Therapy of traumatic brain injury by modern agents and traditional Chinese medicine

Abstract Traumatic brain injury (TBI) is the leading cause of disability and death, and the social burden of mortality and morbidity caused by TBI is significant. Under the influence of comprehensive factors, such as social environment, lifestyle, and employment type, the incidence of TBI continues...
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Autor*in:	Chunzhu Wei [verfasserIn] Jingbo Wang [verfasserIn] Jintao Yu [verfasserIn] Qing Tang [verfasserIn] Xinjie Liu [verfasserIn] Yanlong Zhang [verfasserIn] Dandan Cui [verfasserIn] Yanqiong Zhu [verfasserIn] Yanli Mei [verfasserIn] Yanjun Wang [verfasserIn] Wenzhu Wang [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2023

Schlagwörter:	Traumatic brain injury Pharmacological therapies Traditional Chinese medicine Modern agents

Übergeordnetes Werk:	In: Chinese Medicine - BMC, 2006, 18(2023), 1, Seite 19
Übergeordnetes Werk:	volume:18 ; year:2023 ; number:1 ; pages:19

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.1186/s13020-023-00731-x

Katalog-ID:	DOAJ087702134

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520			\|a Abstract Traumatic brain injury (TBI) is the leading cause of disability and death, and the social burden of mortality and morbidity caused by TBI is significant. Under the influence of comprehensive factors, such as social environment, lifestyle, and employment type, the incidence of TBI continues to increase annually. Current pharmacotherapy of TBI mainly focuses on symptomatic supportive treatment, aiming to reduce intracranial pressure, ease pain, alleviate irritability, and fight infection. In this study, we summarized numerous studies covering the use of neuroprotective agents in different animal models and clinical trials after TBI. However, we found that no drug has been approved as specifically effective for the treatment of TBI. Effective therapeutic strategies for TBI remain an urgent need, and attention is turning toward traditional Chinese medicine. We analyzed the reasons why existing high-profile drugs had failed to show clinical benefits and offered our views on the research of traditional herbal medicine for treating TBI.
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allfields	10.1186/s13020-023-00731-x doi (DE-627)DOAJ087702134 (DE-599)DOAJb2b5af21faef4c8a8ba5bafa1d8c65f5 DE-627 ger DE-627 rakwb eng RZ201-999 Chunzhu Wei verfasserin aut Therapy of traumatic brain injury by modern agents and traditional Chinese medicine 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Traumatic brain injury (TBI) is the leading cause of disability and death, and the social burden of mortality and morbidity caused by TBI is significant. Under the influence of comprehensive factors, such as social environment, lifestyle, and employment type, the incidence of TBI continues to increase annually. Current pharmacotherapy of TBI mainly focuses on symptomatic supportive treatment, aiming to reduce intracranial pressure, ease pain, alleviate irritability, and fight infection. In this study, we summarized numerous studies covering the use of neuroprotective agents in different animal models and clinical trials after TBI. However, we found that no drug has been approved as specifically effective for the treatment of TBI. Effective therapeutic strategies for TBI remain an urgent need, and attention is turning toward traditional Chinese medicine. We analyzed the reasons why existing high-profile drugs had failed to show clinical benefits and offered our views on the research of traditional herbal medicine for treating TBI. Traumatic brain injury Pharmacological therapies Traditional Chinese medicine Modern agents Other systems of medicine Jingbo Wang verfasserin aut Jintao Yu verfasserin aut Qing Tang verfasserin aut Xinjie Liu verfasserin aut Yanlong Zhang verfasserin aut Dandan Cui verfasserin aut Yanqiong Zhu verfasserin aut Yanli Mei verfasserin aut Yanjun Wang verfasserin aut Wenzhu Wang verfasserin aut In Chinese Medicine BMC, 2006 18(2023), 1, Seite 19 (DE-627)521457025 (DE-600)2260322-0 17498546 nnns volume:18 year:2023 number:1 pages:19 https://doi.org/10.1186/s13020-023-00731-x kostenfrei https://doaj.org/article/b2b5af21faef4c8a8ba5bafa1d8c65f5 kostenfrei https://doi.org/10.1186/s13020-023-00731-x kostenfrei https://doaj.org/toc/1749-8546 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 18 2023 1 19
spelling	10.1186/s13020-023-00731-x doi (DE-627)DOAJ087702134 (DE-599)DOAJb2b5af21faef4c8a8ba5bafa1d8c65f5 DE-627 ger DE-627 rakwb eng RZ201-999 Chunzhu Wei verfasserin aut Therapy of traumatic brain injury by modern agents and traditional Chinese medicine 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Traumatic brain injury (TBI) is the leading cause of disability and death, and the social burden of mortality and morbidity caused by TBI is significant. Under the influence of comprehensive factors, such as social environment, lifestyle, and employment type, the incidence of TBI continues to increase annually. Current pharmacotherapy of TBI mainly focuses on symptomatic supportive treatment, aiming to reduce intracranial pressure, ease pain, alleviate irritability, and fight infection. In this study, we summarized numerous studies covering the use of neuroprotective agents in different animal models and clinical trials after TBI. However, we found that no drug has been approved as specifically effective for the treatment of TBI. Effective therapeutic strategies for TBI remain an urgent need, and attention is turning toward traditional Chinese medicine. We analyzed the reasons why existing high-profile drugs had failed to show clinical benefits and offered our views on the research of traditional herbal medicine for treating TBI. Traumatic brain injury Pharmacological therapies Traditional Chinese medicine Modern agents Other systems of medicine Jingbo Wang verfasserin aut Jintao Yu verfasserin aut Qing Tang verfasserin aut Xinjie Liu verfasserin aut Yanlong Zhang verfasserin aut Dandan Cui verfasserin aut Yanqiong Zhu verfasserin aut Yanli Mei verfasserin aut Yanjun Wang verfasserin aut Wenzhu Wang verfasserin aut In Chinese Medicine BMC, 2006 18(2023), 1, Seite 19 (DE-627)521457025 (DE-600)2260322-0 17498546 nnns volume:18 year:2023 number:1 pages:19 https://doi.org/10.1186/s13020-023-00731-x kostenfrei https://doaj.org/article/b2b5af21faef4c8a8ba5bafa1d8c65f5 kostenfrei https://doi.org/10.1186/s13020-023-00731-x kostenfrei https://doaj.org/toc/1749-8546 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 18 2023 1 19
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author	Chunzhu Wei
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topic_title	RZ201-999 Therapy of traumatic brain injury by modern agents and traditional Chinese medicine Traumatic brain injury Pharmacological therapies Traditional Chinese medicine Modern agents
topic	misc RZ201-999 misc Traumatic brain injury misc Pharmacological therapies misc Traditional Chinese medicine misc Modern agents misc Other systems of medicine
topic_unstemmed	misc RZ201-999 misc Traumatic brain injury misc Pharmacological therapies misc Traditional Chinese medicine misc Modern agents misc Other systems of medicine
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title_auth	Therapy of traumatic brain injury by modern agents and traditional Chinese medicine
abstract	Abstract Traumatic brain injury (TBI) is the leading cause of disability and death, and the social burden of mortality and morbidity caused by TBI is significant. Under the influence of comprehensive factors, such as social environment, lifestyle, and employment type, the incidence of TBI continues to increase annually. Current pharmacotherapy of TBI mainly focuses on symptomatic supportive treatment, aiming to reduce intracranial pressure, ease pain, alleviate irritability, and fight infection. In this study, we summarized numerous studies covering the use of neuroprotective agents in different animal models and clinical trials after TBI. However, we found that no drug has been approved as specifically effective for the treatment of TBI. Effective therapeutic strategies for TBI remain an urgent need, and attention is turning toward traditional Chinese medicine. We analyzed the reasons why existing high-profile drugs had failed to show clinical benefits and offered our views on the research of traditional herbal medicine for treating TBI.
abstractGer	Abstract Traumatic brain injury (TBI) is the leading cause of disability and death, and the social burden of mortality and morbidity caused by TBI is significant. Under the influence of comprehensive factors, such as social environment, lifestyle, and employment type, the incidence of TBI continues to increase annually. Current pharmacotherapy of TBI mainly focuses on symptomatic supportive treatment, aiming to reduce intracranial pressure, ease pain, alleviate irritability, and fight infection. In this study, we summarized numerous studies covering the use of neuroprotective agents in different animal models and clinical trials after TBI. However, we found that no drug has been approved as specifically effective for the treatment of TBI. Effective therapeutic strategies for TBI remain an urgent need, and attention is turning toward traditional Chinese medicine. We analyzed the reasons why existing high-profile drugs had failed to show clinical benefits and offered our views on the research of traditional herbal medicine for treating TBI.
abstract_unstemmed	Abstract Traumatic brain injury (TBI) is the leading cause of disability and death, and the social burden of mortality and morbidity caused by TBI is significant. Under the influence of comprehensive factors, such as social environment, lifestyle, and employment type, the incidence of TBI continues to increase annually. Current pharmacotherapy of TBI mainly focuses on symptomatic supportive treatment, aiming to reduce intracranial pressure, ease pain, alleviate irritability, and fight infection. In this study, we summarized numerous studies covering the use of neuroprotective agents in different animal models and clinical trials after TBI. However, we found that no drug has been approved as specifically effective for the treatment of TBI. Effective therapeutic strategies for TBI remain an urgent need, and attention is turning toward traditional Chinese medicine. We analyzed the reasons why existing high-profile drugs had failed to show clinical benefits and offered our views on the research of traditional herbal medicine for treating TBI.
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title_short	Therapy of traumatic brain injury by modern agents and traditional Chinese medicine
url	https://doi.org/10.1186/s13020-023-00731-x https://doaj.org/article/b2b5af21faef4c8a8ba5bafa1d8c65f5 https://doaj.org/toc/1749-8546
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