Pancreatic Cancer Organoids: An Emerging Platform for Precision Medicine?

Despite recent therapeutic advances, pancreatic ductal adenocarcinoma (PDAC) remains one of the most aggressive malignancies, with remarkable resistance to treatment, poor prognosis, and poor clinical outcome. More efficient therapeutic approaches are urgently needed to improve patients’ survival. R...
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Autor*in:	Evangelia Sereti [verfasserIn] Irida Papapostolou [verfasserIn] Konstantinos Dimas [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2023

Schlagwörter:	pancreatic organoids pancreatic cancer precision medicine

Übergeordnetes Werk:	In: Biomedicines - MDPI AG, 2014, 11(2023), 3, p 890
Übergeordnetes Werk:	volume:11 ; year:2023 ; number:3, p 890

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3390/biomedicines11030890

Katalog-ID:	DOAJ087428288

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callnumber-first	Q - Science
author	Evangelia Sereti
spellingShingle	Evangelia Sereti misc QH301-705.5 misc pancreatic organoids misc pancreatic cancer misc precision medicine misc Biology (General) Pancreatic Cancer Organoids: An Emerging Platform for Precision Medicine?
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topic_title	QH301-705.5 Pancreatic Cancer Organoids: An Emerging Platform for Precision Medicine? pancreatic organoids pancreatic cancer precision medicine
topic	misc QH301-705.5 misc pancreatic organoids misc pancreatic cancer misc precision medicine misc Biology (General)
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title	Pancreatic Cancer Organoids: An Emerging Platform for Precision Medicine?
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title_full	Pancreatic Cancer Organoids: An Emerging Platform for Precision Medicine?
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author_browse	Evangelia Sereti Irida Papapostolou Konstantinos Dimas
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title_sort	pancreatic cancer organoids: an emerging platform for precision medicine?
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title_auth	Pancreatic Cancer Organoids: An Emerging Platform for Precision Medicine?
abstract	Despite recent therapeutic advances, pancreatic ductal adenocarcinoma (PDAC) remains one of the most aggressive malignancies, with remarkable resistance to treatment, poor prognosis, and poor clinical outcome. More efficient therapeutic approaches are urgently needed to improve patients’ survival. Recently, the development of organoid culture systems has gained substantial attention as an emerging preclinical research model. PDAC organoids have been developed to study pancreatic cancer biology, progression, and treatment response, filling the translational gap between <i<in vitro</i< and <i<in vivo</i< models. Here, we review the rapidly evolving field of PDAC organoids and their potential as powerful preclinical tools that could pave the way towards precision medicine for pancreatic cancer.
abstractGer	Despite recent therapeutic advances, pancreatic ductal adenocarcinoma (PDAC) remains one of the most aggressive malignancies, with remarkable resistance to treatment, poor prognosis, and poor clinical outcome. More efficient therapeutic approaches are urgently needed to improve patients’ survival. Recently, the development of organoid culture systems has gained substantial attention as an emerging preclinical research model. PDAC organoids have been developed to study pancreatic cancer biology, progression, and treatment response, filling the translational gap between <i<in vitro</i< and <i<in vivo</i< models. Here, we review the rapidly evolving field of PDAC organoids and their potential as powerful preclinical tools that could pave the way towards precision medicine for pancreatic cancer.
abstract_unstemmed	Despite recent therapeutic advances, pancreatic ductal adenocarcinoma (PDAC) remains one of the most aggressive malignancies, with remarkable resistance to treatment, poor prognosis, and poor clinical outcome. More efficient therapeutic approaches are urgently needed to improve patients’ survival. Recently, the development of organoid culture systems has gained substantial attention as an emerging preclinical research model. PDAC organoids have been developed to study pancreatic cancer biology, progression, and treatment response, filling the translational gap between <i<in vitro</i< and <i<in vivo</i< models. Here, we review the rapidly evolving field of PDAC organoids and their potential as powerful preclinical tools that could pave the way towards precision medicine for pancreatic cancer.
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title_short	Pancreatic Cancer Organoids: An Emerging Platform for Precision Medicine?
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