Increased levels of anti-PfCSP antibodies in post-pubertal females versus males immunized with PfSPZ Vaccine does not translate into increased protective efficacy

BackgroundWhile prior research has shown differences in the risk of malaria infection and sickness between males and females, little is known about sex differences in vaccine-induced immunity to malaria. Identifying such differences could elucidate important aspects of malaria biology and facilitate development of improved approaches to malaria vaccination.MethodsUsing a standardized enzyme-linked immunosorbent assay, IgG antibodies to the major surface protein on Plasmodium falciparum (Pf) sporozoites (SPZ), the Pf circumsporozoite protein (PfCSP), were measured before and two weeks after administration of a PfSPZ-based malaria vaccine (PfSPZ Vaccine) to 5-month to 61-year-olds in 11 clinical trials in Germany, the US and five countries in Africa, to determine if there were differences in vaccine elicited antibody response between males and females and if these differences were associated with differential protection against naturally transmitted Pf malaria (Africa) or controlled human malaria infection (Germany, the US and Africa).ResultsFemales ≥ 11 years of age made significantly higher levels of antibodies to PfCSP than did males in most trials, while there was no indication of such differences in infants or children. Although adult females had higher levels of antibodies, there was no evidence of improved protection compared to males. In 2 of the 7 trials with sufficient data, protected males had significantly higher levels of antibodies than unprotected males, and in 3 other trials protected females had higher levels of antibodies than did unprotected females.ConclusionImmunization with PfSPZ Vaccine induced higher levels of antibodies in post-pubertal females but showed equivalent protection in males and females. We conclude that the increased antibody levels in post-pubertal females did not contribute substantially to improved protection. We hypothesize that while antibodies to PfCSP (and PfSPZ) may potentially contribute directly to protection, they primarily correlate with other, potentially protective immune mechanisms, such as antibody dependent and antibody independent cellular responses in the liver. Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Natasha KC [verfasserIn] L. W. Preston Church [verfasserIn] Pouria Riyahi [verfasserIn] Sumana Chakravarty [verfasserIn] Robert A. Seder [verfasserIn] Judith E. Epstein [verfasserIn] Kirsten E. Lyke [verfasserIn] Benjamin Mordmüller [verfasserIn] Peter G. Kremsner [verfasserIn] Mahamadou S. Sissoko [verfasserIn] Sara Healy [verfasserIn] Patrick E. Duffy [verfasserIn] Said A. Jongo [verfasserIn] Vicente Urbano Nsue Ndong Nchama [verfasserIn] Salim Abdulla [verfasserIn] Maxmillian Mpina [verfasserIn] Sodiomon B. Sirima [verfasserIn] Matthew B. Laurens [verfasserIn] Laura C. Steinhardt [verfasserIn] Martina Oneko [verfasserIn] MingLin Li [verfasserIn] Tooba Murshedkar [verfasserIn] Peter F. Billingsley [verfasserIn] B. Kim Lee Sim [verfasserIn] Thomas L. Richie [verfasserIn] Stephen L. Hoffman [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2022

Schlagwörter:	PfSPZ Vaccine malaria vaccine Plasmodium falciparum PfCSP antibodies humoral immunity

Übergeordnetes Werk:	In: Frontiers in Immunology - Frontiers Media S.A., 2011, 13(2022)
Übergeordnetes Werk:	volume:13 ; year:2022

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3389/fimmu.2022.1006716

Katalog-ID:	DOAJ086977997

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245	1	0	\|a Increased levels of anti-PfCSP antibodies in post-pubertal females versus males immunized with PfSPZ Vaccine does not translate into increased protective efficacy
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520			\|a BackgroundWhile prior research has shown differences in the risk of malaria infection and sickness between males and females, little is known about sex differences in vaccine-induced immunity to malaria. Identifying such differences could elucidate important aspects of malaria biology and facilitate development of improved approaches to malaria vaccination.MethodsUsing a standardized enzyme-linked immunosorbent assay, IgG antibodies to the major surface protein on Plasmodium falciparum (Pf) sporozoites (SPZ), the Pf circumsporozoite protein (PfCSP), were measured before and two weeks after administration of a PfSPZ-based malaria vaccine (PfSPZ Vaccine) to 5-month to 61-year-olds in 11 clinical trials in Germany, the US and five countries in Africa, to determine if there were differences in vaccine elicited antibody response between males and females and if these differences were associated with differential protection against naturally transmitted Pf malaria (Africa) or controlled human malaria infection (Germany, the US and Africa).ResultsFemales ≥ 11 years of age made significantly higher levels of antibodies to PfCSP than did males in most trials, while there was no indication of such differences in infants or children. Although adult females had higher levels of antibodies, there was no evidence of improved protection compared to males. In 2 of the 7 trials with sufficient data, protected males had significantly higher levels of antibodies than unprotected males, and in 3 other trials protected females had higher levels of antibodies than did unprotected females.ConclusionImmunization with PfSPZ Vaccine induced higher levels of antibodies in post-pubertal females but showed equivalent protection in males and females. We conclude that the increased antibody levels in post-pubertal females did not contribute substantially to improved protection. We hypothesize that while antibodies to PfCSP (and PfSPZ) may potentially contribute directly to protection, they primarily correlate with other, potentially protective immune mechanisms, such as antibody dependent and antibody independent cellular responses in the liver.
650		4	\|a PfSPZ Vaccine
650		4	\|a malaria vaccine
650		4	\|a Plasmodium falciparum
650		4	\|a PfCSP
650		4	\|a antibodies
650		4	\|a humoral immunity
653		0	\|a Immunologic diseases. Allergy
700	0		\|a L. W. Preston Church \|e verfasserin \|4 aut
700	0		\|a Pouria Riyahi \|e verfasserin \|4 aut
700	0		\|a Sumana Chakravarty \|e verfasserin \|4 aut
700	0		\|a Robert A. Seder \|e verfasserin \|4 aut
700	0		\|a Judith E. Epstein \|e verfasserin \|4 aut
700	0		\|a Kirsten E. Lyke \|e verfasserin \|4 aut
700	0		\|a Benjamin Mordmüller \|e verfasserin \|4 aut
700	0		\|a Benjamin Mordmüller \|e verfasserin \|4 aut
700	0		\|a Peter G. Kremsner \|e verfasserin \|4 aut
700	0		\|a Peter G. Kremsner \|e verfasserin \|4 aut
700	0		\|a Mahamadou S. Sissoko \|e verfasserin \|4 aut
700	0		\|a Sara Healy \|e verfasserin \|4 aut
700	0		\|a Patrick E. Duffy \|e verfasserin \|4 aut
700	0		\|a Said A. Jongo \|e verfasserin \|4 aut
700	0		\|a Vicente Urbano Nsue Ndong Nchama \|e verfasserin \|4 aut
700	0		\|a Salim Abdulla \|e verfasserin \|4 aut
700	0		\|a Maxmillian Mpina \|e verfasserin \|4 aut
700	0		\|a Maxmillian Mpina \|e verfasserin \|4 aut
700	0		\|a Maxmillian Mpina \|e verfasserin \|4 aut
700	0		\|a Sodiomon B. Sirima \|e verfasserin \|4 aut
700	0		\|a Sodiomon B. Sirima \|e verfasserin \|4 aut
700	0		\|a Matthew B. Laurens \|e verfasserin \|4 aut
700	0		\|a Laura C. Steinhardt \|e verfasserin \|4 aut
700	0		\|a Martina Oneko \|e verfasserin \|4 aut
700	0		\|a MingLin Li \|e verfasserin \|4 aut
700	0		\|a Tooba Murshedkar \|e verfasserin \|4 aut
700	0		\|a Peter F. Billingsley \|e verfasserin \|4 aut
700	0		\|a B. Kim Lee Sim \|e verfasserin \|4 aut
700	0		\|a Thomas L. Richie \|e verfasserin \|4 aut
700	0		\|a Stephen L. Hoffman \|e verfasserin \|4 aut
773	0	8	\|i In \|t Frontiers in Immunology \|d Frontiers Media S.A., 2011 \|g 13(2022) \|w (DE-627)657998354 \|w (DE-600)2606827-8 \|x 16643224 \|7 nnns
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912			\|a GBV_ILN_293
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912			\|a GBV_ILN_2003
912			\|a GBV_ILN_2014
912			\|a GBV_ILN_4012
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912			\|a GBV_ILN_4112
912			\|a GBV_ILN_4125
912			\|a GBV_ILN_4126
912			\|a GBV_ILN_4249
912			\|a GBV_ILN_4305
912			\|a GBV_ILN_4306
912			\|a GBV_ILN_4307
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Indexfelder

author_variant	n k nk l w p c lwpc p r pr s c sc r a s ras j e e jee k e l kel b m bm b m bm p g k pgk p g k pgk m s s mss s h sh p e d ped s a j saj v u n n n vunnn s a sa m m mm m m mm m m mm s b s sbs s b s sbs m b l mbl l c s lcs m o mo m l ml t m tm p f b pfb b k l s bkls t l r tlr s l h slh
matchkey_str	article:16643224:2022----::nraelvloatpcpnioisnotuetleaevrumlsmuiewtpszacndentrn
hierarchy_sort_str	2022
callnumber-subject-code	RC
publishDate	2022
allfields	10.3389/fimmu.2022.1006716 doi (DE-627)DOAJ086977997 (DE-599)DOAJd6334f1741f1482b91e5bb9239e66e76 DE-627 ger DE-627 rakwb eng RC581-607 Natasha KC verfasserin aut Increased levels of anti-PfCSP antibodies in post-pubertal females versus males immunized with PfSPZ Vaccine does not translate into increased protective efficacy 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier BackgroundWhile prior research has shown differences in the risk of malaria infection and sickness between males and females, little is known about sex differences in vaccine-induced immunity to malaria. Identifying such differences could elucidate important aspects of malaria biology and facilitate development of improved approaches to malaria vaccination.MethodsUsing a standardized enzyme-linked immunosorbent assay, IgG antibodies to the major surface protein on Plasmodium falciparum (Pf) sporozoites (SPZ), the Pf circumsporozoite protein (PfCSP), were measured before and two weeks after administration of a PfSPZ-based malaria vaccine (PfSPZ Vaccine) to 5-month to 61-year-olds in 11 clinical trials in Germany, the US and five countries in Africa, to determine if there were differences in vaccine elicited antibody response between males and females and if these differences were associated with differential protection against naturally transmitted Pf malaria (Africa) or controlled human malaria infection (Germany, the US and Africa).ResultsFemales ≥ 11 years of age made significantly higher levels of antibodies to PfCSP than did males in most trials, while there was no indication of such differences in infants or children. Although adult females had higher levels of antibodies, there was no evidence of improved protection compared to males. In 2 of the 7 trials with sufficient data, protected males had significantly higher levels of antibodies than unprotected males, and in 3 other trials protected females had higher levels of antibodies than did unprotected females.ConclusionImmunization with PfSPZ Vaccine induced higher levels of antibodies in post-pubertal females but showed equivalent protection in males and females. We conclude that the increased antibody levels in post-pubertal females did not contribute substantially to improved protection. We hypothesize that while antibodies to PfCSP (and PfSPZ) may potentially contribute directly to protection, they primarily correlate with other, potentially protective immune mechanisms, such as antibody dependent and antibody independent cellular responses in the liver. PfSPZ Vaccine malaria vaccine Plasmodium falciparum PfCSP antibodies humoral immunity Immunologic diseases. Allergy L. W. Preston Church verfasserin aut Pouria Riyahi verfasserin aut Sumana Chakravarty verfasserin aut Robert A. Seder verfasserin aut Judith E. Epstein verfasserin aut Kirsten E. Lyke verfasserin aut Benjamin Mordmüller verfasserin aut Benjamin Mordmüller verfasserin aut Peter G. Kremsner verfasserin aut Peter G. Kremsner verfasserin aut Mahamadou S. Sissoko verfasserin aut Sara Healy verfasserin aut Patrick E. Duffy verfasserin aut Said A. Jongo verfasserin aut Vicente Urbano Nsue Ndong Nchama verfasserin aut Salim Abdulla verfasserin aut Maxmillian Mpina verfasserin aut Maxmillian Mpina verfasserin aut Maxmillian Mpina verfasserin aut Sodiomon B. Sirima verfasserin aut Sodiomon B. Sirima verfasserin aut Matthew B. Laurens verfasserin aut Laura C. Steinhardt verfasserin aut Martina Oneko verfasserin aut MingLin Li verfasserin aut Tooba Murshedkar verfasserin aut Peter F. Billingsley verfasserin aut B. Kim Lee Sim verfasserin aut Thomas L. Richie verfasserin aut Stephen L. Hoffman verfasserin aut In Frontiers in Immunology Frontiers Media S.A., 2011 13(2022) (DE-627)657998354 (DE-600)2606827-8 16643224 nnns volume:13 year:2022 https://doi.org/10.3389/fimmu.2022.1006716 kostenfrei https://doaj.org/article/d6334f1741f1482b91e5bb9239e66e76 kostenfrei https://www.frontiersin.org/articles/10.3389/fimmu.2022.1006716/full kostenfrei https://doaj.org/toc/1664-3224 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 13 2022
spelling	10.3389/fimmu.2022.1006716 doi (DE-627)DOAJ086977997 (DE-599)DOAJd6334f1741f1482b91e5bb9239e66e76 DE-627 ger DE-627 rakwb eng RC581-607 Natasha KC verfasserin aut Increased levels of anti-PfCSP antibodies in post-pubertal females versus males immunized with PfSPZ Vaccine does not translate into increased protective efficacy 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier BackgroundWhile prior research has shown differences in the risk of malaria infection and sickness between males and females, little is known about sex differences in vaccine-induced immunity to malaria. Identifying such differences could elucidate important aspects of malaria biology and facilitate development of improved approaches to malaria vaccination.MethodsUsing a standardized enzyme-linked immunosorbent assay, IgG antibodies to the major surface protein on Plasmodium falciparum (Pf) sporozoites (SPZ), the Pf circumsporozoite protein (PfCSP), were measured before and two weeks after administration of a PfSPZ-based malaria vaccine (PfSPZ Vaccine) to 5-month to 61-year-olds in 11 clinical trials in Germany, the US and five countries in Africa, to determine if there were differences in vaccine elicited antibody response between males and females and if these differences were associated with differential protection against naturally transmitted Pf malaria (Africa) or controlled human malaria infection (Germany, the US and Africa).ResultsFemales ≥ 11 years of age made significantly higher levels of antibodies to PfCSP than did males in most trials, while there was no indication of such differences in infants or children. Although adult females had higher levels of antibodies, there was no evidence of improved protection compared to males. In 2 of the 7 trials with sufficient data, protected males had significantly higher levels of antibodies than unprotected males, and in 3 other trials protected females had higher levels of antibodies than did unprotected females.ConclusionImmunization with PfSPZ Vaccine induced higher levels of antibodies in post-pubertal females but showed equivalent protection in males and females. We conclude that the increased antibody levels in post-pubertal females did not contribute substantially to improved protection. We hypothesize that while antibodies to PfCSP (and PfSPZ) may potentially contribute directly to protection, they primarily correlate with other, potentially protective immune mechanisms, such as antibody dependent and antibody independent cellular responses in the liver. PfSPZ Vaccine malaria vaccine Plasmodium falciparum PfCSP antibodies humoral immunity Immunologic diseases. Allergy L. W. Preston Church verfasserin aut Pouria Riyahi verfasserin aut Sumana Chakravarty verfasserin aut Robert A. Seder verfasserin aut Judith E. Epstein verfasserin aut Kirsten E. Lyke verfasserin aut Benjamin Mordmüller verfasserin aut Benjamin Mordmüller verfasserin aut Peter G. Kremsner verfasserin aut Peter G. Kremsner verfasserin aut Mahamadou S. Sissoko verfasserin aut Sara Healy verfasserin aut Patrick E. Duffy verfasserin aut Said A. Jongo verfasserin aut Vicente Urbano Nsue Ndong Nchama verfasserin aut Salim Abdulla verfasserin aut Maxmillian Mpina verfasserin aut Maxmillian Mpina verfasserin aut Maxmillian Mpina verfasserin aut Sodiomon B. Sirima verfasserin aut Sodiomon B. Sirima verfasserin aut Matthew B. Laurens verfasserin aut Laura C. Steinhardt verfasserin aut Martina Oneko verfasserin aut MingLin Li verfasserin aut Tooba Murshedkar verfasserin aut Peter F. Billingsley verfasserin aut B. Kim Lee Sim verfasserin aut Thomas L. Richie verfasserin aut Stephen L. Hoffman verfasserin aut In Frontiers in Immunology Frontiers Media S.A., 2011 13(2022) (DE-627)657998354 (DE-600)2606827-8 16643224 nnns volume:13 year:2022 https://doi.org/10.3389/fimmu.2022.1006716 kostenfrei https://doaj.org/article/d6334f1741f1482b91e5bb9239e66e76 kostenfrei https://www.frontiersin.org/articles/10.3389/fimmu.2022.1006716/full kostenfrei https://doaj.org/toc/1664-3224 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 13 2022
allfields_unstemmed	10.3389/fimmu.2022.1006716 doi (DE-627)DOAJ086977997 (DE-599)DOAJd6334f1741f1482b91e5bb9239e66e76 DE-627 ger DE-627 rakwb eng RC581-607 Natasha KC verfasserin aut Increased levels of anti-PfCSP antibodies in post-pubertal females versus males immunized with PfSPZ Vaccine does not translate into increased protective efficacy 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier BackgroundWhile prior research has shown differences in the risk of malaria infection and sickness between males and females, little is known about sex differences in vaccine-induced immunity to malaria. Identifying such differences could elucidate important aspects of malaria biology and facilitate development of improved approaches to malaria vaccination.MethodsUsing a standardized enzyme-linked immunosorbent assay, IgG antibodies to the major surface protein on Plasmodium falciparum (Pf) sporozoites (SPZ), the Pf circumsporozoite protein (PfCSP), were measured before and two weeks after administration of a PfSPZ-based malaria vaccine (PfSPZ Vaccine) to 5-month to 61-year-olds in 11 clinical trials in Germany, the US and five countries in Africa, to determine if there were differences in vaccine elicited antibody response between males and females and if these differences were associated with differential protection against naturally transmitted Pf malaria (Africa) or controlled human malaria infection (Germany, the US and Africa).ResultsFemales ≥ 11 years of age made significantly higher levels of antibodies to PfCSP than did males in most trials, while there was no indication of such differences in infants or children. Although adult females had higher levels of antibodies, there was no evidence of improved protection compared to males. In 2 of the 7 trials with sufficient data, protected males had significantly higher levels of antibodies than unprotected males, and in 3 other trials protected females had higher levels of antibodies than did unprotected females.ConclusionImmunization with PfSPZ Vaccine induced higher levels of antibodies in post-pubertal females but showed equivalent protection in males and females. We conclude that the increased antibody levels in post-pubertal females did not contribute substantially to improved protection. We hypothesize that while antibodies to PfCSP (and PfSPZ) may potentially contribute directly to protection, they primarily correlate with other, potentially protective immune mechanisms, such as antibody dependent and antibody independent cellular responses in the liver. PfSPZ Vaccine malaria vaccine Plasmodium falciparum PfCSP antibodies humoral immunity Immunologic diseases. Allergy L. W. Preston Church verfasserin aut Pouria Riyahi verfasserin aut Sumana Chakravarty verfasserin aut Robert A. Seder verfasserin aut Judith E. Epstein verfasserin aut Kirsten E. Lyke verfasserin aut Benjamin Mordmüller verfasserin aut Benjamin Mordmüller verfasserin aut Peter G. Kremsner verfasserin aut Peter G. Kremsner verfasserin aut Mahamadou S. Sissoko verfasserin aut Sara Healy verfasserin aut Patrick E. Duffy verfasserin aut Said A. Jongo verfasserin aut Vicente Urbano Nsue Ndong Nchama verfasserin aut Salim Abdulla verfasserin aut Maxmillian Mpina verfasserin aut Maxmillian Mpina verfasserin aut Maxmillian Mpina verfasserin aut Sodiomon B. Sirima verfasserin aut Sodiomon B. Sirima verfasserin aut Matthew B. Laurens verfasserin aut Laura C. Steinhardt verfasserin aut Martina Oneko verfasserin aut MingLin Li verfasserin aut Tooba Murshedkar verfasserin aut Peter F. Billingsley verfasserin aut B. Kim Lee Sim verfasserin aut Thomas L. Richie verfasserin aut Stephen L. Hoffman verfasserin aut In Frontiers in Immunology Frontiers Media S.A., 2011 13(2022) (DE-627)657998354 (DE-600)2606827-8 16643224 nnns volume:13 year:2022 https://doi.org/10.3389/fimmu.2022.1006716 kostenfrei https://doaj.org/article/d6334f1741f1482b91e5bb9239e66e76 kostenfrei https://www.frontiersin.org/articles/10.3389/fimmu.2022.1006716/full kostenfrei https://doaj.org/toc/1664-3224 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 13 2022
allfieldsGer	10.3389/fimmu.2022.1006716 doi (DE-627)DOAJ086977997 (DE-599)DOAJd6334f1741f1482b91e5bb9239e66e76 DE-627 ger DE-627 rakwb eng RC581-607 Natasha KC verfasserin aut Increased levels of anti-PfCSP antibodies in post-pubertal females versus males immunized with PfSPZ Vaccine does not translate into increased protective efficacy 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier BackgroundWhile prior research has shown differences in the risk of malaria infection and sickness between males and females, little is known about sex differences in vaccine-induced immunity to malaria. Identifying such differences could elucidate important aspects of malaria biology and facilitate development of improved approaches to malaria vaccination.MethodsUsing a standardized enzyme-linked immunosorbent assay, IgG antibodies to the major surface protein on Plasmodium falciparum (Pf) sporozoites (SPZ), the Pf circumsporozoite protein (PfCSP), were measured before and two weeks after administration of a PfSPZ-based malaria vaccine (PfSPZ Vaccine) to 5-month to 61-year-olds in 11 clinical trials in Germany, the US and five countries in Africa, to determine if there were differences in vaccine elicited antibody response between males and females and if these differences were associated with differential protection against naturally transmitted Pf malaria (Africa) or controlled human malaria infection (Germany, the US and Africa).ResultsFemales ≥ 11 years of age made significantly higher levels of antibodies to PfCSP than did males in most trials, while there was no indication of such differences in infants or children. Although adult females had higher levels of antibodies, there was no evidence of improved protection compared to males. In 2 of the 7 trials with sufficient data, protected males had significantly higher levels of antibodies than unprotected males, and in 3 other trials protected females had higher levels of antibodies than did unprotected females.ConclusionImmunization with PfSPZ Vaccine induced higher levels of antibodies in post-pubertal females but showed equivalent protection in males and females. We conclude that the increased antibody levels in post-pubertal females did not contribute substantially to improved protection. We hypothesize that while antibodies to PfCSP (and PfSPZ) may potentially contribute directly to protection, they primarily correlate with other, potentially protective immune mechanisms, such as antibody dependent and antibody independent cellular responses in the liver. PfSPZ Vaccine malaria vaccine Plasmodium falciparum PfCSP antibodies humoral immunity Immunologic diseases. Allergy L. W. Preston Church verfasserin aut Pouria Riyahi verfasserin aut Sumana Chakravarty verfasserin aut Robert A. Seder verfasserin aut Judith E. Epstein verfasserin aut Kirsten E. Lyke verfasserin aut Benjamin Mordmüller verfasserin aut Benjamin Mordmüller verfasserin aut Peter G. Kremsner verfasserin aut Peter G. Kremsner verfasserin aut Mahamadou S. Sissoko verfasserin aut Sara Healy verfasserin aut Patrick E. Duffy verfasserin aut Said A. Jongo verfasserin aut Vicente Urbano Nsue Ndong Nchama verfasserin aut Salim Abdulla verfasserin aut Maxmillian Mpina verfasserin aut Maxmillian Mpina verfasserin aut Maxmillian Mpina verfasserin aut Sodiomon B. Sirima verfasserin aut Sodiomon B. Sirima verfasserin aut Matthew B. Laurens verfasserin aut Laura C. Steinhardt verfasserin aut Martina Oneko verfasserin aut MingLin Li verfasserin aut Tooba Murshedkar verfasserin aut Peter F. Billingsley verfasserin aut B. Kim Lee Sim verfasserin aut Thomas L. Richie verfasserin aut Stephen L. Hoffman verfasserin aut In Frontiers in Immunology Frontiers Media S.A., 2011 13(2022) (DE-627)657998354 (DE-600)2606827-8 16643224 nnns volume:13 year:2022 https://doi.org/10.3389/fimmu.2022.1006716 kostenfrei https://doaj.org/article/d6334f1741f1482b91e5bb9239e66e76 kostenfrei https://www.frontiersin.org/articles/10.3389/fimmu.2022.1006716/full kostenfrei https://doaj.org/toc/1664-3224 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 13 2022
allfieldsSound	10.3389/fimmu.2022.1006716 doi (DE-627)DOAJ086977997 (DE-599)DOAJd6334f1741f1482b91e5bb9239e66e76 DE-627 ger DE-627 rakwb eng RC581-607 Natasha KC verfasserin aut Increased levels of anti-PfCSP antibodies in post-pubertal females versus males immunized with PfSPZ Vaccine does not translate into increased protective efficacy 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier BackgroundWhile prior research has shown differences in the risk of malaria infection and sickness between males and females, little is known about sex differences in vaccine-induced immunity to malaria. Identifying such differences could elucidate important aspects of malaria biology and facilitate development of improved approaches to malaria vaccination.MethodsUsing a standardized enzyme-linked immunosorbent assay, IgG antibodies to the major surface protein on Plasmodium falciparum (Pf) sporozoites (SPZ), the Pf circumsporozoite protein (PfCSP), were measured before and two weeks after administration of a PfSPZ-based malaria vaccine (PfSPZ Vaccine) to 5-month to 61-year-olds in 11 clinical trials in Germany, the US and five countries in Africa, to determine if there were differences in vaccine elicited antibody response between males and females and if these differences were associated with differential protection against naturally transmitted Pf malaria (Africa) or controlled human malaria infection (Germany, the US and Africa).ResultsFemales ≥ 11 years of age made significantly higher levels of antibodies to PfCSP than did males in most trials, while there was no indication of such differences in infants or children. Although adult females had higher levels of antibodies, there was no evidence of improved protection compared to males. In 2 of the 7 trials with sufficient data, protected males had significantly higher levels of antibodies than unprotected males, and in 3 other trials protected females had higher levels of antibodies than did unprotected females.ConclusionImmunization with PfSPZ Vaccine induced higher levels of antibodies in post-pubertal females but showed equivalent protection in males and females. We conclude that the increased antibody levels in post-pubertal females did not contribute substantially to improved protection. We hypothesize that while antibodies to PfCSP (and PfSPZ) may potentially contribute directly to protection, they primarily correlate with other, potentially protective immune mechanisms, such as antibody dependent and antibody independent cellular responses in the liver. PfSPZ Vaccine malaria vaccine Plasmodium falciparum PfCSP antibodies humoral immunity Immunologic diseases. Allergy L. W. Preston Church verfasserin aut Pouria Riyahi verfasserin aut Sumana Chakravarty verfasserin aut Robert A. Seder verfasserin aut Judith E. Epstein verfasserin aut Kirsten E. Lyke verfasserin aut Benjamin Mordmüller verfasserin aut Benjamin Mordmüller verfasserin aut Peter G. Kremsner verfasserin aut Peter G. Kremsner verfasserin aut Mahamadou S. Sissoko verfasserin aut Sara Healy verfasserin aut Patrick E. Duffy verfasserin aut Said A. Jongo verfasserin aut Vicente Urbano Nsue Ndong Nchama verfasserin aut Salim Abdulla verfasserin aut Maxmillian Mpina verfasserin aut Maxmillian Mpina verfasserin aut Maxmillian Mpina verfasserin aut Sodiomon B. Sirima verfasserin aut Sodiomon B. Sirima verfasserin aut Matthew B. Laurens verfasserin aut Laura C. Steinhardt verfasserin aut Martina Oneko verfasserin aut MingLin Li verfasserin aut Tooba Murshedkar verfasserin aut Peter F. Billingsley verfasserin aut B. Kim Lee Sim verfasserin aut Thomas L. Richie verfasserin aut Stephen L. Hoffman verfasserin aut In Frontiers in Immunology Frontiers Media S.A., 2011 13(2022) (DE-627)657998354 (DE-600)2606827-8 16643224 nnns volume:13 year:2022 https://doi.org/10.3389/fimmu.2022.1006716 kostenfrei https://doaj.org/article/d6334f1741f1482b91e5bb9239e66e76 kostenfrei https://www.frontiersin.org/articles/10.3389/fimmu.2022.1006716/full kostenfrei https://doaj.org/toc/1664-3224 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 13 2022
language	English
source	In Frontiers in Immunology 13(2022) volume:13 year:2022
sourceStr	In Frontiers in Immunology 13(2022) volume:13 year:2022
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	PfSPZ Vaccine malaria vaccine Plasmodium falciparum PfCSP antibodies humoral immunity Immunologic diseases. Allergy
isfreeaccess_bool	true
container_title	Frontiers in Immunology
authorswithroles_txt_mv	Natasha KC @@aut@@ L. W. Preston Church @@aut@@ Pouria Riyahi @@aut@@ Sumana Chakravarty @@aut@@ Robert A. Seder @@aut@@ Judith E. Epstein @@aut@@ Kirsten E. Lyke @@aut@@ Benjamin Mordmüller @@aut@@ Peter G. Kremsner @@aut@@ Mahamadou S. Sissoko @@aut@@ Sara Healy @@aut@@ Patrick E. Duffy @@aut@@ Said A. Jongo @@aut@@ Vicente Urbano Nsue Ndong Nchama @@aut@@ Salim Abdulla @@aut@@ Maxmillian Mpina @@aut@@ Sodiomon B. Sirima @@aut@@ Matthew B. Laurens @@aut@@ Laura C. Steinhardt @@aut@@ Martina Oneko @@aut@@ MingLin Li @@aut@@ Tooba Murshedkar @@aut@@ Peter F. Billingsley @@aut@@ B. Kim Lee Sim @@aut@@ Thomas L. Richie @@aut@@ Stephen L. Hoffman @@aut@@
publishDateDaySort_date	2022-01-01T00:00:00Z
hierarchy_top_id	657998354
id	DOAJ086977997
language_de	englisch
fullrecord	<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">DOAJ086977997</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20230501180503.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">230311s2022 xx \|\|\|\|\|o 00\| \|\|eng c</controlfield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.3389/fimmu.2022.1006716</subfield><subfield code="2">doi</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)DOAJ086977997</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-599)DOAJd6334f1741f1482b91e5bb9239e66e76</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="050" ind1=" " ind2="0"><subfield code="a">RC581-607</subfield></datafield><datafield tag="100" ind1="0" ind2=" "><subfield code="a">Natasha KC</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Increased levels of anti-PfCSP antibodies in post-pubertal females versus males immunized with PfSPZ Vaccine does not translate into increased protective efficacy</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2022</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">Text</subfield><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">Computermedien</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">BackgroundWhile prior research has shown differences in the risk of malaria infection and sickness between males and females, little is known about sex differences in vaccine-induced immunity to malaria. Identifying such differences could elucidate important aspects of malaria biology and facilitate development of improved approaches to malaria vaccination.MethodsUsing a standardized enzyme-linked immunosorbent assay, IgG antibodies to the major surface protein on Plasmodium falciparum (Pf) sporozoites (SPZ), the Pf circumsporozoite protein (PfCSP), were measured before and two weeks after administration of a PfSPZ-based malaria vaccine (PfSPZ Vaccine) to 5-month to 61-year-olds in 11 clinical trials in Germany, the US and five countries in Africa, to determine if there were differences in vaccine elicited antibody response between males and females and if these differences were associated with differential protection against naturally transmitted Pf malaria (Africa) or controlled human malaria infection (Germany, the US and Africa).ResultsFemales ≥ 11 years of age made significantly higher levels of antibodies to PfCSP than did males in most trials, while there was no indication of such differences in infants or children. Although adult females had higher levels of antibodies, there was no evidence of improved protection compared to males. In 2 of the 7 trials with sufficient data, protected males had significantly higher levels of antibodies than unprotected males, and in 3 other trials protected females had higher levels of antibodies than did unprotected females.ConclusionImmunization with PfSPZ Vaccine induced higher levels of antibodies in post-pubertal females but showed equivalent protection in males and females. We conclude that the increased antibody levels in post-pubertal females did not contribute substantially to improved protection. We hypothesize that while antibodies to PfCSP (and PfSPZ) may potentially contribute directly to protection, they primarily correlate with other, potentially protective immune mechanisms, such as antibody dependent and antibody independent cellular responses in the liver.</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">PfSPZ Vaccine</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">malaria vaccine</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Plasmodium falciparum</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">PfCSP</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">antibodies</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">humoral immunity</subfield></datafield><datafield tag="653" ind1=" " ind2="0"><subfield code="a">Immunologic diseases. 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callnumber-first	R - Medicine
author	Natasha KC
spellingShingle	Natasha KC misc RC581-607 misc PfSPZ Vaccine misc malaria vaccine misc Plasmodium falciparum misc PfCSP misc antibodies misc humoral immunity misc Immunologic diseases. Allergy Increased levels of anti-PfCSP antibodies in post-pubertal females versus males immunized with PfSPZ Vaccine does not translate into increased protective efficacy
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topic_title	RC581-607 Increased levels of anti-PfCSP antibodies in post-pubertal females versus males immunized with PfSPZ Vaccine does not translate into increased protective efficacy PfSPZ Vaccine malaria vaccine Plasmodium falciparum PfCSP antibodies humoral immunity
topic	misc RC581-607 misc PfSPZ Vaccine misc malaria vaccine misc Plasmodium falciparum misc PfCSP misc antibodies misc humoral immunity misc Immunologic diseases. Allergy
topic_unstemmed	misc RC581-607 misc PfSPZ Vaccine misc malaria vaccine misc Plasmodium falciparum misc PfCSP misc antibodies misc humoral immunity misc Immunologic diseases. Allergy
topic_browse	misc RC581-607 misc PfSPZ Vaccine misc malaria vaccine misc Plasmodium falciparum misc PfCSP misc antibodies misc humoral immunity misc Immunologic diseases. Allergy
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title	Increased levels of anti-PfCSP antibodies in post-pubertal females versus males immunized with PfSPZ Vaccine does not translate into increased protective efficacy
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title_full	Increased levels of anti-PfCSP antibodies in post-pubertal females versus males immunized with PfSPZ Vaccine does not translate into increased protective efficacy
author_sort	Natasha KC
journal	Frontiers in Immunology
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author_browse	Natasha KC L. W. Preston Church Pouria Riyahi Sumana Chakravarty Robert A. Seder Judith E. Epstein Kirsten E. Lyke Benjamin Mordmüller Peter G. Kremsner Mahamadou S. Sissoko Sara Healy Patrick E. Duffy Said A. Jongo Vicente Urbano Nsue Ndong Nchama Salim Abdulla Maxmillian Mpina Sodiomon B. Sirima Matthew B. Laurens Laura C. Steinhardt Martina Oneko MingLin Li Tooba Murshedkar Peter F. Billingsley B. Kim Lee Sim Thomas L. Richie Stephen L. Hoffman
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format_se	Elektronische Aufsätze
author-letter	Natasha KC
doi_str_mv	10.3389/fimmu.2022.1006716
author2-role	verfasserin
title_sort	increased levels of anti-pfcsp antibodies in post-pubertal females versus males immunized with pfspz vaccine does not translate into increased protective efficacy
callnumber	RC581-607
title_auth	Increased levels of anti-PfCSP antibodies in post-pubertal females versus males immunized with PfSPZ Vaccine does not translate into increased protective efficacy
abstract	BackgroundWhile prior research has shown differences in the risk of malaria infection and sickness between males and females, little is known about sex differences in vaccine-induced immunity to malaria. Identifying such differences could elucidate important aspects of malaria biology and facilitate development of improved approaches to malaria vaccination.MethodsUsing a standardized enzyme-linked immunosorbent assay, IgG antibodies to the major surface protein on Plasmodium falciparum (Pf) sporozoites (SPZ), the Pf circumsporozoite protein (PfCSP), were measured before and two weeks after administration of a PfSPZ-based malaria vaccine (PfSPZ Vaccine) to 5-month to 61-year-olds in 11 clinical trials in Germany, the US and five countries in Africa, to determine if there were differences in vaccine elicited antibody response between males and females and if these differences were associated with differential protection against naturally transmitted Pf malaria (Africa) or controlled human malaria infection (Germany, the US and Africa).ResultsFemales ≥ 11 years of age made significantly higher levels of antibodies to PfCSP than did males in most trials, while there was no indication of such differences in infants or children. Although adult females had higher levels of antibodies, there was no evidence of improved protection compared to males. In 2 of the 7 trials with sufficient data, protected males had significantly higher levels of antibodies than unprotected males, and in 3 other trials protected females had higher levels of antibodies than did unprotected females.ConclusionImmunization with PfSPZ Vaccine induced higher levels of antibodies in post-pubertal females but showed equivalent protection in males and females. We conclude that the increased antibody levels in post-pubertal females did not contribute substantially to improved protection. We hypothesize that while antibodies to PfCSP (and PfSPZ) may potentially contribute directly to protection, they primarily correlate with other, potentially protective immune mechanisms, such as antibody dependent and antibody independent cellular responses in the liver.
abstractGer	BackgroundWhile prior research has shown differences in the risk of malaria infection and sickness between males and females, little is known about sex differences in vaccine-induced immunity to malaria. Identifying such differences could elucidate important aspects of malaria biology and facilitate development of improved approaches to malaria vaccination.MethodsUsing a standardized enzyme-linked immunosorbent assay, IgG antibodies to the major surface protein on Plasmodium falciparum (Pf) sporozoites (SPZ), the Pf circumsporozoite protein (PfCSP), were measured before and two weeks after administration of a PfSPZ-based malaria vaccine (PfSPZ Vaccine) to 5-month to 61-year-olds in 11 clinical trials in Germany, the US and five countries in Africa, to determine if there were differences in vaccine elicited antibody response between males and females and if these differences were associated with differential protection against naturally transmitted Pf malaria (Africa) or controlled human malaria infection (Germany, the US and Africa).ResultsFemales ≥ 11 years of age made significantly higher levels of antibodies to PfCSP than did males in most trials, while there was no indication of such differences in infants or children. Although adult females had higher levels of antibodies, there was no evidence of improved protection compared to males. In 2 of the 7 trials with sufficient data, protected males had significantly higher levels of antibodies than unprotected males, and in 3 other trials protected females had higher levels of antibodies than did unprotected females.ConclusionImmunization with PfSPZ Vaccine induced higher levels of antibodies in post-pubertal females but showed equivalent protection in males and females. We conclude that the increased antibody levels in post-pubertal females did not contribute substantially to improved protection. We hypothesize that while antibodies to PfCSP (and PfSPZ) may potentially contribute directly to protection, they primarily correlate with other, potentially protective immune mechanisms, such as antibody dependent and antibody independent cellular responses in the liver.
abstract_unstemmed	BackgroundWhile prior research has shown differences in the risk of malaria infection and sickness between males and females, little is known about sex differences in vaccine-induced immunity to malaria. Identifying such differences could elucidate important aspects of malaria biology and facilitate development of improved approaches to malaria vaccination.MethodsUsing a standardized enzyme-linked immunosorbent assay, IgG antibodies to the major surface protein on Plasmodium falciparum (Pf) sporozoites (SPZ), the Pf circumsporozoite protein (PfCSP), were measured before and two weeks after administration of a PfSPZ-based malaria vaccine (PfSPZ Vaccine) to 5-month to 61-year-olds in 11 clinical trials in Germany, the US and five countries in Africa, to determine if there were differences in vaccine elicited antibody response between males and females and if these differences were associated with differential protection against naturally transmitted Pf malaria (Africa) or controlled human malaria infection (Germany, the US and Africa).ResultsFemales ≥ 11 years of age made significantly higher levels of antibodies to PfCSP than did males in most trials, while there was no indication of such differences in infants or children. Although adult females had higher levels of antibodies, there was no evidence of improved protection compared to males. In 2 of the 7 trials with sufficient data, protected males had significantly higher levels of antibodies than unprotected males, and in 3 other trials protected females had higher levels of antibodies than did unprotected females.ConclusionImmunization with PfSPZ Vaccine induced higher levels of antibodies in post-pubertal females but showed equivalent protection in males and females. We conclude that the increased antibody levels in post-pubertal females did not contribute substantially to improved protection. We hypothesize that while antibodies to PfCSP (and PfSPZ) may potentially contribute directly to protection, they primarily correlate with other, potentially protective immune mechanisms, such as antibody dependent and antibody independent cellular responses in the liver.
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title_short	Increased levels of anti-PfCSP antibodies in post-pubertal females versus males immunized with PfSPZ Vaccine does not translate into increased protective efficacy
url	https://doi.org/10.3389/fimmu.2022.1006716 https://doaj.org/article/d6334f1741f1482b91e5bb9239e66e76 https://www.frontiersin.org/articles/10.3389/fimmu.2022.1006716/full https://doaj.org/toc/1664-3224
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author2	L. W. Preston Church Pouria Riyahi Sumana Chakravarty Robert A. Seder Judith E. Epstein Kirsten E. Lyke Benjamin Mordmüller Peter G. Kremsner Mahamadou S. Sissoko Sara Healy Patrick E. Duffy Said A. Jongo Vicente Urbano Nsue Ndong Nchama Salim Abdulla Maxmillian Mpina Sodiomon B. Sirima Matthew B. Laurens Laura C. Steinhardt Martina Oneko MingLin Li Tooba Murshedkar Peter F. Billingsley B. Kim Lee Sim Thomas L. Richie Stephen L. Hoffman
author2Str	L. W. Preston Church Pouria Riyahi Sumana Chakravarty Robert A. Seder Judith E. Epstein Kirsten E. Lyke Benjamin Mordmüller Peter G. Kremsner Mahamadou S. Sissoko Sara Healy Patrick E. Duffy Said A. Jongo Vicente Urbano Nsue Ndong Nchama Salim Abdulla Maxmillian Mpina Sodiomon B. Sirima Matthew B. Laurens Laura C. Steinhardt Martina Oneko MingLin Li Tooba Murshedkar Peter F. Billingsley B. Kim Lee Sim Thomas L. Richie Stephen L. Hoffman
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fullrecord_marcxml	<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">DOAJ086977997</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20230501180503.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">230311s2022 xx \|\|\|\|\|o 00\| \|\|eng c</controlfield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.3389/fimmu.2022.1006716</subfield><subfield code="2">doi</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)DOAJ086977997</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-599)DOAJd6334f1741f1482b91e5bb9239e66e76</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="050" ind1=" " ind2="0"><subfield code="a">RC581-607</subfield></datafield><datafield tag="100" ind1="0" ind2=" "><subfield code="a">Natasha KC</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Increased levels of anti-PfCSP antibodies in post-pubertal females versus males immunized with PfSPZ Vaccine does not translate into increased protective efficacy</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2022</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">Text</subfield><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">Computermedien</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">BackgroundWhile prior research has shown differences in the risk of malaria infection and sickness between males and females, little is known about sex differences in vaccine-induced immunity to malaria. Identifying such differences could elucidate important aspects of malaria biology and facilitate development of improved approaches to malaria vaccination.MethodsUsing a standardized enzyme-linked immunosorbent assay, IgG antibodies to the major surface protein on Plasmodium falciparum (Pf) sporozoites (SPZ), the Pf circumsporozoite protein (PfCSP), were measured before and two weeks after administration of a PfSPZ-based malaria vaccine (PfSPZ Vaccine) to 5-month to 61-year-olds in 11 clinical trials in Germany, the US and five countries in Africa, to determine if there were differences in vaccine elicited antibody response between males and females and if these differences were associated with differential protection against naturally transmitted Pf malaria (Africa) or controlled human malaria infection (Germany, the US and Africa).ResultsFemales ≥ 11 years of age made significantly higher levels of antibodies to PfCSP than did males in most trials, while there was no indication of such differences in infants or children. Although adult females had higher levels of antibodies, there was no evidence of improved protection compared to males. In 2 of the 7 trials with sufficient data, protected males had significantly higher levels of antibodies than unprotected males, and in 3 other trials protected females had higher levels of antibodies than did unprotected females.ConclusionImmunization with PfSPZ Vaccine induced higher levels of antibodies in post-pubertal females but showed equivalent protection in males and females. We conclude that the increased antibody levels in post-pubertal females did not contribute substantially to improved protection. We hypothesize that while antibodies to PfCSP (and PfSPZ) may potentially contribute directly to protection, they primarily correlate with other, potentially protective immune mechanisms, such as antibody dependent and antibody independent cellular responses in the liver.</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">PfSPZ Vaccine</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">malaria vaccine</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Plasmodium falciparum</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">PfCSP</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">antibodies</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">humoral immunity</subfield></datafield><datafield tag="653" ind1=" " ind2="0"><subfield code="a">Immunologic diseases. 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Kim Lee Sim</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Thomas L. Richie</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Stephen L. 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Increased levels of anti-PfCSP antibodies in post-pubertal females versus males immunized with PfSPZ Vaccine does not translate into increased protective efficacy

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