First Comparative Evaluation of Short-Chain Fatty Acids and Vitamin-K-Dependent Proteins Levels in Mother–Newborn Pairs at Birth

Background: The interplay between vitamin K (vitK) (as carboxylation cofactor, partially produced by the gut microbiota) and short-chain fatty acids (SCFAs), the end-product of fiber fermentation in the gut, has never been assessed in mother–newborn pairs, although newborns are considered vitK defic...
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Autor*in:	Tamás Ilyés [verfasserIn] Marius Pop [verfasserIn] Mihai Surcel [verfasserIn] Daria M. Pop [verfasserIn] Răzvan Rusu [verfasserIn] Ciprian N. Silaghi [verfasserIn] Gabriela C. Zaharie [verfasserIn] Alexandra M. Crăciun [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2023

Schlagwörter:	short-chain fatty acids vitamin-K-dependent proteins matrix Gla protein osteocalcin Gla-rich protein PIVKA

Übergeordnetes Werk:	In: Life - MDPI AG, 2012, 13(2023), 3, p 847
Übergeordnetes Werk:	volume:13 ; year:2023 ; number:3, p 847

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3390/life13030847

Katalog-ID:	DOAJ087312549

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245	1	0	\|a First Comparative Evaluation of Short-Chain Fatty Acids and Vitamin-K-Dependent Proteins Levels in Mother–Newborn Pairs at Birth
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520			\|a Background: The interplay between vitamin K (vitK) (as carboxylation cofactor, partially produced by the gut microbiota) and short-chain fatty acids (SCFAs), the end-product of fiber fermentation in the gut, has never been assessed in mother–newborn pairs, although newborns are considered vitK deficient and with sterile gut. Methods: We collected venous blood from 45 healthy mothers with uncomplicated term pregnancies and umbilical cord blood from their newborns at birth. The concentrations of total SCFAs and hepatic/extra-hepatic vitK-dependent proteins (VKDPs), as proxies of vitK status were assayed: undercarboxylated and total matrix Gla protein (ucMGP and tMGP), undercarboxylated osteocalcin (ucOC), undercarboxylated Gla-rich protein (ucGRP), and protein induced by vitK absence II (PIVKA-II). Results: We found significantly higher ucOC (18.6-fold), ucMGP (9.2-fold), and PIVKA-II (5.6-fold) levels in newborns, while tMGP (5.1-fold) and SCFAs (2.4-fold) were higher in mothers, and ucGRP was insignificantly modified. In mother–newborn pairs, only ucGRP (r = 0.746, <i<p</i< < 0.01) and SCFAs (r = 0.428, <i<p</i< = 0.01) levels were correlated. <b<Conclusions:</b< We report for the first time the presence of SCFAs in humans at birth, probably transferred through the placenta to the fetus. The increased circulating undercarboxylated VKDPSs in newborns revealed a higher vitamin K deficiency at the extrahepatic level compared to liver VKDPs.
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Indexfelder

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allfields	10.3390/life13030847 doi (DE-627)DOAJ087312549 (DE-599)DOAJd187112b8e53403e864a311464d5e347 DE-627 ger DE-627 rakwb eng Tamás Ilyés verfasserin aut First Comparative Evaluation of Short-Chain Fatty Acids and Vitamin-K-Dependent Proteins Levels in Mother–Newborn Pairs at Birth 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: The interplay between vitamin K (vitK) (as carboxylation cofactor, partially produced by the gut microbiota) and short-chain fatty acids (SCFAs), the end-product of fiber fermentation in the gut, has never been assessed in mother–newborn pairs, although newborns are considered vitK deficient and with sterile gut. Methods: We collected venous blood from 45 healthy mothers with uncomplicated term pregnancies and umbilical cord blood from their newborns at birth. The concentrations of total SCFAs and hepatic/extra-hepatic vitK-dependent proteins (VKDPs), as proxies of vitK status were assayed: undercarboxylated and total matrix Gla protein (ucMGP and tMGP), undercarboxylated osteocalcin (ucOC), undercarboxylated Gla-rich protein (ucGRP), and protein induced by vitK absence II (PIVKA-II). Results: We found significantly higher ucOC (18.6-fold), ucMGP (9.2-fold), and PIVKA-II (5.6-fold) levels in newborns, while tMGP (5.1-fold) and SCFAs (2.4-fold) were higher in mothers, and ucGRP was insignificantly modified. In mother–newborn pairs, only ucGRP (r = 0.746, <i<p</i< < 0.01) and SCFAs (r = 0.428, <i<p</i< = 0.01) levels were correlated. <b<Conclusions:</b< We report for the first time the presence of SCFAs in humans at birth, probably transferred through the placenta to the fetus. The increased circulating undercarboxylated VKDPSs in newborns revealed a higher vitamin K deficiency at the extrahepatic level compared to liver VKDPs. short-chain fatty acids vitamin-K-dependent proteins matrix Gla protein osteocalcin Gla-rich protein PIVKA Science Q Marius Pop verfasserin aut Mihai Surcel verfasserin aut Daria M. Pop verfasserin aut Răzvan Rusu verfasserin aut Ciprian N. Silaghi verfasserin aut Gabriela C. Zaharie verfasserin aut Alexandra M. Crăciun verfasserin aut In Life MDPI AG, 2012 13(2023), 3, p 847 (DE-627)718627156 (DE-600)2662250-6 20751729 nnns volume:13 year:2023 number:3, p 847 https://doi.org/10.3390/life13030847 kostenfrei https://doaj.org/article/d187112b8e53403e864a311464d5e347 kostenfrei https://www.mdpi.com/2075-1729/13/3/847 kostenfrei https://doaj.org/toc/2075-1729 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 13 2023 3, p 847
spelling	10.3390/life13030847 doi (DE-627)DOAJ087312549 (DE-599)DOAJd187112b8e53403e864a311464d5e347 DE-627 ger DE-627 rakwb eng Tamás Ilyés verfasserin aut First Comparative Evaluation of Short-Chain Fatty Acids and Vitamin-K-Dependent Proteins Levels in Mother–Newborn Pairs at Birth 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: The interplay between vitamin K (vitK) (as carboxylation cofactor, partially produced by the gut microbiota) and short-chain fatty acids (SCFAs), the end-product of fiber fermentation in the gut, has never been assessed in mother–newborn pairs, although newborns are considered vitK deficient and with sterile gut. Methods: We collected venous blood from 45 healthy mothers with uncomplicated term pregnancies and umbilical cord blood from their newborns at birth. The concentrations of total SCFAs and hepatic/extra-hepatic vitK-dependent proteins (VKDPs), as proxies of vitK status were assayed: undercarboxylated and total matrix Gla protein (ucMGP and tMGP), undercarboxylated osteocalcin (ucOC), undercarboxylated Gla-rich protein (ucGRP), and protein induced by vitK absence II (PIVKA-II). Results: We found significantly higher ucOC (18.6-fold), ucMGP (9.2-fold), and PIVKA-II (5.6-fold) levels in newborns, while tMGP (5.1-fold) and SCFAs (2.4-fold) were higher in mothers, and ucGRP was insignificantly modified. In mother–newborn pairs, only ucGRP (r = 0.746, <i<p</i< < 0.01) and SCFAs (r = 0.428, <i<p</i< = 0.01) levels were correlated. <b<Conclusions:</b< We report for the first time the presence of SCFAs in humans at birth, probably transferred through the placenta to the fetus. The increased circulating undercarboxylated VKDPSs in newborns revealed a higher vitamin K deficiency at the extrahepatic level compared to liver VKDPs. short-chain fatty acids vitamin-K-dependent proteins matrix Gla protein osteocalcin Gla-rich protein PIVKA Science Q Marius Pop verfasserin aut Mihai Surcel verfasserin aut Daria M. Pop verfasserin aut Răzvan Rusu verfasserin aut Ciprian N. Silaghi verfasserin aut Gabriela C. Zaharie verfasserin aut Alexandra M. Crăciun verfasserin aut In Life MDPI AG, 2012 13(2023), 3, p 847 (DE-627)718627156 (DE-600)2662250-6 20751729 nnns volume:13 year:2023 number:3, p 847 https://doi.org/10.3390/life13030847 kostenfrei https://doaj.org/article/d187112b8e53403e864a311464d5e347 kostenfrei https://www.mdpi.com/2075-1729/13/3/847 kostenfrei https://doaj.org/toc/2075-1729 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 13 2023 3, p 847
allfields_unstemmed	10.3390/life13030847 doi (DE-627)DOAJ087312549 (DE-599)DOAJd187112b8e53403e864a311464d5e347 DE-627 ger DE-627 rakwb eng Tamás Ilyés verfasserin aut First Comparative Evaluation of Short-Chain Fatty Acids and Vitamin-K-Dependent Proteins Levels in Mother–Newborn Pairs at Birth 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: The interplay between vitamin K (vitK) (as carboxylation cofactor, partially produced by the gut microbiota) and short-chain fatty acids (SCFAs), the end-product of fiber fermentation in the gut, has never been assessed in mother–newborn pairs, although newborns are considered vitK deficient and with sterile gut. Methods: We collected venous blood from 45 healthy mothers with uncomplicated term pregnancies and umbilical cord blood from their newborns at birth. The concentrations of total SCFAs and hepatic/extra-hepatic vitK-dependent proteins (VKDPs), as proxies of vitK status were assayed: undercarboxylated and total matrix Gla protein (ucMGP and tMGP), undercarboxylated osteocalcin (ucOC), undercarboxylated Gla-rich protein (ucGRP), and protein induced by vitK absence II (PIVKA-II). Results: We found significantly higher ucOC (18.6-fold), ucMGP (9.2-fold), and PIVKA-II (5.6-fold) levels in newborns, while tMGP (5.1-fold) and SCFAs (2.4-fold) were higher in mothers, and ucGRP was insignificantly modified. In mother–newborn pairs, only ucGRP (r = 0.746, <i<p</i< < 0.01) and SCFAs (r = 0.428, <i<p</i< = 0.01) levels were correlated. <b<Conclusions:</b< We report for the first time the presence of SCFAs in humans at birth, probably transferred through the placenta to the fetus. The increased circulating undercarboxylated VKDPSs in newborns revealed a higher vitamin K deficiency at the extrahepatic level compared to liver VKDPs. short-chain fatty acids vitamin-K-dependent proteins matrix Gla protein osteocalcin Gla-rich protein PIVKA Science Q Marius Pop verfasserin aut Mihai Surcel verfasserin aut Daria M. Pop verfasserin aut Răzvan Rusu verfasserin aut Ciprian N. Silaghi verfasserin aut Gabriela C. Zaharie verfasserin aut Alexandra M. Crăciun verfasserin aut In Life MDPI AG, 2012 13(2023), 3, p 847 (DE-627)718627156 (DE-600)2662250-6 20751729 nnns volume:13 year:2023 number:3, p 847 https://doi.org/10.3390/life13030847 kostenfrei https://doaj.org/article/d187112b8e53403e864a311464d5e347 kostenfrei https://www.mdpi.com/2075-1729/13/3/847 kostenfrei https://doaj.org/toc/2075-1729 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 13 2023 3, p 847
allfieldsGer	10.3390/life13030847 doi (DE-627)DOAJ087312549 (DE-599)DOAJd187112b8e53403e864a311464d5e347 DE-627 ger DE-627 rakwb eng Tamás Ilyés verfasserin aut First Comparative Evaluation of Short-Chain Fatty Acids and Vitamin-K-Dependent Proteins Levels in Mother–Newborn Pairs at Birth 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: The interplay between vitamin K (vitK) (as carboxylation cofactor, partially produced by the gut microbiota) and short-chain fatty acids (SCFAs), the end-product of fiber fermentation in the gut, has never been assessed in mother–newborn pairs, although newborns are considered vitK deficient and with sterile gut. Methods: We collected venous blood from 45 healthy mothers with uncomplicated term pregnancies and umbilical cord blood from their newborns at birth. The concentrations of total SCFAs and hepatic/extra-hepatic vitK-dependent proteins (VKDPs), as proxies of vitK status were assayed: undercarboxylated and total matrix Gla protein (ucMGP and tMGP), undercarboxylated osteocalcin (ucOC), undercarboxylated Gla-rich protein (ucGRP), and protein induced by vitK absence II (PIVKA-II). Results: We found significantly higher ucOC (18.6-fold), ucMGP (9.2-fold), and PIVKA-II (5.6-fold) levels in newborns, while tMGP (5.1-fold) and SCFAs (2.4-fold) were higher in mothers, and ucGRP was insignificantly modified. In mother–newborn pairs, only ucGRP (r = 0.746, <i<p</i< < 0.01) and SCFAs (r = 0.428, <i<p</i< = 0.01) levels were correlated. <b<Conclusions:</b< We report for the first time the presence of SCFAs in humans at birth, probably transferred through the placenta to the fetus. The increased circulating undercarboxylated VKDPSs in newborns revealed a higher vitamin K deficiency at the extrahepatic level compared to liver VKDPs. short-chain fatty acids vitamin-K-dependent proteins matrix Gla protein osteocalcin Gla-rich protein PIVKA Science Q Marius Pop verfasserin aut Mihai Surcel verfasserin aut Daria M. Pop verfasserin aut Răzvan Rusu verfasserin aut Ciprian N. Silaghi verfasserin aut Gabriela C. Zaharie verfasserin aut Alexandra M. Crăciun verfasserin aut In Life MDPI AG, 2012 13(2023), 3, p 847 (DE-627)718627156 (DE-600)2662250-6 20751729 nnns volume:13 year:2023 number:3, p 847 https://doi.org/10.3390/life13030847 kostenfrei https://doaj.org/article/d187112b8e53403e864a311464d5e347 kostenfrei https://www.mdpi.com/2075-1729/13/3/847 kostenfrei https://doaj.org/toc/2075-1729 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 13 2023 3, p 847
allfieldsSound	10.3390/life13030847 doi (DE-627)DOAJ087312549 (DE-599)DOAJd187112b8e53403e864a311464d5e347 DE-627 ger DE-627 rakwb eng Tamás Ilyés verfasserin aut First Comparative Evaluation of Short-Chain Fatty Acids and Vitamin-K-Dependent Proteins Levels in Mother–Newborn Pairs at Birth 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: The interplay between vitamin K (vitK) (as carboxylation cofactor, partially produced by the gut microbiota) and short-chain fatty acids (SCFAs), the end-product of fiber fermentation in the gut, has never been assessed in mother–newborn pairs, although newborns are considered vitK deficient and with sterile gut. Methods: We collected venous blood from 45 healthy mothers with uncomplicated term pregnancies and umbilical cord blood from their newborns at birth. The concentrations of total SCFAs and hepatic/extra-hepatic vitK-dependent proteins (VKDPs), as proxies of vitK status were assayed: undercarboxylated and total matrix Gla protein (ucMGP and tMGP), undercarboxylated osteocalcin (ucOC), undercarboxylated Gla-rich protein (ucGRP), and protein induced by vitK absence II (PIVKA-II). Results: We found significantly higher ucOC (18.6-fold), ucMGP (9.2-fold), and PIVKA-II (5.6-fold) levels in newborns, while tMGP (5.1-fold) and SCFAs (2.4-fold) were higher in mothers, and ucGRP was insignificantly modified. In mother–newborn pairs, only ucGRP (r = 0.746, <i<p</i< < 0.01) and SCFAs (r = 0.428, <i<p</i< = 0.01) levels were correlated. <b<Conclusions:</b< We report for the first time the presence of SCFAs in humans at birth, probably transferred through the placenta to the fetus. The increased circulating undercarboxylated VKDPSs in newborns revealed a higher vitamin K deficiency at the extrahepatic level compared to liver VKDPs. short-chain fatty acids vitamin-K-dependent proteins matrix Gla protein osteocalcin Gla-rich protein PIVKA Science Q Marius Pop verfasserin aut Mihai Surcel verfasserin aut Daria M. Pop verfasserin aut Răzvan Rusu verfasserin aut Ciprian N. Silaghi verfasserin aut Gabriela C. Zaharie verfasserin aut Alexandra M. Crăciun verfasserin aut In Life MDPI AG, 2012 13(2023), 3, p 847 (DE-627)718627156 (DE-600)2662250-6 20751729 nnns volume:13 year:2023 number:3, p 847 https://doi.org/10.3390/life13030847 kostenfrei https://doaj.org/article/d187112b8e53403e864a311464d5e347 kostenfrei https://www.mdpi.com/2075-1729/13/3/847 kostenfrei https://doaj.org/toc/2075-1729 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 13 2023 3, p 847
language	English
source	In Life 13(2023), 3, p 847 volume:13 year:2023 number:3, p 847
sourceStr	In Life 13(2023), 3, p 847 volume:13 year:2023 number:3, p 847
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institution	findex.gbv.de
topic_facet	short-chain fatty acids vitamin-K-dependent proteins matrix Gla protein osteocalcin Gla-rich protein PIVKA Science Q
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container_title	Life
authorswithroles_txt_mv	Tamás Ilyés @@aut@@ Marius Pop @@aut@@ Mihai Surcel @@aut@@ Daria M. Pop @@aut@@ Răzvan Rusu @@aut@@ Ciprian N. Silaghi @@aut@@ Gabriela C. Zaharie @@aut@@ Alexandra M. Crăciun @@aut@@
publishDateDaySort_date	2023-01-01T00:00:00Z
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author	Tamás Ilyés
spellingShingle	Tamás Ilyés misc short-chain fatty acids misc vitamin-K-dependent proteins misc matrix Gla protein misc osteocalcin misc Gla-rich protein misc PIVKA misc Science misc Q First Comparative Evaluation of Short-Chain Fatty Acids and Vitamin-K-Dependent Proteins Levels in Mother–Newborn Pairs at Birth
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topic_title	First Comparative Evaluation of Short-Chain Fatty Acids and Vitamin-K-Dependent Proteins Levels in Mother–Newborn Pairs at Birth short-chain fatty acids vitamin-K-dependent proteins matrix Gla protein osteocalcin Gla-rich protein PIVKA
topic	misc short-chain fatty acids misc vitamin-K-dependent proteins misc matrix Gla protein misc osteocalcin misc Gla-rich protein misc PIVKA misc Science misc Q
topic_unstemmed	misc short-chain fatty acids misc vitamin-K-dependent proteins misc matrix Gla protein misc osteocalcin misc Gla-rich protein misc PIVKA misc Science misc Q
topic_browse	misc short-chain fatty acids misc vitamin-K-dependent proteins misc matrix Gla protein misc osteocalcin misc Gla-rich protein misc PIVKA misc Science misc Q
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title	First Comparative Evaluation of Short-Chain Fatty Acids and Vitamin-K-Dependent Proteins Levels in Mother–Newborn Pairs at Birth
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title_full	First Comparative Evaluation of Short-Chain Fatty Acids and Vitamin-K-Dependent Proteins Levels in Mother–Newborn Pairs at Birth
author_sort	Tamás Ilyés
journal	Life
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author_browse	Tamás Ilyés Marius Pop Mihai Surcel Daria M. Pop Răzvan Rusu Ciprian N. Silaghi Gabriela C. Zaharie Alexandra M. Crăciun
container_volume	13
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author-letter	Tamás Ilyés
doi_str_mv	10.3390/life13030847
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title_sort	first comparative evaluation of short-chain fatty acids and vitamin-k-dependent proteins levels in mother–newborn pairs at birth
title_auth	First Comparative Evaluation of Short-Chain Fatty Acids and Vitamin-K-Dependent Proteins Levels in Mother–Newborn Pairs at Birth
abstract	Background: The interplay between vitamin K (vitK) (as carboxylation cofactor, partially produced by the gut microbiota) and short-chain fatty acids (SCFAs), the end-product of fiber fermentation in the gut, has never been assessed in mother–newborn pairs, although newborns are considered vitK deficient and with sterile gut. Methods: We collected venous blood from 45 healthy mothers with uncomplicated term pregnancies and umbilical cord blood from their newborns at birth. The concentrations of total SCFAs and hepatic/extra-hepatic vitK-dependent proteins (VKDPs), as proxies of vitK status were assayed: undercarboxylated and total matrix Gla protein (ucMGP and tMGP), undercarboxylated osteocalcin (ucOC), undercarboxylated Gla-rich protein (ucGRP), and protein induced by vitK absence II (PIVKA-II). Results: We found significantly higher ucOC (18.6-fold), ucMGP (9.2-fold), and PIVKA-II (5.6-fold) levels in newborns, while tMGP (5.1-fold) and SCFAs (2.4-fold) were higher in mothers, and ucGRP was insignificantly modified. In mother–newborn pairs, only ucGRP (r = 0.746, <i<p</i< < 0.01) and SCFAs (r = 0.428, <i<p</i< = 0.01) levels were correlated. <b<Conclusions:</b< We report for the first time the presence of SCFAs in humans at birth, probably transferred through the placenta to the fetus. The increased circulating undercarboxylated VKDPSs in newborns revealed a higher vitamin K deficiency at the extrahepatic level compared to liver VKDPs.
abstractGer	Background: The interplay between vitamin K (vitK) (as carboxylation cofactor, partially produced by the gut microbiota) and short-chain fatty acids (SCFAs), the end-product of fiber fermentation in the gut, has never been assessed in mother–newborn pairs, although newborns are considered vitK deficient and with sterile gut. Methods: We collected venous blood from 45 healthy mothers with uncomplicated term pregnancies and umbilical cord blood from their newborns at birth. The concentrations of total SCFAs and hepatic/extra-hepatic vitK-dependent proteins (VKDPs), as proxies of vitK status were assayed: undercarboxylated and total matrix Gla protein (ucMGP and tMGP), undercarboxylated osteocalcin (ucOC), undercarboxylated Gla-rich protein (ucGRP), and protein induced by vitK absence II (PIVKA-II). Results: We found significantly higher ucOC (18.6-fold), ucMGP (9.2-fold), and PIVKA-II (5.6-fold) levels in newborns, while tMGP (5.1-fold) and SCFAs (2.4-fold) were higher in mothers, and ucGRP was insignificantly modified. In mother–newborn pairs, only ucGRP (r = 0.746, <i<p</i< < 0.01) and SCFAs (r = 0.428, <i<p</i< = 0.01) levels were correlated. <b<Conclusions:</b< We report for the first time the presence of SCFAs in humans at birth, probably transferred through the placenta to the fetus. The increased circulating undercarboxylated VKDPSs in newborns revealed a higher vitamin K deficiency at the extrahepatic level compared to liver VKDPs.
abstract_unstemmed	Background: The interplay between vitamin K (vitK) (as carboxylation cofactor, partially produced by the gut microbiota) and short-chain fatty acids (SCFAs), the end-product of fiber fermentation in the gut, has never been assessed in mother–newborn pairs, although newborns are considered vitK deficient and with sterile gut. Methods: We collected venous blood from 45 healthy mothers with uncomplicated term pregnancies and umbilical cord blood from their newborns at birth. The concentrations of total SCFAs and hepatic/extra-hepatic vitK-dependent proteins (VKDPs), as proxies of vitK status were assayed: undercarboxylated and total matrix Gla protein (ucMGP and tMGP), undercarboxylated osteocalcin (ucOC), undercarboxylated Gla-rich protein (ucGRP), and protein induced by vitK absence II (PIVKA-II). Results: We found significantly higher ucOC (18.6-fold), ucMGP (9.2-fold), and PIVKA-II (5.6-fold) levels in newborns, while tMGP (5.1-fold) and SCFAs (2.4-fold) were higher in mothers, and ucGRP was insignificantly modified. In mother–newborn pairs, only ucGRP (r = 0.746, <i<p</i< < 0.01) and SCFAs (r = 0.428, <i<p</i< = 0.01) levels were correlated. <b<Conclusions:</b< We report for the first time the presence of SCFAs in humans at birth, probably transferred through the placenta to the fetus. The increased circulating undercarboxylated VKDPSs in newborns revealed a higher vitamin K deficiency at the extrahepatic level compared to liver VKDPs.
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title_short	First Comparative Evaluation of Short-Chain Fatty Acids and Vitamin-K-Dependent Proteins Levels in Mother–Newborn Pairs at Birth
url	https://doi.org/10.3390/life13030847 https://doaj.org/article/d187112b8e53403e864a311464d5e347 https://www.mdpi.com/2075-1729/13/3/847 https://doaj.org/toc/2075-1729
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author2	Marius Pop Mihai Surcel Daria M. Pop Răzvan Rusu Ciprian N. Silaghi Gabriela C. Zaharie Alexandra M. Crăciun
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up_date	2024-07-04T01:09:15.817Z
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