Dietary Lactiplantibacillus plantarum KX041 attenuates colitis-associated tumorigenesis and modulates gut microbiota

Colorectal cancer (CRC) is one of the most common cancers and supplementation of probiotics may be a promising intervention method. The present study aimed to investigate the anti-CRC effects of Lactiplantibacillus plantarum KX041 on a CRC mouse model. The CRC mice were induced by 10 mg/kg azoxymeth...
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Autor*in:	Tao Wang [verfasserIn] Panpan Wang [verfasserIn] Li Yin [verfasserIn] Xiuchao Wang [verfasserIn] Yuanyuan Shan [verfasserIn] Yanglei Yi [verfasserIn] Yuan Zhou [verfasserIn] Bianfang Liu [verfasserIn] Xin Wang [verfasserIn] Xin Lü [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2023

Schlagwörter:	Lactiplantibacillus plantarum KX041 Colorectal cancer Gut microbiota Inflammation Intestinal permeability

Übergeordnetes Werk:	In: Food Science and Human Wellness - KeAi Communications Co., Ltd., 2016, 12(2023), 5, Seite 1626-1636
Übergeordnetes Werk:	volume:12 ; year:2023 ; number:5 ; pages:1626-1636

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.1016/j.fshw.2023.02.012

Katalog-ID:	DOAJ087663317

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520			\|a Colorectal cancer (CRC) is one of the most common cancers and supplementation of probiotics may be a promising intervention method. The present study aimed to investigate the anti-CRC effects of Lactiplantibacillus plantarum KX041 on a CRC mouse model. The CRC mice were induced by 10 mg/kg azoxymethane and 2 % dextran sulfate sodium. L. plantarum KX041 was orally administrated once daily (1 × 109 CFU/mouse). Results showed that L. plantarum KX041 could significantly inhibit inflammation, tumor formation, and induce tumor cells apoptosis. Moreover, this probiotic could ameliorate the damage of intestinal barrier by recovering tight junction protein expression (like Occludin, Claudin-1, and ZO-1) and preventing goblet cell loss. Furthermore, the oxidative stress was alleviated by increasing the level of antioxidant mediators (like GSH and SOD) and reducing the level of oxidative mediators (like MDA and MPO). In addition, treatment with L. plantarum KX041 could directly regulate gut microbiota, thereby increasing the abundance of beneficial bacteria (like SCFAs-producing bacteria, Akkermansia) and decreasing the abundance of harmful bacteria (like pro-inflammatory bacteria, Parasutterella), which in turn raised SCFAs levels and lowered LPS levels. In conclusion, L. plantarum KX041 could effectively ameliorate CRC via reshaping intestinal microenvironment, alleviating inflammation, maintaining intestinal permeability, and attenuating oxidative stress.
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allfields	10.1016/j.fshw.2023.02.012 doi (DE-627)DOAJ087663317 (DE-599)DOAJ8edd6c9a93964f4aa96efb37fa233418 DE-627 ger DE-627 rakwb eng TX341-641 Tao Wang verfasserin aut Dietary Lactiplantibacillus plantarum KX041 attenuates colitis-associated tumorigenesis and modulates gut microbiota 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Colorectal cancer (CRC) is one of the most common cancers and supplementation of probiotics may be a promising intervention method. The present study aimed to investigate the anti-CRC effects of Lactiplantibacillus plantarum KX041 on a CRC mouse model. The CRC mice were induced by 10 mg/kg azoxymethane and 2 % dextran sulfate sodium. L. plantarum KX041 was orally administrated once daily (1 × 109 CFU/mouse). Results showed that L. plantarum KX041 could significantly inhibit inflammation, tumor formation, and induce tumor cells apoptosis. Moreover, this probiotic could ameliorate the damage of intestinal barrier by recovering tight junction protein expression (like Occludin, Claudin-1, and ZO-1) and preventing goblet cell loss. Furthermore, the oxidative stress was alleviated by increasing the level of antioxidant mediators (like GSH and SOD) and reducing the level of oxidative mediators (like MDA and MPO). In addition, treatment with L. plantarum KX041 could directly regulate gut microbiota, thereby increasing the abundance of beneficial bacteria (like SCFAs-producing bacteria, Akkermansia) and decreasing the abundance of harmful bacteria (like pro-inflammatory bacteria, Parasutterella), which in turn raised SCFAs levels and lowered LPS levels. In conclusion, L. plantarum KX041 could effectively ameliorate CRC via reshaping intestinal microenvironment, alleviating inflammation, maintaining intestinal permeability, and attenuating oxidative stress. Lactiplantibacillus plantarum KX041 Colorectal cancer Gut microbiota Inflammation Intestinal permeability Nutrition. Foods and food supply Panpan Wang verfasserin aut Li Yin verfasserin aut Xiuchao Wang verfasserin aut Yuanyuan Shan verfasserin aut Yanglei Yi verfasserin aut Yuan Zhou verfasserin aut Bianfang Liu verfasserin aut Xin Wang verfasserin aut Xin Lü verfasserin aut In Food Science and Human Wellness KeAi Communications Co., Ltd., 2016 12(2023), 5, Seite 1626-1636 (DE-627)742744027 (DE-600)2712869-6 22134530 nnns volume:12 year:2023 number:5 pages:1626-1636 https://doi.org/10.1016/j.fshw.2023.02.012 kostenfrei https://doaj.org/article/8edd6c9a93964f4aa96efb37fa233418 kostenfrei http://www.sciencedirect.com/science/article/pii/S2213453023000125 kostenfrei https://doaj.org/toc/2213-4530 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4367 GBV_ILN_4700 AR 12 2023 5 1626-1636
spelling	10.1016/j.fshw.2023.02.012 doi (DE-627)DOAJ087663317 (DE-599)DOAJ8edd6c9a93964f4aa96efb37fa233418 DE-627 ger DE-627 rakwb eng TX341-641 Tao Wang verfasserin aut Dietary Lactiplantibacillus plantarum KX041 attenuates colitis-associated tumorigenesis and modulates gut microbiota 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Colorectal cancer (CRC) is one of the most common cancers and supplementation of probiotics may be a promising intervention method. The present study aimed to investigate the anti-CRC effects of Lactiplantibacillus plantarum KX041 on a CRC mouse model. The CRC mice were induced by 10 mg/kg azoxymethane and 2 % dextran sulfate sodium. L. plantarum KX041 was orally administrated once daily (1 × 109 CFU/mouse). Results showed that L. plantarum KX041 could significantly inhibit inflammation, tumor formation, and induce tumor cells apoptosis. Moreover, this probiotic could ameliorate the damage of intestinal barrier by recovering tight junction protein expression (like Occludin, Claudin-1, and ZO-1) and preventing goblet cell loss. Furthermore, the oxidative stress was alleviated by increasing the level of antioxidant mediators (like GSH and SOD) and reducing the level of oxidative mediators (like MDA and MPO). In addition, treatment with L. plantarum KX041 could directly regulate gut microbiota, thereby increasing the abundance of beneficial bacteria (like SCFAs-producing bacteria, Akkermansia) and decreasing the abundance of harmful bacteria (like pro-inflammatory bacteria, Parasutterella), which in turn raised SCFAs levels and lowered LPS levels. In conclusion, L. plantarum KX041 could effectively ameliorate CRC via reshaping intestinal microenvironment, alleviating inflammation, maintaining intestinal permeability, and attenuating oxidative stress. Lactiplantibacillus plantarum KX041 Colorectal cancer Gut microbiota Inflammation Intestinal permeability Nutrition. Foods and food supply Panpan Wang verfasserin aut Li Yin verfasserin aut Xiuchao Wang verfasserin aut Yuanyuan Shan verfasserin aut Yanglei Yi verfasserin aut Yuan Zhou verfasserin aut Bianfang Liu verfasserin aut Xin Wang verfasserin aut Xin Lü verfasserin aut In Food Science and Human Wellness KeAi Communications Co., Ltd., 2016 12(2023), 5, Seite 1626-1636 (DE-627)742744027 (DE-600)2712869-6 22134530 nnns volume:12 year:2023 number:5 pages:1626-1636 https://doi.org/10.1016/j.fshw.2023.02.012 kostenfrei https://doaj.org/article/8edd6c9a93964f4aa96efb37fa233418 kostenfrei http://www.sciencedirect.com/science/article/pii/S2213453023000125 kostenfrei https://doaj.org/toc/2213-4530 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4367 GBV_ILN_4700 AR 12 2023 5 1626-1636
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allfieldsGer	10.1016/j.fshw.2023.02.012 doi (DE-627)DOAJ087663317 (DE-599)DOAJ8edd6c9a93964f4aa96efb37fa233418 DE-627 ger DE-627 rakwb eng TX341-641 Tao Wang verfasserin aut Dietary Lactiplantibacillus plantarum KX041 attenuates colitis-associated tumorigenesis and modulates gut microbiota 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Colorectal cancer (CRC) is one of the most common cancers and supplementation of probiotics may be a promising intervention method. The present study aimed to investigate the anti-CRC effects of Lactiplantibacillus plantarum KX041 on a CRC mouse model. The CRC mice were induced by 10 mg/kg azoxymethane and 2 % dextran sulfate sodium. L. plantarum KX041 was orally administrated once daily (1 × 109 CFU/mouse). Results showed that L. plantarum KX041 could significantly inhibit inflammation, tumor formation, and induce tumor cells apoptosis. Moreover, this probiotic could ameliorate the damage of intestinal barrier by recovering tight junction protein expression (like Occludin, Claudin-1, and ZO-1) and preventing goblet cell loss. Furthermore, the oxidative stress was alleviated by increasing the level of antioxidant mediators (like GSH and SOD) and reducing the level of oxidative mediators (like MDA and MPO). In addition, treatment with L. plantarum KX041 could directly regulate gut microbiota, thereby increasing the abundance of beneficial bacteria (like SCFAs-producing bacteria, Akkermansia) and decreasing the abundance of harmful bacteria (like pro-inflammatory bacteria, Parasutterella), which in turn raised SCFAs levels and lowered LPS levels. In conclusion, L. plantarum KX041 could effectively ameliorate CRC via reshaping intestinal microenvironment, alleviating inflammation, maintaining intestinal permeability, and attenuating oxidative stress. Lactiplantibacillus plantarum KX041 Colorectal cancer Gut microbiota Inflammation Intestinal permeability Nutrition. Foods and food supply Panpan Wang verfasserin aut Li Yin verfasserin aut Xiuchao Wang verfasserin aut Yuanyuan Shan verfasserin aut Yanglei Yi verfasserin aut Yuan Zhou verfasserin aut Bianfang Liu verfasserin aut Xin Wang verfasserin aut Xin Lü verfasserin aut In Food Science and Human Wellness KeAi Communications Co., Ltd., 2016 12(2023), 5, Seite 1626-1636 (DE-627)742744027 (DE-600)2712869-6 22134530 nnns volume:12 year:2023 number:5 pages:1626-1636 https://doi.org/10.1016/j.fshw.2023.02.012 kostenfrei https://doaj.org/article/8edd6c9a93964f4aa96efb37fa233418 kostenfrei http://www.sciencedirect.com/science/article/pii/S2213453023000125 kostenfrei https://doaj.org/toc/2213-4530 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4367 GBV_ILN_4700 AR 12 2023 5 1626-1636
allfieldsSound	10.1016/j.fshw.2023.02.012 doi (DE-627)DOAJ087663317 (DE-599)DOAJ8edd6c9a93964f4aa96efb37fa233418 DE-627 ger DE-627 rakwb eng TX341-641 Tao Wang verfasserin aut Dietary Lactiplantibacillus plantarum KX041 attenuates colitis-associated tumorigenesis and modulates gut microbiota 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Colorectal cancer (CRC) is one of the most common cancers and supplementation of probiotics may be a promising intervention method. The present study aimed to investigate the anti-CRC effects of Lactiplantibacillus plantarum KX041 on a CRC mouse model. The CRC mice were induced by 10 mg/kg azoxymethane and 2 % dextran sulfate sodium. L. plantarum KX041 was orally administrated once daily (1 × 109 CFU/mouse). Results showed that L. plantarum KX041 could significantly inhibit inflammation, tumor formation, and induce tumor cells apoptosis. Moreover, this probiotic could ameliorate the damage of intestinal barrier by recovering tight junction protein expression (like Occludin, Claudin-1, and ZO-1) and preventing goblet cell loss. Furthermore, the oxidative stress was alleviated by increasing the level of antioxidant mediators (like GSH and SOD) and reducing the level of oxidative mediators (like MDA and MPO). In addition, treatment with L. plantarum KX041 could directly regulate gut microbiota, thereby increasing the abundance of beneficial bacteria (like SCFAs-producing bacteria, Akkermansia) and decreasing the abundance of harmful bacteria (like pro-inflammatory bacteria, Parasutterella), which in turn raised SCFAs levels and lowered LPS levels. In conclusion, L. plantarum KX041 could effectively ameliorate CRC via reshaping intestinal microenvironment, alleviating inflammation, maintaining intestinal permeability, and attenuating oxidative stress. Lactiplantibacillus plantarum KX041 Colorectal cancer Gut microbiota Inflammation Intestinal permeability Nutrition. Foods and food supply Panpan Wang verfasserin aut Li Yin verfasserin aut Xiuchao Wang verfasserin aut Yuanyuan Shan verfasserin aut Yanglei Yi verfasserin aut Yuan Zhou verfasserin aut Bianfang Liu verfasserin aut Xin Wang verfasserin aut Xin Lü verfasserin aut In Food Science and Human Wellness KeAi Communications Co., Ltd., 2016 12(2023), 5, Seite 1626-1636 (DE-627)742744027 (DE-600)2712869-6 22134530 nnns volume:12 year:2023 number:5 pages:1626-1636 https://doi.org/10.1016/j.fshw.2023.02.012 kostenfrei https://doaj.org/article/8edd6c9a93964f4aa96efb37fa233418 kostenfrei http://www.sciencedirect.com/science/article/pii/S2213453023000125 kostenfrei https://doaj.org/toc/2213-4530 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4367 GBV_ILN_4700 AR 12 2023 5 1626-1636
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callnumber-first	T - Technology
author	Tao Wang
spellingShingle	Tao Wang misc TX341-641 misc Lactiplantibacillus plantarum KX041 misc Colorectal cancer misc Gut microbiota misc Inflammation misc Intestinal permeability misc Nutrition. Foods and food supply Dietary Lactiplantibacillus plantarum KX041 attenuates colitis-associated tumorigenesis and modulates gut microbiota
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topic_title	TX341-641 Dietary Lactiplantibacillus plantarum KX041 attenuates colitis-associated tumorigenesis and modulates gut microbiota Lactiplantibacillus plantarum KX041 Colorectal cancer Gut microbiota Inflammation Intestinal permeability
topic	misc TX341-641 misc Lactiplantibacillus plantarum KX041 misc Colorectal cancer misc Gut microbiota misc Inflammation misc Intestinal permeability misc Nutrition. Foods and food supply
topic_unstemmed	misc TX341-641 misc Lactiplantibacillus plantarum KX041 misc Colorectal cancer misc Gut microbiota misc Inflammation misc Intestinal permeability misc Nutrition. Foods and food supply
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title	Dietary Lactiplantibacillus plantarum KX041 attenuates colitis-associated tumorigenesis and modulates gut microbiota
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title_full	Dietary Lactiplantibacillus plantarum KX041 attenuates colitis-associated tumorigenesis and modulates gut microbiota
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title_sort	dietary lactiplantibacillus plantarum kx041 attenuates colitis-associated tumorigenesis and modulates gut microbiota
callnumber	TX341-641
title_auth	Dietary Lactiplantibacillus plantarum KX041 attenuates colitis-associated tumorigenesis and modulates gut microbiota
abstract	Colorectal cancer (CRC) is one of the most common cancers and supplementation of probiotics may be a promising intervention method. The present study aimed to investigate the anti-CRC effects of Lactiplantibacillus plantarum KX041 on a CRC mouse model. The CRC mice were induced by 10 mg/kg azoxymethane and 2 % dextran sulfate sodium. L. plantarum KX041 was orally administrated once daily (1 × 109 CFU/mouse). Results showed that L. plantarum KX041 could significantly inhibit inflammation, tumor formation, and induce tumor cells apoptosis. Moreover, this probiotic could ameliorate the damage of intestinal barrier by recovering tight junction protein expression (like Occludin, Claudin-1, and ZO-1) and preventing goblet cell loss. Furthermore, the oxidative stress was alleviated by increasing the level of antioxidant mediators (like GSH and SOD) and reducing the level of oxidative mediators (like MDA and MPO). In addition, treatment with L. plantarum KX041 could directly regulate gut microbiota, thereby increasing the abundance of beneficial bacteria (like SCFAs-producing bacteria, Akkermansia) and decreasing the abundance of harmful bacteria (like pro-inflammatory bacteria, Parasutterella), which in turn raised SCFAs levels and lowered LPS levels. In conclusion, L. plantarum KX041 could effectively ameliorate CRC via reshaping intestinal microenvironment, alleviating inflammation, maintaining intestinal permeability, and attenuating oxidative stress.
abstractGer	Colorectal cancer (CRC) is one of the most common cancers and supplementation of probiotics may be a promising intervention method. The present study aimed to investigate the anti-CRC effects of Lactiplantibacillus plantarum KX041 on a CRC mouse model. The CRC mice were induced by 10 mg/kg azoxymethane and 2 % dextran sulfate sodium. L. plantarum KX041 was orally administrated once daily (1 × 109 CFU/mouse). Results showed that L. plantarum KX041 could significantly inhibit inflammation, tumor formation, and induce tumor cells apoptosis. Moreover, this probiotic could ameliorate the damage of intestinal barrier by recovering tight junction protein expression (like Occludin, Claudin-1, and ZO-1) and preventing goblet cell loss. Furthermore, the oxidative stress was alleviated by increasing the level of antioxidant mediators (like GSH and SOD) and reducing the level of oxidative mediators (like MDA and MPO). In addition, treatment with L. plantarum KX041 could directly regulate gut microbiota, thereby increasing the abundance of beneficial bacteria (like SCFAs-producing bacteria, Akkermansia) and decreasing the abundance of harmful bacteria (like pro-inflammatory bacteria, Parasutterella), which in turn raised SCFAs levels and lowered LPS levels. In conclusion, L. plantarum KX041 could effectively ameliorate CRC via reshaping intestinal microenvironment, alleviating inflammation, maintaining intestinal permeability, and attenuating oxidative stress.
abstract_unstemmed	Colorectal cancer (CRC) is one of the most common cancers and supplementation of probiotics may be a promising intervention method. The present study aimed to investigate the anti-CRC effects of Lactiplantibacillus plantarum KX041 on a CRC mouse model. The CRC mice were induced by 10 mg/kg azoxymethane and 2 % dextran sulfate sodium. L. plantarum KX041 was orally administrated once daily (1 × 109 CFU/mouse). Results showed that L. plantarum KX041 could significantly inhibit inflammation, tumor formation, and induce tumor cells apoptosis. Moreover, this probiotic could ameliorate the damage of intestinal barrier by recovering tight junction protein expression (like Occludin, Claudin-1, and ZO-1) and preventing goblet cell loss. Furthermore, the oxidative stress was alleviated by increasing the level of antioxidant mediators (like GSH and SOD) and reducing the level of oxidative mediators (like MDA and MPO). In addition, treatment with L. plantarum KX041 could directly regulate gut microbiota, thereby increasing the abundance of beneficial bacteria (like SCFAs-producing bacteria, Akkermansia) and decreasing the abundance of harmful bacteria (like pro-inflammatory bacteria, Parasutterella), which in turn raised SCFAs levels and lowered LPS levels. In conclusion, L. plantarum KX041 could effectively ameliorate CRC via reshaping intestinal microenvironment, alleviating inflammation, maintaining intestinal permeability, and attenuating oxidative stress.
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title_short	Dietary Lactiplantibacillus plantarum KX041 attenuates colitis-associated tumorigenesis and modulates gut microbiota
url	https://doi.org/10.1016/j.fshw.2023.02.012 https://doaj.org/article/8edd6c9a93964f4aa96efb37fa233418 http://www.sciencedirect.com/science/article/pii/S2213453023000125 https://doaj.org/toc/2213-4530
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author2	Panpan Wang Li Yin Xiuchao Wang Yuanyuan Shan Yanglei Yi Yuan Zhou Bianfang Liu Xin Wang Xin Lü
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up_date	2024-07-04T02:30:40.310Z
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In addition, treatment with L. plantarum KX041 could directly regulate gut microbiota, thereby increasing the abundance of beneficial bacteria (like SCFAs-producing bacteria, Akkermansia) and decreasing the abundance of harmful bacteria (like pro-inflammatory bacteria, Parasutterella), which in turn raised SCFAs levels and lowered LPS levels. 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Dietary Lactiplantibacillus plantarum KX041 attenuates colitis-associated tumorigenesis and modulates gut microbiota

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