Integration between Novel Imaging Technologies and Modern Radiotherapy Techniques: How the Eye Drove the Chisel

Introduction: Targeted dose-escalation and reduction of dose to adjacent organs at risk have been the main goal of radiotherapy in the last decade. Prostate cancer benefited the most from this process. In recent years, the development of Intensity Modulated Radiation Therapy (IMRT) and Stereotactic...
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Gespeichert in:

Autor*in:	Giulio Francolini [verfasserIn] Ilaria Morelli [verfasserIn] Maria Grazia Carnevale [verfasserIn] Roberta Grassi [verfasserIn] Valerio Nardone [verfasserIn] Mauro Loi [verfasserIn] Marianna Valzano [verfasserIn] Viola Salvestrini [verfasserIn] Lorenzo Livi [verfasserIn] Isacco Desideri [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2022

Schlagwörter:	prostate cancer radiomics multi-parametric magnetic resonance imaging prostate imaging-reporting and data systems prostate-specific membrane antigen PET/CT

Übergeordnetes Werk:	In: Cancers - MDPI AG, 2010, 14(2022), 21, p 5277
Übergeordnetes Werk:	volume:14 ; year:2022 ; number:21, p 5277

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3390/cancers14215277

Katalog-ID:	DOAJ086492888

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allfields	10.3390/cancers14215277 doi (DE-627)DOAJ086492888 (DE-599)DOAJ0b35254216a94b328ea2d91848548ffd DE-627 ger DE-627 rakwb eng RC254-282 Giulio Francolini verfasserin aut Integration between Novel Imaging Technologies and Modern Radiotherapy Techniques: How the Eye Drove the Chisel 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Introduction: Targeted dose-escalation and reduction of dose to adjacent organs at risk have been the main goal of radiotherapy in the last decade. Prostate cancer benefited the most from this process. In recent years, the development of Intensity Modulated Radiation Therapy (IMRT) and Stereotactic Body Radiotherapy (SBRT) radically changed clinical practice, also thanks to the availability of modern imaging techniques. The aim of this paper is to explore the relationship between diagnostic imaging and prostate cancer radiotherapy techniques. Materials and Methods: Aiming to provide an overview of the integration between modern imaging and radiotherapy techniques, we performed a non-systematic search of papers exploring the predictive value of imaging before treatment, the role of radiomics in predicting treatment outcomes, implementation of novel imaging in RT planning and influence of imaging integration on use of RT in current clinical practice. Three independent authors (GF, IM and ID) performed an independent review focusing on these issues. Key references were derived from a PubMed query. Hand searching and clinicaltrials.gov were also used, and grey literature was searched for further papers of interest. The final choice of papers included was discussed between all co-authors. Results: This paper contains a narrative report and a critical discussion of the role of new modern techniques in predicting outcomes before treatment, in radiotherapy planning and in the integration with systemic therapy in the management of prostate cancer. Also, the role of radiomics in a tailored treatment approach is explored. Conclusions: Integration between diagnostic imaging and radiotherapy is of great importance for the modern treatment of prostate cancer. Future clinical trials should be aimed at exploring the real clinical benefit of complex workflows in clinical practice. prostate cancer radiomics multi-parametric magnetic resonance imaging prostate imaging-reporting and data systems prostate-specific membrane antigen PET/CT Neoplasms. Tumors. Oncology. Including cancer and carcinogens Ilaria Morelli verfasserin aut Maria Grazia Carnevale verfasserin aut Roberta Grassi verfasserin aut Valerio Nardone verfasserin aut Mauro Loi verfasserin aut Marianna Valzano verfasserin aut Viola Salvestrini verfasserin aut Lorenzo Livi verfasserin aut Isacco Desideri verfasserin aut In Cancers MDPI AG, 2010 14(2022), 21, p 5277 (DE-627)614095670 (DE-600)2527080-1 20726694 nnns volume:14 year:2022 number:21, p 5277 https://doi.org/10.3390/cancers14215277 kostenfrei https://doaj.org/article/0b35254216a94b328ea2d91848548ffd kostenfrei https://www.mdpi.com/2072-6694/14/21/5277 kostenfrei https://doaj.org/toc/2072-6694 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 14 2022 21, p 5277
spelling	10.3390/cancers14215277 doi (DE-627)DOAJ086492888 (DE-599)DOAJ0b35254216a94b328ea2d91848548ffd DE-627 ger DE-627 rakwb eng RC254-282 Giulio Francolini verfasserin aut Integration between Novel Imaging Technologies and Modern Radiotherapy Techniques: How the Eye Drove the Chisel 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Introduction: Targeted dose-escalation and reduction of dose to adjacent organs at risk have been the main goal of radiotherapy in the last decade. Prostate cancer benefited the most from this process. In recent years, the development of Intensity Modulated Radiation Therapy (IMRT) and Stereotactic Body Radiotherapy (SBRT) radically changed clinical practice, also thanks to the availability of modern imaging techniques. The aim of this paper is to explore the relationship between diagnostic imaging and prostate cancer radiotherapy techniques. Materials and Methods: Aiming to provide an overview of the integration between modern imaging and radiotherapy techniques, we performed a non-systematic search of papers exploring the predictive value of imaging before treatment, the role of radiomics in predicting treatment outcomes, implementation of novel imaging in RT planning and influence of imaging integration on use of RT in current clinical practice. Three independent authors (GF, IM and ID) performed an independent review focusing on these issues. Key references were derived from a PubMed query. Hand searching and clinicaltrials.gov were also used, and grey literature was searched for further papers of interest. The final choice of papers included was discussed between all co-authors. Results: This paper contains a narrative report and a critical discussion of the role of new modern techniques in predicting outcomes before treatment, in radiotherapy planning and in the integration with systemic therapy in the management of prostate cancer. Also, the role of radiomics in a tailored treatment approach is explored. Conclusions: Integration between diagnostic imaging and radiotherapy is of great importance for the modern treatment of prostate cancer. Future clinical trials should be aimed at exploring the real clinical benefit of complex workflows in clinical practice. prostate cancer radiomics multi-parametric magnetic resonance imaging prostate imaging-reporting and data systems prostate-specific membrane antigen PET/CT Neoplasms. Tumors. Oncology. Including cancer and carcinogens Ilaria Morelli verfasserin aut Maria Grazia Carnevale verfasserin aut Roberta Grassi verfasserin aut Valerio Nardone verfasserin aut Mauro Loi verfasserin aut Marianna Valzano verfasserin aut Viola Salvestrini verfasserin aut Lorenzo Livi verfasserin aut Isacco Desideri verfasserin aut In Cancers MDPI AG, 2010 14(2022), 21, p 5277 (DE-627)614095670 (DE-600)2527080-1 20726694 nnns volume:14 year:2022 number:21, p 5277 https://doi.org/10.3390/cancers14215277 kostenfrei https://doaj.org/article/0b35254216a94b328ea2d91848548ffd kostenfrei https://www.mdpi.com/2072-6694/14/21/5277 kostenfrei https://doaj.org/toc/2072-6694 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 14 2022 21, p 5277
allfields_unstemmed	10.3390/cancers14215277 doi (DE-627)DOAJ086492888 (DE-599)DOAJ0b35254216a94b328ea2d91848548ffd DE-627 ger DE-627 rakwb eng RC254-282 Giulio Francolini verfasserin aut Integration between Novel Imaging Technologies and Modern Radiotherapy Techniques: How the Eye Drove the Chisel 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Introduction: Targeted dose-escalation and reduction of dose to adjacent organs at risk have been the main goal of radiotherapy in the last decade. Prostate cancer benefited the most from this process. In recent years, the development of Intensity Modulated Radiation Therapy (IMRT) and Stereotactic Body Radiotherapy (SBRT) radically changed clinical practice, also thanks to the availability of modern imaging techniques. The aim of this paper is to explore the relationship between diagnostic imaging and prostate cancer radiotherapy techniques. Materials and Methods: Aiming to provide an overview of the integration between modern imaging and radiotherapy techniques, we performed a non-systematic search of papers exploring the predictive value of imaging before treatment, the role of radiomics in predicting treatment outcomes, implementation of novel imaging in RT planning and influence of imaging integration on use of RT in current clinical practice. Three independent authors (GF, IM and ID) performed an independent review focusing on these issues. Key references were derived from a PubMed query. Hand searching and clinicaltrials.gov were also used, and grey literature was searched for further papers of interest. The final choice of papers included was discussed between all co-authors. Results: This paper contains a narrative report and a critical discussion of the role of new modern techniques in predicting outcomes before treatment, in radiotherapy planning and in the integration with systemic therapy in the management of prostate cancer. Also, the role of radiomics in a tailored treatment approach is explored. Conclusions: Integration between diagnostic imaging and radiotherapy is of great importance for the modern treatment of prostate cancer. Future clinical trials should be aimed at exploring the real clinical benefit of complex workflows in clinical practice. prostate cancer radiomics multi-parametric magnetic resonance imaging prostate imaging-reporting and data systems prostate-specific membrane antigen PET/CT Neoplasms. Tumors. Oncology. Including cancer and carcinogens Ilaria Morelli verfasserin aut Maria Grazia Carnevale verfasserin aut Roberta Grassi verfasserin aut Valerio Nardone verfasserin aut Mauro Loi verfasserin aut Marianna Valzano verfasserin aut Viola Salvestrini verfasserin aut Lorenzo Livi verfasserin aut Isacco Desideri verfasserin aut In Cancers MDPI AG, 2010 14(2022), 21, p 5277 (DE-627)614095670 (DE-600)2527080-1 20726694 nnns volume:14 year:2022 number:21, p 5277 https://doi.org/10.3390/cancers14215277 kostenfrei https://doaj.org/article/0b35254216a94b328ea2d91848548ffd kostenfrei https://www.mdpi.com/2072-6694/14/21/5277 kostenfrei https://doaj.org/toc/2072-6694 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 14 2022 21, p 5277
allfieldsGer	10.3390/cancers14215277 doi (DE-627)DOAJ086492888 (DE-599)DOAJ0b35254216a94b328ea2d91848548ffd DE-627 ger DE-627 rakwb eng RC254-282 Giulio Francolini verfasserin aut Integration between Novel Imaging Technologies and Modern Radiotherapy Techniques: How the Eye Drove the Chisel 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Introduction: Targeted dose-escalation and reduction of dose to adjacent organs at risk have been the main goal of radiotherapy in the last decade. Prostate cancer benefited the most from this process. In recent years, the development of Intensity Modulated Radiation Therapy (IMRT) and Stereotactic Body Radiotherapy (SBRT) radically changed clinical practice, also thanks to the availability of modern imaging techniques. The aim of this paper is to explore the relationship between diagnostic imaging and prostate cancer radiotherapy techniques. Materials and Methods: Aiming to provide an overview of the integration between modern imaging and radiotherapy techniques, we performed a non-systematic search of papers exploring the predictive value of imaging before treatment, the role of radiomics in predicting treatment outcomes, implementation of novel imaging in RT planning and influence of imaging integration on use of RT in current clinical practice. Three independent authors (GF, IM and ID) performed an independent review focusing on these issues. Key references were derived from a PubMed query. Hand searching and clinicaltrials.gov were also used, and grey literature was searched for further papers of interest. The final choice of papers included was discussed between all co-authors. Results: This paper contains a narrative report and a critical discussion of the role of new modern techniques in predicting outcomes before treatment, in radiotherapy planning and in the integration with systemic therapy in the management of prostate cancer. Also, the role of radiomics in a tailored treatment approach is explored. Conclusions: Integration between diagnostic imaging and radiotherapy is of great importance for the modern treatment of prostate cancer. Future clinical trials should be aimed at exploring the real clinical benefit of complex workflows in clinical practice. prostate cancer radiomics multi-parametric magnetic resonance imaging prostate imaging-reporting and data systems prostate-specific membrane antigen PET/CT Neoplasms. Tumors. Oncology. Including cancer and carcinogens Ilaria Morelli verfasserin aut Maria Grazia Carnevale verfasserin aut Roberta Grassi verfasserin aut Valerio Nardone verfasserin aut Mauro Loi verfasserin aut Marianna Valzano verfasserin aut Viola Salvestrini verfasserin aut Lorenzo Livi verfasserin aut Isacco Desideri verfasserin aut In Cancers MDPI AG, 2010 14(2022), 21, p 5277 (DE-627)614095670 (DE-600)2527080-1 20726694 nnns volume:14 year:2022 number:21, p 5277 https://doi.org/10.3390/cancers14215277 kostenfrei https://doaj.org/article/0b35254216a94b328ea2d91848548ffd kostenfrei https://www.mdpi.com/2072-6694/14/21/5277 kostenfrei https://doaj.org/toc/2072-6694 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 14 2022 21, p 5277
allfieldsSound	10.3390/cancers14215277 doi (DE-627)DOAJ086492888 (DE-599)DOAJ0b35254216a94b328ea2d91848548ffd DE-627 ger DE-627 rakwb eng RC254-282 Giulio Francolini verfasserin aut Integration between Novel Imaging Technologies and Modern Radiotherapy Techniques: How the Eye Drove the Chisel 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Introduction: Targeted dose-escalation and reduction of dose to adjacent organs at risk have been the main goal of radiotherapy in the last decade. Prostate cancer benefited the most from this process. In recent years, the development of Intensity Modulated Radiation Therapy (IMRT) and Stereotactic Body Radiotherapy (SBRT) radically changed clinical practice, also thanks to the availability of modern imaging techniques. The aim of this paper is to explore the relationship between diagnostic imaging and prostate cancer radiotherapy techniques. Materials and Methods: Aiming to provide an overview of the integration between modern imaging and radiotherapy techniques, we performed a non-systematic search of papers exploring the predictive value of imaging before treatment, the role of radiomics in predicting treatment outcomes, implementation of novel imaging in RT planning and influence of imaging integration on use of RT in current clinical practice. Three independent authors (GF, IM and ID) performed an independent review focusing on these issues. Key references were derived from a PubMed query. Hand searching and clinicaltrials.gov were also used, and grey literature was searched for further papers of interest. The final choice of papers included was discussed between all co-authors. Results: This paper contains a narrative report and a critical discussion of the role of new modern techniques in predicting outcomes before treatment, in radiotherapy planning and in the integration with systemic therapy in the management of prostate cancer. Also, the role of radiomics in a tailored treatment approach is explored. Conclusions: Integration between diagnostic imaging and radiotherapy is of great importance for the modern treatment of prostate cancer. Future clinical trials should be aimed at exploring the real clinical benefit of complex workflows in clinical practice. prostate cancer radiomics multi-parametric magnetic resonance imaging prostate imaging-reporting and data systems prostate-specific membrane antigen PET/CT Neoplasms. Tumors. Oncology. Including cancer and carcinogens Ilaria Morelli verfasserin aut Maria Grazia Carnevale verfasserin aut Roberta Grassi verfasserin aut Valerio Nardone verfasserin aut Mauro Loi verfasserin aut Marianna Valzano verfasserin aut Viola Salvestrini verfasserin aut Lorenzo Livi verfasserin aut Isacco Desideri verfasserin aut In Cancers MDPI AG, 2010 14(2022), 21, p 5277 (DE-627)614095670 (DE-600)2527080-1 20726694 nnns volume:14 year:2022 number:21, p 5277 https://doi.org/10.3390/cancers14215277 kostenfrei https://doaj.org/article/0b35254216a94b328ea2d91848548ffd kostenfrei https://www.mdpi.com/2072-6694/14/21/5277 kostenfrei https://doaj.org/toc/2072-6694 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 14 2022 21, p 5277
language	English
source	In Cancers 14(2022), 21, p 5277 volume:14 year:2022 number:21, p 5277
sourceStr	In Cancers 14(2022), 21, p 5277 volume:14 year:2022 number:21, p 5277
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author	Giulio Francolini
spellingShingle	Giulio Francolini misc RC254-282 misc prostate cancer misc radiomics misc multi-parametric magnetic resonance imaging misc prostate imaging-reporting and data systems misc prostate-specific membrane antigen PET/CT misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens Integration between Novel Imaging Technologies and Modern Radiotherapy Techniques: How the Eye Drove the Chisel
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topic_title	RC254-282 Integration between Novel Imaging Technologies and Modern Radiotherapy Techniques: How the Eye Drove the Chisel prostate cancer radiomics multi-parametric magnetic resonance imaging prostate imaging-reporting and data systems prostate-specific membrane antigen PET/CT
topic	misc RC254-282 misc prostate cancer misc radiomics misc multi-parametric magnetic resonance imaging misc prostate imaging-reporting and data systems misc prostate-specific membrane antigen PET/CT misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens
topic_unstemmed	misc RC254-282 misc prostate cancer misc radiomics misc multi-parametric magnetic resonance imaging misc prostate imaging-reporting and data systems misc prostate-specific membrane antigen PET/CT misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens
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title_sort	integration between novel imaging technologies and modern radiotherapy techniques: how the eye drove the chisel
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title_auth	Integration between Novel Imaging Technologies and Modern Radiotherapy Techniques: How the Eye Drove the Chisel
abstract	Introduction: Targeted dose-escalation and reduction of dose to adjacent organs at risk have been the main goal of radiotherapy in the last decade. Prostate cancer benefited the most from this process. In recent years, the development of Intensity Modulated Radiation Therapy (IMRT) and Stereotactic Body Radiotherapy (SBRT) radically changed clinical practice, also thanks to the availability of modern imaging techniques. The aim of this paper is to explore the relationship between diagnostic imaging and prostate cancer radiotherapy techniques. Materials and Methods: Aiming to provide an overview of the integration between modern imaging and radiotherapy techniques, we performed a non-systematic search of papers exploring the predictive value of imaging before treatment, the role of radiomics in predicting treatment outcomes, implementation of novel imaging in RT planning and influence of imaging integration on use of RT in current clinical practice. Three independent authors (GF, IM and ID) performed an independent review focusing on these issues. Key references were derived from a PubMed query. Hand searching and clinicaltrials.gov were also used, and grey literature was searched for further papers of interest. The final choice of papers included was discussed between all co-authors. Results: This paper contains a narrative report and a critical discussion of the role of new modern techniques in predicting outcomes before treatment, in radiotherapy planning and in the integration with systemic therapy in the management of prostate cancer. Also, the role of radiomics in a tailored treatment approach is explored. Conclusions: Integration between diagnostic imaging and radiotherapy is of great importance for the modern treatment of prostate cancer. Future clinical trials should be aimed at exploring the real clinical benefit of complex workflows in clinical practice.
abstractGer	Introduction: Targeted dose-escalation and reduction of dose to adjacent organs at risk have been the main goal of radiotherapy in the last decade. Prostate cancer benefited the most from this process. In recent years, the development of Intensity Modulated Radiation Therapy (IMRT) and Stereotactic Body Radiotherapy (SBRT) radically changed clinical practice, also thanks to the availability of modern imaging techniques. The aim of this paper is to explore the relationship between diagnostic imaging and prostate cancer radiotherapy techniques. Materials and Methods: Aiming to provide an overview of the integration between modern imaging and radiotherapy techniques, we performed a non-systematic search of papers exploring the predictive value of imaging before treatment, the role of radiomics in predicting treatment outcomes, implementation of novel imaging in RT planning and influence of imaging integration on use of RT in current clinical practice. Three independent authors (GF, IM and ID) performed an independent review focusing on these issues. Key references were derived from a PubMed query. Hand searching and clinicaltrials.gov were also used, and grey literature was searched for further papers of interest. The final choice of papers included was discussed between all co-authors. Results: This paper contains a narrative report and a critical discussion of the role of new modern techniques in predicting outcomes before treatment, in radiotherapy planning and in the integration with systemic therapy in the management of prostate cancer. Also, the role of radiomics in a tailored treatment approach is explored. Conclusions: Integration between diagnostic imaging and radiotherapy is of great importance for the modern treatment of prostate cancer. Future clinical trials should be aimed at exploring the real clinical benefit of complex workflows in clinical practice.
abstract_unstemmed	Introduction: Targeted dose-escalation and reduction of dose to adjacent organs at risk have been the main goal of radiotherapy in the last decade. Prostate cancer benefited the most from this process. In recent years, the development of Intensity Modulated Radiation Therapy (IMRT) and Stereotactic Body Radiotherapy (SBRT) radically changed clinical practice, also thanks to the availability of modern imaging techniques. The aim of this paper is to explore the relationship between diagnostic imaging and prostate cancer radiotherapy techniques. Materials and Methods: Aiming to provide an overview of the integration between modern imaging and radiotherapy techniques, we performed a non-systematic search of papers exploring the predictive value of imaging before treatment, the role of radiomics in predicting treatment outcomes, implementation of novel imaging in RT planning and influence of imaging integration on use of RT in current clinical practice. Three independent authors (GF, IM and ID) performed an independent review focusing on these issues. Key references were derived from a PubMed query. Hand searching and clinicaltrials.gov were also used, and grey literature was searched for further papers of interest. The final choice of papers included was discussed between all co-authors. Results: This paper contains a narrative report and a critical discussion of the role of new modern techniques in predicting outcomes before treatment, in radiotherapy planning and in the integration with systemic therapy in the management of prostate cancer. Also, the role of radiomics in a tailored treatment approach is explored. Conclusions: Integration between diagnostic imaging and radiotherapy is of great importance for the modern treatment of prostate cancer. Future clinical trials should be aimed at exploring the real clinical benefit of complex workflows in clinical practice.
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title_short	Integration between Novel Imaging Technologies and Modern Radiotherapy Techniques: How the Eye Drove the Chisel
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Hand searching and clinicaltrials.gov were also used, and grey literature was searched for further papers of interest. The final choice of papers included was discussed between all co-authors. Results: This paper contains a narrative report and a critical discussion of the role of new modern techniques in predicting outcomes before treatment, in radiotherapy planning and in the integration with systemic therapy in the management of prostate cancer. Also, the role of radiomics in a tailored treatment approach is explored. Conclusions: Integration between diagnostic imaging and radiotherapy is of great importance for the modern treatment of prostate cancer. 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