Conditioned Medium of Mesenchymal Stromal Cells Loaded with Paclitaxel Is Effective in Preclinical Models of Triple-Negative Breast Cancer (TNBC)

Triple-negative breast cancer (TNBC) is a very aggressive disease even in its early stages and is characterized by a severe prognosis. Neoadjuvant chemotherapy is one of the milestones of treatment, and paclitaxel (PTX) is among the most active drugs used in this setting. However, despite its effica...
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Autor*in:	Nicoletta Cordani [verfasserIn] Daniela Lisini [verfasserIn] Valentina Coccè [verfasserIn] Giuseppe Paglia [verfasserIn] Ramona Meanti [verfasserIn] Maria Grazia Cerrito [verfasserIn] Pietro Tettamanti [verfasserIn] Luca Bonaffini [verfasserIn] Francesca Paino [verfasserIn] Giulio Alessandri [verfasserIn] Angela Marcianti [verfasserIn] Aldo Giannì [verfasserIn] Chiara Villa [verfasserIn] Mario Mauri [verfasserIn] Luca Mologni [verfasserIn] Antonio Torsello [verfasserIn] Augusto Pessina [verfasserIn] Marina Elena Cazzaniga [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2023

Schlagwörter:	paclitaxel mesenchymal stromal cells triple-negative breast cancer

Übergeordnetes Werk:	In: International Journal of Molecular Sciences - MDPI AG, 2003, 24(2023), 6, p 5864
Übergeordnetes Werk:	volume:24 ; year:2023 ; number:6, p 5864

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc Journal toc

DOI / URN:	10.3390/ijms24065864

Katalog-ID:	DOAJ087337371

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allfieldsSound	10.3390/ijms24065864 doi (DE-627)DOAJ087337371 (DE-599)DOAJe11a3b513a2041e0bac041e02afa0900 DE-627 ger DE-627 rakwb eng QH301-705.5 QD1-999 Nicoletta Cordani verfasserin aut Conditioned Medium of Mesenchymal Stromal Cells Loaded with Paclitaxel Is Effective in Preclinical Models of Triple-Negative Breast Cancer (TNBC) 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Triple-negative breast cancer (TNBC) is a very aggressive disease even in its early stages and is characterized by a severe prognosis. Neoadjuvant chemotherapy is one of the milestones of treatment, and paclitaxel (PTX) is among the most active drugs used in this setting. However, despite its efficacy, peripheral neuropathy occurs in approximately 20–25% of cases and represents the dose-limiting toxicity of this drug. New deliverable strategies to ameliorate drug delivery and reduce side effects are keenly awaited to improve patients’ outcomes. Mesenchymal stromal cells (MSCs) have recently been demonstrated as promising drug delivery vectors for cancer treatment. The aim of the present preclinical study is to explore the possibility of a cell therapy approach based on the use of MSCs loaded with PTX to treat TNBC-affected patients. For this purpose, we in vitro evaluated the viability, migration and colony formation of two TNBC cell lines, namely, MDA-MB-231 and BT549, treated with MSC-PTX conditioned medium (MSC-CM PTX) in comparison with both CM of MSCs not loaded with PTX (CTRL) and free PTX. We observed stronger inhibitory effects on survival, migration and tumorigenicity for MSC-CM PTX than for CTRL and free PTX in TNBC cell lines. Further studies will provide more information about activity and potentially open the possibility of using this new drug delivery vector in the context of a clinical study. paclitaxel mesenchymal stromal cells triple-negative breast cancer Biology (General) Chemistry Daniela Lisini verfasserin aut Valentina Coccè verfasserin aut Giuseppe Paglia verfasserin aut Ramona Meanti verfasserin aut Maria Grazia Cerrito verfasserin aut Pietro Tettamanti verfasserin aut Luca Bonaffini verfasserin aut Francesca Paino verfasserin aut Giulio Alessandri verfasserin aut Angela Marcianti verfasserin aut Aldo Giannì verfasserin aut Chiara Villa verfasserin aut Mario Mauri verfasserin aut Luca Mologni verfasserin aut Antonio Torsello verfasserin aut Augusto Pessina verfasserin aut Marina Elena Cazzaniga verfasserin aut In International Journal of Molecular Sciences MDPI AG, 2003 24(2023), 6, p 5864 (DE-627)316340715 (DE-600)2019364-6 14220067 nnns volume:24 year:2023 number:6, p 5864 https://doi.org/10.3390/ijms24065864 kostenfrei https://doaj.org/article/e11a3b513a2041e0bac041e02afa0900 kostenfrei https://www.mdpi.com/1422-0067/24/6/5864 kostenfrei https://doaj.org/toc/1661-6596 Journal toc kostenfrei https://doaj.org/toc/1422-0067 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 24 2023 6, p 5864
language	English
source	In International Journal of Molecular Sciences 24(2023), 6, p 5864 volume:24 year:2023 number:6, p 5864
sourceStr	In International Journal of Molecular Sciences 24(2023), 6, p 5864 volume:24 year:2023 number:6, p 5864
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	paclitaxel mesenchymal stromal cells triple-negative breast cancer Biology (General) Chemistry
isfreeaccess_bool	true
container_title	International Journal of Molecular Sciences
authorswithroles_txt_mv	Nicoletta Cordani @@aut@@ Daniela Lisini @@aut@@ Valentina Coccè @@aut@@ Giuseppe Paglia @@aut@@ Ramona Meanti @@aut@@ Maria Grazia Cerrito @@aut@@ Pietro Tettamanti @@aut@@ Luca Bonaffini @@aut@@ Francesca Paino @@aut@@ Giulio Alessandri @@aut@@ Angela Marcianti @@aut@@ Aldo Giannì @@aut@@ Chiara Villa @@aut@@ Mario Mauri @@aut@@ Luca Mologni @@aut@@ Antonio Torsello @@aut@@ Augusto Pessina @@aut@@ Marina Elena Cazzaniga @@aut@@
publishDateDaySort_date	2023-01-01T00:00:00Z
hierarchy_top_id	316340715
id	DOAJ087337371
language_de	englisch
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callnumber-first	Q - Science
author	Nicoletta Cordani
spellingShingle	Nicoletta Cordani misc QH301-705.5 misc QD1-999 misc paclitaxel misc mesenchymal stromal cells misc triple-negative breast cancer misc Biology (General) misc Chemistry Conditioned Medium of Mesenchymal Stromal Cells Loaded with Paclitaxel Is Effective in Preclinical Models of Triple-Negative Breast Cancer (TNBC)
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topic_title	QH301-705.5 QD1-999 Conditioned Medium of Mesenchymal Stromal Cells Loaded with Paclitaxel Is Effective in Preclinical Models of Triple-Negative Breast Cancer (TNBC) paclitaxel mesenchymal stromal cells triple-negative breast cancer
topic	misc QH301-705.5 misc QD1-999 misc paclitaxel misc mesenchymal stromal cells misc triple-negative breast cancer misc Biology (General) misc Chemistry
topic_unstemmed	misc QH301-705.5 misc QD1-999 misc paclitaxel misc mesenchymal stromal cells misc triple-negative breast cancer misc Biology (General) misc Chemistry
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title	Conditioned Medium of Mesenchymal Stromal Cells Loaded with Paclitaxel Is Effective in Preclinical Models of Triple-Negative Breast Cancer (TNBC)
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title_full	Conditioned Medium of Mesenchymal Stromal Cells Loaded with Paclitaxel Is Effective in Preclinical Models of Triple-Negative Breast Cancer (TNBC)
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author_browse	Nicoletta Cordani Daniela Lisini Valentina Coccè Giuseppe Paglia Ramona Meanti Maria Grazia Cerrito Pietro Tettamanti Luca Bonaffini Francesca Paino Giulio Alessandri Angela Marcianti Aldo Giannì Chiara Villa Mario Mauri Luca Mologni Antonio Torsello Augusto Pessina Marina Elena Cazzaniga
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title_sort	conditioned medium of mesenchymal stromal cells loaded with paclitaxel is effective in preclinical models of triple-negative breast cancer (tnbc)
callnumber	QH301-705.5
title_auth	Conditioned Medium of Mesenchymal Stromal Cells Loaded with Paclitaxel Is Effective in Preclinical Models of Triple-Negative Breast Cancer (TNBC)
abstract	Triple-negative breast cancer (TNBC) is a very aggressive disease even in its early stages and is characterized by a severe prognosis. Neoadjuvant chemotherapy is one of the milestones of treatment, and paclitaxel (PTX) is among the most active drugs used in this setting. However, despite its efficacy, peripheral neuropathy occurs in approximately 20–25% of cases and represents the dose-limiting toxicity of this drug. New deliverable strategies to ameliorate drug delivery and reduce side effects are keenly awaited to improve patients’ outcomes. Mesenchymal stromal cells (MSCs) have recently been demonstrated as promising drug delivery vectors for cancer treatment. The aim of the present preclinical study is to explore the possibility of a cell therapy approach based on the use of MSCs loaded with PTX to treat TNBC-affected patients. For this purpose, we in vitro evaluated the viability, migration and colony formation of two TNBC cell lines, namely, MDA-MB-231 and BT549, treated with MSC-PTX conditioned medium (MSC-CM PTX) in comparison with both CM of MSCs not loaded with PTX (CTRL) and free PTX. We observed stronger inhibitory effects on survival, migration and tumorigenicity for MSC-CM PTX than for CTRL and free PTX in TNBC cell lines. Further studies will provide more information about activity and potentially open the possibility of using this new drug delivery vector in the context of a clinical study.
abstractGer	Triple-negative breast cancer (TNBC) is a very aggressive disease even in its early stages and is characterized by a severe prognosis. Neoadjuvant chemotherapy is one of the milestones of treatment, and paclitaxel (PTX) is among the most active drugs used in this setting. However, despite its efficacy, peripheral neuropathy occurs in approximately 20–25% of cases and represents the dose-limiting toxicity of this drug. New deliverable strategies to ameliorate drug delivery and reduce side effects are keenly awaited to improve patients’ outcomes. Mesenchymal stromal cells (MSCs) have recently been demonstrated as promising drug delivery vectors for cancer treatment. The aim of the present preclinical study is to explore the possibility of a cell therapy approach based on the use of MSCs loaded with PTX to treat TNBC-affected patients. For this purpose, we in vitro evaluated the viability, migration and colony formation of two TNBC cell lines, namely, MDA-MB-231 and BT549, treated with MSC-PTX conditioned medium (MSC-CM PTX) in comparison with both CM of MSCs not loaded with PTX (CTRL) and free PTX. We observed stronger inhibitory effects on survival, migration and tumorigenicity for MSC-CM PTX than for CTRL and free PTX in TNBC cell lines. Further studies will provide more information about activity and potentially open the possibility of using this new drug delivery vector in the context of a clinical study.
abstract_unstemmed	Triple-negative breast cancer (TNBC) is a very aggressive disease even in its early stages and is characterized by a severe prognosis. Neoadjuvant chemotherapy is one of the milestones of treatment, and paclitaxel (PTX) is among the most active drugs used in this setting. However, despite its efficacy, peripheral neuropathy occurs in approximately 20–25% of cases and represents the dose-limiting toxicity of this drug. New deliverable strategies to ameliorate drug delivery and reduce side effects are keenly awaited to improve patients’ outcomes. Mesenchymal stromal cells (MSCs) have recently been demonstrated as promising drug delivery vectors for cancer treatment. The aim of the present preclinical study is to explore the possibility of a cell therapy approach based on the use of MSCs loaded with PTX to treat TNBC-affected patients. For this purpose, we in vitro evaluated the viability, migration and colony formation of two TNBC cell lines, namely, MDA-MB-231 and BT549, treated with MSC-PTX conditioned medium (MSC-CM PTX) in comparison with both CM of MSCs not loaded with PTX (CTRL) and free PTX. We observed stronger inhibitory effects on survival, migration and tumorigenicity for MSC-CM PTX than for CTRL and free PTX in TNBC cell lines. Further studies will provide more information about activity and potentially open the possibility of using this new drug delivery vector in the context of a clinical study.
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container_issue	6, p 5864
title_short	Conditioned Medium of Mesenchymal Stromal Cells Loaded with Paclitaxel Is Effective in Preclinical Models of Triple-Negative Breast Cancer (TNBC)
url	https://doi.org/10.3390/ijms24065864 https://doaj.org/article/e11a3b513a2041e0bac041e02afa0900 https://www.mdpi.com/1422-0067/24/6/5864 https://doaj.org/toc/1661-6596 https://doaj.org/toc/1422-0067
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author2Str	Daniela Lisini Valentina Coccè Giuseppe Paglia Ramona Meanti Maria Grazia Cerrito Pietro Tettamanti Luca Bonaffini Francesca Paino Giulio Alessandri Angela Marcianti Aldo Giannì Chiara Villa Mario Mauri Luca Mologni Antonio Torsello Augusto Pessina Marina Elena Cazzaniga
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Conditioned Medium of Mesenchymal Stromal Cells Loaded with Paclitaxel Is Effective in Preclinical Models of Triple-Negative Breast Cancer (TNBC)

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