Response of Human Gingival Fibroblasts and <i<Porphyromonas gingivalis</i< to UVC-Activated Titanium Surfaces

Ultraviolet (UV) photofunctionalization has been demonstrated to synergistically improve the osteoblast response and reduce biofilm formation on titanium (Ti) surfaces. However, it remains obscure how photofunctionalization affects soft tissue integration and microbial adhesion on the transmucosal p...
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Autor*in:	Yin Wen [verfasserIn] Hao Dong [verfasserIn] Jiating Lin [verfasserIn] Xianxian Zhuang [verfasserIn] Ruoting Xian [verfasserIn] Ping Li [verfasserIn] Shaobing Li [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2023

Schlagwörter:	titanium dental implants gingival sealing biofilm gingival fibroblasts

Übergeordnetes Werk:	In: Journal of Functional Biomaterials - MDPI AG, 2011, 14(2023), 3, p 137
Übergeordnetes Werk:	volume:14 ; year:2023 ; number:3, p 137

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3390/jfb14030137

Katalog-ID:	DOAJ087327244

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520			\|a Ultraviolet (UV) photofunctionalization has been demonstrated to synergistically improve the osteoblast response and reduce biofilm formation on titanium (Ti) surfaces. However, it remains obscure how photofunctionalization affects soft tissue integration and microbial adhesion on the transmucosal part of a dental implant. This study aimed to investigate the effect of UVC (100–280 nm) pretreatment on the response of human gingival fibroblasts (HGFs) and <i<Porphyromonas gingivalis</i< (<i<P. g.</i<) to Ti-based implant surfaces. The smooth and anodized nano-engineered Ti-based surfaces were triggered by UVC irradiation, respectively. The results showed that both smooth and nano-surfaces acquired super hydrophilicity without structural alteration after UVC photofunctionalization. UVC-activated smooth surfaces enhanced the adhesion and proliferation of HGFs compared to the untreated smooth ones. Regarding the anodized nano-engineered surfaces, UVC pretreatment weakened the fibroblast attachment but had no adverse effects on proliferation and the related gene expression. Additionally, both Ti-based surfaces could effectively inhibit <i<P. g</i<. adhesion after UVC irradiation. Therefore, the UVC photofunctionalization could be more potentially favorable to synergistically improve the fibroblast response and inhibit <i<P. g.</i< adhesion on the smooth Ti-based surfaces.
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callnumber-first	T - Technology
author	Yin Wen
spellingShingle	Yin Wen misc TP248.13-248.65 misc R5-920 misc titanium misc dental implants misc gingival sealing misc biofilm misc gingival fibroblasts misc <i<Porphyromonas gingivalis</i< misc Biotechnology misc Medicine (General) Response of Human Gingival Fibroblasts and <i<Porphyromonas gingivalis</i< to UVC-Activated Titanium Surfaces
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topic_title	TP248.13-248.65 R5-920 Response of Human Gingival Fibroblasts and <i<Porphyromonas gingivalis</i< to UVC-Activated Titanium Surfaces titanium dental implants gingival sealing biofilm gingival fibroblasts <i<Porphyromonas gingivalis</i<
topic	misc TP248.13-248.65 misc R5-920 misc titanium misc dental implants misc gingival sealing misc biofilm misc gingival fibroblasts misc <i<Porphyromonas gingivalis</i< misc Biotechnology misc Medicine (General)
topic_unstemmed	misc TP248.13-248.65 misc R5-920 misc titanium misc dental implants misc gingival sealing misc biofilm misc gingival fibroblasts misc <i<Porphyromonas gingivalis</i< misc Biotechnology misc Medicine (General)
topic_browse	misc TP248.13-248.65 misc R5-920 misc titanium misc dental implants misc gingival sealing misc biofilm misc gingival fibroblasts misc <i<Porphyromonas gingivalis</i< misc Biotechnology misc Medicine (General)
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title	Response of Human Gingival Fibroblasts and <i<Porphyromonas gingivalis</i< to UVC-Activated Titanium Surfaces
ctrlnum	(DE-627)DOAJ087327244 (DE-599)DOAJ528720f334904132b374828230dd15f2
title_full	Response of Human Gingival Fibroblasts and <i<Porphyromonas gingivalis</i< to UVC-Activated Titanium Surfaces
author_sort	Yin Wen
journal	Journal of Functional Biomaterials
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author_browse	Yin Wen Hao Dong Jiating Lin Xianxian Zhuang Ruoting Xian Ping Li Shaobing Li
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format_se	Elektronische Aufsätze
author-letter	Yin Wen
doi_str_mv	10.3390/jfb14030137
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title_sort	response of human gingival fibroblasts and <i<porphyromonas gingivalis</i< to uvc-activated titanium surfaces
callnumber	TP248.13-248.65
title_auth	Response of Human Gingival Fibroblasts and <i<Porphyromonas gingivalis</i< to UVC-Activated Titanium Surfaces
abstract	Ultraviolet (UV) photofunctionalization has been demonstrated to synergistically improve the osteoblast response and reduce biofilm formation on titanium (Ti) surfaces. However, it remains obscure how photofunctionalization affects soft tissue integration and microbial adhesion on the transmucosal part of a dental implant. This study aimed to investigate the effect of UVC (100–280 nm) pretreatment on the response of human gingival fibroblasts (HGFs) and <i<Porphyromonas gingivalis</i< (<i<P. g.</i<) to Ti-based implant surfaces. The smooth and anodized nano-engineered Ti-based surfaces were triggered by UVC irradiation, respectively. The results showed that both smooth and nano-surfaces acquired super hydrophilicity without structural alteration after UVC photofunctionalization. UVC-activated smooth surfaces enhanced the adhesion and proliferation of HGFs compared to the untreated smooth ones. Regarding the anodized nano-engineered surfaces, UVC pretreatment weakened the fibroblast attachment but had no adverse effects on proliferation and the related gene expression. Additionally, both Ti-based surfaces could effectively inhibit <i<P. g</i<. adhesion after UVC irradiation. Therefore, the UVC photofunctionalization could be more potentially favorable to synergistically improve the fibroblast response and inhibit <i<P. g.</i< adhesion on the smooth Ti-based surfaces.
abstractGer	Ultraviolet (UV) photofunctionalization has been demonstrated to synergistically improve the osteoblast response and reduce biofilm formation on titanium (Ti) surfaces. However, it remains obscure how photofunctionalization affects soft tissue integration and microbial adhesion on the transmucosal part of a dental implant. This study aimed to investigate the effect of UVC (100–280 nm) pretreatment on the response of human gingival fibroblasts (HGFs) and <i<Porphyromonas gingivalis</i< (<i<P. g.</i<) to Ti-based implant surfaces. The smooth and anodized nano-engineered Ti-based surfaces were triggered by UVC irradiation, respectively. The results showed that both smooth and nano-surfaces acquired super hydrophilicity without structural alteration after UVC photofunctionalization. UVC-activated smooth surfaces enhanced the adhesion and proliferation of HGFs compared to the untreated smooth ones. Regarding the anodized nano-engineered surfaces, UVC pretreatment weakened the fibroblast attachment but had no adverse effects on proliferation and the related gene expression. Additionally, both Ti-based surfaces could effectively inhibit <i<P. g</i<. adhesion after UVC irradiation. Therefore, the UVC photofunctionalization could be more potentially favorable to synergistically improve the fibroblast response and inhibit <i<P. g.</i< adhesion on the smooth Ti-based surfaces.
abstract_unstemmed	Ultraviolet (UV) photofunctionalization has been demonstrated to synergistically improve the osteoblast response and reduce biofilm formation on titanium (Ti) surfaces. However, it remains obscure how photofunctionalization affects soft tissue integration and microbial adhesion on the transmucosal part of a dental implant. This study aimed to investigate the effect of UVC (100–280 nm) pretreatment on the response of human gingival fibroblasts (HGFs) and <i<Porphyromonas gingivalis</i< (<i<P. g.</i<) to Ti-based implant surfaces. The smooth and anodized nano-engineered Ti-based surfaces were triggered by UVC irradiation, respectively. The results showed that both smooth and nano-surfaces acquired super hydrophilicity without structural alteration after UVC photofunctionalization. UVC-activated smooth surfaces enhanced the adhesion and proliferation of HGFs compared to the untreated smooth ones. Regarding the anodized nano-engineered surfaces, UVC pretreatment weakened the fibroblast attachment but had no adverse effects on proliferation and the related gene expression. Additionally, both Ti-based surfaces could effectively inhibit <i<P. g</i<. adhesion after UVC irradiation. Therefore, the UVC photofunctionalization could be more potentially favorable to synergistically improve the fibroblast response and inhibit <i<P. g.</i< adhesion on the smooth Ti-based surfaces.
collection_details	GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700
container_issue	3, p 137
title_short	Response of Human Gingival Fibroblasts and <i<Porphyromonas gingivalis</i< to UVC-Activated Titanium Surfaces
url	https://doi.org/10.3390/jfb14030137 https://doaj.org/article/528720f334904132b374828230dd15f2 https://www.mdpi.com/2079-4983/14/3/137 https://doaj.org/toc/2079-4983
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author2	Hao Dong Jiating Lin Xianxian Zhuang Ruoting Xian Ping Li Shaobing Li
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up_date	2024-07-04T01:13:02.361Z
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Response of Human Gingival Fibroblasts and <i<Porphyromonas gingivalis</i< to UVC-Activated Titanium Surfaces

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