Adaptation of the INFOGEST Digestion for the Elderly Population to Assess Sterol Bioaccessibility in a Plant Sterol-Enriched Wholemeal Rye Bread

The fortification of foods with cholesterol-lowering agents such as plant sterols (PS) is allowed in Europe and could be of interest to the elderly since aging may lead to higher cardiovascular risk. To date, no studies have analyzed how the gastrointestinal conditions of the elderly affect PS bioac...
Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Diego Miedes [verfasserIn] Mussa Makran [verfasserIn] Guadalupe Garcia-Llatas [verfasserIn] Reyes Barberá [verfasserIn] Antonio Cilla [verfasserIn] Amparo Alegría [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2022

Schlagwörter:	elderly simulated digestion cereal enrichment

Übergeordnetes Werk:	In: Biology and Life Sciences Forum - MDPI AG, 2023, 18(2022), 1, p 8
Übergeordnetes Werk:	volume:18 ; year:2022 ; number:1, p 8

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3390/Foods2022-13025

Katalog-ID:	DOAJ087421925

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callnumber-first	Q - Science
author	Diego Miedes
spellingShingle	Diego Miedes misc QK900-989 misc QP501-801 misc QH301-705.5 misc elderly misc simulated digestion misc cereal misc enrichment misc Plant ecology misc Animal biochemistry misc Biology (General) Adaptation of the INFOGEST Digestion for the Elderly Population to Assess Sterol Bioaccessibility in a Plant Sterol-Enriched Wholemeal Rye Bread
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topic_title	QK900-989 QP501-801 QH301-705.5 Adaptation of the INFOGEST Digestion for the Elderly Population to Assess Sterol Bioaccessibility in a Plant Sterol-Enriched Wholemeal Rye Bread elderly simulated digestion cereal enrichment
topic	misc QK900-989 misc QP501-801 misc QH301-705.5 misc elderly misc simulated digestion misc cereal misc enrichment misc Plant ecology misc Animal biochemistry misc Biology (General)
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title	Adaptation of the INFOGEST Digestion for the Elderly Population to Assess Sterol Bioaccessibility in a Plant Sterol-Enriched Wholemeal Rye Bread
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title_full	Adaptation of the INFOGEST Digestion for the Elderly Population to Assess Sterol Bioaccessibility in a Plant Sterol-Enriched Wholemeal Rye Bread
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title_sort	adaptation of the infogest digestion for the elderly population to assess sterol bioaccessibility in a plant sterol-enriched wholemeal rye bread
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title_auth	Adaptation of the INFOGEST Digestion for the Elderly Population to Assess Sterol Bioaccessibility in a Plant Sterol-Enriched Wholemeal Rye Bread
abstract	The fortification of foods with cholesterol-lowering agents such as plant sterols (PS) is allowed in Europe and could be of interest to the elderly since aging may lead to higher cardiovascular risk. To date, no studies have analyzed how the gastrointestinal conditions of the elderly affect PS bioaccessibility. Thus, this study evaluates the impact of adapting the standardized INFOGEST 2.0 method for adult to elderly physiological conditions on the bioaccessibility (BA) of PS-enriched wholemeal rye bread. For this purpose, changes in gastric or gastric and intestinal phase conditions (enzyme activity, pH, digestion time, or agitation) were made. Compared to adults, only when gastric and intestinal phase conditions were modified, the BA (%) decreased for individual (10.9–20.5 vs. 19.5–36.3) and total PSs (11.4 ± 1.7 vs. 20.5 ± 1.0), demonstrating that this reduction is due to intestinal phase modifications. However, the order of BA was not modified under any of the conditions tested, following the increasing rank: β-sitosterol, campesterol, Δ7-stigmasterol, sitostanol, Δ5,24, stigmastadienol, Δ5-avenasterol, Δ7avenasterol, stigmasterol, and campestanol. This complex matrix, very rich in fiber, such as wholemeal rye bread, may be responsible for the enzymatic reduction affecting PS solubility in the adapted digestion elderly model.
abstractGer	The fortification of foods with cholesterol-lowering agents such as plant sterols (PS) is allowed in Europe and could be of interest to the elderly since aging may lead to higher cardiovascular risk. To date, no studies have analyzed how the gastrointestinal conditions of the elderly affect PS bioaccessibility. Thus, this study evaluates the impact of adapting the standardized INFOGEST 2.0 method for adult to elderly physiological conditions on the bioaccessibility (BA) of PS-enriched wholemeal rye bread. For this purpose, changes in gastric or gastric and intestinal phase conditions (enzyme activity, pH, digestion time, or agitation) were made. Compared to adults, only when gastric and intestinal phase conditions were modified, the BA (%) decreased for individual (10.9–20.5 vs. 19.5–36.3) and total PSs (11.4 ± 1.7 vs. 20.5 ± 1.0), demonstrating that this reduction is due to intestinal phase modifications. However, the order of BA was not modified under any of the conditions tested, following the increasing rank: β-sitosterol, campesterol, Δ7-stigmasterol, sitostanol, Δ5,24, stigmastadienol, Δ5-avenasterol, Δ7avenasterol, stigmasterol, and campestanol. This complex matrix, very rich in fiber, such as wholemeal rye bread, may be responsible for the enzymatic reduction affecting PS solubility in the adapted digestion elderly model.
abstract_unstemmed	The fortification of foods with cholesterol-lowering agents such as plant sterols (PS) is allowed in Europe and could be of interest to the elderly since aging may lead to higher cardiovascular risk. To date, no studies have analyzed how the gastrointestinal conditions of the elderly affect PS bioaccessibility. Thus, this study evaluates the impact of adapting the standardized INFOGEST 2.0 method for adult to elderly physiological conditions on the bioaccessibility (BA) of PS-enriched wholemeal rye bread. For this purpose, changes in gastric or gastric and intestinal phase conditions (enzyme activity, pH, digestion time, or agitation) were made. Compared to adults, only when gastric and intestinal phase conditions were modified, the BA (%) decreased for individual (10.9–20.5 vs. 19.5–36.3) and total PSs (11.4 ± 1.7 vs. 20.5 ± 1.0), demonstrating that this reduction is due to intestinal phase modifications. However, the order of BA was not modified under any of the conditions tested, following the increasing rank: β-sitosterol, campesterol, Δ7-stigmasterol, sitostanol, Δ5,24, stigmastadienol, Δ5-avenasterol, Δ7avenasterol, stigmasterol, and campestanol. This complex matrix, very rich in fiber, such as wholemeal rye bread, may be responsible for the enzymatic reduction affecting PS solubility in the adapted digestion elderly model.
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title_short	Adaptation of the INFOGEST Digestion for the Elderly Population to Assess Sterol Bioaccessibility in a Plant Sterol-Enriched Wholemeal Rye Bread
url	https://doi.org/10.3390/Foods2022-13025 https://doaj.org/article/ebfb30372888439cb3c0e0baa2b4d019 https://www.mdpi.com/2673-9976/18/1/8 https://doaj.org/toc/2673-9976
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author2	Mussa Makran Guadalupe Garcia-Llatas Reyes Barberá Antonio Cilla Amparo Alegría
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To date, no studies have analyzed how the gastrointestinal conditions of the elderly affect PS bioaccessibility. Thus, this study evaluates the impact of adapting the standardized INFOGEST 2.0 method for adult to elderly physiological conditions on the bioaccessibility (BA) of PS-enriched wholemeal rye bread. For this purpose, changes in gastric or gastric and intestinal phase conditions (enzyme activity, pH, digestion time, or agitation) were made. Compared to adults, only when gastric and intestinal phase conditions were modified, the BA (%) decreased for individual (10.9–20.5 vs. 19.5–36.3) and total PSs (11.4 ± 1.7 vs. 20.5 ± 1.0), demonstrating that this reduction is due to intestinal phase modifications. However, the order of BA was not modified under any of the conditions tested, following the increasing rank: β-sitosterol, campesterol, Δ7-stigmasterol, sitostanol, Δ5,24, stigmastadienol, Δ5-avenasterol, Δ7avenasterol, stigmasterol, and campestanol. 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Adaptation of the INFOGEST Digestion for the Elderly Population to Assess Sterol Bioaccessibility in a Plant Sterol-Enriched Wholemeal Rye Bread

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