Genome-Wide Analysis of Dental Caries Variability Reveals Genotype-by-Environment Interactions

Genotype-by-environment interactions (GEI) may influence dental caries, although their effects are difficult to detect. Variance quantitative trait loci (vQTL) may serve as an indicator of underlying GEI effects. The aim of this study was to investigate GEI effects on dental caries by prioritizing v...
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Autor*in:	Tianyu Zou [verfasserIn] Betsy Foxman [verfasserIn] Daniel W. McNeil [verfasserIn] Seth M. Weinberg [verfasserIn] Mary L. Marazita [verfasserIn] John R. Shaffer [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2023

Schlagwörter:	genome-wide vQTL genotype-by-environment interactions dental caries

Übergeordnetes Werk:	In: Genes - MDPI AG, 2010, 14(2023), 3, p 736
Übergeordnetes Werk:	volume:14 ; year:2023 ; number:3, p 736

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3390/genes14030736

Katalog-ID:	DOAJ087357542

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callnumber-first	Q - Science
author	Tianyu Zou
spellingShingle	Tianyu Zou misc QH426-470 misc genome-wide vQTL misc genotype-by-environment interactions misc dental caries misc Genetics Genome-Wide Analysis of Dental Caries Variability Reveals Genotype-by-Environment Interactions
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topic_title	QH426-470 Genome-Wide Analysis of Dental Caries Variability Reveals Genotype-by-Environment Interactions genome-wide vQTL genotype-by-environment interactions dental caries
topic	misc QH426-470 misc genome-wide vQTL misc genotype-by-environment interactions misc dental caries misc Genetics
topic_unstemmed	misc QH426-470 misc genome-wide vQTL misc genotype-by-environment interactions misc dental caries misc Genetics
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title	Genome-Wide Analysis of Dental Caries Variability Reveals Genotype-by-Environment Interactions
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title_sort	genome-wide analysis of dental caries variability reveals genotype-by-environment interactions
callnumber	QH426-470
title_auth	Genome-Wide Analysis of Dental Caries Variability Reveals Genotype-by-Environment Interactions
abstract	Genotype-by-environment interactions (GEI) may influence dental caries, although their effects are difficult to detect. Variance quantitative trait loci (vQTL) may serve as an indicator of underlying GEI effects. The aim of this study was to investigate GEI effects on dental caries by prioritizing variants from genome-wide vQTL analysis. First, we identified vQTLs from ~4.3 M genome-wide variants in three cohorts of white children aged 3–5 (n = 396, n = 328, n = 773) using Levene’s test. A total of 39 independent vQTLs with <i<p</i< < 1 × 10<sup<−6</sup< were identified, some of which were located in or near genes with plausible biological roles in dental caries (<i<IGFBP7</i<, <i<SLC5A8</i<, and <i<SHH</i< involved in tooth development and enamel mineralization). Next, we used linear regression to test GEI effects on dental caries with the 39 prioritized variants and self-reported environmental factors (demographic, socioeconomic, behavioral, and dietary factors) in the three cohorts separately. We identified eight significant GEIs indicating that children with vQTL risk genotypes had higher caries experience if they had less educated parents, lower household/parental income, brushed their teeth less frequently, consumed sugar-sweetened beverages more frequently, were not breastfed, and were female. We reported the first genome-wide vQTL analysis of dental caries in children nominating several novel genes and GEI for further investigations.
abstractGer	Genotype-by-environment interactions (GEI) may influence dental caries, although their effects are difficult to detect. Variance quantitative trait loci (vQTL) may serve as an indicator of underlying GEI effects. The aim of this study was to investigate GEI effects on dental caries by prioritizing variants from genome-wide vQTL analysis. First, we identified vQTLs from ~4.3 M genome-wide variants in three cohorts of white children aged 3–5 (n = 396, n = 328, n = 773) using Levene’s test. A total of 39 independent vQTLs with <i<p</i< < 1 × 10<sup<−6</sup< were identified, some of which were located in or near genes with plausible biological roles in dental caries (<i<IGFBP7</i<, <i<SLC5A8</i<, and <i<SHH</i< involved in tooth development and enamel mineralization). Next, we used linear regression to test GEI effects on dental caries with the 39 prioritized variants and self-reported environmental factors (demographic, socioeconomic, behavioral, and dietary factors) in the three cohorts separately. We identified eight significant GEIs indicating that children with vQTL risk genotypes had higher caries experience if they had less educated parents, lower household/parental income, brushed their teeth less frequently, consumed sugar-sweetened beverages more frequently, were not breastfed, and were female. We reported the first genome-wide vQTL analysis of dental caries in children nominating several novel genes and GEI for further investigations.
abstract_unstemmed	Genotype-by-environment interactions (GEI) may influence dental caries, although their effects are difficult to detect. Variance quantitative trait loci (vQTL) may serve as an indicator of underlying GEI effects. The aim of this study was to investigate GEI effects on dental caries by prioritizing variants from genome-wide vQTL analysis. First, we identified vQTLs from ~4.3 M genome-wide variants in three cohorts of white children aged 3–5 (n = 396, n = 328, n = 773) using Levene’s test. A total of 39 independent vQTLs with <i<p</i< < 1 × 10<sup<−6</sup< were identified, some of which were located in or near genes with plausible biological roles in dental caries (<i<IGFBP7</i<, <i<SLC5A8</i<, and <i<SHH</i< involved in tooth development and enamel mineralization). Next, we used linear regression to test GEI effects on dental caries with the 39 prioritized variants and self-reported environmental factors (demographic, socioeconomic, behavioral, and dietary factors) in the three cohorts separately. We identified eight significant GEIs indicating that children with vQTL risk genotypes had higher caries experience if they had less educated parents, lower household/parental income, brushed their teeth less frequently, consumed sugar-sweetened beverages more frequently, were not breastfed, and were female. We reported the first genome-wide vQTL analysis of dental caries in children nominating several novel genes and GEI for further investigations.
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title_short	Genome-Wide Analysis of Dental Caries Variability Reveals Genotype-by-Environment Interactions
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