Naamines and Naamidines as Novel Agents against a Plant Virus and Phytopathogenic Fungi

Naamines, naamidines and various derivatives of these marine natural products were synthesized and characterized by means of nuclear magnetic resonance (NMR) spectroscopy and mass spectrometry. The activities of these alkaloids against a plant virus and phytopathogenic fungi were evaluated for the f...
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Autor*in:	Pengbin Guo [verfasserIn] Gang Li [verfasserIn] Yuxiu Liu [verfasserIn] Aidang Lu [verfasserIn] Ziwen Wang [verfasserIn] Qingmin Wang [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2018

Schlagwörter:	marine natural products naamines naamidines anti-tobacco mosaic virus (TMV) activity fungicidal activity

Übergeordnetes Werk:	In: Marine Drugs - MDPI AG, 2005, 16(2018), 9, p 311
Übergeordnetes Werk:	volume:16 ; year:2018 ; number:9, p 311

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3390/md16090311

Katalog-ID:	DOAJ086758616

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allfields	10.3390/md16090311 doi (DE-627)DOAJ086758616 (DE-599)DOAJeecfd16eb6d34ddaa152c5cf7130c4a7 DE-627 ger DE-627 rakwb eng QH301-705.5 Pengbin Guo verfasserin aut Naamines and Naamidines as Novel Agents against a Plant Virus and Phytopathogenic Fungi 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Naamines, naamidines and various derivatives of these marine natural products were synthesized and characterized by means of nuclear magnetic resonance (NMR) spectroscopy and mass spectrometry. The activities of these alkaloids against a plant virus and phytopathogenic fungi were evaluated for the first time. A benzyloxy naamine derivative 15d displayed excellent in vivo activity against tobacco mosaic virus at 500 μg/mL (inactivation activity, 46%; curative activity, 49%; and protective activity, 41%); its activities were higher than the corresponding activities of the commercial plant virucide ribavirin (32%, 35%, and 34%, respectively), making it a promising new lead compound for antiviral research. In vitro assays revealed that the test compounds exhibited very good antifungal activity against 14 kinds of phytopathogenic fungi. Again, the benzyloxy naamine derivative 15d exhibited broad-spectrum fungicidal activity, emerging as a new lead compound for fungicidal research. Additional in vivo assays indicated that many of the compounds displayed inhibitory effects >30%. marine natural products naamines naamidines anti-tobacco mosaic virus (TMV) activity fungicidal activity Biology (General) Gang Li verfasserin aut Yuxiu Liu verfasserin aut Aidang Lu verfasserin aut Ziwen Wang verfasserin aut Qingmin Wang verfasserin aut In Marine Drugs MDPI AG, 2005 16(2018), 9, p 311 (DE-627)477992420 (DE-600)2175190-0 16603397 nnns volume:16 year:2018 number:9, p 311 https://doi.org/10.3390/md16090311 kostenfrei https://doaj.org/article/eecfd16eb6d34ddaa152c5cf7130c4a7 kostenfrei http://www.mdpi.com/1660-3397/16/9/311 kostenfrei https://doaj.org/toc/1660-3397 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_381 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 16 2018 9, p 311
spelling	10.3390/md16090311 doi (DE-627)DOAJ086758616 (DE-599)DOAJeecfd16eb6d34ddaa152c5cf7130c4a7 DE-627 ger DE-627 rakwb eng QH301-705.5 Pengbin Guo verfasserin aut Naamines and Naamidines as Novel Agents against a Plant Virus and Phytopathogenic Fungi 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Naamines, naamidines and various derivatives of these marine natural products were synthesized and characterized by means of nuclear magnetic resonance (NMR) spectroscopy and mass spectrometry. The activities of these alkaloids against a plant virus and phytopathogenic fungi were evaluated for the first time. A benzyloxy naamine derivative 15d displayed excellent in vivo activity against tobacco mosaic virus at 500 μg/mL (inactivation activity, 46%; curative activity, 49%; and protective activity, 41%); its activities were higher than the corresponding activities of the commercial plant virucide ribavirin (32%, 35%, and 34%, respectively), making it a promising new lead compound for antiviral research. In vitro assays revealed that the test compounds exhibited very good antifungal activity against 14 kinds of phytopathogenic fungi. Again, the benzyloxy naamine derivative 15d exhibited broad-spectrum fungicidal activity, emerging as a new lead compound for fungicidal research. Additional in vivo assays indicated that many of the compounds displayed inhibitory effects >30%. marine natural products naamines naamidines anti-tobacco mosaic virus (TMV) activity fungicidal activity Biology (General) Gang Li verfasserin aut Yuxiu Liu verfasserin aut Aidang Lu verfasserin aut Ziwen Wang verfasserin aut Qingmin Wang verfasserin aut In Marine Drugs MDPI AG, 2005 16(2018), 9, p 311 (DE-627)477992420 (DE-600)2175190-0 16603397 nnns volume:16 year:2018 number:9, p 311 https://doi.org/10.3390/md16090311 kostenfrei https://doaj.org/article/eecfd16eb6d34ddaa152c5cf7130c4a7 kostenfrei http://www.mdpi.com/1660-3397/16/9/311 kostenfrei https://doaj.org/toc/1660-3397 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_381 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 16 2018 9, p 311
allfields_unstemmed	10.3390/md16090311 doi (DE-627)DOAJ086758616 (DE-599)DOAJeecfd16eb6d34ddaa152c5cf7130c4a7 DE-627 ger DE-627 rakwb eng QH301-705.5 Pengbin Guo verfasserin aut Naamines and Naamidines as Novel Agents against a Plant Virus and Phytopathogenic Fungi 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Naamines, naamidines and various derivatives of these marine natural products were synthesized and characterized by means of nuclear magnetic resonance (NMR) spectroscopy and mass spectrometry. The activities of these alkaloids against a plant virus and phytopathogenic fungi were evaluated for the first time. A benzyloxy naamine derivative 15d displayed excellent in vivo activity against tobacco mosaic virus at 500 μg/mL (inactivation activity, 46%; curative activity, 49%; and protective activity, 41%); its activities were higher than the corresponding activities of the commercial plant virucide ribavirin (32%, 35%, and 34%, respectively), making it a promising new lead compound for antiviral research. In vitro assays revealed that the test compounds exhibited very good antifungal activity against 14 kinds of phytopathogenic fungi. Again, the benzyloxy naamine derivative 15d exhibited broad-spectrum fungicidal activity, emerging as a new lead compound for fungicidal research. Additional in vivo assays indicated that many of the compounds displayed inhibitory effects >30%. marine natural products naamines naamidines anti-tobacco mosaic virus (TMV) activity fungicidal activity Biology (General) Gang Li verfasserin aut Yuxiu Liu verfasserin aut Aidang Lu verfasserin aut Ziwen Wang verfasserin aut Qingmin Wang verfasserin aut In Marine Drugs MDPI AG, 2005 16(2018), 9, p 311 (DE-627)477992420 (DE-600)2175190-0 16603397 nnns volume:16 year:2018 number:9, p 311 https://doi.org/10.3390/md16090311 kostenfrei https://doaj.org/article/eecfd16eb6d34ddaa152c5cf7130c4a7 kostenfrei http://www.mdpi.com/1660-3397/16/9/311 kostenfrei https://doaj.org/toc/1660-3397 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_381 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 16 2018 9, p 311
allfieldsGer	10.3390/md16090311 doi (DE-627)DOAJ086758616 (DE-599)DOAJeecfd16eb6d34ddaa152c5cf7130c4a7 DE-627 ger DE-627 rakwb eng QH301-705.5 Pengbin Guo verfasserin aut Naamines and Naamidines as Novel Agents against a Plant Virus and Phytopathogenic Fungi 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Naamines, naamidines and various derivatives of these marine natural products were synthesized and characterized by means of nuclear magnetic resonance (NMR) spectroscopy and mass spectrometry. The activities of these alkaloids against a plant virus and phytopathogenic fungi were evaluated for the first time. A benzyloxy naamine derivative 15d displayed excellent in vivo activity against tobacco mosaic virus at 500 μg/mL (inactivation activity, 46%; curative activity, 49%; and protective activity, 41%); its activities were higher than the corresponding activities of the commercial plant virucide ribavirin (32%, 35%, and 34%, respectively), making it a promising new lead compound for antiviral research. In vitro assays revealed that the test compounds exhibited very good antifungal activity against 14 kinds of phytopathogenic fungi. Again, the benzyloxy naamine derivative 15d exhibited broad-spectrum fungicidal activity, emerging as a new lead compound for fungicidal research. Additional in vivo assays indicated that many of the compounds displayed inhibitory effects >30%. marine natural products naamines naamidines anti-tobacco mosaic virus (TMV) activity fungicidal activity Biology (General) Gang Li verfasserin aut Yuxiu Liu verfasserin aut Aidang Lu verfasserin aut Ziwen Wang verfasserin aut Qingmin Wang verfasserin aut In Marine Drugs MDPI AG, 2005 16(2018), 9, p 311 (DE-627)477992420 (DE-600)2175190-0 16603397 nnns volume:16 year:2018 number:9, p 311 https://doi.org/10.3390/md16090311 kostenfrei https://doaj.org/article/eecfd16eb6d34ddaa152c5cf7130c4a7 kostenfrei http://www.mdpi.com/1660-3397/16/9/311 kostenfrei https://doaj.org/toc/1660-3397 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_381 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 16 2018 9, p 311
allfieldsSound	10.3390/md16090311 doi (DE-627)DOAJ086758616 (DE-599)DOAJeecfd16eb6d34ddaa152c5cf7130c4a7 DE-627 ger DE-627 rakwb eng QH301-705.5 Pengbin Guo verfasserin aut Naamines and Naamidines as Novel Agents against a Plant Virus and Phytopathogenic Fungi 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Naamines, naamidines and various derivatives of these marine natural products were synthesized and characterized by means of nuclear magnetic resonance (NMR) spectroscopy and mass spectrometry. The activities of these alkaloids against a plant virus and phytopathogenic fungi were evaluated for the first time. A benzyloxy naamine derivative 15d displayed excellent in vivo activity against tobacco mosaic virus at 500 μg/mL (inactivation activity, 46%; curative activity, 49%; and protective activity, 41%); its activities were higher than the corresponding activities of the commercial plant virucide ribavirin (32%, 35%, and 34%, respectively), making it a promising new lead compound for antiviral research. In vitro assays revealed that the test compounds exhibited very good antifungal activity against 14 kinds of phytopathogenic fungi. Again, the benzyloxy naamine derivative 15d exhibited broad-spectrum fungicidal activity, emerging as a new lead compound for fungicidal research. Additional in vivo assays indicated that many of the compounds displayed inhibitory effects >30%. marine natural products naamines naamidines anti-tobacco mosaic virus (TMV) activity fungicidal activity Biology (General) Gang Li verfasserin aut Yuxiu Liu verfasserin aut Aidang Lu verfasserin aut Ziwen Wang verfasserin aut Qingmin Wang verfasserin aut In Marine Drugs MDPI AG, 2005 16(2018), 9, p 311 (DE-627)477992420 (DE-600)2175190-0 16603397 nnns volume:16 year:2018 number:9, p 311 https://doi.org/10.3390/md16090311 kostenfrei https://doaj.org/article/eecfd16eb6d34ddaa152c5cf7130c4a7 kostenfrei http://www.mdpi.com/1660-3397/16/9/311 kostenfrei https://doaj.org/toc/1660-3397 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_381 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 16 2018 9, p 311
language	English
source	In Marine Drugs 16(2018), 9, p 311 volume:16 year:2018 number:9, p 311
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callnumber-first	Q - Science
author	Pengbin Guo
spellingShingle	Pengbin Guo misc QH301-705.5 misc marine natural products misc naamines misc naamidines misc anti-tobacco mosaic virus (TMV) activity misc fungicidal activity misc Biology (General) Naamines and Naamidines as Novel Agents against a Plant Virus and Phytopathogenic Fungi
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topic_title	QH301-705.5 Naamines and Naamidines as Novel Agents against a Plant Virus and Phytopathogenic Fungi marine natural products naamines naamidines anti-tobacco mosaic virus (TMV) activity fungicidal activity
topic	misc QH301-705.5 misc marine natural products misc naamines misc naamidines misc anti-tobacco mosaic virus (TMV) activity misc fungicidal activity misc Biology (General)
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title	Naamines and Naamidines as Novel Agents against a Plant Virus and Phytopathogenic Fungi
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title_sort	naamines and naamidines as novel agents against a plant virus and phytopathogenic fungi
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title_auth	Naamines and Naamidines as Novel Agents against a Plant Virus and Phytopathogenic Fungi
abstract	Naamines, naamidines and various derivatives of these marine natural products were synthesized and characterized by means of nuclear magnetic resonance (NMR) spectroscopy and mass spectrometry. The activities of these alkaloids against a plant virus and phytopathogenic fungi were evaluated for the first time. A benzyloxy naamine derivative 15d displayed excellent in vivo activity against tobacco mosaic virus at 500 μg/mL (inactivation activity, 46%; curative activity, 49%; and protective activity, 41%); its activities were higher than the corresponding activities of the commercial plant virucide ribavirin (32%, 35%, and 34%, respectively), making it a promising new lead compound for antiviral research. In vitro assays revealed that the test compounds exhibited very good antifungal activity against 14 kinds of phytopathogenic fungi. Again, the benzyloxy naamine derivative 15d exhibited broad-spectrum fungicidal activity, emerging as a new lead compound for fungicidal research. Additional in vivo assays indicated that many of the compounds displayed inhibitory effects >30%.
abstractGer	Naamines, naamidines and various derivatives of these marine natural products were synthesized and characterized by means of nuclear magnetic resonance (NMR) spectroscopy and mass spectrometry. The activities of these alkaloids against a plant virus and phytopathogenic fungi were evaluated for the first time. A benzyloxy naamine derivative 15d displayed excellent in vivo activity against tobacco mosaic virus at 500 μg/mL (inactivation activity, 46%; curative activity, 49%; and protective activity, 41%); its activities were higher than the corresponding activities of the commercial plant virucide ribavirin (32%, 35%, and 34%, respectively), making it a promising new lead compound for antiviral research. In vitro assays revealed that the test compounds exhibited very good antifungal activity against 14 kinds of phytopathogenic fungi. Again, the benzyloxy naamine derivative 15d exhibited broad-spectrum fungicidal activity, emerging as a new lead compound for fungicidal research. Additional in vivo assays indicated that many of the compounds displayed inhibitory effects >30%.
abstract_unstemmed	Naamines, naamidines and various derivatives of these marine natural products were synthesized and characterized by means of nuclear magnetic resonance (NMR) spectroscopy and mass spectrometry. The activities of these alkaloids against a plant virus and phytopathogenic fungi were evaluated for the first time. A benzyloxy naamine derivative 15d displayed excellent in vivo activity against tobacco mosaic virus at 500 μg/mL (inactivation activity, 46%; curative activity, 49%; and protective activity, 41%); its activities were higher than the corresponding activities of the commercial plant virucide ribavirin (32%, 35%, and 34%, respectively), making it a promising new lead compound for antiviral research. In vitro assays revealed that the test compounds exhibited very good antifungal activity against 14 kinds of phytopathogenic fungi. Again, the benzyloxy naamine derivative 15d exhibited broad-spectrum fungicidal activity, emerging as a new lead compound for fungicidal research. Additional in vivo assays indicated that many of the compounds displayed inhibitory effects >30%.
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title_short	Naamines and Naamidines as Novel Agents against a Plant Virus and Phytopathogenic Fungi
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