The Administration of the Synbiotic <i<Lactobacillus bulgaricus</i< 6c3 Strain, Inulin and Fructooligosaccharide Decreases the Concentrations of Indoxyl Sulfate and Kidney Damage in a Rat Model

Indoxyl sulfate (IS) is involved in the progression of chronic kidney disease (CKD) and in its cardiovascular complications. One of the approaches proposed to decrease IS is the administration of synbiotics. This work aimed to search for a probiotic strain capable to decrease serum IS levels and mix...
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Autor*in:	Alonso Jerez-Morales [verfasserIn] José S. Merino [verfasserIn] Sindy T. Díaz-Castillo [verfasserIn] Carlos T. Smith [verfasserIn] Jorge Fuentealba [verfasserIn] Humberto Bernasconi [verfasserIn] Gerson Echeverría [verfasserIn] Apolinaria García-Cancino [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2021

Schlagwörter:	CKD indoxyl sulfate CVD renal fibrosis synbiotic

Übergeordnetes Werk:	In: Toxins - MDPI AG, 2010, 13(2021), 3, p 192
Übergeordnetes Werk:	volume:13 ; year:2021 ; number:3, p 192

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3390/toxins13030192

Katalog-ID:	DOAJ086618369

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allfieldsSound	10.3390/toxins13030192 doi (DE-627)DOAJ086618369 (DE-599)DOAJ802a7c5c0d5b4c54ab7aaf0333134ed1 DE-627 ger DE-627 rakwb eng Alonso Jerez-Morales verfasserin aut The Administration of the Synbiotic <i<Lactobacillus bulgaricus</i< 6c3 Strain, Inulin and Fructooligosaccharide Decreases the Concentrations of Indoxyl Sulfate and Kidney Damage in a Rat Model 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Indoxyl sulfate (IS) is involved in the progression of chronic kidney disease (CKD) and in its cardiovascular complications. One of the approaches proposed to decrease IS is the administration of synbiotics. This work aimed to search for a probiotic strain capable to decrease serum IS levels and mix it with two prebiotics (inulin and fructooligosaccharide (FOS)) to produce a putative synbiotic and test it in a rat CKD model. Two groups of Sprague-Dawley rats were nephrectomized. One group (Lac) received the mixture for 16 weeks in drinking water and the other no (Nef). A control group (C) included sham-nephrectomized rats. Serum creatinine and IS concentrations were measured using high-performance liquid chromatography with diode array detector (HPLC-DAD). Optical microscopy and two-photon excitation microscopy was used to study kidney and heart samples. The Lac group, which received the synbiotic, reduced IS by 0.8% while the Nef group increased it by 38.8%. Histological analysis of kidneys showed that the Lac group increased fibrotic areas by 12% and the Nef group did it by 25%. The synbiotic did not reduce cardiac fibrosis. Therefore, the putative synbiotic showed that function reducing IS and the progression of CKD in a rat model, but no heart protection was observed. CKD indoxyl sulfate CVD renal fibrosis synbiotic Medicine R José S. Merino verfasserin aut Sindy T. Díaz-Castillo verfasserin aut Carlos T. Smith verfasserin aut Jorge Fuentealba verfasserin aut Humberto Bernasconi verfasserin aut Gerson Echeverría verfasserin aut Apolinaria García-Cancino verfasserin aut In Toxins MDPI AG, 2010 13(2021), 3, p 192 (DE-627)610604236 (DE-600)2518395-3 20726651 nnns volume:13 year:2021 number:3, p 192 https://doi.org/10.3390/toxins13030192 kostenfrei https://doaj.org/article/802a7c5c0d5b4c54ab7aaf0333134ed1 kostenfrei https://www.mdpi.com/2072-6651/13/3/192 kostenfrei https://doaj.org/toc/2072-6651 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 13 2021 3, p 192
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author	Alonso Jerez-Morales
spellingShingle	Alonso Jerez-Morales misc CKD misc indoxyl sulfate misc CVD misc renal fibrosis misc synbiotic misc Medicine misc R The Administration of the Synbiotic <i<Lactobacillus bulgaricus</i< 6c3 Strain, Inulin and Fructooligosaccharide Decreases the Concentrations of Indoxyl Sulfate and Kidney Damage in a Rat Model
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topic_title	The Administration of the Synbiotic <i<Lactobacillus bulgaricus</i< 6c3 Strain, Inulin and Fructooligosaccharide Decreases the Concentrations of Indoxyl Sulfate and Kidney Damage in a Rat Model CKD indoxyl sulfate CVD renal fibrosis synbiotic
topic	misc CKD misc indoxyl sulfate misc CVD misc renal fibrosis misc synbiotic misc Medicine misc R
topic_unstemmed	misc CKD misc indoxyl sulfate misc CVD misc renal fibrosis misc synbiotic misc Medicine misc R
topic_browse	misc CKD misc indoxyl sulfate misc CVD misc renal fibrosis misc synbiotic misc Medicine misc R
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title	The Administration of the Synbiotic <i<Lactobacillus bulgaricus</i< 6c3 Strain, Inulin and Fructooligosaccharide Decreases the Concentrations of Indoxyl Sulfate and Kidney Damage in a Rat Model
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title_full	The Administration of the Synbiotic <i<Lactobacillus bulgaricus</i< 6c3 Strain, Inulin and Fructooligosaccharide Decreases the Concentrations of Indoxyl Sulfate and Kidney Damage in a Rat Model
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title_sort	administration of the synbiotic <i<lactobacillus bulgaricus</i< 6c3 strain, inulin and fructooligosaccharide decreases the concentrations of indoxyl sulfate and kidney damage in a rat model
title_auth	The Administration of the Synbiotic <i<Lactobacillus bulgaricus</i< 6c3 Strain, Inulin and Fructooligosaccharide Decreases the Concentrations of Indoxyl Sulfate and Kidney Damage in a Rat Model
abstract	Indoxyl sulfate (IS) is involved in the progression of chronic kidney disease (CKD) and in its cardiovascular complications. One of the approaches proposed to decrease IS is the administration of synbiotics. This work aimed to search for a probiotic strain capable to decrease serum IS levels and mix it with two prebiotics (inulin and fructooligosaccharide (FOS)) to produce a putative synbiotic and test it in a rat CKD model. Two groups of Sprague-Dawley rats were nephrectomized. One group (Lac) received the mixture for 16 weeks in drinking water and the other no (Nef). A control group (C) included sham-nephrectomized rats. Serum creatinine and IS concentrations were measured using high-performance liquid chromatography with diode array detector (HPLC-DAD). Optical microscopy and two-photon excitation microscopy was used to study kidney and heart samples. The Lac group, which received the synbiotic, reduced IS by 0.8% while the Nef group increased it by 38.8%. Histological analysis of kidneys showed that the Lac group increased fibrotic areas by 12% and the Nef group did it by 25%. The synbiotic did not reduce cardiac fibrosis. Therefore, the putative synbiotic showed that function reducing IS and the progression of CKD in a rat model, but no heart protection was observed.
abstractGer	Indoxyl sulfate (IS) is involved in the progression of chronic kidney disease (CKD) and in its cardiovascular complications. One of the approaches proposed to decrease IS is the administration of synbiotics. This work aimed to search for a probiotic strain capable to decrease serum IS levels and mix it with two prebiotics (inulin and fructooligosaccharide (FOS)) to produce a putative synbiotic and test it in a rat CKD model. Two groups of Sprague-Dawley rats were nephrectomized. One group (Lac) received the mixture for 16 weeks in drinking water and the other no (Nef). A control group (C) included sham-nephrectomized rats. Serum creatinine and IS concentrations were measured using high-performance liquid chromatography with diode array detector (HPLC-DAD). Optical microscopy and two-photon excitation microscopy was used to study kidney and heart samples. The Lac group, which received the synbiotic, reduced IS by 0.8% while the Nef group increased it by 38.8%. Histological analysis of kidneys showed that the Lac group increased fibrotic areas by 12% and the Nef group did it by 25%. The synbiotic did not reduce cardiac fibrosis. Therefore, the putative synbiotic showed that function reducing IS and the progression of CKD in a rat model, but no heart protection was observed.
abstract_unstemmed	Indoxyl sulfate (IS) is involved in the progression of chronic kidney disease (CKD) and in its cardiovascular complications. One of the approaches proposed to decrease IS is the administration of synbiotics. This work aimed to search for a probiotic strain capable to decrease serum IS levels and mix it with two prebiotics (inulin and fructooligosaccharide (FOS)) to produce a putative synbiotic and test it in a rat CKD model. Two groups of Sprague-Dawley rats were nephrectomized. One group (Lac) received the mixture for 16 weeks in drinking water and the other no (Nef). A control group (C) included sham-nephrectomized rats. Serum creatinine and IS concentrations were measured using high-performance liquid chromatography with diode array detector (HPLC-DAD). Optical microscopy and two-photon excitation microscopy was used to study kidney and heart samples. The Lac group, which received the synbiotic, reduced IS by 0.8% while the Nef group increased it by 38.8%. Histological analysis of kidneys showed that the Lac group increased fibrotic areas by 12% and the Nef group did it by 25%. The synbiotic did not reduce cardiac fibrosis. Therefore, the putative synbiotic showed that function reducing IS and the progression of CKD in a rat model, but no heart protection was observed.
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title_short	The Administration of the Synbiotic <i<Lactobacillus bulgaricus</i< 6c3 Strain, Inulin and Fructooligosaccharide Decreases the Concentrations of Indoxyl Sulfate and Kidney Damage in a Rat Model
url	https://doi.org/10.3390/toxins13030192 https://doaj.org/article/802a7c5c0d5b4c54ab7aaf0333134ed1 https://www.mdpi.com/2072-6651/13/3/192 https://doaj.org/toc/2072-6651
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up_date	2024-07-03T21:45:52.905Z
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The Administration of the Synbiotic <i<Lactobacillus bulgaricus</i< 6c3 Strain, Inulin and Fructooligosaccharide Decreases the Concentrations of Indoxyl Sulfate and Kidney Damage in a Rat Model

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