Array Formatting of the Heat-Transfer Method (HTM) for the Detection of Small Organic Molecules by Molecularly Imprinted Polymers

In this work we present the first steps towards a molecularly imprinted polymer (MIP)-based biomimetic sensor array for the detection of small organic molecules via the heat-transfer method (HTM). HTM relies on the change in thermal resistance upon binding of the target molecule to the MIP-type rec...
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Gespeichert in:

Autor*in:	Gideon Wackers [verfasserIn] Thijs Vandenryt [verfasserIn] Peter Cornelis [verfasserIn] Evelien Kellens [verfasserIn] Ronald Thoelen [verfasserIn] Ward De Ceuninck [verfasserIn] Patricia Losada-Pérez [verfasserIn] Bart van Grinsven [verfasserIn] Marloes Peeters [verfasserIn] Patrick Wagner [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2014

Schlagwörter:	heat-transfer method (HTM) molecularly imprinted polymers (MIPs) serotonin histamine L-nicotine array format

Übergeordnetes Werk:	In: Sensors - MDPI AG, 2003, 14(2014), 6, Seite 11016-11030
Übergeordnetes Werk:	volume:14 ; year:2014 ; number:6 ; pages:11016-11030

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3390/s140611016

Katalog-ID:	DOAJ086588265

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allfields	10.3390/s140611016 doi (DE-627)DOAJ086588265 (DE-599)DOAJba3352d223e24e1c90b3e5a899dc1670 DE-627 ger DE-627 rakwb eng TP1-1185 Gideon Wackers verfasserin aut Array Formatting of the Heat-Transfer Method (HTM) for the Detection of Small Organic Molecules by Molecularly Imprinted Polymers 2014 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier In this work we present the first steps towards a molecularly imprinted polymer (MIP)-based biomimetic sensor array for the detection of small organic molecules via the heat-transfer method (HTM). HTM relies on the change in thermal resistance upon binding of the target molecule to the MIP-type receptor. A flow-through sensor cell was developed, which is segmented into four quadrants with a volume of 2.5 μL each, allowing four measurements to be done simultaneously on a single substrate. Verification measurements were conducted, in which all quadrants received a uniform treatment and all four channels exhibited a similar response. Subsequently, measurements were performed in quadrants, which were functionalized with different MIP particles. Each of these quadrants was exposed to the same buffer solution, spiked with different molecules, according to the MIP under analysis. With the flow cell design we could discriminate between similar small organic molecules and observed no significant cross-selectivity. Therefore, the MIP array sensor platform with HTM as a readout technique, has the potential to become a low-cost analysis tool for bioanalytical applications. heat-transfer method (HTM) molecularly imprinted polymers (MIPs) serotonin histamine L-nicotine array format Chemical technology Thijs Vandenryt verfasserin aut Peter Cornelis verfasserin aut Evelien Kellens verfasserin aut Ronald Thoelen verfasserin aut Ward De Ceuninck verfasserin aut Patricia Losada-Pérez verfasserin aut Bart van Grinsven verfasserin aut Marloes Peeters verfasserin aut Patrick Wagner verfasserin aut In Sensors MDPI AG, 2003 14(2014), 6, Seite 11016-11030 (DE-627)331640910 (DE-600)2052857-7 14248220 nnns volume:14 year:2014 number:6 pages:11016-11030 https://doi.org/10.3390/s140611016 kostenfrei https://doaj.org/article/ba3352d223e24e1c90b3e5a899dc1670 kostenfrei http://www.mdpi.com/1424-8220/14/6/11016 kostenfrei https://doaj.org/toc/1424-8220 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2111 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 14 2014 6 11016-11030
spelling	10.3390/s140611016 doi (DE-627)DOAJ086588265 (DE-599)DOAJba3352d223e24e1c90b3e5a899dc1670 DE-627 ger DE-627 rakwb eng TP1-1185 Gideon Wackers verfasserin aut Array Formatting of the Heat-Transfer Method (HTM) for the Detection of Small Organic Molecules by Molecularly Imprinted Polymers 2014 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier In this work we present the first steps towards a molecularly imprinted polymer (MIP)-based biomimetic sensor array for the detection of small organic molecules via the heat-transfer method (HTM). HTM relies on the change in thermal resistance upon binding of the target molecule to the MIP-type receptor. A flow-through sensor cell was developed, which is segmented into four quadrants with a volume of 2.5 μL each, allowing four measurements to be done simultaneously on a single substrate. Verification measurements were conducted, in which all quadrants received a uniform treatment and all four channels exhibited a similar response. Subsequently, measurements were performed in quadrants, which were functionalized with different MIP particles. Each of these quadrants was exposed to the same buffer solution, spiked with different molecules, according to the MIP under analysis. With the flow cell design we could discriminate between similar small organic molecules and observed no significant cross-selectivity. Therefore, the MIP array sensor platform with HTM as a readout technique, has the potential to become a low-cost analysis tool for bioanalytical applications. heat-transfer method (HTM) molecularly imprinted polymers (MIPs) serotonin histamine L-nicotine array format Chemical technology Thijs Vandenryt verfasserin aut Peter Cornelis verfasserin aut Evelien Kellens verfasserin aut Ronald Thoelen verfasserin aut Ward De Ceuninck verfasserin aut Patricia Losada-Pérez verfasserin aut Bart van Grinsven verfasserin aut Marloes Peeters verfasserin aut Patrick Wagner verfasserin aut In Sensors MDPI AG, 2003 14(2014), 6, Seite 11016-11030 (DE-627)331640910 (DE-600)2052857-7 14248220 nnns volume:14 year:2014 number:6 pages:11016-11030 https://doi.org/10.3390/s140611016 kostenfrei https://doaj.org/article/ba3352d223e24e1c90b3e5a899dc1670 kostenfrei http://www.mdpi.com/1424-8220/14/6/11016 kostenfrei https://doaj.org/toc/1424-8220 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2111 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 14 2014 6 11016-11030
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allfieldsGer	10.3390/s140611016 doi (DE-627)DOAJ086588265 (DE-599)DOAJba3352d223e24e1c90b3e5a899dc1670 DE-627 ger DE-627 rakwb eng TP1-1185 Gideon Wackers verfasserin aut Array Formatting of the Heat-Transfer Method (HTM) for the Detection of Small Organic Molecules by Molecularly Imprinted Polymers 2014 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier In this work we present the first steps towards a molecularly imprinted polymer (MIP)-based biomimetic sensor array for the detection of small organic molecules via the heat-transfer method (HTM). HTM relies on the change in thermal resistance upon binding of the target molecule to the MIP-type receptor. A flow-through sensor cell was developed, which is segmented into four quadrants with a volume of 2.5 μL each, allowing four measurements to be done simultaneously on a single substrate. Verification measurements were conducted, in which all quadrants received a uniform treatment and all four channels exhibited a similar response. Subsequently, measurements were performed in quadrants, which were functionalized with different MIP particles. Each of these quadrants was exposed to the same buffer solution, spiked with different molecules, according to the MIP under analysis. With the flow cell design we could discriminate between similar small organic molecules and observed no significant cross-selectivity. Therefore, the MIP array sensor platform with HTM as a readout technique, has the potential to become a low-cost analysis tool for bioanalytical applications. heat-transfer method (HTM) molecularly imprinted polymers (MIPs) serotonin histamine L-nicotine array format Chemical technology Thijs Vandenryt verfasserin aut Peter Cornelis verfasserin aut Evelien Kellens verfasserin aut Ronald Thoelen verfasserin aut Ward De Ceuninck verfasserin aut Patricia Losada-Pérez verfasserin aut Bart van Grinsven verfasserin aut Marloes Peeters verfasserin aut Patrick Wagner verfasserin aut In Sensors MDPI AG, 2003 14(2014), 6, Seite 11016-11030 (DE-627)331640910 (DE-600)2052857-7 14248220 nnns volume:14 year:2014 number:6 pages:11016-11030 https://doi.org/10.3390/s140611016 kostenfrei https://doaj.org/article/ba3352d223e24e1c90b3e5a899dc1670 kostenfrei http://www.mdpi.com/1424-8220/14/6/11016 kostenfrei https://doaj.org/toc/1424-8220 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2111 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 14 2014 6 11016-11030
allfieldsSound	10.3390/s140611016 doi (DE-627)DOAJ086588265 (DE-599)DOAJba3352d223e24e1c90b3e5a899dc1670 DE-627 ger DE-627 rakwb eng TP1-1185 Gideon Wackers verfasserin aut Array Formatting of the Heat-Transfer Method (HTM) for the Detection of Small Organic Molecules by Molecularly Imprinted Polymers 2014 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier In this work we present the first steps towards a molecularly imprinted polymer (MIP)-based biomimetic sensor array for the detection of small organic molecules via the heat-transfer method (HTM). HTM relies on the change in thermal resistance upon binding of the target molecule to the MIP-type receptor. A flow-through sensor cell was developed, which is segmented into four quadrants with a volume of 2.5 μL each, allowing four measurements to be done simultaneously on a single substrate. Verification measurements were conducted, in which all quadrants received a uniform treatment and all four channels exhibited a similar response. Subsequently, measurements were performed in quadrants, which were functionalized with different MIP particles. Each of these quadrants was exposed to the same buffer solution, spiked with different molecules, according to the MIP under analysis. With the flow cell design we could discriminate between similar small organic molecules and observed no significant cross-selectivity. Therefore, the MIP array sensor platform with HTM as a readout technique, has the potential to become a low-cost analysis tool for bioanalytical applications. heat-transfer method (HTM) molecularly imprinted polymers (MIPs) serotonin histamine L-nicotine array format Chemical technology Thijs Vandenryt verfasserin aut Peter Cornelis verfasserin aut Evelien Kellens verfasserin aut Ronald Thoelen verfasserin aut Ward De Ceuninck verfasserin aut Patricia Losada-Pérez verfasserin aut Bart van Grinsven verfasserin aut Marloes Peeters verfasserin aut Patrick Wagner verfasserin aut In Sensors MDPI AG, 2003 14(2014), 6, Seite 11016-11030 (DE-627)331640910 (DE-600)2052857-7 14248220 nnns volume:14 year:2014 number:6 pages:11016-11030 https://doi.org/10.3390/s140611016 kostenfrei https://doaj.org/article/ba3352d223e24e1c90b3e5a899dc1670 kostenfrei http://www.mdpi.com/1424-8220/14/6/11016 kostenfrei https://doaj.org/toc/1424-8220 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2111 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 14 2014 6 11016-11030
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callnumber-first	T - Technology
author	Gideon Wackers
spellingShingle	Gideon Wackers misc TP1-1185 misc heat-transfer method (HTM) misc molecularly imprinted polymers (MIPs) misc serotonin misc histamine misc L-nicotine misc array format misc Chemical technology Array Formatting of the Heat-Transfer Method (HTM) for the Detection of Small Organic Molecules by Molecularly Imprinted Polymers
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topic_title	TP1-1185 Array Formatting of the Heat-Transfer Method (HTM) for the Detection of Small Organic Molecules by Molecularly Imprinted Polymers heat-transfer method (HTM) molecularly imprinted polymers (MIPs) serotonin histamine L-nicotine array format
topic	misc TP1-1185 misc heat-transfer method (HTM) misc molecularly imprinted polymers (MIPs) misc serotonin misc histamine misc L-nicotine misc array format misc Chemical technology
topic_unstemmed	misc TP1-1185 misc heat-transfer method (HTM) misc molecularly imprinted polymers (MIPs) misc serotonin misc histamine misc L-nicotine misc array format misc Chemical technology
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title	Array Formatting of the Heat-Transfer Method (HTM) for the Detection of Small Organic Molecules by Molecularly Imprinted Polymers
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title_full	Array Formatting of the Heat-Transfer Method (HTM) for the Detection of Small Organic Molecules by Molecularly Imprinted Polymers
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title_sort	array formatting of the heat-transfer method (htm) for the detection of small organic molecules by molecularly imprinted polymers
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title_auth	Array Formatting of the Heat-Transfer Method (HTM) for the Detection of Small Organic Molecules by Molecularly Imprinted Polymers
abstract	In this work we present the first steps towards a molecularly imprinted polymer (MIP)-based biomimetic sensor array for the detection of small organic molecules via the heat-transfer method (HTM). HTM relies on the change in thermal resistance upon binding of the target molecule to the MIP-type receptor. A flow-through sensor cell was developed, which is segmented into four quadrants with a volume of 2.5 μL each, allowing four measurements to be done simultaneously on a single substrate. Verification measurements were conducted, in which all quadrants received a uniform treatment and all four channels exhibited a similar response. Subsequently, measurements were performed in quadrants, which were functionalized with different MIP particles. Each of these quadrants was exposed to the same buffer solution, spiked with different molecules, according to the MIP under analysis. With the flow cell design we could discriminate between similar small organic molecules and observed no significant cross-selectivity. Therefore, the MIP array sensor platform with HTM as a readout technique, has the potential to become a low-cost analysis tool for bioanalytical applications.
abstractGer	In this work we present the first steps towards a molecularly imprinted polymer (MIP)-based biomimetic sensor array for the detection of small organic molecules via the heat-transfer method (HTM). HTM relies on the change in thermal resistance upon binding of the target molecule to the MIP-type receptor. A flow-through sensor cell was developed, which is segmented into four quadrants with a volume of 2.5 μL each, allowing four measurements to be done simultaneously on a single substrate. Verification measurements were conducted, in which all quadrants received a uniform treatment and all four channels exhibited a similar response. Subsequently, measurements were performed in quadrants, which were functionalized with different MIP particles. Each of these quadrants was exposed to the same buffer solution, spiked with different molecules, according to the MIP under analysis. With the flow cell design we could discriminate between similar small organic molecules and observed no significant cross-selectivity. Therefore, the MIP array sensor platform with HTM as a readout technique, has the potential to become a low-cost analysis tool for bioanalytical applications.
abstract_unstemmed	In this work we present the first steps towards a molecularly imprinted polymer (MIP)-based biomimetic sensor array for the detection of small organic molecules via the heat-transfer method (HTM). HTM relies on the change in thermal resistance upon binding of the target molecule to the MIP-type receptor. A flow-through sensor cell was developed, which is segmented into four quadrants with a volume of 2.5 μL each, allowing four measurements to be done simultaneously on a single substrate. Verification measurements were conducted, in which all quadrants received a uniform treatment and all four channels exhibited a similar response. Subsequently, measurements were performed in quadrants, which were functionalized with different MIP particles. Each of these quadrants was exposed to the same buffer solution, spiked with different molecules, according to the MIP under analysis. With the flow cell design we could discriminate between similar small organic molecules and observed no significant cross-selectivity. Therefore, the MIP array sensor platform with HTM as a readout technique, has the potential to become a low-cost analysis tool for bioanalytical applications.
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title_short	Array Formatting of the Heat-Transfer Method (HTM) for the Detection of Small Organic Molecules by Molecularly Imprinted Polymers
url	https://doi.org/10.3390/s140611016 https://doaj.org/article/ba3352d223e24e1c90b3e5a899dc1670 http://www.mdpi.com/1424-8220/14/6/11016 https://doaj.org/toc/1424-8220
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up_date	2024-07-03T21:34:39.944Z
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HTM relies on the change in thermal resistance upon binding of the target molecule to the MIP-type receptor. A flow-through sensor cell was developed, which is segmented into four quadrants with a volume of 2.5 μL each, allowing four measurements to be done simultaneously on a single substrate. Verification measurements were conducted, in which all quadrants received a uniform treatment and all four channels exhibited a similar response. Subsequently, measurements were performed in quadrants, which were functionalized with different MIP particles. Each of these quadrants was exposed to the same buffer solution, spiked with different molecules, according to the MIP under analysis. With the flow cell design we could discriminate between similar small organic molecules and observed no significant cross-selectivity. 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Array Formatting of the Heat-Transfer Method (HTM) for the Detection of Small Organic Molecules by Molecularly Imprinted Polymers

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