Cu-doped TiO2 nanoparticles improve local antitumor immune activation and optimize dendritic cell vaccine strategies
Abstract Nanoparticle-mediated cancer immunotherapy holds great promise, but more efforts are needed to obtain nanoformulations that result in a full scale activation of innate and adaptive immune components that specifically target the tumors. We generated a series of copper-doped TiO2 nanoparticle...
Ausführliche Beschreibung
Autor*in: |
Evelien Hesemans [verfasserIn] Neshat Saffarzadeh [verfasserIn] Christy Maksoudian [verfasserIn] Mukaddes Izci [verfasserIn] Tianjiao Chu [verfasserIn] Carla Rios Luci [verfasserIn] Yuqing Wang [verfasserIn] Hendrik Naatz [verfasserIn] Sebastian Thieme [verfasserIn] Cornelia Richter [verfasserIn] Bella B. Manshian [verfasserIn] Suman Pokhrel [verfasserIn] Lutz Mädler [verfasserIn] Stefaan J. Soenen [verfasserIn] |
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E-Artikel |
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Sprache: |
Englisch |
Erschienen: |
2023 |
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Übergeordnetes Werk: |
In: Journal of Nanobiotechnology - BMC, 2003, 21(2023), 1, Seite 28 |
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Übergeordnetes Werk: |
volume:21 ; year:2023 ; number:1 ; pages:28 |
Links: |
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DOI / URN: |
10.1186/s12951-023-01844-z |
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Katalog-ID: |
DOAJ087705877 |
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520 | |a Abstract Nanoparticle-mediated cancer immunotherapy holds great promise, but more efforts are needed to obtain nanoformulations that result in a full scale activation of innate and adaptive immune components that specifically target the tumors. We generated a series of copper-doped TiO2 nanoparticles in order to tune the kinetics and full extent of Cu2+ ion release from the remnant TiO2 nanocrystals. Fine-tuning nanoparticle properties resulted in a formulation of 33% Cu-doped TiO2 which enabled short-lived hyperactivation of dendritic cells and hereby promoted immunotherapy. The nanoparticles result in highly efficient activation of dendritic cells ex vivo, which upon transplantation in tumor bearing mice, exceeded the therapeutic outcomes obtained with classically stimulated dendritic cells. Efficacious but simple nanomaterials that can promote dendritic cancer cell vaccination strategies open up new avenues for improved immunotherapy and human health. Graphical Abstract | ||
650 | 4 | |a Nanomedicine | |
650 | 4 | |a Dendritic cell vaccine | |
650 | 4 | |a Tumor therapy | |
650 | 4 | |a Metal (oxide) nanoparticles | |
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10.1186/s12951-023-01844-z doi (DE-627)DOAJ087705877 (DE-599)DOAJ4edafa41c145433d9a31b1abb2cc5619 DE-627 ger DE-627 rakwb eng TP248.13-248.65 R855-855.5 Evelien Hesemans verfasserin aut Cu-doped TiO2 nanoparticles improve local antitumor immune activation and optimize dendritic cell vaccine strategies 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Nanoparticle-mediated cancer immunotherapy holds great promise, but more efforts are needed to obtain nanoformulations that result in a full scale activation of innate and adaptive immune components that specifically target the tumors. We generated a series of copper-doped TiO2 nanoparticles in order to tune the kinetics and full extent of Cu2+ ion release from the remnant TiO2 nanocrystals. Fine-tuning nanoparticle properties resulted in a formulation of 33% Cu-doped TiO2 which enabled short-lived hyperactivation of dendritic cells and hereby promoted immunotherapy. The nanoparticles result in highly efficient activation of dendritic cells ex vivo, which upon transplantation in tumor bearing mice, exceeded the therapeutic outcomes obtained with classically stimulated dendritic cells. Efficacious but simple nanomaterials that can promote dendritic cancer cell vaccination strategies open up new avenues for improved immunotherapy and human health. Graphical Abstract Nanomedicine Dendritic cell vaccine Tumor therapy Metal (oxide) nanoparticles Biotechnology Medical technology Neshat Saffarzadeh verfasserin aut Christy Maksoudian verfasserin aut Mukaddes Izci verfasserin aut Tianjiao Chu verfasserin aut Carla Rios Luci verfasserin aut Yuqing Wang verfasserin aut Hendrik Naatz verfasserin aut Sebastian Thieme verfasserin aut Cornelia Richter verfasserin aut Bella B. Manshian verfasserin aut Suman Pokhrel verfasserin aut Lutz Mädler verfasserin aut Stefaan J. Soenen verfasserin aut In Journal of Nanobiotechnology BMC, 2003 21(2023), 1, Seite 28 (DE-627)362770328 (DE-600)2100022-0 14773155 nnns volume:21 year:2023 number:1 pages:28 https://doi.org/10.1186/s12951-023-01844-z kostenfrei https://doaj.org/article/4edafa41c145433d9a31b1abb2cc5619 kostenfrei https://doi.org/10.1186/s12951-023-01844-z kostenfrei https://doaj.org/toc/1477-3155 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2027 GBV_ILN_2055 GBV_ILN_2108 GBV_ILN_2111 GBV_ILN_2119 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 21 2023 1 28 |
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Evelien Hesemans @@aut@@ Neshat Saffarzadeh @@aut@@ Christy Maksoudian @@aut@@ Mukaddes Izci @@aut@@ Tianjiao Chu @@aut@@ Carla Rios Luci @@aut@@ Yuqing Wang @@aut@@ Hendrik Naatz @@aut@@ Sebastian Thieme @@aut@@ Cornelia Richter @@aut@@ Bella B. Manshian @@aut@@ Suman Pokhrel @@aut@@ Lutz Mädler @@aut@@ Stefaan J. Soenen @@aut@@ |
publishDateDaySort_date |
2023-01-01T00:00:00Z |
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362770328 |
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DOAJ087705877 |
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englisch |
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Cu-doped TiO2 nanoparticles improve local antitumor immune activation and optimize dendritic cell vaccine strategies |
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Abstract Nanoparticle-mediated cancer immunotherapy holds great promise, but more efforts are needed to obtain nanoformulations that result in a full scale activation of innate and adaptive immune components that specifically target the tumors. We generated a series of copper-doped TiO2 nanoparticles in order to tune the kinetics and full extent of Cu2+ ion release from the remnant TiO2 nanocrystals. Fine-tuning nanoparticle properties resulted in a formulation of 33% Cu-doped TiO2 which enabled short-lived hyperactivation of dendritic cells and hereby promoted immunotherapy. The nanoparticles result in highly efficient activation of dendritic cells ex vivo, which upon transplantation in tumor bearing mice, exceeded the therapeutic outcomes obtained with classically stimulated dendritic cells. Efficacious but simple nanomaterials that can promote dendritic cancer cell vaccination strategies open up new avenues for improved immunotherapy and human health. Graphical Abstract |
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Abstract Nanoparticle-mediated cancer immunotherapy holds great promise, but more efforts are needed to obtain nanoformulations that result in a full scale activation of innate and adaptive immune components that specifically target the tumors. We generated a series of copper-doped TiO2 nanoparticles in order to tune the kinetics and full extent of Cu2+ ion release from the remnant TiO2 nanocrystals. Fine-tuning nanoparticle properties resulted in a formulation of 33% Cu-doped TiO2 which enabled short-lived hyperactivation of dendritic cells and hereby promoted immunotherapy. The nanoparticles result in highly efficient activation of dendritic cells ex vivo, which upon transplantation in tumor bearing mice, exceeded the therapeutic outcomes obtained with classically stimulated dendritic cells. Efficacious but simple nanomaterials that can promote dendritic cancer cell vaccination strategies open up new avenues for improved immunotherapy and human health. Graphical Abstract |
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Abstract Nanoparticle-mediated cancer immunotherapy holds great promise, but more efforts are needed to obtain nanoformulations that result in a full scale activation of innate and adaptive immune components that specifically target the tumors. We generated a series of copper-doped TiO2 nanoparticles in order to tune the kinetics and full extent of Cu2+ ion release from the remnant TiO2 nanocrystals. Fine-tuning nanoparticle properties resulted in a formulation of 33% Cu-doped TiO2 which enabled short-lived hyperactivation of dendritic cells and hereby promoted immunotherapy. The nanoparticles result in highly efficient activation of dendritic cells ex vivo, which upon transplantation in tumor bearing mice, exceeded the therapeutic outcomes obtained with classically stimulated dendritic cells. Efficacious but simple nanomaterials that can promote dendritic cancer cell vaccination strategies open up new avenues for improved immunotherapy and human health. Graphical Abstract |
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We generated a series of copper-doped TiO2 nanoparticles in order to tune the kinetics and full extent of Cu2+ ion release from the remnant TiO2 nanocrystals. Fine-tuning nanoparticle properties resulted in a formulation of 33% Cu-doped TiO2 which enabled short-lived hyperactivation of dendritic cells and hereby promoted immunotherapy. The nanoparticles result in highly efficient activation of dendritic cells ex vivo, which upon transplantation in tumor bearing mice, exceeded the therapeutic outcomes obtained with classically stimulated dendritic cells. Efficacious but simple nanomaterials that can promote dendritic cancer cell vaccination strategies open up new avenues for improved immunotherapy and human health. 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