A Mixture of <i<Artemisia argyi</i< and <i<Saururus chinensis</i< Improves PM<sub<2.5</sub<-Induced Cognitive Dysfunction by Regulating Oxidative Stress and Inflammatory Response in the Lung and Brain

This study was performed to investigate the improving effect of a mixture of <i<Artemisia argyi</i< and <i<Saururus chinensis</i< (AASC) on cognitive dysfunction in mice with long-term exposure to fine particles (particulate matter smaller than 2.5 µm: PM<sub<2.5</su...
Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Jin-Yong Kang [verfasserIn] Jong-Min Kim [verfasserIn] Seon-Kyeong Park [verfasserIn] Hyo-Lim Lee [verfasserIn] Ho-Jin Heo [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2023

Schlagwörter:	fine particles cognitive dysfunction inflammation oxidative stress

Übergeordnetes Werk:	In: Plants - MDPI AG, 2013, 12(2023), 6, p 1230
Übergeordnetes Werk:	volume:12 ; year:2023 ; number:6, p 1230

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3390/plants12061230

Katalog-ID:	DOAJ087262185

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245	1	2	\|a A Mixture of <i<Artemisia argyi</i< and <i<Saururus chinensis</i< Improves PM<sub<2.5</sub<-Induced Cognitive Dysfunction by Regulating Oxidative Stress and Inflammatory Response in the Lung and Brain
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authorswithroles_txt_mv	Jin-Yong Kang @@aut@@ Jong-Min Kim @@aut@@ Seon-Kyeong Park @@aut@@ Hyo-Lim Lee @@aut@@ Ho-Jin Heo @@aut@@
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callnumber-first	Q - Science
author	Jin-Yong Kang
spellingShingle	Jin-Yong Kang misc QK1-989 misc <i<Artemisia argyi</i< misc <i<Saururus chinensis</i< misc fine particles misc cognitive dysfunction misc inflammation misc oxidative stress misc Botany A Mixture of <i<Artemisia argyi</i< and <i<Saururus chinensis</i< Improves PM<sub<2.5</sub<-Induced Cognitive Dysfunction by Regulating Oxidative Stress and Inflammatory Response in the Lung and Brain
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topic_title	QK1-989 A Mixture of <i<Artemisia argyi</i< and <i<Saururus chinensis</i< Improves PM<sub<2.5</sub<-Induced Cognitive Dysfunction by Regulating Oxidative Stress and Inflammatory Response in the Lung and Brain <i<Artemisia argyi</i< <i<Saururus chinensis</i< fine particles cognitive dysfunction inflammation oxidative stress
topic	misc QK1-989 misc <i<Artemisia argyi</i< misc <i<Saururus chinensis</i< misc fine particles misc cognitive dysfunction misc inflammation misc oxidative stress misc Botany
topic_unstemmed	misc QK1-989 misc <i<Artemisia argyi</i< misc <i<Saururus chinensis</i< misc fine particles misc cognitive dysfunction misc inflammation misc oxidative stress misc Botany
topic_browse	misc QK1-989 misc <i<Artemisia argyi</i< misc <i<Saururus chinensis</i< misc fine particles misc cognitive dysfunction misc inflammation misc oxidative stress misc Botany
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title	A Mixture of <i<Artemisia argyi</i< and <i<Saururus chinensis</i< Improves PM<sub<2.5</sub<-Induced Cognitive Dysfunction by Regulating Oxidative Stress and Inflammatory Response in the Lung and Brain
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title_full	A Mixture of <i<Artemisia argyi</i< and <i<Saururus chinensis</i< Improves PM<sub<2.5</sub<-Induced Cognitive Dysfunction by Regulating Oxidative Stress and Inflammatory Response in the Lung and Brain
author_sort	Jin-Yong Kang
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author_browse	Jin-Yong Kang Jong-Min Kim Seon-Kyeong Park Hyo-Lim Lee Ho-Jin Heo
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class	QK1-989
format_se	Elektronische Aufsätze
author-letter	Jin-Yong Kang
doi_str_mv	10.3390/plants12061230
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title_sort	mixture of <i<artemisia argyi</i< and <i<saururus chinensis</i< improves pm<sub<2.5</sub<-induced cognitive dysfunction by regulating oxidative stress and inflammatory response in the lung and brain
callnumber	QK1-989
title_auth	A Mixture of <i<Artemisia argyi</i< and <i<Saururus chinensis</i< Improves PM<sub<2.5</sub<-Induced Cognitive Dysfunction by Regulating Oxidative Stress and Inflammatory Response in the Lung and Brain
abstract	This study was performed to investigate the improving effect of a mixture of <i<Artemisia argyi</i< and <i<Saururus chinensis</i< (AASC) on cognitive dysfunction in mice with long-term exposure to fine particles (particulate matter smaller than 2.5 µm: PM<sub<2.5</sub<). The main compounds of AASC were identified as dicaffeoylquinic acid isomers of <i<A. argyi</i< and a quercetin-3-glucoside of <i<S. chinesis</i<. As a result of behavioral tests for the evaluation of cognitive function, it was confirmed that cognitive dysfunction was induced in the PM<sub<2.5</sub< exposure group, and a tendency to improve in the AASC group was confirmed. Increased oxidative stress and inflammatory response and mitochondrial dysfunction were observed in the brain and lung tissues of the PM group. Damage to the brain and lung affected the accumulation of amyloid beta (Aβ) in the brain. It increased Aβ and induced the cholinergic dysfunction, hyperphosphorylation of the tau protein, and activation of apoptosis, leading to cognitive impairment. However, AASC suppressed brain and lung oxidative stress and inflammation, thereby suppressing brain Aβ expression. Consequently, this study shows the potential that a steady intake of plant resources with antioxidant and anti-inflammatory activity could prevent cognitive impairment caused by PM<sub<2.5</sub<.
abstractGer	This study was performed to investigate the improving effect of a mixture of <i<Artemisia argyi</i< and <i<Saururus chinensis</i< (AASC) on cognitive dysfunction in mice with long-term exposure to fine particles (particulate matter smaller than 2.5 µm: PM<sub<2.5</sub<). The main compounds of AASC were identified as dicaffeoylquinic acid isomers of <i<A. argyi</i< and a quercetin-3-glucoside of <i<S. chinesis</i<. As a result of behavioral tests for the evaluation of cognitive function, it was confirmed that cognitive dysfunction was induced in the PM<sub<2.5</sub< exposure group, and a tendency to improve in the AASC group was confirmed. Increased oxidative stress and inflammatory response and mitochondrial dysfunction were observed in the brain and lung tissues of the PM group. Damage to the brain and lung affected the accumulation of amyloid beta (Aβ) in the brain. It increased Aβ and induced the cholinergic dysfunction, hyperphosphorylation of the tau protein, and activation of apoptosis, leading to cognitive impairment. However, AASC suppressed brain and lung oxidative stress and inflammation, thereby suppressing brain Aβ expression. Consequently, this study shows the potential that a steady intake of plant resources with antioxidant and anti-inflammatory activity could prevent cognitive impairment caused by PM<sub<2.5</sub<.
abstract_unstemmed	This study was performed to investigate the improving effect of a mixture of <i<Artemisia argyi</i< and <i<Saururus chinensis</i< (AASC) on cognitive dysfunction in mice with long-term exposure to fine particles (particulate matter smaller than 2.5 µm: PM<sub<2.5</sub<). The main compounds of AASC were identified as dicaffeoylquinic acid isomers of <i<A. argyi</i< and a quercetin-3-glucoside of <i<S. chinesis</i<. As a result of behavioral tests for the evaluation of cognitive function, it was confirmed that cognitive dysfunction was induced in the PM<sub<2.5</sub< exposure group, and a tendency to improve in the AASC group was confirmed. Increased oxidative stress and inflammatory response and mitochondrial dysfunction were observed in the brain and lung tissues of the PM group. Damage to the brain and lung affected the accumulation of amyloid beta (Aβ) in the brain. It increased Aβ and induced the cholinergic dysfunction, hyperphosphorylation of the tau protein, and activation of apoptosis, leading to cognitive impairment. However, AASC suppressed brain and lung oxidative stress and inflammation, thereby suppressing brain Aβ expression. Consequently, this study shows the potential that a steady intake of plant resources with antioxidant and anti-inflammatory activity could prevent cognitive impairment caused by PM<sub<2.5</sub<.
collection_details	GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700
container_issue	6, p 1230
title_short	A Mixture of <i<Artemisia argyi</i< and <i<Saururus chinensis</i< Improves PM<sub<2.5</sub<-Induced Cognitive Dysfunction by Regulating Oxidative Stress and Inflammatory Response in the Lung and Brain
url	https://doi.org/10.3390/plants12061230 https://doaj.org/article/88e02c1b8acb4090b4806e8ad9fe142e https://www.mdpi.com/2223-7747/12/6/1230 https://doaj.org/toc/2223-7747
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author2	Jong-Min Kim Seon-Kyeong Park Hyo-Lim Lee Ho-Jin Heo
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doi_str	10.3390/plants12061230
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up_date	2024-07-04T00:56:01.273Z
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A Mixture of <i<Artemisia argyi</i< and <i<Saururus chinensis</i< Improves PM<sub<2.5</sub<-Induced Cognitive Dysfunction by Regulating Oxidative Stress and Inflammatory Response in the Lung and Brain

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