How Low Can You Go? Transfer of Low-Grade Blastocysts
Background: Low grade blastocyst (LGB) transfer results in varied live birth rates (5-39%). Only limited studies with small sample sizes (n=10-440) exist, due to LGB transfer being less desirable. Definitions of LGB and study designs are heterogenous, further confounding outcome interpretation. Aim:...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Haowen ZOU [verfasserIn] James KEMPER [verfasserIn] Elizabeth HAMMOND [verfasserIn] Yanhe LIU [verfasserIn] Fengqin XU [verfasserIn] Gensheng LIU [verfasserIn] Haitao XI [verfasserIn] Lintao XUE [verfasserIn] Xiaohong BAI [verfasserIn] Hongqing LIAO [verfasserIn] Songguo XUE [verfasserIn] Shuqin ZHAO [verfasserIn] Aijun ZHANG [verfasserIn] Masoud AFNAN [verfasserIn] Rui WANG [verfasserIn] Ben MOL [verfasserIn] Dean MORBECK [verfasserIn] |
|---|
| Format: |
E-Artikel |
|---|---|
| Sprache: |
Englisch |
| Erschienen: |
2022 |
|---|
| Übergeordnetes Werk: |
In: Fertility & Reproduction - World Scientific Publishing, 2021, 04(2022), 03n04, Seite 170-171 |
|---|---|
| Übergeordnetes Werk: |
volume:04 ; year:2022 ; number:03n04 ; pages:170-171 |
| Links: |
Link aufrufen |
|---|
| DOI / URN: |
10.1142/S2661318222740826 |
|---|
| Katalog-ID: |
DOAJ086527274 |
|---|
| LEADER | 01000naa a22002652 4500 | ||
|---|---|---|---|
| 001 | DOAJ086527274 | ||
| 003 | DE-627 | ||
| 005 | 20230311051537.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 230311s2022 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1142/S2661318222740826 |2 doi | |
| 035 | |a (DE-627)DOAJ086527274 | ||
| 035 | |a (DE-599)DOAJ2c1bbd5828914c41b1d23185b2458b04 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 050 | 0 | |a QH471-489 | |
| 100 | 0 | |a Haowen ZOU |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a How Low Can You Go? Transfer of Low-Grade Blastocysts |
| 264 | 1 | |c 2022 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 520 | |a Background: Low grade blastocyst (LGB) transfer results in varied live birth rates (5-39%). Only limited studies with small sample sizes (n=10-440) exist, due to LGB transfer being less desirable. Definitions of LGB and study designs are heterogenous, further confounding outcome interpretation. Aim: This study aimed to obtain sufficient LGB transfers to determine live birth rates, as well as allow subgroup analysis by blastocyst quality and maternal age. Method: This study was a multicentre, multinational retrospective cohort study across nine IVF clinics in China and New Zealand between 2012 to 2019. 6966 single blastocyst transfer cycles on days 5-7 (fresh and frozen) were collected; of these, 875 transfers were from LGBs (<3BB). Blastocysts with expansion stage 1 or 2 (early blastocysts) were excluded. The main outcome was live birth rate. Blastocysts were grouped according to quality grade: good-grade blastocysts (GGBs; n=3849, AA, AB and BA), moderate-grade blastocysts (MGBs; n=2242, BB) and LGBs (n=875, AC, CA, BC, CB and CC). Live birth rates were compared using the Pearson Chi-squared test. A logistic regression analysis examined the relationship between blastocyst grade and live birth after adjustment for confounders: clinic, female age, expansion stage, and blastocyst age. Results: Live birth rates for GGBs, MGBs and LGBs were 45%, 36% and 28% respectively (p<0.0001). Within the LGB group, the highest live birth rates were for grade C TE (30%) and the lowest were for grade C ICM (19%). The lowest combined grade (CC) had a 15% live birth rate (n=7/48). The odds of live birth were 2.33 (95% CI = 1.88-2.89) for GGBs compared to LGBs and 1.56 (95% CI = 1.28-1.92) for MGBs compared to LGBs following fresh and frozen blastocyst transfers (p<0.0001). The odds of live birth according to ICM grade were 1.31 (A versus B; 95% CI = 1.15-1.48), 2.82 (A versus C; 95% CI = 1.91-4.18) and 2.16 (B versus C; 95% CI = 1.48-3.16; all p<0.0001). The odds of live birth according to TE grade were 1.33 (A versus B; 95% CI = 1.17-1.50, p<0.0001), 1.85 (A versus C; 95% CI = 1.45-2.34, p<0.0001) and 1.39 (B versus C; 95% CI = 1.12-1.73, p=0.0024). Conclusion: The live birth rate for LGBs is 28%, with rates ranging between 15-31% for the different inner cell mass (ICM) and trophectoderm (TE) subgroups of LGBs. Even those in the lowest grading tier maintain modest live birth rates (15%; CC). Thus, these can be considered for transfer in women with few other options. | ||
| 653 | 0 | |a Reproduction | |
| 700 | 0 | |a James KEMPER |e verfasserin |4 aut | |
| 700 | 0 | |a Elizabeth HAMMOND |e verfasserin |4 aut | |
| 700 | 0 | |a Yanhe LIU |e verfasserin |4 aut | |
| 700 | 0 | |a Fengqin XU |e verfasserin |4 aut | |
| 700 | 0 | |a Gensheng LIU |e verfasserin |4 aut | |
| 700 | 0 | |a Haitao XI |e verfasserin |4 aut | |
| 700 | 0 | |a Lintao XUE |e verfasserin |4 aut | |
| 700 | 0 | |a Xiaohong BAI |e verfasserin |4 aut | |
| 700 | 0 | |a Hongqing LIAO |e verfasserin |4 aut | |
| 700 | 0 | |a Songguo XUE |e verfasserin |4 aut | |
| 700 | 0 | |a Shuqin ZHAO |e verfasserin |4 aut | |
| 700 | 0 | |a Aijun ZHANG |e verfasserin |4 aut | |
| 700 | 0 | |a Masoud AFNAN |e verfasserin |4 aut | |
| 700 | 0 | |a Rui WANG |e verfasserin |4 aut | |
| 700 | 0 | |a Ben MOL |e verfasserin |4 aut | |
| 700 | 0 | |a Dean MORBECK |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i In |t Fertility & Reproduction |d World Scientific Publishing, 2021 |g 04(2022), 03n04, Seite 170-171 |w (DE-627)1745873104 |x 26613174 |7 nnns |
| 773 | 1 | 8 | |g volume:04 |g year:2022 |g number:03n04 |g pages:170-171 |
| 856 | 4 | 0 | |u https://doi.org/10.1142/S2661318222740826 |z kostenfrei |
| 856 | 4 | 0 | |u https://doaj.org/article/2c1bbd5828914c41b1d23185b2458b04 |z kostenfrei |
| 856 | 4 | 0 | |u https://www.worldscientific.com/doi/10.1142/S2661318222740826 |z kostenfrei |
| 856 | 4 | 2 | |u https://doaj.org/toc/2661-3182 |y Journal toc |z kostenfrei |
| 856 | 4 | 2 | |u https://doaj.org/toc/2661-3174 |y Journal toc |z kostenfrei |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a SYSFLAG_A | ||
| 912 | |a GBV_DOAJ | ||
| 912 | |a GBV_ILN_20 | ||
| 912 | |a GBV_ILN_22 | ||
| 912 | |a GBV_ILN_23 | ||
| 912 | |a GBV_ILN_24 | ||
| 912 | |a GBV_ILN_31 | ||
| 912 | |a GBV_ILN_39 | ||
| 912 | |a GBV_ILN_40 | ||
| 912 | |a GBV_ILN_60 | ||
| 912 | |a GBV_ILN_62 | ||
| 912 | |a GBV_ILN_63 | ||
| 912 | |a GBV_ILN_65 | ||
| 912 | |a GBV_ILN_69 | ||
| 912 | |a GBV_ILN_73 | ||
| 912 | |a GBV_ILN_74 | ||
| 912 | |a GBV_ILN_95 | ||
| 912 | |a GBV_ILN_105 | ||
| 912 | |a GBV_ILN_110 | ||
| 912 | |a GBV_ILN_151 | ||
| 912 | |a GBV_ILN_161 | ||
| 912 | |a GBV_ILN_170 | ||
| 912 | |a GBV_ILN_206 | ||
| 912 | |a GBV_ILN_213 | ||
| 912 | |a GBV_ILN_230 | ||
| 912 | |a GBV_ILN_285 | ||
| 912 | |a GBV_ILN_293 | ||
| 912 | |a GBV_ILN_602 | ||
| 912 | |a GBV_ILN_2014 | ||
| 912 | |a GBV_ILN_4012 | ||
| 912 | |a GBV_ILN_4037 | ||
| 912 | |a GBV_ILN_4112 | ||
| 912 | |a GBV_ILN_4125 | ||
| 912 | |a GBV_ILN_4126 | ||
| 912 | |a GBV_ILN_4249 | ||
| 912 | |a GBV_ILN_4305 | ||
| 912 | |a GBV_ILN_4306 | ||
| 912 | |a GBV_ILN_4307 | ||
| 912 | |a GBV_ILN_4313 | ||
| 912 | |a GBV_ILN_4322 | ||
| 912 | |a GBV_ILN_4323 | ||
| 912 | |a GBV_ILN_4324 | ||
| 912 | |a GBV_ILN_4325 | ||
| 912 | |a GBV_ILN_4338 | ||
| 912 | |a GBV_ILN_4367 | ||
| 912 | |a GBV_ILN_4700 | ||
| 951 | |a AR | ||
| 952 | |d 04 |j 2022 |e 03n04 |h 170-171 | ||
| author_variant |
h z hz j k jk e h eh y l yl f x fx g l gl h x hx l x lx x b xb h l hl s x sx s z sz a z az m a ma r w rw b m bm d m dm |
|---|---|
| matchkey_str |
article:26613174:2022----::olwayuornfrfoga |
| hierarchy_sort_str |
2022 |
| callnumber-subject-code |
QH |
| publishDate |
2022 |
| allfields |
10.1142/S2661318222740826 doi (DE-627)DOAJ086527274 (DE-599)DOAJ2c1bbd5828914c41b1d23185b2458b04 DE-627 ger DE-627 rakwb eng QH471-489 Haowen ZOU verfasserin aut How Low Can You Go? Transfer of Low-Grade Blastocysts 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: Low grade blastocyst (LGB) transfer results in varied live birth rates (5-39%). Only limited studies with small sample sizes (n=10-440) exist, due to LGB transfer being less desirable. Definitions of LGB and study designs are heterogenous, further confounding outcome interpretation. Aim: This study aimed to obtain sufficient LGB transfers to determine live birth rates, as well as allow subgroup analysis by blastocyst quality and maternal age. Method: This study was a multicentre, multinational retrospective cohort study across nine IVF clinics in China and New Zealand between 2012 to 2019. 6966 single blastocyst transfer cycles on days 5-7 (fresh and frozen) were collected; of these, 875 transfers were from LGBs (<3BB). Blastocysts with expansion stage 1 or 2 (early blastocysts) were excluded. The main outcome was live birth rate. Blastocysts were grouped according to quality grade: good-grade blastocysts (GGBs; n=3849, AA, AB and BA), moderate-grade blastocysts (MGBs; n=2242, BB) and LGBs (n=875, AC, CA, BC, CB and CC). Live birth rates were compared using the Pearson Chi-squared test. A logistic regression analysis examined the relationship between blastocyst grade and live birth after adjustment for confounders: clinic, female age, expansion stage, and blastocyst age. Results: Live birth rates for GGBs, MGBs and LGBs were 45%, 36% and 28% respectively (p<0.0001). Within the LGB group, the highest live birth rates were for grade C TE (30%) and the lowest were for grade C ICM (19%). The lowest combined grade (CC) had a 15% live birth rate (n=7/48). The odds of live birth were 2.33 (95% CI = 1.88-2.89) for GGBs compared to LGBs and 1.56 (95% CI = 1.28-1.92) for MGBs compared to LGBs following fresh and frozen blastocyst transfers (p<0.0001). The odds of live birth according to ICM grade were 1.31 (A versus B; 95% CI = 1.15-1.48), 2.82 (A versus C; 95% CI = 1.91-4.18) and 2.16 (B versus C; 95% CI = 1.48-3.16; all p<0.0001). The odds of live birth according to TE grade were 1.33 (A versus B; 95% CI = 1.17-1.50, p<0.0001), 1.85 (A versus C; 95% CI = 1.45-2.34, p<0.0001) and 1.39 (B versus C; 95% CI = 1.12-1.73, p=0.0024). Conclusion: The live birth rate for LGBs is 28%, with rates ranging between 15-31% for the different inner cell mass (ICM) and trophectoderm (TE) subgroups of LGBs. Even those in the lowest grading tier maintain modest live birth rates (15%; CC). Thus, these can be considered for transfer in women with few other options. Reproduction James KEMPER verfasserin aut Elizabeth HAMMOND verfasserin aut Yanhe LIU verfasserin aut Fengqin XU verfasserin aut Gensheng LIU verfasserin aut Haitao XI verfasserin aut Lintao XUE verfasserin aut Xiaohong BAI verfasserin aut Hongqing LIAO verfasserin aut Songguo XUE verfasserin aut Shuqin ZHAO verfasserin aut Aijun ZHANG verfasserin aut Masoud AFNAN verfasserin aut Rui WANG verfasserin aut Ben MOL verfasserin aut Dean MORBECK verfasserin aut In Fertility & Reproduction World Scientific Publishing, 2021 04(2022), 03n04, Seite 170-171 (DE-627)1745873104 26613174 nnns volume:04 year:2022 number:03n04 pages:170-171 https://doi.org/10.1142/S2661318222740826 kostenfrei https://doaj.org/article/2c1bbd5828914c41b1d23185b2458b04 kostenfrei https://www.worldscientific.com/doi/10.1142/S2661318222740826 kostenfrei https://doaj.org/toc/2661-3182 Journal toc kostenfrei https://doaj.org/toc/2661-3174 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 04 2022 03n04 170-171 |
| spelling |
10.1142/S2661318222740826 doi (DE-627)DOAJ086527274 (DE-599)DOAJ2c1bbd5828914c41b1d23185b2458b04 DE-627 ger DE-627 rakwb eng QH471-489 Haowen ZOU verfasserin aut How Low Can You Go? Transfer of Low-Grade Blastocysts 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: Low grade blastocyst (LGB) transfer results in varied live birth rates (5-39%). Only limited studies with small sample sizes (n=10-440) exist, due to LGB transfer being less desirable. Definitions of LGB and study designs are heterogenous, further confounding outcome interpretation. Aim: This study aimed to obtain sufficient LGB transfers to determine live birth rates, as well as allow subgroup analysis by blastocyst quality and maternal age. Method: This study was a multicentre, multinational retrospective cohort study across nine IVF clinics in China and New Zealand between 2012 to 2019. 6966 single blastocyst transfer cycles on days 5-7 (fresh and frozen) were collected; of these, 875 transfers were from LGBs (<3BB). Blastocysts with expansion stage 1 or 2 (early blastocysts) were excluded. The main outcome was live birth rate. Blastocysts were grouped according to quality grade: good-grade blastocysts (GGBs; n=3849, AA, AB and BA), moderate-grade blastocysts (MGBs; n=2242, BB) and LGBs (n=875, AC, CA, BC, CB and CC). Live birth rates were compared using the Pearson Chi-squared test. A logistic regression analysis examined the relationship between blastocyst grade and live birth after adjustment for confounders: clinic, female age, expansion stage, and blastocyst age. Results: Live birth rates for GGBs, MGBs and LGBs were 45%, 36% and 28% respectively (p<0.0001). Within the LGB group, the highest live birth rates were for grade C TE (30%) and the lowest were for grade C ICM (19%). The lowest combined grade (CC) had a 15% live birth rate (n=7/48). The odds of live birth were 2.33 (95% CI = 1.88-2.89) for GGBs compared to LGBs and 1.56 (95% CI = 1.28-1.92) for MGBs compared to LGBs following fresh and frozen blastocyst transfers (p<0.0001). The odds of live birth according to ICM grade were 1.31 (A versus B; 95% CI = 1.15-1.48), 2.82 (A versus C; 95% CI = 1.91-4.18) and 2.16 (B versus C; 95% CI = 1.48-3.16; all p<0.0001). The odds of live birth according to TE grade were 1.33 (A versus B; 95% CI = 1.17-1.50, p<0.0001), 1.85 (A versus C; 95% CI = 1.45-2.34, p<0.0001) and 1.39 (B versus C; 95% CI = 1.12-1.73, p=0.0024). Conclusion: The live birth rate for LGBs is 28%, with rates ranging between 15-31% for the different inner cell mass (ICM) and trophectoderm (TE) subgroups of LGBs. Even those in the lowest grading tier maintain modest live birth rates (15%; CC). Thus, these can be considered for transfer in women with few other options. Reproduction James KEMPER verfasserin aut Elizabeth HAMMOND verfasserin aut Yanhe LIU verfasserin aut Fengqin XU verfasserin aut Gensheng LIU verfasserin aut Haitao XI verfasserin aut Lintao XUE verfasserin aut Xiaohong BAI verfasserin aut Hongqing LIAO verfasserin aut Songguo XUE verfasserin aut Shuqin ZHAO verfasserin aut Aijun ZHANG verfasserin aut Masoud AFNAN verfasserin aut Rui WANG verfasserin aut Ben MOL verfasserin aut Dean MORBECK verfasserin aut In Fertility & Reproduction World Scientific Publishing, 2021 04(2022), 03n04, Seite 170-171 (DE-627)1745873104 26613174 nnns volume:04 year:2022 number:03n04 pages:170-171 https://doi.org/10.1142/S2661318222740826 kostenfrei https://doaj.org/article/2c1bbd5828914c41b1d23185b2458b04 kostenfrei https://www.worldscientific.com/doi/10.1142/S2661318222740826 kostenfrei https://doaj.org/toc/2661-3182 Journal toc kostenfrei https://doaj.org/toc/2661-3174 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 04 2022 03n04 170-171 |
| allfields_unstemmed |
10.1142/S2661318222740826 doi (DE-627)DOAJ086527274 (DE-599)DOAJ2c1bbd5828914c41b1d23185b2458b04 DE-627 ger DE-627 rakwb eng QH471-489 Haowen ZOU verfasserin aut How Low Can You Go? Transfer of Low-Grade Blastocysts 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: Low grade blastocyst (LGB) transfer results in varied live birth rates (5-39%). Only limited studies with small sample sizes (n=10-440) exist, due to LGB transfer being less desirable. Definitions of LGB and study designs are heterogenous, further confounding outcome interpretation. Aim: This study aimed to obtain sufficient LGB transfers to determine live birth rates, as well as allow subgroup analysis by blastocyst quality and maternal age. Method: This study was a multicentre, multinational retrospective cohort study across nine IVF clinics in China and New Zealand between 2012 to 2019. 6966 single blastocyst transfer cycles on days 5-7 (fresh and frozen) were collected; of these, 875 transfers were from LGBs (<3BB). Blastocysts with expansion stage 1 or 2 (early blastocysts) were excluded. The main outcome was live birth rate. Blastocysts were grouped according to quality grade: good-grade blastocysts (GGBs; n=3849, AA, AB and BA), moderate-grade blastocysts (MGBs; n=2242, BB) and LGBs (n=875, AC, CA, BC, CB and CC). Live birth rates were compared using the Pearson Chi-squared test. A logistic regression analysis examined the relationship between blastocyst grade and live birth after adjustment for confounders: clinic, female age, expansion stage, and blastocyst age. Results: Live birth rates for GGBs, MGBs and LGBs were 45%, 36% and 28% respectively (p<0.0001). Within the LGB group, the highest live birth rates were for grade C TE (30%) and the lowest were for grade C ICM (19%). The lowest combined grade (CC) had a 15% live birth rate (n=7/48). The odds of live birth were 2.33 (95% CI = 1.88-2.89) for GGBs compared to LGBs and 1.56 (95% CI = 1.28-1.92) for MGBs compared to LGBs following fresh and frozen blastocyst transfers (p<0.0001). The odds of live birth according to ICM grade were 1.31 (A versus B; 95% CI = 1.15-1.48), 2.82 (A versus C; 95% CI = 1.91-4.18) and 2.16 (B versus C; 95% CI = 1.48-3.16; all p<0.0001). The odds of live birth according to TE grade were 1.33 (A versus B; 95% CI = 1.17-1.50, p<0.0001), 1.85 (A versus C; 95% CI = 1.45-2.34, p<0.0001) and 1.39 (B versus C; 95% CI = 1.12-1.73, p=0.0024). Conclusion: The live birth rate for LGBs is 28%, with rates ranging between 15-31% for the different inner cell mass (ICM) and trophectoderm (TE) subgroups of LGBs. Even those in the lowest grading tier maintain modest live birth rates (15%; CC). Thus, these can be considered for transfer in women with few other options. Reproduction James KEMPER verfasserin aut Elizabeth HAMMOND verfasserin aut Yanhe LIU verfasserin aut Fengqin XU verfasserin aut Gensheng LIU verfasserin aut Haitao XI verfasserin aut Lintao XUE verfasserin aut Xiaohong BAI verfasserin aut Hongqing LIAO verfasserin aut Songguo XUE verfasserin aut Shuqin ZHAO verfasserin aut Aijun ZHANG verfasserin aut Masoud AFNAN verfasserin aut Rui WANG verfasserin aut Ben MOL verfasserin aut Dean MORBECK verfasserin aut In Fertility & Reproduction World Scientific Publishing, 2021 04(2022), 03n04, Seite 170-171 (DE-627)1745873104 26613174 nnns volume:04 year:2022 number:03n04 pages:170-171 https://doi.org/10.1142/S2661318222740826 kostenfrei https://doaj.org/article/2c1bbd5828914c41b1d23185b2458b04 kostenfrei https://www.worldscientific.com/doi/10.1142/S2661318222740826 kostenfrei https://doaj.org/toc/2661-3182 Journal toc kostenfrei https://doaj.org/toc/2661-3174 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 04 2022 03n04 170-171 |
| allfieldsGer |
10.1142/S2661318222740826 doi (DE-627)DOAJ086527274 (DE-599)DOAJ2c1bbd5828914c41b1d23185b2458b04 DE-627 ger DE-627 rakwb eng QH471-489 Haowen ZOU verfasserin aut How Low Can You Go? Transfer of Low-Grade Blastocysts 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: Low grade blastocyst (LGB) transfer results in varied live birth rates (5-39%). Only limited studies with small sample sizes (n=10-440) exist, due to LGB transfer being less desirable. Definitions of LGB and study designs are heterogenous, further confounding outcome interpretation. Aim: This study aimed to obtain sufficient LGB transfers to determine live birth rates, as well as allow subgroup analysis by blastocyst quality and maternal age. Method: This study was a multicentre, multinational retrospective cohort study across nine IVF clinics in China and New Zealand between 2012 to 2019. 6966 single blastocyst transfer cycles on days 5-7 (fresh and frozen) were collected; of these, 875 transfers were from LGBs (<3BB). Blastocysts with expansion stage 1 or 2 (early blastocysts) were excluded. The main outcome was live birth rate. Blastocysts were grouped according to quality grade: good-grade blastocysts (GGBs; n=3849, AA, AB and BA), moderate-grade blastocysts (MGBs; n=2242, BB) and LGBs (n=875, AC, CA, BC, CB and CC). Live birth rates were compared using the Pearson Chi-squared test. A logistic regression analysis examined the relationship between blastocyst grade and live birth after adjustment for confounders: clinic, female age, expansion stage, and blastocyst age. Results: Live birth rates for GGBs, MGBs and LGBs were 45%, 36% and 28% respectively (p<0.0001). Within the LGB group, the highest live birth rates were for grade C TE (30%) and the lowest were for grade C ICM (19%). The lowest combined grade (CC) had a 15% live birth rate (n=7/48). The odds of live birth were 2.33 (95% CI = 1.88-2.89) for GGBs compared to LGBs and 1.56 (95% CI = 1.28-1.92) for MGBs compared to LGBs following fresh and frozen blastocyst transfers (p<0.0001). The odds of live birth according to ICM grade were 1.31 (A versus B; 95% CI = 1.15-1.48), 2.82 (A versus C; 95% CI = 1.91-4.18) and 2.16 (B versus C; 95% CI = 1.48-3.16; all p<0.0001). The odds of live birth according to TE grade were 1.33 (A versus B; 95% CI = 1.17-1.50, p<0.0001), 1.85 (A versus C; 95% CI = 1.45-2.34, p<0.0001) and 1.39 (B versus C; 95% CI = 1.12-1.73, p=0.0024). Conclusion: The live birth rate for LGBs is 28%, with rates ranging between 15-31% for the different inner cell mass (ICM) and trophectoderm (TE) subgroups of LGBs. Even those in the lowest grading tier maintain modest live birth rates (15%; CC). Thus, these can be considered for transfer in women with few other options. Reproduction James KEMPER verfasserin aut Elizabeth HAMMOND verfasserin aut Yanhe LIU verfasserin aut Fengqin XU verfasserin aut Gensheng LIU verfasserin aut Haitao XI verfasserin aut Lintao XUE verfasserin aut Xiaohong BAI verfasserin aut Hongqing LIAO verfasserin aut Songguo XUE verfasserin aut Shuqin ZHAO verfasserin aut Aijun ZHANG verfasserin aut Masoud AFNAN verfasserin aut Rui WANG verfasserin aut Ben MOL verfasserin aut Dean MORBECK verfasserin aut In Fertility & Reproduction World Scientific Publishing, 2021 04(2022), 03n04, Seite 170-171 (DE-627)1745873104 26613174 nnns volume:04 year:2022 number:03n04 pages:170-171 https://doi.org/10.1142/S2661318222740826 kostenfrei https://doaj.org/article/2c1bbd5828914c41b1d23185b2458b04 kostenfrei https://www.worldscientific.com/doi/10.1142/S2661318222740826 kostenfrei https://doaj.org/toc/2661-3182 Journal toc kostenfrei https://doaj.org/toc/2661-3174 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 04 2022 03n04 170-171 |
| allfieldsSound |
10.1142/S2661318222740826 doi (DE-627)DOAJ086527274 (DE-599)DOAJ2c1bbd5828914c41b1d23185b2458b04 DE-627 ger DE-627 rakwb eng QH471-489 Haowen ZOU verfasserin aut How Low Can You Go? Transfer of Low-Grade Blastocysts 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: Low grade blastocyst (LGB) transfer results in varied live birth rates (5-39%). Only limited studies with small sample sizes (n=10-440) exist, due to LGB transfer being less desirable. Definitions of LGB and study designs are heterogenous, further confounding outcome interpretation. Aim: This study aimed to obtain sufficient LGB transfers to determine live birth rates, as well as allow subgroup analysis by blastocyst quality and maternal age. Method: This study was a multicentre, multinational retrospective cohort study across nine IVF clinics in China and New Zealand between 2012 to 2019. 6966 single blastocyst transfer cycles on days 5-7 (fresh and frozen) were collected; of these, 875 transfers were from LGBs (<3BB). Blastocysts with expansion stage 1 or 2 (early blastocysts) were excluded. The main outcome was live birth rate. Blastocysts were grouped according to quality grade: good-grade blastocysts (GGBs; n=3849, AA, AB and BA), moderate-grade blastocysts (MGBs; n=2242, BB) and LGBs (n=875, AC, CA, BC, CB and CC). Live birth rates were compared using the Pearson Chi-squared test. A logistic regression analysis examined the relationship between blastocyst grade and live birth after adjustment for confounders: clinic, female age, expansion stage, and blastocyst age. Results: Live birth rates for GGBs, MGBs and LGBs were 45%, 36% and 28% respectively (p<0.0001). Within the LGB group, the highest live birth rates were for grade C TE (30%) and the lowest were for grade C ICM (19%). The lowest combined grade (CC) had a 15% live birth rate (n=7/48). The odds of live birth were 2.33 (95% CI = 1.88-2.89) for GGBs compared to LGBs and 1.56 (95% CI = 1.28-1.92) for MGBs compared to LGBs following fresh and frozen blastocyst transfers (p<0.0001). The odds of live birth according to ICM grade were 1.31 (A versus B; 95% CI = 1.15-1.48), 2.82 (A versus C; 95% CI = 1.91-4.18) and 2.16 (B versus C; 95% CI = 1.48-3.16; all p<0.0001). The odds of live birth according to TE grade were 1.33 (A versus B; 95% CI = 1.17-1.50, p<0.0001), 1.85 (A versus C; 95% CI = 1.45-2.34, p<0.0001) and 1.39 (B versus C; 95% CI = 1.12-1.73, p=0.0024). Conclusion: The live birth rate for LGBs is 28%, with rates ranging between 15-31% for the different inner cell mass (ICM) and trophectoderm (TE) subgroups of LGBs. Even those in the lowest grading tier maintain modest live birth rates (15%; CC). Thus, these can be considered for transfer in women with few other options. Reproduction James KEMPER verfasserin aut Elizabeth HAMMOND verfasserin aut Yanhe LIU verfasserin aut Fengqin XU verfasserin aut Gensheng LIU verfasserin aut Haitao XI verfasserin aut Lintao XUE verfasserin aut Xiaohong BAI verfasserin aut Hongqing LIAO verfasserin aut Songguo XUE verfasserin aut Shuqin ZHAO verfasserin aut Aijun ZHANG verfasserin aut Masoud AFNAN verfasserin aut Rui WANG verfasserin aut Ben MOL verfasserin aut Dean MORBECK verfasserin aut In Fertility & Reproduction World Scientific Publishing, 2021 04(2022), 03n04, Seite 170-171 (DE-627)1745873104 26613174 nnns volume:04 year:2022 number:03n04 pages:170-171 https://doi.org/10.1142/S2661318222740826 kostenfrei https://doaj.org/article/2c1bbd5828914c41b1d23185b2458b04 kostenfrei https://www.worldscientific.com/doi/10.1142/S2661318222740826 kostenfrei https://doaj.org/toc/2661-3182 Journal toc kostenfrei https://doaj.org/toc/2661-3174 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 04 2022 03n04 170-171 |
| language |
English |
| source |
In Fertility & Reproduction 04(2022), 03n04, Seite 170-171 volume:04 year:2022 number:03n04 pages:170-171 |
| sourceStr |
In Fertility & Reproduction 04(2022), 03n04, Seite 170-171 volume:04 year:2022 number:03n04 pages:170-171 |
| format_phy_str_mv |
Article |
| institution |
findex.gbv.de |
| topic_facet |
Reproduction |
| isfreeaccess_bool |
true |
| container_title |
Fertility & Reproduction |
| authorswithroles_txt_mv |
Haowen ZOU @@aut@@ James KEMPER @@aut@@ Elizabeth HAMMOND @@aut@@ Yanhe LIU @@aut@@ Fengqin XU @@aut@@ Gensheng LIU @@aut@@ Haitao XI @@aut@@ Lintao XUE @@aut@@ Xiaohong BAI @@aut@@ Hongqing LIAO @@aut@@ Songguo XUE @@aut@@ Shuqin ZHAO @@aut@@ Aijun ZHANG @@aut@@ Masoud AFNAN @@aut@@ Rui WANG @@aut@@ Ben MOL @@aut@@ Dean MORBECK @@aut@@ |
| publishDateDaySort_date |
2022-01-01T00:00:00Z |
| hierarchy_top_id |
1745873104 |
| id |
DOAJ086527274 |
| language_de |
englisch |
| fullrecord |
<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000naa a22002652 4500</leader><controlfield tag="001">DOAJ086527274</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20230311051537.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">230311s2022 xx |||||o 00| ||eng c</controlfield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.1142/S2661318222740826</subfield><subfield code="2">doi</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)DOAJ086527274</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-599)DOAJ2c1bbd5828914c41b1d23185b2458b04</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="050" ind1=" " ind2="0"><subfield code="a">QH471-489</subfield></datafield><datafield tag="100" ind1="0" ind2=" "><subfield code="a">Haowen ZOU</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">How Low Can You Go? Transfer of Low-Grade Blastocysts</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2022</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">Text</subfield><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">Computermedien</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Background: Low grade blastocyst (LGB) transfer results in varied live birth rates (5-39%). Only limited studies with small sample sizes (n=10-440) exist, due to LGB transfer being less desirable. Definitions of LGB and study designs are heterogenous, further confounding outcome interpretation. Aim: This study aimed to obtain sufficient LGB transfers to determine live birth rates, as well as allow subgroup analysis by blastocyst quality and maternal age. Method: This study was a multicentre, multinational retrospective cohort study across nine IVF clinics in China and New Zealand between 2012 to 2019. 6966 single blastocyst transfer cycles on days 5-7 (fresh and frozen) were collected; of these, 875 transfers were from LGBs (<3BB). Blastocysts with expansion stage 1 or 2 (early blastocysts) were excluded. The main outcome was live birth rate. Blastocysts were grouped according to quality grade: good-grade blastocysts (GGBs; n=3849, AA, AB and BA), moderate-grade blastocysts (MGBs; n=2242, BB) and LGBs (n=875, AC, CA, BC, CB and CC). Live birth rates were compared using the Pearson Chi-squared test. A logistic regression analysis examined the relationship between blastocyst grade and live birth after adjustment for confounders: clinic, female age, expansion stage, and blastocyst age. Results: Live birth rates for GGBs, MGBs and LGBs were 45%, 36% and 28% respectively (p<0.0001). Within the LGB group, the highest live birth rates were for grade C TE (30%) and the lowest were for grade C ICM (19%). The lowest combined grade (CC) had a 15% live birth rate (n=7/48). The odds of live birth were 2.33 (95% CI = 1.88-2.89) for GGBs compared to LGBs and 1.56 (95% CI = 1.28-1.92) for MGBs compared to LGBs following fresh and frozen blastocyst transfers (p<0.0001). The odds of live birth according to ICM grade were 1.31 (A versus B; 95% CI = 1.15-1.48), 2.82 (A versus C; 95% CI = 1.91-4.18) and 2.16 (B versus C; 95% CI = 1.48-3.16; all p<0.0001). The odds of live birth according to TE grade were 1.33 (A versus B; 95% CI = 1.17-1.50, p<0.0001), 1.85 (A versus C; 95% CI = 1.45-2.34, p<0.0001) and 1.39 (B versus C; 95% CI = 1.12-1.73, p=0.0024). Conclusion: The live birth rate for LGBs is 28%, with rates ranging between 15-31% for the different inner cell mass (ICM) and trophectoderm (TE) subgroups of LGBs. Even those in the lowest grading tier maintain modest live birth rates (15%; CC). Thus, these can be considered for transfer in women with few other options.</subfield></datafield><datafield tag="653" ind1=" " ind2="0"><subfield code="a">Reproduction</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">James KEMPER</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Elizabeth HAMMOND</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Yanhe LIU</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Fengqin XU</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Gensheng LIU</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Haitao XI</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Lintao XUE</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Xiaohong BAI</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Hongqing LIAO</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Songguo XUE</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Shuqin ZHAO</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Aijun ZHANG</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Masoud AFNAN</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Rui WANG</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Ben MOL</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Dean MORBECK</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="773" ind1="0" ind2="8"><subfield code="i">In</subfield><subfield code="t">Fertility & Reproduction</subfield><subfield code="d">World Scientific Publishing, 2021</subfield><subfield code="g">04(2022), 03n04, Seite 170-171</subfield><subfield code="w">(DE-627)1745873104</subfield><subfield code="x">26613174</subfield><subfield code="7">nnns</subfield></datafield><datafield tag="773" ind1="1" ind2="8"><subfield code="g">volume:04</subfield><subfield code="g">year:2022</subfield><subfield code="g">number:03n04</subfield><subfield code="g">pages:170-171</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">https://doi.org/10.1142/S2661318222740826</subfield><subfield code="z">kostenfrei</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">https://doaj.org/article/2c1bbd5828914c41b1d23185b2458b04</subfield><subfield code="z">kostenfrei</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">https://www.worldscientific.com/doi/10.1142/S2661318222740826</subfield><subfield code="z">kostenfrei</subfield></datafield><datafield tag="856" ind1="4" ind2="2"><subfield code="u">https://doaj.org/toc/2661-3182</subfield><subfield code="y">Journal toc</subfield><subfield code="z">kostenfrei</subfield></datafield><datafield tag="856" ind1="4" ind2="2"><subfield code="u">https://doaj.org/toc/2661-3174</subfield><subfield code="y">Journal toc</subfield><subfield code="z">kostenfrei</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_USEFLAG_A</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">SYSFLAG_A</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_DOAJ</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_20</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_22</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_23</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_24</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_31</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_39</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_40</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_60</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_62</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_63</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_65</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_69</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_73</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_74</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_95</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_105</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_110</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_151</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_161</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_170</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_206</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_213</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_230</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_285</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_293</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_602</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2014</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4012</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4037</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4112</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4125</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4126</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4249</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4305</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4306</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4307</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4313</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4322</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4323</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4324</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4325</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4338</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4367</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4700</subfield></datafield><datafield tag="951" ind1=" " ind2=" "><subfield code="a">AR</subfield></datafield><datafield tag="952" ind1=" " ind2=" "><subfield code="d">04</subfield><subfield code="j">2022</subfield><subfield code="e">03n04</subfield><subfield code="h">170-171</subfield></datafield></record></collection>
|
| callnumber-first |
Q - Science |
| author |
Haowen ZOU |
| spellingShingle |
Haowen ZOU misc QH471-489 misc Reproduction How Low Can You Go? Transfer of Low-Grade Blastocysts |
| authorStr |
Haowen ZOU |
| ppnlink_with_tag_str_mv |
@@773@@(DE-627)1745873104 |
| format |
electronic Article |
| delete_txt_mv |
keep |
| author_role |
aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut |
| collection |
DOAJ |
| remote_str |
true |
| callnumber-label |
QH471-489 |
| illustrated |
Not Illustrated |
| issn |
26613174 |
| topic_title |
QH471-489 How Low Can You Go? Transfer of Low-Grade Blastocysts |
| topic |
misc QH471-489 misc Reproduction |
| topic_unstemmed |
misc QH471-489 misc Reproduction |
| topic_browse |
misc QH471-489 misc Reproduction |
| format_facet |
Elektronische Aufsätze Aufsätze Elektronische Ressource |
| format_main_str_mv |
Text Zeitschrift/Artikel |
| carriertype_str_mv |
cr |
| hierarchy_parent_title |
Fertility & Reproduction |
| hierarchy_parent_id |
1745873104 |
| hierarchy_top_title |
Fertility & Reproduction |
| isfreeaccess_txt |
true |
| familylinks_str_mv |
(DE-627)1745873104 |
| title |
How Low Can You Go? Transfer of Low-Grade Blastocysts |
| ctrlnum |
(DE-627)DOAJ086527274 (DE-599)DOAJ2c1bbd5828914c41b1d23185b2458b04 |
| title_full |
How Low Can You Go? Transfer of Low-Grade Blastocysts |
| author_sort |
Haowen ZOU |
| journal |
Fertility & Reproduction |
| journalStr |
Fertility & Reproduction |
| callnumber-first-code |
Q |
| lang_code |
eng |
| isOA_bool |
true |
| recordtype |
marc |
| publishDateSort |
2022 |
| contenttype_str_mv |
txt |
| container_start_page |
170 |
| author_browse |
Haowen ZOU James KEMPER Elizabeth HAMMOND Yanhe LIU Fengqin XU Gensheng LIU Haitao XI Lintao XUE Xiaohong BAI Hongqing LIAO Songguo XUE Shuqin ZHAO Aijun ZHANG Masoud AFNAN Rui WANG Ben MOL Dean MORBECK |
| container_volume |
04 |
| class |
QH471-489 |
| format_se |
Elektronische Aufsätze |
| author-letter |
Haowen ZOU |
| doi_str_mv |
10.1142/S2661318222740826 |
| author2-role |
verfasserin |
| title_sort |
how low can you go? transfer of low-grade blastocysts |
| callnumber |
QH471-489 |
| title_auth |
How Low Can You Go? Transfer of Low-Grade Blastocysts |
| abstract |
Background: Low grade blastocyst (LGB) transfer results in varied live birth rates (5-39%). Only limited studies with small sample sizes (n=10-440) exist, due to LGB transfer being less desirable. Definitions of LGB and study designs are heterogenous, further confounding outcome interpretation. Aim: This study aimed to obtain sufficient LGB transfers to determine live birth rates, as well as allow subgroup analysis by blastocyst quality and maternal age. Method: This study was a multicentre, multinational retrospective cohort study across nine IVF clinics in China and New Zealand between 2012 to 2019. 6966 single blastocyst transfer cycles on days 5-7 (fresh and frozen) were collected; of these, 875 transfers were from LGBs (<3BB). Blastocysts with expansion stage 1 or 2 (early blastocysts) were excluded. The main outcome was live birth rate. Blastocysts were grouped according to quality grade: good-grade blastocysts (GGBs; n=3849, AA, AB and BA), moderate-grade blastocysts (MGBs; n=2242, BB) and LGBs (n=875, AC, CA, BC, CB and CC). Live birth rates were compared using the Pearson Chi-squared test. A logistic regression analysis examined the relationship between blastocyst grade and live birth after adjustment for confounders: clinic, female age, expansion stage, and blastocyst age. Results: Live birth rates for GGBs, MGBs and LGBs were 45%, 36% and 28% respectively (p<0.0001). Within the LGB group, the highest live birth rates were for grade C TE (30%) and the lowest were for grade C ICM (19%). The lowest combined grade (CC) had a 15% live birth rate (n=7/48). The odds of live birth were 2.33 (95% CI = 1.88-2.89) for GGBs compared to LGBs and 1.56 (95% CI = 1.28-1.92) for MGBs compared to LGBs following fresh and frozen blastocyst transfers (p<0.0001). The odds of live birth according to ICM grade were 1.31 (A versus B; 95% CI = 1.15-1.48), 2.82 (A versus C; 95% CI = 1.91-4.18) and 2.16 (B versus C; 95% CI = 1.48-3.16; all p<0.0001). The odds of live birth according to TE grade were 1.33 (A versus B; 95% CI = 1.17-1.50, p<0.0001), 1.85 (A versus C; 95% CI = 1.45-2.34, p<0.0001) and 1.39 (B versus C; 95% CI = 1.12-1.73, p=0.0024). Conclusion: The live birth rate for LGBs is 28%, with rates ranging between 15-31% for the different inner cell mass (ICM) and trophectoderm (TE) subgroups of LGBs. Even those in the lowest grading tier maintain modest live birth rates (15%; CC). Thus, these can be considered for transfer in women with few other options. |
| abstractGer |
Background: Low grade blastocyst (LGB) transfer results in varied live birth rates (5-39%). Only limited studies with small sample sizes (n=10-440) exist, due to LGB transfer being less desirable. Definitions of LGB and study designs are heterogenous, further confounding outcome interpretation. Aim: This study aimed to obtain sufficient LGB transfers to determine live birth rates, as well as allow subgroup analysis by blastocyst quality and maternal age. Method: This study was a multicentre, multinational retrospective cohort study across nine IVF clinics in China and New Zealand between 2012 to 2019. 6966 single blastocyst transfer cycles on days 5-7 (fresh and frozen) were collected; of these, 875 transfers were from LGBs (<3BB). Blastocysts with expansion stage 1 or 2 (early blastocysts) were excluded. The main outcome was live birth rate. Blastocysts were grouped according to quality grade: good-grade blastocysts (GGBs; n=3849, AA, AB and BA), moderate-grade blastocysts (MGBs; n=2242, BB) and LGBs (n=875, AC, CA, BC, CB and CC). Live birth rates were compared using the Pearson Chi-squared test. A logistic regression analysis examined the relationship between blastocyst grade and live birth after adjustment for confounders: clinic, female age, expansion stage, and blastocyst age. Results: Live birth rates for GGBs, MGBs and LGBs were 45%, 36% and 28% respectively (p<0.0001). Within the LGB group, the highest live birth rates were for grade C TE (30%) and the lowest were for grade C ICM (19%). The lowest combined grade (CC) had a 15% live birth rate (n=7/48). The odds of live birth were 2.33 (95% CI = 1.88-2.89) for GGBs compared to LGBs and 1.56 (95% CI = 1.28-1.92) for MGBs compared to LGBs following fresh and frozen blastocyst transfers (p<0.0001). The odds of live birth according to ICM grade were 1.31 (A versus B; 95% CI = 1.15-1.48), 2.82 (A versus C; 95% CI = 1.91-4.18) and 2.16 (B versus C; 95% CI = 1.48-3.16; all p<0.0001). The odds of live birth according to TE grade were 1.33 (A versus B; 95% CI = 1.17-1.50, p<0.0001), 1.85 (A versus C; 95% CI = 1.45-2.34, p<0.0001) and 1.39 (B versus C; 95% CI = 1.12-1.73, p=0.0024). Conclusion: The live birth rate for LGBs is 28%, with rates ranging between 15-31% for the different inner cell mass (ICM) and trophectoderm (TE) subgroups of LGBs. Even those in the lowest grading tier maintain modest live birth rates (15%; CC). Thus, these can be considered for transfer in women with few other options. |
| abstract_unstemmed |
Background: Low grade blastocyst (LGB) transfer results in varied live birth rates (5-39%). Only limited studies with small sample sizes (n=10-440) exist, due to LGB transfer being less desirable. Definitions of LGB and study designs are heterogenous, further confounding outcome interpretation. Aim: This study aimed to obtain sufficient LGB transfers to determine live birth rates, as well as allow subgroup analysis by blastocyst quality and maternal age. Method: This study was a multicentre, multinational retrospective cohort study across nine IVF clinics in China and New Zealand between 2012 to 2019. 6966 single blastocyst transfer cycles on days 5-7 (fresh and frozen) were collected; of these, 875 transfers were from LGBs (<3BB). Blastocysts with expansion stage 1 or 2 (early blastocysts) were excluded. The main outcome was live birth rate. Blastocysts were grouped according to quality grade: good-grade blastocysts (GGBs; n=3849, AA, AB and BA), moderate-grade blastocysts (MGBs; n=2242, BB) and LGBs (n=875, AC, CA, BC, CB and CC). Live birth rates were compared using the Pearson Chi-squared test. A logistic regression analysis examined the relationship between blastocyst grade and live birth after adjustment for confounders: clinic, female age, expansion stage, and blastocyst age. Results: Live birth rates for GGBs, MGBs and LGBs were 45%, 36% and 28% respectively (p<0.0001). Within the LGB group, the highest live birth rates were for grade C TE (30%) and the lowest were for grade C ICM (19%). The lowest combined grade (CC) had a 15% live birth rate (n=7/48). The odds of live birth were 2.33 (95% CI = 1.88-2.89) for GGBs compared to LGBs and 1.56 (95% CI = 1.28-1.92) for MGBs compared to LGBs following fresh and frozen blastocyst transfers (p<0.0001). The odds of live birth according to ICM grade were 1.31 (A versus B; 95% CI = 1.15-1.48), 2.82 (A versus C; 95% CI = 1.91-4.18) and 2.16 (B versus C; 95% CI = 1.48-3.16; all p<0.0001). The odds of live birth according to TE grade were 1.33 (A versus B; 95% CI = 1.17-1.50, p<0.0001), 1.85 (A versus C; 95% CI = 1.45-2.34, p<0.0001) and 1.39 (B versus C; 95% CI = 1.12-1.73, p=0.0024). Conclusion: The live birth rate for LGBs is 28%, with rates ranging between 15-31% for the different inner cell mass (ICM) and trophectoderm (TE) subgroups of LGBs. Even those in the lowest grading tier maintain modest live birth rates (15%; CC). Thus, these can be considered for transfer in women with few other options. |
| collection_details |
GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 |
| container_issue |
03n04 |
| title_short |
How Low Can You Go? Transfer of Low-Grade Blastocysts |
| url |
https://doi.org/10.1142/S2661318222740826 https://doaj.org/article/2c1bbd5828914c41b1d23185b2458b04 https://www.worldscientific.com/doi/10.1142/S2661318222740826 https://doaj.org/toc/2661-3182 https://doaj.org/toc/2661-3174 |
| remote_bool |
true |
| author2 |
James KEMPER Elizabeth HAMMOND Yanhe LIU Fengqin XU Gensheng LIU Haitao XI Lintao XUE Xiaohong BAI Hongqing LIAO Songguo XUE Shuqin ZHAO Aijun ZHANG Masoud AFNAN Rui WANG Ben MOL Dean MORBECK |
| author2Str |
James KEMPER Elizabeth HAMMOND Yanhe LIU Fengqin XU Gensheng LIU Haitao XI Lintao XUE Xiaohong BAI Hongqing LIAO Songguo XUE Shuqin ZHAO Aijun ZHANG Masoud AFNAN Rui WANG Ben MOL Dean MORBECK |
| ppnlink |
1745873104 |
| callnumber-subject |
QH - Natural History and Biology |
| mediatype_str_mv |
c |
| isOA_txt |
true |
| hochschulschrift_bool |
false |
| doi_str |
10.1142/S2661318222740826 |
| callnumber-a |
QH471-489 |
| up_date |
2024-07-03T21:13:00.193Z |
| _version_ |
1803593900567298048 |
| fullrecord_marcxml |
<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000naa a22002652 4500</leader><controlfield tag="001">DOAJ086527274</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20230311051537.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">230311s2022 xx |||||o 00| ||eng c</controlfield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.1142/S2661318222740826</subfield><subfield code="2">doi</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)DOAJ086527274</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-599)DOAJ2c1bbd5828914c41b1d23185b2458b04</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="050" ind1=" " ind2="0"><subfield code="a">QH471-489</subfield></datafield><datafield tag="100" ind1="0" ind2=" "><subfield code="a">Haowen ZOU</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">How Low Can You Go? Transfer of Low-Grade Blastocysts</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2022</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">Text</subfield><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">Computermedien</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Background: Low grade blastocyst (LGB) transfer results in varied live birth rates (5-39%). Only limited studies with small sample sizes (n=10-440) exist, due to LGB transfer being less desirable. Definitions of LGB and study designs are heterogenous, further confounding outcome interpretation. Aim: This study aimed to obtain sufficient LGB transfers to determine live birth rates, as well as allow subgroup analysis by blastocyst quality and maternal age. Method: This study was a multicentre, multinational retrospective cohort study across nine IVF clinics in China and New Zealand between 2012 to 2019. 6966 single blastocyst transfer cycles on days 5-7 (fresh and frozen) were collected; of these, 875 transfers were from LGBs (<3BB). Blastocysts with expansion stage 1 or 2 (early blastocysts) were excluded. The main outcome was live birth rate. Blastocysts were grouped according to quality grade: good-grade blastocysts (GGBs; n=3849, AA, AB and BA), moderate-grade blastocysts (MGBs; n=2242, BB) and LGBs (n=875, AC, CA, BC, CB and CC). Live birth rates were compared using the Pearson Chi-squared test. A logistic regression analysis examined the relationship between blastocyst grade and live birth after adjustment for confounders: clinic, female age, expansion stage, and blastocyst age. Results: Live birth rates for GGBs, MGBs and LGBs were 45%, 36% and 28% respectively (p<0.0001). Within the LGB group, the highest live birth rates were for grade C TE (30%) and the lowest were for grade C ICM (19%). The lowest combined grade (CC) had a 15% live birth rate (n=7/48). The odds of live birth were 2.33 (95% CI = 1.88-2.89) for GGBs compared to LGBs and 1.56 (95% CI = 1.28-1.92) for MGBs compared to LGBs following fresh and frozen blastocyst transfers (p<0.0001). The odds of live birth according to ICM grade were 1.31 (A versus B; 95% CI = 1.15-1.48), 2.82 (A versus C; 95% CI = 1.91-4.18) and 2.16 (B versus C; 95% CI = 1.48-3.16; all p<0.0001). The odds of live birth according to TE grade were 1.33 (A versus B; 95% CI = 1.17-1.50, p<0.0001), 1.85 (A versus C; 95% CI = 1.45-2.34, p<0.0001) and 1.39 (B versus C; 95% CI = 1.12-1.73, p=0.0024). Conclusion: The live birth rate for LGBs is 28%, with rates ranging between 15-31% for the different inner cell mass (ICM) and trophectoderm (TE) subgroups of LGBs. Even those in the lowest grading tier maintain modest live birth rates (15%; CC). Thus, these can be considered for transfer in women with few other options.</subfield></datafield><datafield tag="653" ind1=" " ind2="0"><subfield code="a">Reproduction</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">James KEMPER</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Elizabeth HAMMOND</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Yanhe LIU</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Fengqin XU</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Gensheng LIU</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Haitao XI</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Lintao XUE</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Xiaohong BAI</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Hongqing LIAO</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Songguo XUE</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Shuqin ZHAO</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Aijun ZHANG</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Masoud AFNAN</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Rui WANG</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Ben MOL</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Dean MORBECK</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="773" ind1="0" ind2="8"><subfield code="i">In</subfield><subfield code="t">Fertility & Reproduction</subfield><subfield code="d">World Scientific Publishing, 2021</subfield><subfield code="g">04(2022), 03n04, Seite 170-171</subfield><subfield code="w">(DE-627)1745873104</subfield><subfield code="x">26613174</subfield><subfield code="7">nnns</subfield></datafield><datafield tag="773" ind1="1" ind2="8"><subfield code="g">volume:04</subfield><subfield code="g">year:2022</subfield><subfield code="g">number:03n04</subfield><subfield code="g">pages:170-171</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">https://doi.org/10.1142/S2661318222740826</subfield><subfield code="z">kostenfrei</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">https://doaj.org/article/2c1bbd5828914c41b1d23185b2458b04</subfield><subfield code="z">kostenfrei</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">https://www.worldscientific.com/doi/10.1142/S2661318222740826</subfield><subfield code="z">kostenfrei</subfield></datafield><datafield tag="856" ind1="4" ind2="2"><subfield code="u">https://doaj.org/toc/2661-3182</subfield><subfield code="y">Journal toc</subfield><subfield code="z">kostenfrei</subfield></datafield><datafield tag="856" ind1="4" ind2="2"><subfield code="u">https://doaj.org/toc/2661-3174</subfield><subfield code="y">Journal toc</subfield><subfield code="z">kostenfrei</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_USEFLAG_A</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">SYSFLAG_A</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_DOAJ</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_20</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_22</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_23</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_24</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_31</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_39</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_40</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_60</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_62</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_63</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_65</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_69</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_73</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_74</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_95</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_105</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_110</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_151</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_161</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_170</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_206</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_213</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_230</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_285</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_293</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_602</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2014</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4012</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4037</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4112</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4125</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4126</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4249</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4305</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4306</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4307</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4313</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4322</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4323</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4324</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4325</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4338</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4367</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4700</subfield></datafield><datafield tag="951" ind1=" " ind2=" "><subfield code="a">AR</subfield></datafield><datafield tag="952" ind1=" " ind2=" "><subfield code="d">04</subfield><subfield code="j">2022</subfield><subfield code="e">03n04</subfield><subfield code="h">170-171</subfield></datafield></record></collection>
|
| score |
7.39876 |