Study title: A systematic review of RCTs to examine the risk of adverse cardiovascular events with nicotine use

Associations between cigarette smoking and increased risk of cardiovascular disease are well established. However, it is unclear whether the association is mediated by exposure to nicotine and/or to other constituents in cigarette smoke. The objective of this systematic review and meta-analysis of r...
Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Mimi M. Kim [verfasserIn] Isabella Steffensen [verfasserIn] Red Thaddeus D. Miguel [verfasserIn] Tanja Babic [verfasserIn] Aubrey D. Johnson [verfasserIn] Julien Carlone [verfasserIn] Ryan Potts [verfasserIn] Christopher S. Junker [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2023

Schlagwörter:	systematic review and meta-analysis nicotine adverse event (AE) cardiovascular PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analysis)

Übergeordnetes Werk:	In: Frontiers in Cardiovascular Medicine - Frontiers Media S.A., 2015, 10(2023)
Übergeordnetes Werk:	volume:10 ; year:2023

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3389/fcvm.2023.1111673

Katalog-ID:	DOAJ087843153

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callnumber-first	R - Medicine
author	Mimi M. Kim
spellingShingle	Mimi M. Kim misc RC666-701 misc systematic review and meta-analysis misc nicotine misc adverse event (AE) misc cardiovascular misc PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analysis) misc Diseases of the circulatory (Cardiovascular) system Study title: A systematic review of RCTs to examine the risk of adverse cardiovascular events with nicotine use
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topic_title	RC666-701 Study title: A systematic review of RCTs to examine the risk of adverse cardiovascular events with nicotine use systematic review and meta-analysis nicotine adverse event (AE) cardiovascular PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analysis)
topic	misc RC666-701 misc systematic review and meta-analysis misc nicotine misc adverse event (AE) misc cardiovascular misc PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analysis) misc Diseases of the circulatory (Cardiovascular) system
topic_unstemmed	misc RC666-701 misc systematic review and meta-analysis misc nicotine misc adverse event (AE) misc cardiovascular misc PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analysis) misc Diseases of the circulatory (Cardiovascular) system
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title	Study title: A systematic review of RCTs to examine the risk of adverse cardiovascular events with nicotine use
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title_full	Study title: A systematic review of RCTs to examine the risk of adverse cardiovascular events with nicotine use
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title_sort	study title: a systematic review of rcts to examine the risk of adverse cardiovascular events with nicotine use
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title_auth	Study title: A systematic review of RCTs to examine the risk of adverse cardiovascular events with nicotine use
abstract	Associations between cigarette smoking and increased risk of cardiovascular disease are well established. However, it is unclear whether the association is mediated by exposure to nicotine and/or to other constituents in cigarette smoke. The objective of this systematic review and meta-analysis of randomized control trials (RCTs) was to identify any potential associations between exposure to nicotine and the risk of clinically diagnosed adverse cardiovascular events in adult current users and nonusers of tobacco products. Among 1,996 results, 42 studies, comparing nicotine and non-nicotine groups, were included and were both qualitatively and quantitatively synthesized across the outcomes of arrhythmia, nonfatal myocardial infarction, nonfatal stroke, and cardiovascular death. The majority of studies evaluating nonfatal myocardial infarction, nonfatal stroke, and cardiovascular death reported no events that occurred in either the nicotine or non-nicotine control groups. Among the studies that reported events, rates of adverse events were similarly low between both groups. Consistent with findings from previous systematic reviews and meta-analyses, pooled data showed that rates for arrhythmia, nonfatal myocardial infarction, nonfatal stroke, and cardiovascular death were not significantly different between nicotine and non-nicotine groups. The overall quality of the body of evidence for each of the four outcomes of interest was graded as “moderate,” limited only by the imprecision of results. The findings of this systematic review and meta-analysis indicate that, with moderate certainty, there are no significant associations between the use of nicotine and the risk of clinically diagnosed adverse cardiovascular events—specifically, arrhythmia, nonfatal myocardial infarction, nonfatal stroke, and cardiovascular death.
abstractGer	Associations between cigarette smoking and increased risk of cardiovascular disease are well established. However, it is unclear whether the association is mediated by exposure to nicotine and/or to other constituents in cigarette smoke. The objective of this systematic review and meta-analysis of randomized control trials (RCTs) was to identify any potential associations between exposure to nicotine and the risk of clinically diagnosed adverse cardiovascular events in adult current users and nonusers of tobacco products. Among 1,996 results, 42 studies, comparing nicotine and non-nicotine groups, were included and were both qualitatively and quantitatively synthesized across the outcomes of arrhythmia, nonfatal myocardial infarction, nonfatal stroke, and cardiovascular death. The majority of studies evaluating nonfatal myocardial infarction, nonfatal stroke, and cardiovascular death reported no events that occurred in either the nicotine or non-nicotine control groups. Among the studies that reported events, rates of adverse events were similarly low between both groups. Consistent with findings from previous systematic reviews and meta-analyses, pooled data showed that rates for arrhythmia, nonfatal myocardial infarction, nonfatal stroke, and cardiovascular death were not significantly different between nicotine and non-nicotine groups. The overall quality of the body of evidence for each of the four outcomes of interest was graded as “moderate,” limited only by the imprecision of results. The findings of this systematic review and meta-analysis indicate that, with moderate certainty, there are no significant associations between the use of nicotine and the risk of clinically diagnosed adverse cardiovascular events—specifically, arrhythmia, nonfatal myocardial infarction, nonfatal stroke, and cardiovascular death.
abstract_unstemmed	Associations between cigarette smoking and increased risk of cardiovascular disease are well established. However, it is unclear whether the association is mediated by exposure to nicotine and/or to other constituents in cigarette smoke. The objective of this systematic review and meta-analysis of randomized control trials (RCTs) was to identify any potential associations between exposure to nicotine and the risk of clinically diagnosed adverse cardiovascular events in adult current users and nonusers of tobacco products. Among 1,996 results, 42 studies, comparing nicotine and non-nicotine groups, were included and were both qualitatively and quantitatively synthesized across the outcomes of arrhythmia, nonfatal myocardial infarction, nonfatal stroke, and cardiovascular death. The majority of studies evaluating nonfatal myocardial infarction, nonfatal stroke, and cardiovascular death reported no events that occurred in either the nicotine or non-nicotine control groups. Among the studies that reported events, rates of adverse events were similarly low between both groups. Consistent with findings from previous systematic reviews and meta-analyses, pooled data showed that rates for arrhythmia, nonfatal myocardial infarction, nonfatal stroke, and cardiovascular death were not significantly different between nicotine and non-nicotine groups. The overall quality of the body of evidence for each of the four outcomes of interest was graded as “moderate,” limited only by the imprecision of results. The findings of this systematic review and meta-analysis indicate that, with moderate certainty, there are no significant associations between the use of nicotine and the risk of clinically diagnosed adverse cardiovascular events—specifically, arrhythmia, nonfatal myocardial infarction, nonfatal stroke, and cardiovascular death.
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title_short	Study title: A systematic review of RCTs to examine the risk of adverse cardiovascular events with nicotine use
url	https://doi.org/10.3389/fcvm.2023.1111673 https://doaj.org/article/866e82d8810f4bae95620d42062dd47a https://www.frontiersin.org/articles/10.3389/fcvm.2023.1111673/full https://doaj.org/toc/2297-055X
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author2	Isabella Steffensen Red Thaddeus D. Miguel Tanja Babic Aubrey D. Johnson Julien Carlone Ryan Potts Christopher S. Junker
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up_date	2024-07-03T14:17:17.594Z
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Consistent with findings from previous systematic reviews and meta-analyses, pooled data showed that rates for arrhythmia, nonfatal myocardial infarction, nonfatal stroke, and cardiovascular death were not significantly different between nicotine and non-nicotine groups. The overall quality of the body of evidence for each of the four outcomes of interest was graded as “moderate,” limited only by the imprecision of results. 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Miguel</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Tanja Babic</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Aubrey D. Johnson</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Julien Carlone</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Ryan Potts</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Christopher S. 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Study title: A systematic review of RCTs to examine the risk of adverse cardiovascular events with nicotine use

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