Prefrontal EEG slowing, synchronization, and ERP peak latency in association with predementia stages of Alzheimer’s disease

BackgroundEarly screening of elderly individuals who are at risk of dementia allows timely medical interventions to prevent disease progression. The portable and low-cost electroencephalography (EEG) technique has the potential to serve it.ObjectiveWe examined prefrontal EEG and event-related potential (ERP) variables in association with the predementia stages of Alzheimer’s disease (AD).MethodsOne hundred elderly individuals were recruited from the GARD cohort. The participants were classified into four groups according to their amyloid beta deposition (A+ or A−) and neurodegeneration status (N+ or N−): cognitively normal (CN; A−N−, n = 27), asymptomatic AD (aAD; A + N−, n = 15), mild cognitive impairment (MCI) with AD pathology (pAD; A+N+, n = 16), and MCI with non-AD pathology (MCI(−); A−N+, n = 42). Prefrontal resting-state eyes-closed EEG measurements were recorded for five minutes and auditory ERP measurements were recorded for 8 min. Three variables of median frequency (MDF), spectrum triangular index (STI), and positive-peak latency (PPL) were employed to reflect EEG slowing, temporal synchrony, and ERP latency, respectively.ResultsDecreasing prefrontal MDF and increasing PPL were observed in the MCI with AD pathology. Interestingly, after controlling for age, sex, and education, we found a significant negative association between MDF and the aAD and pAD stages with an odds ratio (OR) of 0.58. Similarly, PPL exhibited a significant positive association with these AD stages with an OR of 2.36. Additionally, compared with the MCI(-) group, significant negative associations were demonstrated by the aAD group with STI and those in the pAD group with MDF with ORs of 0.30 and 0.42, respectively.ConclusionSlow intrinsic EEG oscillation is associated with MCI due to AD, and a delayed ERP peak latency is likely associated with general cognitive impairment. MCI individuals without AD pathology exhibited better cortical temporal synchronization and faster EEG oscillations than those with aAD or pAD.SignificanceThe EEG/ERP variables obtained from prefrontal EEG techniques are associated with early cognitive impairment due to AD and non-AD pathology. This result suggests that prefrontal EEG/ERP metrics may serve as useful indicators to screen elderly individuals’ early stages on the AD continuum as well as overall cognitive impairment. Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Jungmi Choi [verfasserIn] Boncho Ku [verfasserIn] Dieu Ni Thi Doan [verfasserIn] Junwoo Park [verfasserIn] Wonseok Cha [verfasserIn] Jaeuk U. Kim [verfasserIn] Kun Ho Lee [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2023

Schlagwörter:	electroencephalography (EEG) event-related potential (ERP) Alzheimer’s disease (AD) mild cognitive impairment (MCI) amyloid deposition neurodegeneration

Übergeordnetes Werk:	In: Frontiers in Aging Neuroscience - Frontiers Media S.A., 2010, 15(2023)
Übergeordnetes Werk:	volume:15 ; year:2023

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3389/fnagi.2023.1131857

Katalog-ID:	DOAJ08765931X

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245	1	0	\|a Prefrontal EEG slowing, synchronization, and ERP peak latency in association with predementia stages of Alzheimer’s disease
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520			\|a BackgroundEarly screening of elderly individuals who are at risk of dementia allows timely medical interventions to prevent disease progression. The portable and low-cost electroencephalography (EEG) technique has the potential to serve it.ObjectiveWe examined prefrontal EEG and event-related potential (ERP) variables in association with the predementia stages of Alzheimer’s disease (AD).MethodsOne hundred elderly individuals were recruited from the GARD cohort. The participants were classified into four groups according to their amyloid beta deposition (A+ or A−) and neurodegeneration status (N+ or N−): cognitively normal (CN; A−N−, n = 27), asymptomatic AD (aAD; A + N−, n = 15), mild cognitive impairment (MCI) with AD pathology (pAD; A+N+, n = 16), and MCI with non-AD pathology (MCI(−); A−N+, n = 42). Prefrontal resting-state eyes-closed EEG measurements were recorded for five minutes and auditory ERP measurements were recorded for 8 min. Three variables of median frequency (MDF), spectrum triangular index (STI), and positive-peak latency (PPL) were employed to reflect EEG slowing, temporal synchrony, and ERP latency, respectively.ResultsDecreasing prefrontal MDF and increasing PPL were observed in the MCI with AD pathology. Interestingly, after controlling for age, sex, and education, we found a significant negative association between MDF and the aAD and pAD stages with an odds ratio (OR) of 0.58. Similarly, PPL exhibited a significant positive association with these AD stages with an OR of 2.36. Additionally, compared with the MCI(-) group, significant negative associations were demonstrated by the aAD group with STI and those in the pAD group with MDF with ORs of 0.30 and 0.42, respectively.ConclusionSlow intrinsic EEG oscillation is associated with MCI due to AD, and a delayed ERP peak latency is likely associated with general cognitive impairment. MCI individuals without AD pathology exhibited better cortical temporal synchronization and faster EEG oscillations than those with aAD or pAD.SignificanceThe EEG/ERP variables obtained from prefrontal EEG techniques are associated with early cognitive impairment due to AD and non-AD pathology. This result suggests that prefrontal EEG/ERP metrics may serve as useful indicators to screen elderly individuals’ early stages on the AD continuum as well as overall cognitive impairment.
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allfields	10.3389/fnagi.2023.1131857 doi (DE-627)DOAJ08765931X (DE-599)DOAJ20201c1a1b2c43c0a07473544314fc90 DE-627 ger DE-627 rakwb eng RC321-571 Jungmi Choi verfasserin aut Prefrontal EEG slowing, synchronization, and ERP peak latency in association with predementia stages of Alzheimer’s disease 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier BackgroundEarly screening of elderly individuals who are at risk of dementia allows timely medical interventions to prevent disease progression. The portable and low-cost electroencephalography (EEG) technique has the potential to serve it.ObjectiveWe examined prefrontal EEG and event-related potential (ERP) variables in association with the predementia stages of Alzheimer’s disease (AD).MethodsOne hundred elderly individuals were recruited from the GARD cohort. The participants were classified into four groups according to their amyloid beta deposition (A+ or A−) and neurodegeneration status (N+ or N−): cognitively normal (CN; A−N−, n = 27), asymptomatic AD (aAD; A + N−, n = 15), mild cognitive impairment (MCI) with AD pathology (pAD; A+N+, n = 16), and MCI with non-AD pathology (MCI(−); A−N+, n = 42). Prefrontal resting-state eyes-closed EEG measurements were recorded for five minutes and auditory ERP measurements were recorded for 8 min. Three variables of median frequency (MDF), spectrum triangular index (STI), and positive-peak latency (PPL) were employed to reflect EEG slowing, temporal synchrony, and ERP latency, respectively.ResultsDecreasing prefrontal MDF and increasing PPL were observed in the MCI with AD pathology. Interestingly, after controlling for age, sex, and education, we found a significant negative association between MDF and the aAD and pAD stages with an odds ratio (OR) of 0.58. Similarly, PPL exhibited a significant positive association with these AD stages with an OR of 2.36. Additionally, compared with the MCI(-) group, significant negative associations were demonstrated by the aAD group with STI and those in the pAD group with MDF with ORs of 0.30 and 0.42, respectively.ConclusionSlow intrinsic EEG oscillation is associated with MCI due to AD, and a delayed ERP peak latency is likely associated with general cognitive impairment. MCI individuals without AD pathology exhibited better cortical temporal synchronization and faster EEG oscillations than those with aAD or pAD.SignificanceThe EEG/ERP variables obtained from prefrontal EEG techniques are associated with early cognitive impairment due to AD and non-AD pathology. This result suggests that prefrontal EEG/ERP metrics may serve as useful indicators to screen elderly individuals’ early stages on the AD continuum as well as overall cognitive impairment. electroencephalography (EEG) event-related potential (ERP) Alzheimer’s disease (AD) mild cognitive impairment (MCI) amyloid deposition neurodegeneration Neurosciences. Biological psychiatry. Neuropsychiatry Boncho Ku verfasserin aut Dieu Ni Thi Doan verfasserin aut Dieu Ni Thi Doan verfasserin aut Junwoo Park verfasserin aut Wonseok Cha verfasserin aut Jaeuk U. Kim verfasserin aut Jaeuk U. Kim verfasserin aut Kun Ho Lee verfasserin aut Kun Ho Lee verfasserin aut Kun Ho Lee verfasserin aut In Frontiers in Aging Neuroscience Frontiers Media S.A., 2010 15(2023) (DE-627)629834350 (DE-600)2558898-9 16634365 nnns volume:15 year:2023 https://doi.org/10.3389/fnagi.2023.1131857 kostenfrei https://doaj.org/article/20201c1a1b2c43c0a07473544314fc90 kostenfrei https://www.frontiersin.org/articles/10.3389/fnagi.2023.1131857/full kostenfrei https://doaj.org/toc/1663-4365 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 15 2023
spelling	10.3389/fnagi.2023.1131857 doi (DE-627)DOAJ08765931X (DE-599)DOAJ20201c1a1b2c43c0a07473544314fc90 DE-627 ger DE-627 rakwb eng RC321-571 Jungmi Choi verfasserin aut Prefrontal EEG slowing, synchronization, and ERP peak latency in association with predementia stages of Alzheimer’s disease 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier BackgroundEarly screening of elderly individuals who are at risk of dementia allows timely medical interventions to prevent disease progression. The portable and low-cost electroencephalography (EEG) technique has the potential to serve it.ObjectiveWe examined prefrontal EEG and event-related potential (ERP) variables in association with the predementia stages of Alzheimer’s disease (AD).MethodsOne hundred elderly individuals were recruited from the GARD cohort. The participants were classified into four groups according to their amyloid beta deposition (A+ or A−) and neurodegeneration status (N+ or N−): cognitively normal (CN; A−N−, n = 27), asymptomatic AD (aAD; A + N−, n = 15), mild cognitive impairment (MCI) with AD pathology (pAD; A+N+, n = 16), and MCI with non-AD pathology (MCI(−); A−N+, n = 42). Prefrontal resting-state eyes-closed EEG measurements were recorded for five minutes and auditory ERP measurements were recorded for 8 min. Three variables of median frequency (MDF), spectrum triangular index (STI), and positive-peak latency (PPL) were employed to reflect EEG slowing, temporal synchrony, and ERP latency, respectively.ResultsDecreasing prefrontal MDF and increasing PPL were observed in the MCI with AD pathology. Interestingly, after controlling for age, sex, and education, we found a significant negative association between MDF and the aAD and pAD stages with an odds ratio (OR) of 0.58. Similarly, PPL exhibited a significant positive association with these AD stages with an OR of 2.36. Additionally, compared with the MCI(-) group, significant negative associations were demonstrated by the aAD group with STI and those in the pAD group with MDF with ORs of 0.30 and 0.42, respectively.ConclusionSlow intrinsic EEG oscillation is associated with MCI due to AD, and a delayed ERP peak latency is likely associated with general cognitive impairment. MCI individuals without AD pathology exhibited better cortical temporal synchronization and faster EEG oscillations than those with aAD or pAD.SignificanceThe EEG/ERP variables obtained from prefrontal EEG techniques are associated with early cognitive impairment due to AD and non-AD pathology. This result suggests that prefrontal EEG/ERP metrics may serve as useful indicators to screen elderly individuals’ early stages on the AD continuum as well as overall cognitive impairment. electroencephalography (EEG) event-related potential (ERP) Alzheimer’s disease (AD) mild cognitive impairment (MCI) amyloid deposition neurodegeneration Neurosciences. Biological psychiatry. Neuropsychiatry Boncho Ku verfasserin aut Dieu Ni Thi Doan verfasserin aut Dieu Ni Thi Doan verfasserin aut Junwoo Park verfasserin aut Wonseok Cha verfasserin aut Jaeuk U. Kim verfasserin aut Jaeuk U. Kim verfasserin aut Kun Ho Lee verfasserin aut Kun Ho Lee verfasserin aut Kun Ho Lee verfasserin aut In Frontiers in Aging Neuroscience Frontiers Media S.A., 2010 15(2023) (DE-627)629834350 (DE-600)2558898-9 16634365 nnns volume:15 year:2023 https://doi.org/10.3389/fnagi.2023.1131857 kostenfrei https://doaj.org/article/20201c1a1b2c43c0a07473544314fc90 kostenfrei https://www.frontiersin.org/articles/10.3389/fnagi.2023.1131857/full kostenfrei https://doaj.org/toc/1663-4365 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 15 2023
allfields_unstemmed	10.3389/fnagi.2023.1131857 doi (DE-627)DOAJ08765931X (DE-599)DOAJ20201c1a1b2c43c0a07473544314fc90 DE-627 ger DE-627 rakwb eng RC321-571 Jungmi Choi verfasserin aut Prefrontal EEG slowing, synchronization, and ERP peak latency in association with predementia stages of Alzheimer’s disease 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier BackgroundEarly screening of elderly individuals who are at risk of dementia allows timely medical interventions to prevent disease progression. The portable and low-cost electroencephalography (EEG) technique has the potential to serve it.ObjectiveWe examined prefrontal EEG and event-related potential (ERP) variables in association with the predementia stages of Alzheimer’s disease (AD).MethodsOne hundred elderly individuals were recruited from the GARD cohort. The participants were classified into four groups according to their amyloid beta deposition (A+ or A−) and neurodegeneration status (N+ or N−): cognitively normal (CN; A−N−, n = 27), asymptomatic AD (aAD; A + N−, n = 15), mild cognitive impairment (MCI) with AD pathology (pAD; A+N+, n = 16), and MCI with non-AD pathology (MCI(−); A−N+, n = 42). Prefrontal resting-state eyes-closed EEG measurements were recorded for five minutes and auditory ERP measurements were recorded for 8 min. Three variables of median frequency (MDF), spectrum triangular index (STI), and positive-peak latency (PPL) were employed to reflect EEG slowing, temporal synchrony, and ERP latency, respectively.ResultsDecreasing prefrontal MDF and increasing PPL were observed in the MCI with AD pathology. Interestingly, after controlling for age, sex, and education, we found a significant negative association between MDF and the aAD and pAD stages with an odds ratio (OR) of 0.58. Similarly, PPL exhibited a significant positive association with these AD stages with an OR of 2.36. Additionally, compared with the MCI(-) group, significant negative associations were demonstrated by the aAD group with STI and those in the pAD group with MDF with ORs of 0.30 and 0.42, respectively.ConclusionSlow intrinsic EEG oscillation is associated with MCI due to AD, and a delayed ERP peak latency is likely associated with general cognitive impairment. MCI individuals without AD pathology exhibited better cortical temporal synchronization and faster EEG oscillations than those with aAD or pAD.SignificanceThe EEG/ERP variables obtained from prefrontal EEG techniques are associated with early cognitive impairment due to AD and non-AD pathology. This result suggests that prefrontal EEG/ERP metrics may serve as useful indicators to screen elderly individuals’ early stages on the AD continuum as well as overall cognitive impairment. electroencephalography (EEG) event-related potential (ERP) Alzheimer’s disease (AD) mild cognitive impairment (MCI) amyloid deposition neurodegeneration Neurosciences. Biological psychiatry. Neuropsychiatry Boncho Ku verfasserin aut Dieu Ni Thi Doan verfasserin aut Dieu Ni Thi Doan verfasserin aut Junwoo Park verfasserin aut Wonseok Cha verfasserin aut Jaeuk U. Kim verfasserin aut Jaeuk U. Kim verfasserin aut Kun Ho Lee verfasserin aut Kun Ho Lee verfasserin aut Kun Ho Lee verfasserin aut In Frontiers in Aging Neuroscience Frontiers Media S.A., 2010 15(2023) (DE-627)629834350 (DE-600)2558898-9 16634365 nnns volume:15 year:2023 https://doi.org/10.3389/fnagi.2023.1131857 kostenfrei https://doaj.org/article/20201c1a1b2c43c0a07473544314fc90 kostenfrei https://www.frontiersin.org/articles/10.3389/fnagi.2023.1131857/full kostenfrei https://doaj.org/toc/1663-4365 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 15 2023
allfieldsGer	10.3389/fnagi.2023.1131857 doi (DE-627)DOAJ08765931X (DE-599)DOAJ20201c1a1b2c43c0a07473544314fc90 DE-627 ger DE-627 rakwb eng RC321-571 Jungmi Choi verfasserin aut Prefrontal EEG slowing, synchronization, and ERP peak latency in association with predementia stages of Alzheimer’s disease 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier BackgroundEarly screening of elderly individuals who are at risk of dementia allows timely medical interventions to prevent disease progression. The portable and low-cost electroencephalography (EEG) technique has the potential to serve it.ObjectiveWe examined prefrontal EEG and event-related potential (ERP) variables in association with the predementia stages of Alzheimer’s disease (AD).MethodsOne hundred elderly individuals were recruited from the GARD cohort. The participants were classified into four groups according to their amyloid beta deposition (A+ or A−) and neurodegeneration status (N+ or N−): cognitively normal (CN; A−N−, n = 27), asymptomatic AD (aAD; A + N−, n = 15), mild cognitive impairment (MCI) with AD pathology (pAD; A+N+, n = 16), and MCI with non-AD pathology (MCI(−); A−N+, n = 42). Prefrontal resting-state eyes-closed EEG measurements were recorded for five minutes and auditory ERP measurements were recorded for 8 min. Three variables of median frequency (MDF), spectrum triangular index (STI), and positive-peak latency (PPL) were employed to reflect EEG slowing, temporal synchrony, and ERP latency, respectively.ResultsDecreasing prefrontal MDF and increasing PPL were observed in the MCI with AD pathology. Interestingly, after controlling for age, sex, and education, we found a significant negative association between MDF and the aAD and pAD stages with an odds ratio (OR) of 0.58. Similarly, PPL exhibited a significant positive association with these AD stages with an OR of 2.36. Additionally, compared with the MCI(-) group, significant negative associations were demonstrated by the aAD group with STI and those in the pAD group with MDF with ORs of 0.30 and 0.42, respectively.ConclusionSlow intrinsic EEG oscillation is associated with MCI due to AD, and a delayed ERP peak latency is likely associated with general cognitive impairment. MCI individuals without AD pathology exhibited better cortical temporal synchronization and faster EEG oscillations than those with aAD or pAD.SignificanceThe EEG/ERP variables obtained from prefrontal EEG techniques are associated with early cognitive impairment due to AD and non-AD pathology. This result suggests that prefrontal EEG/ERP metrics may serve as useful indicators to screen elderly individuals’ early stages on the AD continuum as well as overall cognitive impairment. electroencephalography (EEG) event-related potential (ERP) Alzheimer’s disease (AD) mild cognitive impairment (MCI) amyloid deposition neurodegeneration Neurosciences. Biological psychiatry. Neuropsychiatry Boncho Ku verfasserin aut Dieu Ni Thi Doan verfasserin aut Dieu Ni Thi Doan verfasserin aut Junwoo Park verfasserin aut Wonseok Cha verfasserin aut Jaeuk U. Kim verfasserin aut Jaeuk U. Kim verfasserin aut Kun Ho Lee verfasserin aut Kun Ho Lee verfasserin aut Kun Ho Lee verfasserin aut In Frontiers in Aging Neuroscience Frontiers Media S.A., 2010 15(2023) (DE-627)629834350 (DE-600)2558898-9 16634365 nnns volume:15 year:2023 https://doi.org/10.3389/fnagi.2023.1131857 kostenfrei https://doaj.org/article/20201c1a1b2c43c0a07473544314fc90 kostenfrei https://www.frontiersin.org/articles/10.3389/fnagi.2023.1131857/full kostenfrei https://doaj.org/toc/1663-4365 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 15 2023
allfieldsSound	10.3389/fnagi.2023.1131857 doi (DE-627)DOAJ08765931X (DE-599)DOAJ20201c1a1b2c43c0a07473544314fc90 DE-627 ger DE-627 rakwb eng RC321-571 Jungmi Choi verfasserin aut Prefrontal EEG slowing, synchronization, and ERP peak latency in association with predementia stages of Alzheimer’s disease 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier BackgroundEarly screening of elderly individuals who are at risk of dementia allows timely medical interventions to prevent disease progression. The portable and low-cost electroencephalography (EEG) technique has the potential to serve it.ObjectiveWe examined prefrontal EEG and event-related potential (ERP) variables in association with the predementia stages of Alzheimer’s disease (AD).MethodsOne hundred elderly individuals were recruited from the GARD cohort. The participants were classified into four groups according to their amyloid beta deposition (A+ or A−) and neurodegeneration status (N+ or N−): cognitively normal (CN; A−N−, n = 27), asymptomatic AD (aAD; A + N−, n = 15), mild cognitive impairment (MCI) with AD pathology (pAD; A+N+, n = 16), and MCI with non-AD pathology (MCI(−); A−N+, n = 42). Prefrontal resting-state eyes-closed EEG measurements were recorded for five minutes and auditory ERP measurements were recorded for 8 min. Three variables of median frequency (MDF), spectrum triangular index (STI), and positive-peak latency (PPL) were employed to reflect EEG slowing, temporal synchrony, and ERP latency, respectively.ResultsDecreasing prefrontal MDF and increasing PPL were observed in the MCI with AD pathology. Interestingly, after controlling for age, sex, and education, we found a significant negative association between MDF and the aAD and pAD stages with an odds ratio (OR) of 0.58. Similarly, PPL exhibited a significant positive association with these AD stages with an OR of 2.36. Additionally, compared with the MCI(-) group, significant negative associations were demonstrated by the aAD group with STI and those in the pAD group with MDF with ORs of 0.30 and 0.42, respectively.ConclusionSlow intrinsic EEG oscillation is associated with MCI due to AD, and a delayed ERP peak latency is likely associated with general cognitive impairment. MCI individuals without AD pathology exhibited better cortical temporal synchronization and faster EEG oscillations than those with aAD or pAD.SignificanceThe EEG/ERP variables obtained from prefrontal EEG techniques are associated with early cognitive impairment due to AD and non-AD pathology. This result suggests that prefrontal EEG/ERP metrics may serve as useful indicators to screen elderly individuals’ early stages on the AD continuum as well as overall cognitive impairment. electroencephalography (EEG) event-related potential (ERP) Alzheimer’s disease (AD) mild cognitive impairment (MCI) amyloid deposition neurodegeneration Neurosciences. Biological psychiatry. Neuropsychiatry Boncho Ku verfasserin aut Dieu Ni Thi Doan verfasserin aut Dieu Ni Thi Doan verfasserin aut Junwoo Park verfasserin aut Wonseok Cha verfasserin aut Jaeuk U. Kim verfasserin aut Jaeuk U. Kim verfasserin aut Kun Ho Lee verfasserin aut Kun Ho Lee verfasserin aut Kun Ho Lee verfasserin aut In Frontiers in Aging Neuroscience Frontiers Media S.A., 2010 15(2023) (DE-627)629834350 (DE-600)2558898-9 16634365 nnns volume:15 year:2023 https://doi.org/10.3389/fnagi.2023.1131857 kostenfrei https://doaj.org/article/20201c1a1b2c43c0a07473544314fc90 kostenfrei https://www.frontiersin.org/articles/10.3389/fnagi.2023.1131857/full kostenfrei https://doaj.org/toc/1663-4365 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 15 2023
language	English
source	In Frontiers in Aging Neuroscience 15(2023) volume:15 year:2023
sourceStr	In Frontiers in Aging Neuroscience 15(2023) volume:15 year:2023
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	electroencephalography (EEG) event-related potential (ERP) Alzheimer’s disease (AD) mild cognitive impairment (MCI) amyloid deposition neurodegeneration Neurosciences. Biological psychiatry. Neuropsychiatry
isfreeaccess_bool	true
container_title	Frontiers in Aging Neuroscience
authorswithroles_txt_mv	Jungmi Choi @@aut@@ Boncho Ku @@aut@@ Dieu Ni Thi Doan @@aut@@ Junwoo Park @@aut@@ Wonseok Cha @@aut@@ Jaeuk U. Kim @@aut@@ Kun Ho Lee @@aut@@
publishDateDaySort_date	2023-01-01T00:00:00Z
hierarchy_top_id	629834350
id	DOAJ08765931X
language_de	englisch
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The portable and low-cost electroencephalography (EEG) technique has the potential to serve it.ObjectiveWe examined prefrontal EEG and event-related potential (ERP) variables in association with the predementia stages of Alzheimer’s disease (AD).MethodsOne hundred elderly individuals were recruited from the GARD cohort. The participants were classified into four groups according to their amyloid beta deposition (A+ or A−) and neurodegeneration status (N+ or N−): cognitively normal (CN; A−N−, n = 27), asymptomatic AD (aAD; A + N−, n = 15), mild cognitive impairment (MCI) with AD pathology (pAD; A+N+, n = 16), and MCI with non-AD pathology (MCI(−); A−N+, n = 42). Prefrontal resting-state eyes-closed EEG measurements were recorded for five minutes and auditory ERP measurements were recorded for 8 min. Three variables of median frequency (MDF), spectrum triangular index (STI), and positive-peak latency (PPL) were employed to reflect EEG slowing, temporal synchrony, and ERP latency, respectively.ResultsDecreasing prefrontal MDF and increasing PPL were observed in the MCI with AD pathology. Interestingly, after controlling for age, sex, and education, we found a significant negative association between MDF and the aAD and pAD stages with an odds ratio (OR) of 0.58. Similarly, PPL exhibited a significant positive association with these AD stages with an OR of 2.36. Additionally, compared with the MCI(-) group, significant negative associations were demonstrated by the aAD group with STI and those in the pAD group with MDF with ORs of 0.30 and 0.42, respectively.ConclusionSlow intrinsic EEG oscillation is associated with MCI due to AD, and a delayed ERP peak latency is likely associated with general cognitive impairment. MCI individuals without AD pathology exhibited better cortical temporal synchronization and faster EEG oscillations than those with aAD or pAD.SignificanceThe EEG/ERP variables obtained from prefrontal EEG techniques are associated with early cognitive impairment due to AD and non-AD pathology. 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callnumber-first	R - Medicine
author	Jungmi Choi
spellingShingle	Jungmi Choi misc RC321-571 misc electroencephalography (EEG) misc event-related potential (ERP) misc Alzheimer’s disease (AD) misc mild cognitive impairment (MCI) misc amyloid deposition misc neurodegeneration misc Neurosciences. Biological psychiatry. Neuropsychiatry Prefrontal EEG slowing, synchronization, and ERP peak latency in association with predementia stages of Alzheimer’s disease
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topic_title	RC321-571 Prefrontal EEG slowing, synchronization, and ERP peak latency in association with predementia stages of Alzheimer’s disease electroencephalography (EEG) event-related potential (ERP) Alzheimer’s disease (AD) mild cognitive impairment (MCI) amyloid deposition neurodegeneration
topic	misc RC321-571 misc electroencephalography (EEG) misc event-related potential (ERP) misc Alzheimer’s disease (AD) misc mild cognitive impairment (MCI) misc amyloid deposition misc neurodegeneration misc Neurosciences. Biological psychiatry. Neuropsychiatry
topic_unstemmed	misc RC321-571 misc electroencephalography (EEG) misc event-related potential (ERP) misc Alzheimer’s disease (AD) misc mild cognitive impairment (MCI) misc amyloid deposition misc neurodegeneration misc Neurosciences. Biological psychiatry. Neuropsychiatry
topic_browse	misc RC321-571 misc electroencephalography (EEG) misc event-related potential (ERP) misc Alzheimer’s disease (AD) misc mild cognitive impairment (MCI) misc amyloid deposition misc neurodegeneration misc Neurosciences. Biological psychiatry. Neuropsychiatry
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title	Prefrontal EEG slowing, synchronization, and ERP peak latency in association with predementia stages of Alzheimer’s disease
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title_full	Prefrontal EEG slowing, synchronization, and ERP peak latency in association with predementia stages of Alzheimer’s disease
author_sort	Jungmi Choi
journal	Frontiers in Aging Neuroscience
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author_browse	Jungmi Choi Boncho Ku Dieu Ni Thi Doan Junwoo Park Wonseok Cha Jaeuk U. Kim Kun Ho Lee
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title_sort	prefrontal eeg slowing, synchronization, and erp peak latency in association with predementia stages of alzheimer’s disease
callnumber	RC321-571
title_auth	Prefrontal EEG slowing, synchronization, and ERP peak latency in association with predementia stages of Alzheimer’s disease
abstract	BackgroundEarly screening of elderly individuals who are at risk of dementia allows timely medical interventions to prevent disease progression. The portable and low-cost electroencephalography (EEG) technique has the potential to serve it.ObjectiveWe examined prefrontal EEG and event-related potential (ERP) variables in association with the predementia stages of Alzheimer’s disease (AD).MethodsOne hundred elderly individuals were recruited from the GARD cohort. The participants were classified into four groups according to their amyloid beta deposition (A+ or A−) and neurodegeneration status (N+ or N−): cognitively normal (CN; A−N−, n = 27), asymptomatic AD (aAD; A + N−, n = 15), mild cognitive impairment (MCI) with AD pathology (pAD; A+N+, n = 16), and MCI with non-AD pathology (MCI(−); A−N+, n = 42). Prefrontal resting-state eyes-closed EEG measurements were recorded for five minutes and auditory ERP measurements were recorded for 8 min. Three variables of median frequency (MDF), spectrum triangular index (STI), and positive-peak latency (PPL) were employed to reflect EEG slowing, temporal synchrony, and ERP latency, respectively.ResultsDecreasing prefrontal MDF and increasing PPL were observed in the MCI with AD pathology. Interestingly, after controlling for age, sex, and education, we found a significant negative association between MDF and the aAD and pAD stages with an odds ratio (OR) of 0.58. Similarly, PPL exhibited a significant positive association with these AD stages with an OR of 2.36. Additionally, compared with the MCI(-) group, significant negative associations were demonstrated by the aAD group with STI and those in the pAD group with MDF with ORs of 0.30 and 0.42, respectively.ConclusionSlow intrinsic EEG oscillation is associated with MCI due to AD, and a delayed ERP peak latency is likely associated with general cognitive impairment. MCI individuals without AD pathology exhibited better cortical temporal synchronization and faster EEG oscillations than those with aAD or pAD.SignificanceThe EEG/ERP variables obtained from prefrontal EEG techniques are associated with early cognitive impairment due to AD and non-AD pathology. This result suggests that prefrontal EEG/ERP metrics may serve as useful indicators to screen elderly individuals’ early stages on the AD continuum as well as overall cognitive impairment.
abstractGer	BackgroundEarly screening of elderly individuals who are at risk of dementia allows timely medical interventions to prevent disease progression. The portable and low-cost electroencephalography (EEG) technique has the potential to serve it.ObjectiveWe examined prefrontal EEG and event-related potential (ERP) variables in association with the predementia stages of Alzheimer’s disease (AD).MethodsOne hundred elderly individuals were recruited from the GARD cohort. The participants were classified into four groups according to their amyloid beta deposition (A+ or A−) and neurodegeneration status (N+ or N−): cognitively normal (CN; A−N−, n = 27), asymptomatic AD (aAD; A + N−, n = 15), mild cognitive impairment (MCI) with AD pathology (pAD; A+N+, n = 16), and MCI with non-AD pathology (MCI(−); A−N+, n = 42). Prefrontal resting-state eyes-closed EEG measurements were recorded for five minutes and auditory ERP measurements were recorded for 8 min. Three variables of median frequency (MDF), spectrum triangular index (STI), and positive-peak latency (PPL) were employed to reflect EEG slowing, temporal synchrony, and ERP latency, respectively.ResultsDecreasing prefrontal MDF and increasing PPL were observed in the MCI with AD pathology. Interestingly, after controlling for age, sex, and education, we found a significant negative association between MDF and the aAD and pAD stages with an odds ratio (OR) of 0.58. Similarly, PPL exhibited a significant positive association with these AD stages with an OR of 2.36. Additionally, compared with the MCI(-) group, significant negative associations were demonstrated by the aAD group with STI and those in the pAD group with MDF with ORs of 0.30 and 0.42, respectively.ConclusionSlow intrinsic EEG oscillation is associated with MCI due to AD, and a delayed ERP peak latency is likely associated with general cognitive impairment. MCI individuals without AD pathology exhibited better cortical temporal synchronization and faster EEG oscillations than those with aAD or pAD.SignificanceThe EEG/ERP variables obtained from prefrontal EEG techniques are associated with early cognitive impairment due to AD and non-AD pathology. This result suggests that prefrontal EEG/ERP metrics may serve as useful indicators to screen elderly individuals’ early stages on the AD continuum as well as overall cognitive impairment.
abstract_unstemmed	BackgroundEarly screening of elderly individuals who are at risk of dementia allows timely medical interventions to prevent disease progression. The portable and low-cost electroencephalography (EEG) technique has the potential to serve it.ObjectiveWe examined prefrontal EEG and event-related potential (ERP) variables in association with the predementia stages of Alzheimer’s disease (AD).MethodsOne hundred elderly individuals were recruited from the GARD cohort. The participants were classified into four groups according to their amyloid beta deposition (A+ or A−) and neurodegeneration status (N+ or N−): cognitively normal (CN; A−N−, n = 27), asymptomatic AD (aAD; A + N−, n = 15), mild cognitive impairment (MCI) with AD pathology (pAD; A+N+, n = 16), and MCI with non-AD pathology (MCI(−); A−N+, n = 42). Prefrontal resting-state eyes-closed EEG measurements were recorded for five minutes and auditory ERP measurements were recorded for 8 min. Three variables of median frequency (MDF), spectrum triangular index (STI), and positive-peak latency (PPL) were employed to reflect EEG slowing, temporal synchrony, and ERP latency, respectively.ResultsDecreasing prefrontal MDF and increasing PPL were observed in the MCI with AD pathology. Interestingly, after controlling for age, sex, and education, we found a significant negative association between MDF and the aAD and pAD stages with an odds ratio (OR) of 0.58. Similarly, PPL exhibited a significant positive association with these AD stages with an OR of 2.36. Additionally, compared with the MCI(-) group, significant negative associations were demonstrated by the aAD group with STI and those in the pAD group with MDF with ORs of 0.30 and 0.42, respectively.ConclusionSlow intrinsic EEG oscillation is associated with MCI due to AD, and a delayed ERP peak latency is likely associated with general cognitive impairment. MCI individuals without AD pathology exhibited better cortical temporal synchronization and faster EEG oscillations than those with aAD or pAD.SignificanceThe EEG/ERP variables obtained from prefrontal EEG techniques are associated with early cognitive impairment due to AD and non-AD pathology. This result suggests that prefrontal EEG/ERP metrics may serve as useful indicators to screen elderly individuals’ early stages on the AD continuum as well as overall cognitive impairment.
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title_short	Prefrontal EEG slowing, synchronization, and ERP peak latency in association with predementia stages of Alzheimer’s disease
url	https://doi.org/10.3389/fnagi.2023.1131857 https://doaj.org/article/20201c1a1b2c43c0a07473544314fc90 https://www.frontiersin.org/articles/10.3389/fnagi.2023.1131857/full https://doaj.org/toc/1663-4365
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author2	Boncho Ku Dieu Ni Thi Doan Junwoo Park Wonseok Cha Jaeuk U. Kim Kun Ho Lee
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Prefrontal EEG slowing, synchronization, and ERP peak latency in association with predementia stages of Alzheimer’s disease

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