only achieves unsatisfactory effects. It is hoped that these dynamical results can provide insights into the treatment of epilepsy as well as other neurological disorders.
abstractGer	This paper attempts to explore and compare the regulatory mechanisms of optogenetic stimulation (OS), deep brain stimulation (DBS) and electromagnetic induction on epilepsy. Based on the Wilson–Cowan model, we first demonstrate that the external input received by excitatory and inhibitory neural populations can induce rich dynamic bifurcation behaviors such as Hopf bifurcation, and make the system exhibit epileptic and normal states. Then, both OS and DBS are shown to be effective in controlling the epileptic state to a normal low-level state, and the stimulus parameters have a broad effective range. However, electromagnetic induction cannot directly control epilepsy to this desired state, even if it can significantly reduce the oscillation frequency of neural populations. One main difference worth noting is that the high spatiotemporal specificity of OS allows it to target inhibitory neuronal populations, whereas DBS and electromagnetic induction can only stimulate excitatory as well as inhibitory neuronal populations together. Next, the propagation behavior of epilepsy is explored under a typical three-node feedback loop structure. An increase in coupling strength accelerates and exacerbates epileptic activity in other brain regions. Finally, OS and DBS applied to the epileptic focus play similar positive roles in controlling the behavior of the area of seizure propagation, while electromagnetic induction still only achieves unsatisfactory effects. It is hoped that these dynamical results can provide insights into the treatment of epilepsy as well as other neurological disorders.
abstract_unstemmed	This paper attempts to explore and compare the regulatory mechanisms of optogenetic stimulation (OS), deep brain stimulation (DBS) and electromagnetic induction on epilepsy. Based on the Wilson–Cowan model, we first demonstrate that the external input received by excitatory and inhibitory neural populations can induce rich dynamic bifurcation behaviors such as Hopf bifurcation, and make the system exhibit epileptic and normal states. Then, both OS and DBS are shown to be effective in controlling the epileptic state to a normal low-level state, and the stimulus parameters have a broad effective range. However, electromagnetic induction cannot directly control epilepsy to this desired state, even if it can significantly reduce the oscillation frequency of neural populations. One main difference worth noting is that the high spatiotemporal specificity of OS allows it to target inhibitory neuronal populations, whereas DBS and electromagnetic induction can only stimulate excitatory as well as inhibitory neuronal populations together. Next, the propagation behavior of epilepsy is explored under a typical three-node feedback loop structure. An increase in coupling strength accelerates and exacerbates epileptic activity in other brain regions. Finally, OS and DBS applied to the epileptic focus play similar positive roles in controlling the behavior of the area of seizure propagation, while electromagnetic induction still only achieves unsatisfactory effects. It is hoped that these dynamical results can provide insights into the treatment of epilepsy as well as other neurological disorders.
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title_short	Dynamical Mechanism Analysis of Three Neuroregulatory Strategies on the Modulation of Seizures
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Dynamical Mechanism Analysis of Three Neuroregulatory Strategies on the Modulation of Seizures

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