The role of herpesviruses and pneumocysts in infectious complications in children during liver transplantation
Infections occupy one of the central places among the complications of transplants. The frequency of fatal infectious complications during the first twelve months after transplantation ranges from 2.6 to 51.7%. Identifying markers of opportunistic infections before transplantation will help reduce t...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
N. L. Pulnova [verfasserIn] T. N. Rybalkina [verfasserIn] N. V. Karazhas [verfasserIn] R. E. Bosh’ian [verfasserIn] M. N. Kornienko [verfasserIn] O. F. Kabikova [verfasserIn] N. I. Gabrielyan [verfasserIn] I. E. Pashkova [verfasserIn] O. V. Silina [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Russisch |
| Erschienen: |
2022 |
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| Schlagwörter: |
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| Übergeordnetes Werk: |
In: Детские инфекции (Москва) - LLC "Diagnostics and Vaccines", 2016, 21(2022), 4, Seite 21-26 |
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| Übergeordnetes Werk: |
volume:21 ; year:2022 ; number:4 ; pages:21-26 |
| Links: |
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| DOI / URN: |
10.22627/2072-8107-2022-21-4-21-26 |
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| Katalog-ID: |
DOAJ087894688 |
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| 520 | |a Infections occupy one of the central places among the complications of transplants. The frequency of fatal infectious complications during the first twelve months after transplantation ranges from 2.6 to 51.7%. Identifying markers of opportunistic infections before transplantation will help reduce the likelihood of developing these infections after induced immunosuppression. The aim of the study was to study the role of herpesviruses and pneumocysts in the occurrence of infectious complications in children before and after liver transplantation based on the detection of markers of a number of herpesvirus infections and pneumocystosis. The article presents the results of a comprehensive examination for markers of herpesvirus infections and pneumocystosis of 70 children who were treated at the Shumakov Transplantation Research Center. It should be noted that 55 patients (78.6%) were diagnosed with infectious complications, of which 46 people (65.7%) had pneumonia. To detect IgM and IgG antibodies to herpesviruses and pneumocysts, peripheral blood serum samples were examined by enzyme immunoassay (ELISA). Detection of common HBV antigens was carried out by indirect immunofluorescence reaction (NRIF). Early antigens and reproduction of herpesviruses were detected by rapid culture method (BCM) on Vero and M-19 cell cultures for CMVI. In the event of infectious complications (pneumonia) in children who underwent related liver transplantation, the number of patients with active EBI markers increased almost 7 times and active HCV-6 markers increased 3.5 times. The paper shows the need for a broader laboratory screening of opportunistic infections, which will serve to achieve better clinical results, contribute to the formation of more advanced diagnostic algorithms, as well as improve epidemiological surveillance of these infections. | ||
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10.22627/2072-8107-2022-21-4-21-26 doi (DE-627)DOAJ087894688 (DE-599)DOAJ4b20141318fe46afb60cbf08d642bea8 DE-627 ger DE-627 rakwb rus RJ1-570 N. L. Pulnova verfasserin aut The role of herpesviruses and pneumocysts in infectious complications in children during liver transplantation 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Infections occupy one of the central places among the complications of transplants. The frequency of fatal infectious complications during the first twelve months after transplantation ranges from 2.6 to 51.7%. Identifying markers of opportunistic infections before transplantation will help reduce the likelihood of developing these infections after induced immunosuppression. The aim of the study was to study the role of herpesviruses and pneumocysts in the occurrence of infectious complications in children before and after liver transplantation based on the detection of markers of a number of herpesvirus infections and pneumocystosis. The article presents the results of a comprehensive examination for markers of herpesvirus infections and pneumocystosis of 70 children who were treated at the Shumakov Transplantation Research Center. It should be noted that 55 patients (78.6%) were diagnosed with infectious complications, of which 46 people (65.7%) had pneumonia. To detect IgM and IgG antibodies to herpesviruses and pneumocysts, peripheral blood serum samples were examined by enzyme immunoassay (ELISA). Detection of common HBV antigens was carried out by indirect immunofluorescence reaction (NRIF). Early antigens and reproduction of herpesviruses were detected by rapid culture method (BCM) on Vero and M-19 cell cultures for CMVI. In the event of infectious complications (pneumonia) in children who underwent related liver transplantation, the number of patients with active EBI markers increased almost 7 times and active HCV-6 markers increased 3.5 times. The paper shows the need for a broader laboratory screening of opportunistic infections, which will serve to achieve better clinical results, contribute to the formation of more advanced diagnostic algorithms, as well as improve epidemiological surveillance of these infections. антитела вирус иммуносупрессия инфекционные осложнения оппортунистические инфекции пневмоциста трансплантация Pediatrics T. N. Rybalkina verfasserin aut N. V. Karazhas verfasserin aut R. E. Bosh’ian verfasserin aut M. N. Kornienko verfasserin aut O. F. Kabikova verfasserin aut N. I. Gabrielyan verfasserin aut I. E. Pashkova verfasserin aut O. V. Silina verfasserin aut In Детские инфекции (Москва) LLC "Diagnostics and Vaccines", 2016 21(2022), 4, Seite 21-26 (DE-627)1760619124 20728107 nnns volume:21 year:2022 number:4 pages:21-26 https://doi.org/10.22627/2072-8107-2022-21-4-21-26 kostenfrei https://doaj.org/article/4b20141318fe46afb60cbf08d642bea8 kostenfrei https://detinf.elpub.ru/jour/article/view/770 kostenfrei https://doaj.org/toc/2072-8107 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 21 2022 4 21-26 |
| spelling |
10.22627/2072-8107-2022-21-4-21-26 doi (DE-627)DOAJ087894688 (DE-599)DOAJ4b20141318fe46afb60cbf08d642bea8 DE-627 ger DE-627 rakwb rus RJ1-570 N. L. Pulnova verfasserin aut The role of herpesviruses and pneumocysts in infectious complications in children during liver transplantation 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Infections occupy one of the central places among the complications of transplants. The frequency of fatal infectious complications during the first twelve months after transplantation ranges from 2.6 to 51.7%. Identifying markers of opportunistic infections before transplantation will help reduce the likelihood of developing these infections after induced immunosuppression. The aim of the study was to study the role of herpesviruses and pneumocysts in the occurrence of infectious complications in children before and after liver transplantation based on the detection of markers of a number of herpesvirus infections and pneumocystosis. The article presents the results of a comprehensive examination for markers of herpesvirus infections and pneumocystosis of 70 children who were treated at the Shumakov Transplantation Research Center. It should be noted that 55 patients (78.6%) were diagnosed with infectious complications, of which 46 people (65.7%) had pneumonia. To detect IgM and IgG antibodies to herpesviruses and pneumocysts, peripheral blood serum samples were examined by enzyme immunoassay (ELISA). Detection of common HBV antigens was carried out by indirect immunofluorescence reaction (NRIF). Early antigens and reproduction of herpesviruses were detected by rapid culture method (BCM) on Vero and M-19 cell cultures for CMVI. In the event of infectious complications (pneumonia) in children who underwent related liver transplantation, the number of patients with active EBI markers increased almost 7 times and active HCV-6 markers increased 3.5 times. The paper shows the need for a broader laboratory screening of opportunistic infections, which will serve to achieve better clinical results, contribute to the formation of more advanced diagnostic algorithms, as well as improve epidemiological surveillance of these infections. антитела вирус иммуносупрессия инфекционные осложнения оппортунистические инфекции пневмоциста трансплантация Pediatrics T. N. Rybalkina verfasserin aut N. V. Karazhas verfasserin aut R. E. Bosh’ian verfasserin aut M. N. Kornienko verfasserin aut O. F. Kabikova verfasserin aut N. I. Gabrielyan verfasserin aut I. E. Pashkova verfasserin aut O. V. Silina verfasserin aut In Детские инфекции (Москва) LLC "Diagnostics and Vaccines", 2016 21(2022), 4, Seite 21-26 (DE-627)1760619124 20728107 nnns volume:21 year:2022 number:4 pages:21-26 https://doi.org/10.22627/2072-8107-2022-21-4-21-26 kostenfrei https://doaj.org/article/4b20141318fe46afb60cbf08d642bea8 kostenfrei https://detinf.elpub.ru/jour/article/view/770 kostenfrei https://doaj.org/toc/2072-8107 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 21 2022 4 21-26 |
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10.22627/2072-8107-2022-21-4-21-26 doi (DE-627)DOAJ087894688 (DE-599)DOAJ4b20141318fe46afb60cbf08d642bea8 DE-627 ger DE-627 rakwb rus RJ1-570 N. L. Pulnova verfasserin aut The role of herpesviruses and pneumocysts in infectious complications in children during liver transplantation 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Infections occupy one of the central places among the complications of transplants. The frequency of fatal infectious complications during the first twelve months after transplantation ranges from 2.6 to 51.7%. Identifying markers of opportunistic infections before transplantation will help reduce the likelihood of developing these infections after induced immunosuppression. The aim of the study was to study the role of herpesviruses and pneumocysts in the occurrence of infectious complications in children before and after liver transplantation based on the detection of markers of a number of herpesvirus infections and pneumocystosis. The article presents the results of a comprehensive examination for markers of herpesvirus infections and pneumocystosis of 70 children who were treated at the Shumakov Transplantation Research Center. It should be noted that 55 patients (78.6%) were diagnosed with infectious complications, of which 46 people (65.7%) had pneumonia. To detect IgM and IgG antibodies to herpesviruses and pneumocysts, peripheral blood serum samples were examined by enzyme immunoassay (ELISA). Detection of common HBV antigens was carried out by indirect immunofluorescence reaction (NRIF). Early antigens and reproduction of herpesviruses were detected by rapid culture method (BCM) on Vero and M-19 cell cultures for CMVI. In the event of infectious complications (pneumonia) in children who underwent related liver transplantation, the number of patients with active EBI markers increased almost 7 times and active HCV-6 markers increased 3.5 times. The paper shows the need for a broader laboratory screening of opportunistic infections, which will serve to achieve better clinical results, contribute to the formation of more advanced diagnostic algorithms, as well as improve epidemiological surveillance of these infections. антитела вирус иммуносупрессия инфекционные осложнения оппортунистические инфекции пневмоциста трансплантация Pediatrics T. N. Rybalkina verfasserin aut N. V. Karazhas verfasserin aut R. E. Bosh’ian verfasserin aut M. N. Kornienko verfasserin aut O. F. Kabikova verfasserin aut N. I. Gabrielyan verfasserin aut I. E. Pashkova verfasserin aut O. V. Silina verfasserin aut In Детские инфекции (Москва) LLC "Diagnostics and Vaccines", 2016 21(2022), 4, Seite 21-26 (DE-627)1760619124 20728107 nnns volume:21 year:2022 number:4 pages:21-26 https://doi.org/10.22627/2072-8107-2022-21-4-21-26 kostenfrei https://doaj.org/article/4b20141318fe46afb60cbf08d642bea8 kostenfrei https://detinf.elpub.ru/jour/article/view/770 kostenfrei https://doaj.org/toc/2072-8107 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 21 2022 4 21-26 |
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10.22627/2072-8107-2022-21-4-21-26 doi (DE-627)DOAJ087894688 (DE-599)DOAJ4b20141318fe46afb60cbf08d642bea8 DE-627 ger DE-627 rakwb rus RJ1-570 N. L. Pulnova verfasserin aut The role of herpesviruses and pneumocysts in infectious complications in children during liver transplantation 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Infections occupy one of the central places among the complications of transplants. The frequency of fatal infectious complications during the first twelve months after transplantation ranges from 2.6 to 51.7%. Identifying markers of opportunistic infections before transplantation will help reduce the likelihood of developing these infections after induced immunosuppression. The aim of the study was to study the role of herpesviruses and pneumocysts in the occurrence of infectious complications in children before and after liver transplantation based on the detection of markers of a number of herpesvirus infections and pneumocystosis. The article presents the results of a comprehensive examination for markers of herpesvirus infections and pneumocystosis of 70 children who were treated at the Shumakov Transplantation Research Center. It should be noted that 55 patients (78.6%) were diagnosed with infectious complications, of which 46 people (65.7%) had pneumonia. To detect IgM and IgG antibodies to herpesviruses and pneumocysts, peripheral blood serum samples were examined by enzyme immunoassay (ELISA). Detection of common HBV antigens was carried out by indirect immunofluorescence reaction (NRIF). Early antigens and reproduction of herpesviruses were detected by rapid culture method (BCM) on Vero and M-19 cell cultures for CMVI. In the event of infectious complications (pneumonia) in children who underwent related liver transplantation, the number of patients with active EBI markers increased almost 7 times and active HCV-6 markers increased 3.5 times. The paper shows the need for a broader laboratory screening of opportunistic infections, which will serve to achieve better clinical results, contribute to the formation of more advanced diagnostic algorithms, as well as improve epidemiological surveillance of these infections. антитела вирус иммуносупрессия инфекционные осложнения оппортунистические инфекции пневмоциста трансплантация Pediatrics T. N. Rybalkina verfasserin aut N. V. Karazhas verfasserin aut R. E. Bosh’ian verfasserin aut M. N. Kornienko verfasserin aut O. F. Kabikova verfasserin aut N. I. Gabrielyan verfasserin aut I. E. Pashkova verfasserin aut O. V. Silina verfasserin aut In Детские инфекции (Москва) LLC "Diagnostics and Vaccines", 2016 21(2022), 4, Seite 21-26 (DE-627)1760619124 20728107 nnns volume:21 year:2022 number:4 pages:21-26 https://doi.org/10.22627/2072-8107-2022-21-4-21-26 kostenfrei https://doaj.org/article/4b20141318fe46afb60cbf08d642bea8 kostenfrei https://detinf.elpub.ru/jour/article/view/770 kostenfrei https://doaj.org/toc/2072-8107 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 21 2022 4 21-26 |
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The role of herpesviruses and pneumocysts in infectious complications in children during liver transplantation |
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Infections occupy one of the central places among the complications of transplants. The frequency of fatal infectious complications during the first twelve months after transplantation ranges from 2.6 to 51.7%. Identifying markers of opportunistic infections before transplantation will help reduce the likelihood of developing these infections after induced immunosuppression. The aim of the study was to study the role of herpesviruses and pneumocysts in the occurrence of infectious complications in children before and after liver transplantation based on the detection of markers of a number of herpesvirus infections and pneumocystosis. The article presents the results of a comprehensive examination for markers of herpesvirus infections and pneumocystosis of 70 children who were treated at the Shumakov Transplantation Research Center. It should be noted that 55 patients (78.6%) were diagnosed with infectious complications, of which 46 people (65.7%) had pneumonia. To detect IgM and IgG antibodies to herpesviruses and pneumocysts, peripheral blood serum samples were examined by enzyme immunoassay (ELISA). Detection of common HBV antigens was carried out by indirect immunofluorescence reaction (NRIF). Early antigens and reproduction of herpesviruses were detected by rapid culture method (BCM) on Vero and M-19 cell cultures for CMVI. In the event of infectious complications (pneumonia) in children who underwent related liver transplantation, the number of patients with active EBI markers increased almost 7 times and active HCV-6 markers increased 3.5 times. The paper shows the need for a broader laboratory screening of opportunistic infections, which will serve to achieve better clinical results, contribute to the formation of more advanced diagnostic algorithms, as well as improve epidemiological surveillance of these infections. |
| abstractGer |
Infections occupy one of the central places among the complications of transplants. The frequency of fatal infectious complications during the first twelve months after transplantation ranges from 2.6 to 51.7%. Identifying markers of opportunistic infections before transplantation will help reduce the likelihood of developing these infections after induced immunosuppression. The aim of the study was to study the role of herpesviruses and pneumocysts in the occurrence of infectious complications in children before and after liver transplantation based on the detection of markers of a number of herpesvirus infections and pneumocystosis. The article presents the results of a comprehensive examination for markers of herpesvirus infections and pneumocystosis of 70 children who were treated at the Shumakov Transplantation Research Center. It should be noted that 55 patients (78.6%) were diagnosed with infectious complications, of which 46 people (65.7%) had pneumonia. To detect IgM and IgG antibodies to herpesviruses and pneumocysts, peripheral blood serum samples were examined by enzyme immunoassay (ELISA). Detection of common HBV antigens was carried out by indirect immunofluorescence reaction (NRIF). Early antigens and reproduction of herpesviruses were detected by rapid culture method (BCM) on Vero and M-19 cell cultures for CMVI. In the event of infectious complications (pneumonia) in children who underwent related liver transplantation, the number of patients with active EBI markers increased almost 7 times and active HCV-6 markers increased 3.5 times. The paper shows the need for a broader laboratory screening of opportunistic infections, which will serve to achieve better clinical results, contribute to the formation of more advanced diagnostic algorithms, as well as improve epidemiological surveillance of these infections. |
| abstract_unstemmed |
Infections occupy one of the central places among the complications of transplants. The frequency of fatal infectious complications during the first twelve months after transplantation ranges from 2.6 to 51.7%. Identifying markers of opportunistic infections before transplantation will help reduce the likelihood of developing these infections after induced immunosuppression. The aim of the study was to study the role of herpesviruses and pneumocysts in the occurrence of infectious complications in children before and after liver transplantation based on the detection of markers of a number of herpesvirus infections and pneumocystosis. The article presents the results of a comprehensive examination for markers of herpesvirus infections and pneumocystosis of 70 children who were treated at the Shumakov Transplantation Research Center. It should be noted that 55 patients (78.6%) were diagnosed with infectious complications, of which 46 people (65.7%) had pneumonia. To detect IgM and IgG antibodies to herpesviruses and pneumocysts, peripheral blood serum samples were examined by enzyme immunoassay (ELISA). Detection of common HBV antigens was carried out by indirect immunofluorescence reaction (NRIF). Early antigens and reproduction of herpesviruses were detected by rapid culture method (BCM) on Vero and M-19 cell cultures for CMVI. In the event of infectious complications (pneumonia) in children who underwent related liver transplantation, the number of patients with active EBI markers increased almost 7 times and active HCV-6 markers increased 3.5 times. The paper shows the need for a broader laboratory screening of opportunistic infections, which will serve to achieve better clinical results, contribute to the formation of more advanced diagnostic algorithms, as well as improve epidemiological surveillance of these infections. |
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| title_short |
The role of herpesviruses and pneumocysts in infectious complications in children during liver transplantation |
| url |
https://doi.org/10.22627/2072-8107-2022-21-4-21-26 https://doaj.org/article/4b20141318fe46afb60cbf08d642bea8 https://detinf.elpub.ru/jour/article/view/770 https://doaj.org/toc/2072-8107 |
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T. N. Rybalkina N. V. Karazhas R. E. Bosh’ian M. N. Kornienko O. F. Kabikova N. I. Gabrielyan I. E. Pashkova O. V. Silina |
| author2Str |
T. N. Rybalkina N. V. Karazhas R. E. Bosh’ian M. N. Kornienko O. F. Kabikova N. I. Gabrielyan I. E. Pashkova O. V. Silina |
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RJ - Pediatrics |
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10.22627/2072-8107-2022-21-4-21-26 |
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| up_date |
2024-07-03T14:36:16.539Z |
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