Heat-Killed <i<Lacticaseibacillus paracasei</i< Ameliorated UVB-Induced Oxidative Damage and Photoaging and Its Underlying Mechanisms

Ultraviolet B (UVB) radiation is a major environmental causative factor of skin oxidative damage and photoaging. <i<Lacticaseibacillus paracasei</i< is a well-known probiotic strain that can regulate skin health. The present study investigated the effects of heat-killed <i<Lacticas...
Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Jing Xu [verfasserIn] Xiaofang Zhang [verfasserIn] Yan Song [verfasserIn] Bin Zheng [verfasserIn] Zhengshun Wen [verfasserIn] Miao Gong [verfasserIn] Lingting Meng [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2022

Schlagwörter:	heat-killed skin cells oxidative damage photoaging UVB

Übergeordnetes Werk:	In: Antioxidants - MDPI AG, 2013, 11(2022), 10, p 1875
Übergeordnetes Werk:	volume:11 ; year:2022 ; number:10, p 1875

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3390/antiox11101875

Katalog-ID:	DOAJ086830201

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520			\|a Ultraviolet B (UVB) radiation is a major environmental causative factor of skin oxidative damage and photoaging. <i<Lacticaseibacillus paracasei</i< is a well-known probiotic strain that can regulate skin health. The present study investigated the effects of heat-killed <i<Lacticaseibacillus paracasei</i< (PL) on UVB linked oxidative damage and photoaging in skin cells (Normal human dermal fibroblast (NHDF) cells and B16F10 murine melanoma cells). Results demonstrated that: (1) PL prevented UVB-induced cytotoxicity relating to decreased DNA damage in NHDF and B16F10 cells; (2) PL alleviated UVB-induced oxidative damage through increasing GSH content, as well as antioxidant enzyme activities and mRNA levels (except MnSOD activity and mRNA levels as well as CAT mRNA level) relating to the activation of Sirt1/PGC-1α/Nrf2 signaling in NHDF cells; (3) PL attenuated UVB-induced photoaging was noticed with a decrease in the percentage of SA-β-gal positive cells in NHDF cells model. Moreover, PL attenuated UVB-induced photoaging through exerting an anti-wrinkling effect by enhancing the type I collagen level relating to the inhibition (JNK, p38)/(c-Fos, c-Jun) of signaling in NHDF cells, and exerting an anti-melanogenic effect by suppressing tyrosinase and TYRP-1 activity and/or expressions relating to the inhibition of PKA/CREB/MITF signaling in B16F10 cells. In conclusion, PL could ameliorate UVB-induced oxidative damage and photoaging. Therefore, PL may be a potential antioxidant and anti-photoaging active ingredient for the cosmetic industry.
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allfieldsSound	10.3390/antiox11101875 doi (DE-627)DOAJ086830201 (DE-599)DOAJa9d88bb647374c55a3f4e797015bd47d DE-627 ger DE-627 rakwb eng RM1-950 Jing Xu verfasserin aut Heat-Killed <i<Lacticaseibacillus paracasei</i< Ameliorated UVB-Induced Oxidative Damage and Photoaging and Its Underlying Mechanisms 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Ultraviolet B (UVB) radiation is a major environmental causative factor of skin oxidative damage and photoaging. <i<Lacticaseibacillus paracasei</i< is a well-known probiotic strain that can regulate skin health. The present study investigated the effects of heat-killed <i<Lacticaseibacillus paracasei</i< (PL) on UVB linked oxidative damage and photoaging in skin cells (Normal human dermal fibroblast (NHDF) cells and B16F10 murine melanoma cells). Results demonstrated that: (1) PL prevented UVB-induced cytotoxicity relating to decreased DNA damage in NHDF and B16F10 cells; (2) PL alleviated UVB-induced oxidative damage through increasing GSH content, as well as antioxidant enzyme activities and mRNA levels (except MnSOD activity and mRNA levels as well as CAT mRNA level) relating to the activation of Sirt1/PGC-1α/Nrf2 signaling in NHDF cells; (3) PL attenuated UVB-induced photoaging was noticed with a decrease in the percentage of SA-β-gal positive cells in NHDF cells model. Moreover, PL attenuated UVB-induced photoaging through exerting an anti-wrinkling effect by enhancing the type I collagen level relating to the inhibition (JNK, p38)/(c-Fos, c-Jun) of signaling in NHDF cells, and exerting an anti-melanogenic effect by suppressing tyrosinase and TYRP-1 activity and/or expressions relating to the inhibition of PKA/CREB/MITF signaling in B16F10 cells. In conclusion, PL could ameliorate UVB-induced oxidative damage and photoaging. Therefore, PL may be a potential antioxidant and anti-photoaging active ingredient for the cosmetic industry. heat-killed <i<Lacticaseibacillus paracasei</i< skin cells oxidative damage photoaging UVB Therapeutics. Pharmacology Xiaofang Zhang verfasserin aut Yan Song verfasserin aut Bin Zheng verfasserin aut Zhengshun Wen verfasserin aut Miao Gong verfasserin aut Lingting Meng verfasserin aut In Antioxidants MDPI AG, 2013 11(2022), 10, p 1875 (DE-627)737287578 (DE-600)2704216-9 20763921 nnns volume:11 year:2022 number:10, p 1875 https://doi.org/10.3390/antiox11101875 kostenfrei https://doaj.org/article/a9d88bb647374c55a3f4e797015bd47d kostenfrei https://www.mdpi.com/2076-3921/11/10/1875 kostenfrei https://doaj.org/toc/2076-3921 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2022 10, p 1875
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callnumber-first	R - Medicine
author	Jing Xu
spellingShingle	Jing Xu misc RM1-950 misc heat-killed <i<Lacticaseibacillus paracasei</i< misc skin cells misc oxidative damage misc photoaging misc UVB misc Therapeutics. Pharmacology Heat-Killed <i<Lacticaseibacillus paracasei</i< Ameliorated UVB-Induced Oxidative Damage and Photoaging and Its Underlying Mechanisms
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topic_title	RM1-950 Heat-Killed <i<Lacticaseibacillus paracasei</i< Ameliorated UVB-Induced Oxidative Damage and Photoaging and Its Underlying Mechanisms heat-killed <i<Lacticaseibacillus paracasei</i< skin cells oxidative damage photoaging UVB
topic	misc RM1-950 misc heat-killed <i<Lacticaseibacillus paracasei</i< misc skin cells misc oxidative damage misc photoaging misc UVB misc Therapeutics. Pharmacology
topic_unstemmed	misc RM1-950 misc heat-killed <i<Lacticaseibacillus paracasei</i< misc skin cells misc oxidative damage misc photoaging misc UVB misc Therapeutics. Pharmacology
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title	Heat-Killed <i<Lacticaseibacillus paracasei</i< Ameliorated UVB-Induced Oxidative Damage and Photoaging and Its Underlying Mechanisms
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author_browse	Jing Xu Xiaofang Zhang Yan Song Bin Zheng Zhengshun Wen Miao Gong Lingting Meng
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title_sort	heat-killed <i<lacticaseibacillus paracasei</i< ameliorated uvb-induced oxidative damage and photoaging and its underlying mechanisms
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title_auth	Heat-Killed <i<Lacticaseibacillus paracasei</i< Ameliorated UVB-Induced Oxidative Damage and Photoaging and Its Underlying Mechanisms
abstract	Ultraviolet B (UVB) radiation is a major environmental causative factor of skin oxidative damage and photoaging. <i<Lacticaseibacillus paracasei</i< is a well-known probiotic strain that can regulate skin health. The present study investigated the effects of heat-killed <i<Lacticaseibacillus paracasei</i< (PL) on UVB linked oxidative damage and photoaging in skin cells (Normal human dermal fibroblast (NHDF) cells and B16F10 murine melanoma cells). Results demonstrated that: (1) PL prevented UVB-induced cytotoxicity relating to decreased DNA damage in NHDF and B16F10 cells; (2) PL alleviated UVB-induced oxidative damage through increasing GSH content, as well as antioxidant enzyme activities and mRNA levels (except MnSOD activity and mRNA levels as well as CAT mRNA level) relating to the activation of Sirt1/PGC-1α/Nrf2 signaling in NHDF cells; (3) PL attenuated UVB-induced photoaging was noticed with a decrease in the percentage of SA-β-gal positive cells in NHDF cells model. Moreover, PL attenuated UVB-induced photoaging through exerting an anti-wrinkling effect by enhancing the type I collagen level relating to the inhibition (JNK, p38)/(c-Fos, c-Jun) of signaling in NHDF cells, and exerting an anti-melanogenic effect by suppressing tyrosinase and TYRP-1 activity and/or expressions relating to the inhibition of PKA/CREB/MITF signaling in B16F10 cells. In conclusion, PL could ameliorate UVB-induced oxidative damage and photoaging. Therefore, PL may be a potential antioxidant and anti-photoaging active ingredient for the cosmetic industry.
abstractGer	Ultraviolet B (UVB) radiation is a major environmental causative factor of skin oxidative damage and photoaging. <i<Lacticaseibacillus paracasei</i< is a well-known probiotic strain that can regulate skin health. The present study investigated the effects of heat-killed <i<Lacticaseibacillus paracasei</i< (PL) on UVB linked oxidative damage and photoaging in skin cells (Normal human dermal fibroblast (NHDF) cells and B16F10 murine melanoma cells). Results demonstrated that: (1) PL prevented UVB-induced cytotoxicity relating to decreased DNA damage in NHDF and B16F10 cells; (2) PL alleviated UVB-induced oxidative damage through increasing GSH content, as well as antioxidant enzyme activities and mRNA levels (except MnSOD activity and mRNA levels as well as CAT mRNA level) relating to the activation of Sirt1/PGC-1α/Nrf2 signaling in NHDF cells; (3) PL attenuated UVB-induced photoaging was noticed with a decrease in the percentage of SA-β-gal positive cells in NHDF cells model. Moreover, PL attenuated UVB-induced photoaging through exerting an anti-wrinkling effect by enhancing the type I collagen level relating to the inhibition (JNK, p38)/(c-Fos, c-Jun) of signaling in NHDF cells, and exerting an anti-melanogenic effect by suppressing tyrosinase and TYRP-1 activity and/or expressions relating to the inhibition of PKA/CREB/MITF signaling in B16F10 cells. In conclusion, PL could ameliorate UVB-induced oxidative damage and photoaging. Therefore, PL may be a potential antioxidant and anti-photoaging active ingredient for the cosmetic industry.
abstract_unstemmed	Ultraviolet B (UVB) radiation is a major environmental causative factor of skin oxidative damage and photoaging. <i<Lacticaseibacillus paracasei</i< is a well-known probiotic strain that can regulate skin health. The present study investigated the effects of heat-killed <i<Lacticaseibacillus paracasei</i< (PL) on UVB linked oxidative damage and photoaging in skin cells (Normal human dermal fibroblast (NHDF) cells and B16F10 murine melanoma cells). Results demonstrated that: (1) PL prevented UVB-induced cytotoxicity relating to decreased DNA damage in NHDF and B16F10 cells; (2) PL alleviated UVB-induced oxidative damage through increasing GSH content, as well as antioxidant enzyme activities and mRNA levels (except MnSOD activity and mRNA levels as well as CAT mRNA level) relating to the activation of Sirt1/PGC-1α/Nrf2 signaling in NHDF cells; (3) PL attenuated UVB-induced photoaging was noticed with a decrease in the percentage of SA-β-gal positive cells in NHDF cells model. Moreover, PL attenuated UVB-induced photoaging through exerting an anti-wrinkling effect by enhancing the type I collagen level relating to the inhibition (JNK, p38)/(c-Fos, c-Jun) of signaling in NHDF cells, and exerting an anti-melanogenic effect by suppressing tyrosinase and TYRP-1 activity and/or expressions relating to the inhibition of PKA/CREB/MITF signaling in B16F10 cells. In conclusion, PL could ameliorate UVB-induced oxidative damage and photoaging. Therefore, PL may be a potential antioxidant and anti-photoaging active ingredient for the cosmetic industry.
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title_short	Heat-Killed <i<Lacticaseibacillus paracasei</i< Ameliorated UVB-Induced Oxidative Damage and Photoaging and Its Underlying Mechanisms
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Moreover, PL attenuated UVB-induced photoaging through exerting an anti-wrinkling effect by enhancing the type I collagen level relating to the inhibition (JNK, p38)/(c-Fos, c-Jun) of signaling in NHDF cells, and exerting an anti-melanogenic effect by suppressing tyrosinase and TYRP-1 activity and/or expressions relating to the inhibition of PKA/CREB/MITF signaling in B16F10 cells. In conclusion, PL could ameliorate UVB-induced oxidative damage and photoaging. 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Heat-Killed <i<Lacticaseibacillus paracasei</i< Ameliorated UVB-Induced Oxidative Damage and Photoaging and Its Underlying Mechanisms

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