Thirty-Days versus Longer Duration of Dual Antiplatelet Treatment after Percutaneous Coronary Interventions with Newer Drug-Eluting Stents: A Systematic Review and Meta-Analysis

Abbreviation of the duration of dual antiplatelet therapy (DAPT) (one or three months) has been recently proposed, especially for high bleeding risk patients, after percutaneous coronary intervention (PCI) with drug-eluting stent (DES). Three databases were screened for eligible randomized control t...
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Autor*in:	Grigorios Tsigkas [verfasserIn] Anastasios Apostolos [verfasserIn] David-Dimitrios Chlorogiannis [verfasserIn] Elena Bousoula [verfasserIn] Georgios Vasilagkos [verfasserIn] Sotirios Tsalamandris [verfasserIn] Ioannis Tsiafoutis [verfasserIn] Konstantinos Katsanos [verfasserIn] Konstantinos Toutouzas [verfasserIn] Adel Aminian [verfasserIn] Dimitrios Alexopoulos [verfasserIn] Periklis Davlouros [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2023

Schlagwörter:	dual antiplatelet therapy DAPT one-month DAPT percutaneous coronary intervention PCI meta-analysis

Übergeordnetes Werk:	In: Life - MDPI AG, 2012, 13(2023), 3, p 666
Übergeordnetes Werk:	volume:13 ; year:2023 ; number:3, p 666

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3390/life13030666

Katalog-ID:	DOAJ087314371

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allfields	10.3390/life13030666 doi (DE-627)DOAJ087314371 (DE-599)DOAJba232e4d4eb34896bdc2b77bccf77ae6 DE-627 ger DE-627 rakwb eng Grigorios Tsigkas verfasserin aut Thirty-Days versus Longer Duration of Dual Antiplatelet Treatment after Percutaneous Coronary Interventions with Newer Drug-Eluting Stents: A Systematic Review and Meta-Analysis 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abbreviation of the duration of dual antiplatelet therapy (DAPT) (one or three months) has been recently proposed, especially for high bleeding risk patients, after percutaneous coronary intervention (PCI) with drug-eluting stent (DES). Three databases were screened for eligible randomized control trials. The primary endpoint was the incidence of net adverse clinical events (NACE). Secondary endpoints consisted of major adverse cardiovascular events (MACE), all-cause and cardiovascular mortality, myocardial infarction, stroke, stent-thrombosis, repeat revascularization and major bleeding. We included four RCTs with a total of 26,576 patients; 13,282 patients were grouped in 30-days DAPT, while the remaining 13,294 were allocated in a longer period of DAPT. One month of DAPT did not significantly reduce NACE (odds ratio [OR]: 0.87, 95% confidence intervals [Cl]: 0.74–1.03); however, major bleedings were significantly reduced by 22% (OR: 0.78, 95% Cl: 0.65–0.94). Mortality or ischemic events (stroke, myocardial infarction, revascularization and stent thrombosis) were not affected. Thus, 30-days DAPT could be considered as safe and feasible after PCI with DES in selected patients, especially those with high bleeding risk. Forthcoming RCTs could shed light on the optimal duration of DAPT. dual antiplatelet therapy DAPT one-month DAPT percutaneous coronary intervention PCI meta-analysis Science Q Anastasios Apostolos verfasserin aut David-Dimitrios Chlorogiannis verfasserin aut Elena Bousoula verfasserin aut Georgios Vasilagkos verfasserin aut Sotirios Tsalamandris verfasserin aut Ioannis Tsiafoutis verfasserin aut Konstantinos Katsanos verfasserin aut Konstantinos Toutouzas verfasserin aut Adel Aminian verfasserin aut Dimitrios Alexopoulos verfasserin aut Periklis Davlouros verfasserin aut In Life MDPI AG, 2012 13(2023), 3, p 666 (DE-627)718627156 (DE-600)2662250-6 20751729 nnns volume:13 year:2023 number:3, p 666 https://doi.org/10.3390/life13030666 kostenfrei https://doaj.org/article/ba232e4d4eb34896bdc2b77bccf77ae6 kostenfrei https://www.mdpi.com/2075-1729/13/3/666 kostenfrei https://doaj.org/toc/2075-1729 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 13 2023 3, p 666
spelling	10.3390/life13030666 doi (DE-627)DOAJ087314371 (DE-599)DOAJba232e4d4eb34896bdc2b77bccf77ae6 DE-627 ger DE-627 rakwb eng Grigorios Tsigkas verfasserin aut Thirty-Days versus Longer Duration of Dual Antiplatelet Treatment after Percutaneous Coronary Interventions with Newer Drug-Eluting Stents: A Systematic Review and Meta-Analysis 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abbreviation of the duration of dual antiplatelet therapy (DAPT) (one or three months) has been recently proposed, especially for high bleeding risk patients, after percutaneous coronary intervention (PCI) with drug-eluting stent (DES). Three databases were screened for eligible randomized control trials. The primary endpoint was the incidence of net adverse clinical events (NACE). Secondary endpoints consisted of major adverse cardiovascular events (MACE), all-cause and cardiovascular mortality, myocardial infarction, stroke, stent-thrombosis, repeat revascularization and major bleeding. We included four RCTs with a total of 26,576 patients; 13,282 patients were grouped in 30-days DAPT, while the remaining 13,294 were allocated in a longer period of DAPT. One month of DAPT did not significantly reduce NACE (odds ratio [OR]: 0.87, 95% confidence intervals [Cl]: 0.74–1.03); however, major bleedings were significantly reduced by 22% (OR: 0.78, 95% Cl: 0.65–0.94). Mortality or ischemic events (stroke, myocardial infarction, revascularization and stent thrombosis) were not affected. Thus, 30-days DAPT could be considered as safe and feasible after PCI with DES in selected patients, especially those with high bleeding risk. Forthcoming RCTs could shed light on the optimal duration of DAPT. dual antiplatelet therapy DAPT one-month DAPT percutaneous coronary intervention PCI meta-analysis Science Q Anastasios Apostolos verfasserin aut David-Dimitrios Chlorogiannis verfasserin aut Elena Bousoula verfasserin aut Georgios Vasilagkos verfasserin aut Sotirios Tsalamandris verfasserin aut Ioannis Tsiafoutis verfasserin aut Konstantinos Katsanos verfasserin aut Konstantinos Toutouzas verfasserin aut Adel Aminian verfasserin aut Dimitrios Alexopoulos verfasserin aut Periklis Davlouros verfasserin aut In Life MDPI AG, 2012 13(2023), 3, p 666 (DE-627)718627156 (DE-600)2662250-6 20751729 nnns volume:13 year:2023 number:3, p 666 https://doi.org/10.3390/life13030666 kostenfrei https://doaj.org/article/ba232e4d4eb34896bdc2b77bccf77ae6 kostenfrei https://www.mdpi.com/2075-1729/13/3/666 kostenfrei https://doaj.org/toc/2075-1729 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 13 2023 3, p 666
allfields_unstemmed	10.3390/life13030666 doi (DE-627)DOAJ087314371 (DE-599)DOAJba232e4d4eb34896bdc2b77bccf77ae6 DE-627 ger DE-627 rakwb eng Grigorios Tsigkas verfasserin aut Thirty-Days versus Longer Duration of Dual Antiplatelet Treatment after Percutaneous Coronary Interventions with Newer Drug-Eluting Stents: A Systematic Review and Meta-Analysis 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abbreviation of the duration of dual antiplatelet therapy (DAPT) (one or three months) has been recently proposed, especially for high bleeding risk patients, after percutaneous coronary intervention (PCI) with drug-eluting stent (DES). Three databases were screened for eligible randomized control trials. The primary endpoint was the incidence of net adverse clinical events (NACE). Secondary endpoints consisted of major adverse cardiovascular events (MACE), all-cause and cardiovascular mortality, myocardial infarction, stroke, stent-thrombosis, repeat revascularization and major bleeding. We included four RCTs with a total of 26,576 patients; 13,282 patients were grouped in 30-days DAPT, while the remaining 13,294 were allocated in a longer period of DAPT. One month of DAPT did not significantly reduce NACE (odds ratio [OR]: 0.87, 95% confidence intervals [Cl]: 0.74–1.03); however, major bleedings were significantly reduced by 22% (OR: 0.78, 95% Cl: 0.65–0.94). Mortality or ischemic events (stroke, myocardial infarction, revascularization and stent thrombosis) were not affected. Thus, 30-days DAPT could be considered as safe and feasible after PCI with DES in selected patients, especially those with high bleeding risk. Forthcoming RCTs could shed light on the optimal duration of DAPT. dual antiplatelet therapy DAPT one-month DAPT percutaneous coronary intervention PCI meta-analysis Science Q Anastasios Apostolos verfasserin aut David-Dimitrios Chlorogiannis verfasserin aut Elena Bousoula verfasserin aut Georgios Vasilagkos verfasserin aut Sotirios Tsalamandris verfasserin aut Ioannis Tsiafoutis verfasserin aut Konstantinos Katsanos verfasserin aut Konstantinos Toutouzas verfasserin aut Adel Aminian verfasserin aut Dimitrios Alexopoulos verfasserin aut Periklis Davlouros verfasserin aut In Life MDPI AG, 2012 13(2023), 3, p 666 (DE-627)718627156 (DE-600)2662250-6 20751729 nnns volume:13 year:2023 number:3, p 666 https://doi.org/10.3390/life13030666 kostenfrei https://doaj.org/article/ba232e4d4eb34896bdc2b77bccf77ae6 kostenfrei https://www.mdpi.com/2075-1729/13/3/666 kostenfrei https://doaj.org/toc/2075-1729 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 13 2023 3, p 666
allfieldsGer	10.3390/life13030666 doi (DE-627)DOAJ087314371 (DE-599)DOAJba232e4d4eb34896bdc2b77bccf77ae6 DE-627 ger DE-627 rakwb eng Grigorios Tsigkas verfasserin aut Thirty-Days versus Longer Duration of Dual Antiplatelet Treatment after Percutaneous Coronary Interventions with Newer Drug-Eluting Stents: A Systematic Review and Meta-Analysis 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abbreviation of the duration of dual antiplatelet therapy (DAPT) (one or three months) has been recently proposed, especially for high bleeding risk patients, after percutaneous coronary intervention (PCI) with drug-eluting stent (DES). Three databases were screened for eligible randomized control trials. The primary endpoint was the incidence of net adverse clinical events (NACE). Secondary endpoints consisted of major adverse cardiovascular events (MACE), all-cause and cardiovascular mortality, myocardial infarction, stroke, stent-thrombosis, repeat revascularization and major bleeding. We included four RCTs with a total of 26,576 patients; 13,282 patients were grouped in 30-days DAPT, while the remaining 13,294 were allocated in a longer period of DAPT. One month of DAPT did not significantly reduce NACE (odds ratio [OR]: 0.87, 95% confidence intervals [Cl]: 0.74–1.03); however, major bleedings were significantly reduced by 22% (OR: 0.78, 95% Cl: 0.65–0.94). Mortality or ischemic events (stroke, myocardial infarction, revascularization and stent thrombosis) were not affected. Thus, 30-days DAPT could be considered as safe and feasible after PCI with DES in selected patients, especially those with high bleeding risk. Forthcoming RCTs could shed light on the optimal duration of DAPT. dual antiplatelet therapy DAPT one-month DAPT percutaneous coronary intervention PCI meta-analysis Science Q Anastasios Apostolos verfasserin aut David-Dimitrios Chlorogiannis verfasserin aut Elena Bousoula verfasserin aut Georgios Vasilagkos verfasserin aut Sotirios Tsalamandris verfasserin aut Ioannis Tsiafoutis verfasserin aut Konstantinos Katsanos verfasserin aut Konstantinos Toutouzas verfasserin aut Adel Aminian verfasserin aut Dimitrios Alexopoulos verfasserin aut Periklis Davlouros verfasserin aut In Life MDPI AG, 2012 13(2023), 3, p 666 (DE-627)718627156 (DE-600)2662250-6 20751729 nnns volume:13 year:2023 number:3, p 666 https://doi.org/10.3390/life13030666 kostenfrei https://doaj.org/article/ba232e4d4eb34896bdc2b77bccf77ae6 kostenfrei https://www.mdpi.com/2075-1729/13/3/666 kostenfrei https://doaj.org/toc/2075-1729 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 13 2023 3, p 666
allfieldsSound	10.3390/life13030666 doi (DE-627)DOAJ087314371 (DE-599)DOAJba232e4d4eb34896bdc2b77bccf77ae6 DE-627 ger DE-627 rakwb eng Grigorios Tsigkas verfasserin aut Thirty-Days versus Longer Duration of Dual Antiplatelet Treatment after Percutaneous Coronary Interventions with Newer Drug-Eluting Stents: A Systematic Review and Meta-Analysis 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abbreviation of the duration of dual antiplatelet therapy (DAPT) (one or three months) has been recently proposed, especially for high bleeding risk patients, after percutaneous coronary intervention (PCI) with drug-eluting stent (DES). Three databases were screened for eligible randomized control trials. The primary endpoint was the incidence of net adverse clinical events (NACE). Secondary endpoints consisted of major adverse cardiovascular events (MACE), all-cause and cardiovascular mortality, myocardial infarction, stroke, stent-thrombosis, repeat revascularization and major bleeding. We included four RCTs with a total of 26,576 patients; 13,282 patients were grouped in 30-days DAPT, while the remaining 13,294 were allocated in a longer period of DAPT. One month of DAPT did not significantly reduce NACE (odds ratio [OR]: 0.87, 95% confidence intervals [Cl]: 0.74–1.03); however, major bleedings were significantly reduced by 22% (OR: 0.78, 95% Cl: 0.65–0.94). Mortality or ischemic events (stroke, myocardial infarction, revascularization and stent thrombosis) were not affected. Thus, 30-days DAPT could be considered as safe and feasible after PCI with DES in selected patients, especially those with high bleeding risk. Forthcoming RCTs could shed light on the optimal duration of DAPT. dual antiplatelet therapy DAPT one-month DAPT percutaneous coronary intervention PCI meta-analysis Science Q Anastasios Apostolos verfasserin aut David-Dimitrios Chlorogiannis verfasserin aut Elena Bousoula verfasserin aut Georgios Vasilagkos verfasserin aut Sotirios Tsalamandris verfasserin aut Ioannis Tsiafoutis verfasserin aut Konstantinos Katsanos verfasserin aut Konstantinos Toutouzas verfasserin aut Adel Aminian verfasserin aut Dimitrios Alexopoulos verfasserin aut Periklis Davlouros verfasserin aut In Life MDPI AG, 2012 13(2023), 3, p 666 (DE-627)718627156 (DE-600)2662250-6 20751729 nnns volume:13 year:2023 number:3, p 666 https://doi.org/10.3390/life13030666 kostenfrei https://doaj.org/article/ba232e4d4eb34896bdc2b77bccf77ae6 kostenfrei https://www.mdpi.com/2075-1729/13/3/666 kostenfrei https://doaj.org/toc/2075-1729 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 13 2023 3, p 666
language	English
source	In Life 13(2023), 3, p 666 volume:13 year:2023 number:3, p 666
sourceStr	In Life 13(2023), 3, p 666 volume:13 year:2023 number:3, p 666
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	dual antiplatelet therapy DAPT one-month DAPT percutaneous coronary intervention PCI meta-analysis Science Q
isfreeaccess_bool	true
container_title	Life
authorswithroles_txt_mv	Grigorios Tsigkas @@aut@@ Anastasios Apostolos @@aut@@ David-Dimitrios Chlorogiannis @@aut@@ Elena Bousoula @@aut@@ Georgios Vasilagkos @@aut@@ Sotirios Tsalamandris @@aut@@ Ioannis Tsiafoutis @@aut@@ Konstantinos Katsanos @@aut@@ Konstantinos Toutouzas @@aut@@ Adel Aminian @@aut@@ Dimitrios Alexopoulos @@aut@@ Periklis Davlouros @@aut@@
publishDateDaySort_date	2023-01-01T00:00:00Z
hierarchy_top_id	718627156
id	DOAJ087314371
language_de	englisch
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author	Grigorios Tsigkas
spellingShingle	Grigorios Tsigkas misc dual antiplatelet therapy misc DAPT misc one-month DAPT misc percutaneous coronary intervention misc PCI misc meta-analysis misc Science misc Q Thirty-Days versus Longer Duration of Dual Antiplatelet Treatment after Percutaneous Coronary Interventions with Newer Drug-Eluting Stents: A Systematic Review and Meta-Analysis
authorStr	Grigorios Tsigkas
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topic_title	Thirty-Days versus Longer Duration of Dual Antiplatelet Treatment after Percutaneous Coronary Interventions with Newer Drug-Eluting Stents: A Systematic Review and Meta-Analysis dual antiplatelet therapy DAPT one-month DAPT percutaneous coronary intervention PCI meta-analysis
topic	misc dual antiplatelet therapy misc DAPT misc one-month DAPT misc percutaneous coronary intervention misc PCI misc meta-analysis misc Science misc Q
topic_unstemmed	misc dual antiplatelet therapy misc DAPT misc one-month DAPT misc percutaneous coronary intervention misc PCI misc meta-analysis misc Science misc Q
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title	Thirty-Days versus Longer Duration of Dual Antiplatelet Treatment after Percutaneous Coronary Interventions with Newer Drug-Eluting Stents: A Systematic Review and Meta-Analysis
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title_full	Thirty-Days versus Longer Duration of Dual Antiplatelet Treatment after Percutaneous Coronary Interventions with Newer Drug-Eluting Stents: A Systematic Review and Meta-Analysis
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author_browse	Grigorios Tsigkas Anastasios Apostolos David-Dimitrios Chlorogiannis Elena Bousoula Georgios Vasilagkos Sotirios Tsalamandris Ioannis Tsiafoutis Konstantinos Katsanos Konstantinos Toutouzas Adel Aminian Dimitrios Alexopoulos Periklis Davlouros
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title_sort	thirty-days versus longer duration of dual antiplatelet treatment after percutaneous coronary interventions with newer drug-eluting stents: a systematic review and meta-analysis
title_auth	Thirty-Days versus Longer Duration of Dual Antiplatelet Treatment after Percutaneous Coronary Interventions with Newer Drug-Eluting Stents: A Systematic Review and Meta-Analysis
abstract	Abbreviation of the duration of dual antiplatelet therapy (DAPT) (one or three months) has been recently proposed, especially for high bleeding risk patients, after percutaneous coronary intervention (PCI) with drug-eluting stent (DES). Three databases were screened for eligible randomized control trials. The primary endpoint was the incidence of net adverse clinical events (NACE). Secondary endpoints consisted of major adverse cardiovascular events (MACE), all-cause and cardiovascular mortality, myocardial infarction, stroke, stent-thrombosis, repeat revascularization and major bleeding. We included four RCTs with a total of 26,576 patients; 13,282 patients were grouped in 30-days DAPT, while the remaining 13,294 were allocated in a longer period of DAPT. One month of DAPT did not significantly reduce NACE (odds ratio [OR]: 0.87, 95% confidence intervals [Cl]: 0.74–1.03); however, major bleedings were significantly reduced by 22% (OR: 0.78, 95% Cl: 0.65–0.94). Mortality or ischemic events (stroke, myocardial infarction, revascularization and stent thrombosis) were not affected. Thus, 30-days DAPT could be considered as safe and feasible after PCI with DES in selected patients, especially those with high bleeding risk. Forthcoming RCTs could shed light on the optimal duration of DAPT.
abstractGer	Abbreviation of the duration of dual antiplatelet therapy (DAPT) (one or three months) has been recently proposed, especially for high bleeding risk patients, after percutaneous coronary intervention (PCI) with drug-eluting stent (DES). Three databases were screened for eligible randomized control trials. The primary endpoint was the incidence of net adverse clinical events (NACE). Secondary endpoints consisted of major adverse cardiovascular events (MACE), all-cause and cardiovascular mortality, myocardial infarction, stroke, stent-thrombosis, repeat revascularization and major bleeding. We included four RCTs with a total of 26,576 patients; 13,282 patients were grouped in 30-days DAPT, while the remaining 13,294 were allocated in a longer period of DAPT. One month of DAPT did not significantly reduce NACE (odds ratio [OR]: 0.87, 95% confidence intervals [Cl]: 0.74–1.03); however, major bleedings were significantly reduced by 22% (OR: 0.78, 95% Cl: 0.65–0.94). Mortality or ischemic events (stroke, myocardial infarction, revascularization and stent thrombosis) were not affected. Thus, 30-days DAPT could be considered as safe and feasible after PCI with DES in selected patients, especially those with high bleeding risk. Forthcoming RCTs could shed light on the optimal duration of DAPT.
abstract_unstemmed	Abbreviation of the duration of dual antiplatelet therapy (DAPT) (one or three months) has been recently proposed, especially for high bleeding risk patients, after percutaneous coronary intervention (PCI) with drug-eluting stent (DES). Three databases were screened for eligible randomized control trials. The primary endpoint was the incidence of net adverse clinical events (NACE). Secondary endpoints consisted of major adverse cardiovascular events (MACE), all-cause and cardiovascular mortality, myocardial infarction, stroke, stent-thrombosis, repeat revascularization and major bleeding. We included four RCTs with a total of 26,576 patients; 13,282 patients were grouped in 30-days DAPT, while the remaining 13,294 were allocated in a longer period of DAPT. One month of DAPT did not significantly reduce NACE (odds ratio [OR]: 0.87, 95% confidence intervals [Cl]: 0.74–1.03); however, major bleedings were significantly reduced by 22% (OR: 0.78, 95% Cl: 0.65–0.94). Mortality or ischemic events (stroke, myocardial infarction, revascularization and stent thrombosis) were not affected. Thus, 30-days DAPT could be considered as safe and feasible after PCI with DES in selected patients, especially those with high bleeding risk. Forthcoming RCTs could shed light on the optimal duration of DAPT.
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title_short	Thirty-Days versus Longer Duration of Dual Antiplatelet Treatment after Percutaneous Coronary Interventions with Newer Drug-Eluting Stents: A Systematic Review and Meta-Analysis
url	https://doi.org/10.3390/life13030666 https://doaj.org/article/ba232e4d4eb34896bdc2b77bccf77ae6 https://www.mdpi.com/2075-1729/13/3/666 https://doaj.org/toc/2075-1729
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author2	Anastasios Apostolos David-Dimitrios Chlorogiannis Elena Bousoula Georgios Vasilagkos Sotirios Tsalamandris Ioannis Tsiafoutis Konstantinos Katsanos Konstantinos Toutouzas Adel Aminian Dimitrios Alexopoulos Periklis Davlouros
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up_date	2024-07-04T01:09:47.827Z
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