Complement Binding Anti-HLA Antibodies and the Survival of Kidney Transplantation

Background: Antibody-mediated rejection (AMR) is one of the most important challenges in the context of renal transplantation, because the binding of de novo donor-specific antibodies (dnDSA) to the kidney graft triggers the activation of the complement, which in turn leads to loss of transplant. In...
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Gespeichert in:

Autor*in:	Claudia M. Muñoz-Herrera [verfasserIn] Juan Francisco Gutiérrez-Bautista [verfasserIn] Miguel Ángel López-Nevot [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2023

Schlagwörter:	AMR, antibody-mediated rejection DSA, donor-specific antibodies dnDSA, de novo donor-specific antibodies complement-fixing DSA renal transplant kidney graft

Übergeordnetes Werk:	In: Journal of Clinical Medicine - MDPI AG, 2013, 12(2023), 6, p 2335
Übergeordnetes Werk:	volume:12 ; year:2023 ; number:6, p 2335

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3390/jcm12062335

Katalog-ID:	DOAJ087329174

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520			\|a Background: Antibody-mediated rejection (AMR) is one of the most important challenges in the context of renal transplantation, because the binding of de novo donor-specific antibodies (dnDSA) to the kidney graft triggers the activation of the complement, which in turn leads to loss of transplant. In this context, the objective of this study was to evaluate the association between complement-fixing dnDSA antibodies and graft loss as well as the possible association between non-complement-fixing antibodies and transplanted organ survival in kidney transplant recipients. Methods: Our study included a cohort of 245 transplant patients over a 5-year period at Virgen de las Nieves University Hospital (HUVN) in Granada, Spain. Results: dnDSA was observed in 26 patients. Of these patients, 17 had non-complement-fixing dnDSA and 9 had complement-fixing dnDSA. Conclusions: Our study demonstrated a significant association between the frequency of rejection and renal graft loss and the presence of C1q-binding dnDSA. Our results show the importance of the individualization of dnDSA, classifying them according to their ability to activate the complement, and suggest that the detection of complement-binding capacity by dnDSA could be used as a prognostic marker to predict AMR outcome and graft survival in kidney transplant patients who develop dnDSA.
650		4	\|a AMR, antibody-mediated rejection
650		4	\|a DSA, donor-specific antibodies
650		4	\|a dnDSA, de novo donor-specific antibodies
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allfields	10.3390/jcm12062335 doi (DE-627)DOAJ087329174 (DE-599)DOAJc3b3601c0f53417b862d75a3a0094245 DE-627 ger DE-627 rakwb eng Claudia M. Muñoz-Herrera verfasserin aut Complement Binding Anti-HLA Antibodies and the Survival of Kidney Transplantation 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: Antibody-mediated rejection (AMR) is one of the most important challenges in the context of renal transplantation, because the binding of de novo donor-specific antibodies (dnDSA) to the kidney graft triggers the activation of the complement, which in turn leads to loss of transplant. In this context, the objective of this study was to evaluate the association between complement-fixing dnDSA antibodies and graft loss as well as the possible association between non-complement-fixing antibodies and transplanted organ survival in kidney transplant recipients. Methods: Our study included a cohort of 245 transplant patients over a 5-year period at Virgen de las Nieves University Hospital (HUVN) in Granada, Spain. Results: dnDSA was observed in 26 patients. Of these patients, 17 had non-complement-fixing dnDSA and 9 had complement-fixing dnDSA. Conclusions: Our study demonstrated a significant association between the frequency of rejection and renal graft loss and the presence of C1q-binding dnDSA. Our results show the importance of the individualization of dnDSA, classifying them according to their ability to activate the complement, and suggest that the detection of complement-binding capacity by dnDSA could be used as a prognostic marker to predict AMR outcome and graft survival in kidney transplant patients who develop dnDSA. AMR, antibody-mediated rejection DSA, donor-specific antibodies dnDSA, de novo donor-specific antibodies complement-fixing DSA renal transplant kidney graft Medicine R Juan Francisco Gutiérrez-Bautista verfasserin aut Miguel Ángel López-Nevot verfasserin aut In Journal of Clinical Medicine MDPI AG, 2013 12(2023), 6, p 2335 (DE-627)718632478 (DE-600)2662592-1 20770383 nnns volume:12 year:2023 number:6, p 2335 https://doi.org/10.3390/jcm12062335 kostenfrei https://doaj.org/article/c3b3601c0f53417b862d75a3a0094245 kostenfrei https://www.mdpi.com/2077-0383/12/6/2335 kostenfrei https://doaj.org/toc/2077-0383 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2023 6, p 2335
spelling	10.3390/jcm12062335 doi (DE-627)DOAJ087329174 (DE-599)DOAJc3b3601c0f53417b862d75a3a0094245 DE-627 ger DE-627 rakwb eng Claudia M. Muñoz-Herrera verfasserin aut Complement Binding Anti-HLA Antibodies and the Survival of Kidney Transplantation 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: Antibody-mediated rejection (AMR) is one of the most important challenges in the context of renal transplantation, because the binding of de novo donor-specific antibodies (dnDSA) to the kidney graft triggers the activation of the complement, which in turn leads to loss of transplant. In this context, the objective of this study was to evaluate the association between complement-fixing dnDSA antibodies and graft loss as well as the possible association between non-complement-fixing antibodies and transplanted organ survival in kidney transplant recipients. Methods: Our study included a cohort of 245 transplant patients over a 5-year period at Virgen de las Nieves University Hospital (HUVN) in Granada, Spain. Results: dnDSA was observed in 26 patients. Of these patients, 17 had non-complement-fixing dnDSA and 9 had complement-fixing dnDSA. Conclusions: Our study demonstrated a significant association between the frequency of rejection and renal graft loss and the presence of C1q-binding dnDSA. Our results show the importance of the individualization of dnDSA, classifying them according to their ability to activate the complement, and suggest that the detection of complement-binding capacity by dnDSA could be used as a prognostic marker to predict AMR outcome and graft survival in kidney transplant patients who develop dnDSA. AMR, antibody-mediated rejection DSA, donor-specific antibodies dnDSA, de novo donor-specific antibodies complement-fixing DSA renal transplant kidney graft Medicine R Juan Francisco Gutiérrez-Bautista verfasserin aut Miguel Ángel López-Nevot verfasserin aut In Journal of Clinical Medicine MDPI AG, 2013 12(2023), 6, p 2335 (DE-627)718632478 (DE-600)2662592-1 20770383 nnns volume:12 year:2023 number:6, p 2335 https://doi.org/10.3390/jcm12062335 kostenfrei https://doaj.org/article/c3b3601c0f53417b862d75a3a0094245 kostenfrei https://www.mdpi.com/2077-0383/12/6/2335 kostenfrei https://doaj.org/toc/2077-0383 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2023 6, p 2335
allfields_unstemmed	10.3390/jcm12062335 doi (DE-627)DOAJ087329174 (DE-599)DOAJc3b3601c0f53417b862d75a3a0094245 DE-627 ger DE-627 rakwb eng Claudia M. Muñoz-Herrera verfasserin aut Complement Binding Anti-HLA Antibodies and the Survival of Kidney Transplantation 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: Antibody-mediated rejection (AMR) is one of the most important challenges in the context of renal transplantation, because the binding of de novo donor-specific antibodies (dnDSA) to the kidney graft triggers the activation of the complement, which in turn leads to loss of transplant. In this context, the objective of this study was to evaluate the association between complement-fixing dnDSA antibodies and graft loss as well as the possible association between non-complement-fixing antibodies and transplanted organ survival in kidney transplant recipients. Methods: Our study included a cohort of 245 transplant patients over a 5-year period at Virgen de las Nieves University Hospital (HUVN) in Granada, Spain. Results: dnDSA was observed in 26 patients. Of these patients, 17 had non-complement-fixing dnDSA and 9 had complement-fixing dnDSA. Conclusions: Our study demonstrated a significant association between the frequency of rejection and renal graft loss and the presence of C1q-binding dnDSA. Our results show the importance of the individualization of dnDSA, classifying them according to their ability to activate the complement, and suggest that the detection of complement-binding capacity by dnDSA could be used as a prognostic marker to predict AMR outcome and graft survival in kidney transplant patients who develop dnDSA. AMR, antibody-mediated rejection DSA, donor-specific antibodies dnDSA, de novo donor-specific antibodies complement-fixing DSA renal transplant kidney graft Medicine R Juan Francisco Gutiérrez-Bautista verfasserin aut Miguel Ángel López-Nevot verfasserin aut In Journal of Clinical Medicine MDPI AG, 2013 12(2023), 6, p 2335 (DE-627)718632478 (DE-600)2662592-1 20770383 nnns volume:12 year:2023 number:6, p 2335 https://doi.org/10.3390/jcm12062335 kostenfrei https://doaj.org/article/c3b3601c0f53417b862d75a3a0094245 kostenfrei https://www.mdpi.com/2077-0383/12/6/2335 kostenfrei https://doaj.org/toc/2077-0383 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2023 6, p 2335
allfieldsGer	10.3390/jcm12062335 doi (DE-627)DOAJ087329174 (DE-599)DOAJc3b3601c0f53417b862d75a3a0094245 DE-627 ger DE-627 rakwb eng Claudia M. Muñoz-Herrera verfasserin aut Complement Binding Anti-HLA Antibodies and the Survival of Kidney Transplantation 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: Antibody-mediated rejection (AMR) is one of the most important challenges in the context of renal transplantation, because the binding of de novo donor-specific antibodies (dnDSA) to the kidney graft triggers the activation of the complement, which in turn leads to loss of transplant. In this context, the objective of this study was to evaluate the association between complement-fixing dnDSA antibodies and graft loss as well as the possible association between non-complement-fixing antibodies and transplanted organ survival in kidney transplant recipients. Methods: Our study included a cohort of 245 transplant patients over a 5-year period at Virgen de las Nieves University Hospital (HUVN) in Granada, Spain. Results: dnDSA was observed in 26 patients. Of these patients, 17 had non-complement-fixing dnDSA and 9 had complement-fixing dnDSA. Conclusions: Our study demonstrated a significant association between the frequency of rejection and renal graft loss and the presence of C1q-binding dnDSA. Our results show the importance of the individualization of dnDSA, classifying them according to their ability to activate the complement, and suggest that the detection of complement-binding capacity by dnDSA could be used as a prognostic marker to predict AMR outcome and graft survival in kidney transplant patients who develop dnDSA. AMR, antibody-mediated rejection DSA, donor-specific antibodies dnDSA, de novo donor-specific antibodies complement-fixing DSA renal transplant kidney graft Medicine R Juan Francisco Gutiérrez-Bautista verfasserin aut Miguel Ángel López-Nevot verfasserin aut In Journal of Clinical Medicine MDPI AG, 2013 12(2023), 6, p 2335 (DE-627)718632478 (DE-600)2662592-1 20770383 nnns volume:12 year:2023 number:6, p 2335 https://doi.org/10.3390/jcm12062335 kostenfrei https://doaj.org/article/c3b3601c0f53417b862d75a3a0094245 kostenfrei https://www.mdpi.com/2077-0383/12/6/2335 kostenfrei https://doaj.org/toc/2077-0383 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2023 6, p 2335
allfieldsSound	10.3390/jcm12062335 doi (DE-627)DOAJ087329174 (DE-599)DOAJc3b3601c0f53417b862d75a3a0094245 DE-627 ger DE-627 rakwb eng Claudia M. Muñoz-Herrera verfasserin aut Complement Binding Anti-HLA Antibodies and the Survival of Kidney Transplantation 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: Antibody-mediated rejection (AMR) is one of the most important challenges in the context of renal transplantation, because the binding of de novo donor-specific antibodies (dnDSA) to the kidney graft triggers the activation of the complement, which in turn leads to loss of transplant. In this context, the objective of this study was to evaluate the association between complement-fixing dnDSA antibodies and graft loss as well as the possible association between non-complement-fixing antibodies and transplanted organ survival in kidney transplant recipients. Methods: Our study included a cohort of 245 transplant patients over a 5-year period at Virgen de las Nieves University Hospital (HUVN) in Granada, Spain. Results: dnDSA was observed in 26 patients. Of these patients, 17 had non-complement-fixing dnDSA and 9 had complement-fixing dnDSA. Conclusions: Our study demonstrated a significant association between the frequency of rejection and renal graft loss and the presence of C1q-binding dnDSA. Our results show the importance of the individualization of dnDSA, classifying them according to their ability to activate the complement, and suggest that the detection of complement-binding capacity by dnDSA could be used as a prognostic marker to predict AMR outcome and graft survival in kidney transplant patients who develop dnDSA. AMR, antibody-mediated rejection DSA, donor-specific antibodies dnDSA, de novo donor-specific antibodies complement-fixing DSA renal transplant kidney graft Medicine R Juan Francisco Gutiérrez-Bautista verfasserin aut Miguel Ángel López-Nevot verfasserin aut In Journal of Clinical Medicine MDPI AG, 2013 12(2023), 6, p 2335 (DE-627)718632478 (DE-600)2662592-1 20770383 nnns volume:12 year:2023 number:6, p 2335 https://doi.org/10.3390/jcm12062335 kostenfrei https://doaj.org/article/c3b3601c0f53417b862d75a3a0094245 kostenfrei https://www.mdpi.com/2077-0383/12/6/2335 kostenfrei https://doaj.org/toc/2077-0383 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2023 6, p 2335
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In this context, the objective of this study was to evaluate the association between complement-fixing dnDSA antibodies and graft loss as well as the possible association between non-complement-fixing antibodies and transplanted organ survival in kidney transplant recipients. Methods: Our study included a cohort of 245 transplant patients over a 5-year period at Virgen de las Nieves University Hospital (HUVN) in Granada, Spain. Results: dnDSA was observed in 26 patients. Of these patients, 17 had non-complement-fixing dnDSA and 9 had complement-fixing dnDSA. Conclusions: Our study demonstrated a significant association between the frequency of rejection and renal graft loss and the presence of C1q-binding dnDSA. 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author	Claudia M. Muñoz-Herrera
spellingShingle	Claudia M. Muñoz-Herrera misc AMR, antibody-mediated rejection misc DSA, donor-specific antibodies misc dnDSA, de novo donor-specific antibodies misc complement-fixing DSA misc renal transplant misc kidney graft misc Medicine misc R Complement Binding Anti-HLA Antibodies and the Survival of Kidney Transplantation
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topic_title	Complement Binding Anti-HLA Antibodies and the Survival of Kidney Transplantation AMR, antibody-mediated rejection DSA, donor-specific antibodies dnDSA, de novo donor-specific antibodies complement-fixing DSA renal transplant kidney graft
topic	misc AMR, antibody-mediated rejection misc DSA, donor-specific antibodies misc dnDSA, de novo donor-specific antibodies misc complement-fixing DSA misc renal transplant misc kidney graft misc Medicine misc R
topic_unstemmed	misc AMR, antibody-mediated rejection misc DSA, donor-specific antibodies misc dnDSA, de novo donor-specific antibodies misc complement-fixing DSA misc renal transplant misc kidney graft misc Medicine misc R
topic_browse	misc AMR, antibody-mediated rejection misc DSA, donor-specific antibodies misc dnDSA, de novo donor-specific antibodies misc complement-fixing DSA misc renal transplant misc kidney graft misc Medicine misc R
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title	Complement Binding Anti-HLA Antibodies and the Survival of Kidney Transplantation
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title_full	Complement Binding Anti-HLA Antibodies and the Survival of Kidney Transplantation
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author_browse	Claudia M. Muñoz-Herrera Juan Francisco Gutiérrez-Bautista Miguel Ángel López-Nevot
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title_sort	complement binding anti-hla antibodies and the survival of kidney transplantation
title_auth	Complement Binding Anti-HLA Antibodies and the Survival of Kidney Transplantation
abstract	Background: Antibody-mediated rejection (AMR) is one of the most important challenges in the context of renal transplantation, because the binding of de novo donor-specific antibodies (dnDSA) to the kidney graft triggers the activation of the complement, which in turn leads to loss of transplant. In this context, the objective of this study was to evaluate the association between complement-fixing dnDSA antibodies and graft loss as well as the possible association between non-complement-fixing antibodies and transplanted organ survival in kidney transplant recipients. Methods: Our study included a cohort of 245 transplant patients over a 5-year period at Virgen de las Nieves University Hospital (HUVN) in Granada, Spain. Results: dnDSA was observed in 26 patients. Of these patients, 17 had non-complement-fixing dnDSA and 9 had complement-fixing dnDSA. Conclusions: Our study demonstrated a significant association between the frequency of rejection and renal graft loss and the presence of C1q-binding dnDSA. Our results show the importance of the individualization of dnDSA, classifying them according to their ability to activate the complement, and suggest that the detection of complement-binding capacity by dnDSA could be used as a prognostic marker to predict AMR outcome and graft survival in kidney transplant patients who develop dnDSA.
abstractGer	Background: Antibody-mediated rejection (AMR) is one of the most important challenges in the context of renal transplantation, because the binding of de novo donor-specific antibodies (dnDSA) to the kidney graft triggers the activation of the complement, which in turn leads to loss of transplant. In this context, the objective of this study was to evaluate the association between complement-fixing dnDSA antibodies and graft loss as well as the possible association between non-complement-fixing antibodies and transplanted organ survival in kidney transplant recipients. Methods: Our study included a cohort of 245 transplant patients over a 5-year period at Virgen de las Nieves University Hospital (HUVN) in Granada, Spain. Results: dnDSA was observed in 26 patients. Of these patients, 17 had non-complement-fixing dnDSA and 9 had complement-fixing dnDSA. Conclusions: Our study demonstrated a significant association between the frequency of rejection and renal graft loss and the presence of C1q-binding dnDSA. Our results show the importance of the individualization of dnDSA, classifying them according to their ability to activate the complement, and suggest that the detection of complement-binding capacity by dnDSA could be used as a prognostic marker to predict AMR outcome and graft survival in kidney transplant patients who develop dnDSA.
abstract_unstemmed	Background: Antibody-mediated rejection (AMR) is one of the most important challenges in the context of renal transplantation, because the binding of de novo donor-specific antibodies (dnDSA) to the kidney graft triggers the activation of the complement, which in turn leads to loss of transplant. In this context, the objective of this study was to evaluate the association between complement-fixing dnDSA antibodies and graft loss as well as the possible association between non-complement-fixing antibodies and transplanted organ survival in kidney transplant recipients. Methods: Our study included a cohort of 245 transplant patients over a 5-year period at Virgen de las Nieves University Hospital (HUVN) in Granada, Spain. Results: dnDSA was observed in 26 patients. Of these patients, 17 had non-complement-fixing dnDSA and 9 had complement-fixing dnDSA. Conclusions: Our study demonstrated a significant association between the frequency of rejection and renal graft loss and the presence of C1q-binding dnDSA. Our results show the importance of the individualization of dnDSA, classifying them according to their ability to activate the complement, and suggest that the detection of complement-binding capacity by dnDSA could be used as a prognostic marker to predict AMR outcome and graft survival in kidney transplant patients who develop dnDSA.
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title_short	Complement Binding Anti-HLA Antibodies and the Survival of Kidney Transplantation
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author2	Juan Francisco Gutiérrez-Bautista Miguel Ángel López-Nevot
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Complement Binding Anti-HLA Antibodies and the Survival of Kidney Transplantation

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