Genetic overlap between endometriosis and endometrial cancer: evidence from cross‐disease genetic correlation and GWAS meta‐analyses

Abstract Epidemiological, biological, and molecular data suggest links between endometriosis and endometrial cancer, with recent epidemiological studies providing evidence for an association between a previous diagnosis of endometriosis and risk of endometrial cancer. We used genetic data as an alte...
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Autor*in:	Jodie N. Painter [verfasserIn] Tracy A. O'Mara [verfasserIn] Andrew P. Morris [verfasserIn] Timothy H. T. Cheng [verfasserIn] Maggie Gorman [verfasserIn] Lynn Martin [verfasserIn] Shirley Hodson [verfasserIn] Angela Jones [verfasserIn] Nicholas G. Martin [verfasserIn] Scott Gordon [verfasserIn] Anjali K. Henders [verfasserIn] John Attia [verfasserIn] Mark McEvoy [verfasserIn] Elizabeth G. Holliday [verfasserIn] Rodney J. Scott [verfasserIn] Penelope M. Webb [verfasserIn] Peter A. Fasching [verfasserIn] Matthias W. Beckmann [verfasserIn] Arif B. Ekici [verfasserIn] Alexander Hein [verfasserIn] Matthias Rübner [verfasserIn] Per Hall [verfasserIn] Kamila Czene [verfasserIn] Thilo Dörk [verfasserIn] Matthias Dürst [verfasserIn] Peter Hillemanns [verfasserIn] Ingo Runnebaum [verfasserIn] Diether Lambrechts [verfasserIn] Frederic Amant [verfasserIn] Daniela Annibali [verfasserIn] Jeroen Depreeuw [verfasserIn] Adriaan Vanderstichele [verfasserIn] Ellen L. Goode [verfasserIn] Julie M. Cunningham [verfasserIn] Sean C. Dowdy [verfasserIn] Stacey J. Winham [verfasserIn] Jone Trovik [verfasserIn] Erling Hoivik [verfasserIn] Henrica M. J. Werner [verfasserIn] Camilla Krakstad [verfasserIn] Katie Ashton [verfasserIn] Geoffrey Otton [verfasserIn] Tony Proietto [verfasserIn] Emma Tham [verfasserIn] Miriam Mints [verfasserIn] Shahana Ahmed [verfasserIn] Catherine S. Healey [verfasserIn] Mitul Shah [verfasserIn] Paul D. P. Pharoah [verfasserIn] Alison M. Dunning [verfasserIn] Joe Dennis [verfasserIn] Manjeet K. Bolla [verfasserIn] Kyriaki Michailidou [verfasserIn] Qin Wang [verfasserIn] Jonathan P. Tyrer [verfasserIn] John L. Hopper [verfasserIn] Julian Peto [verfasserIn] Anthony J. Swerdlow [verfasserIn] Barbara Burwinkel [verfasserIn] Hermann Brenner [verfasserIn] Alfons Meindl [verfasserIn] Hiltrud Brauch [verfasserIn] Annika Lindblom [verfasserIn] Jenny Chang‐Claude [verfasserIn] Fergus J. Couch [verfasserIn] Graham G. Giles [verfasserIn] Vessela N. Kristensen [verfasserIn] Angela Cox [verfasserIn] Krina T. Zondervan [verfasserIn] Dale R. Nyholt [verfasserIn] Stuart MacGregor [verfasserIn] Grant W. Montgomery [verfasserIn] Ian Tomlinson [verfasserIn] Douglas F. Easton [verfasserIn] Deborah J. Thompson [verfasserIn] Amanda B. Spurdle [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2018

Schlagwörter:	Cross‐disease analysis endometrial cancer endometriosis genome‐wide association study genetic correlation

Übergeordnetes Werk:	In: Cancer Medicine - Wiley, 2012, 7(2018), 5, Seite 1978-1987
Übergeordnetes Werk:	volume:7 ; year:2018 ; number:5 ; pages:1978-1987

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.1002/cam4.1445

Katalog-ID:	DOAJ087956071

Internformat


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245	1	0	\|a Genetic overlap between endometriosis and endometrial cancer: evidence from cross‐disease genetic correlation and GWAS meta‐analyses
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520			\|a Abstract Epidemiological, biological, and molecular data suggest links between endometriosis and endometrial cancer, with recent epidemiological studies providing evidence for an association between a previous diagnosis of endometriosis and risk of endometrial cancer. We used genetic data as an alternative approach to investigate shared biological etiology of these two diseases. Genetic correlation analysis of summary level statistics from genomewide association studies (GWAS) using LD Score regression revealed moderate but significant genetic correlation (rg = 0.23, P = 9.3 × 10−3), and SNP effect concordance analysis provided evidence for significant SNP pleiotropy (P = 6.0 × 10−3) and concordance in effect direction (P = 2.0 × 10−3) between the two diseases. Cross‐disease GWAS meta‐analysis highlighted 13 distinct loci associated at P ≤ 10−5 with both endometriosis and endometrial cancer, with one locus (SNP rs2475335) located within PTPRD associated at a genomewide significant level (P = 4.9 × 10−8, OR = 1.11, 95% CI = 1.07–1.15). PTPRD acts in the STAT3 pathway, which has been implicated in both endometriosis and endometrial cancer. This study demonstrates the value of cross‐disease genetic analysis to support epidemiological observations and to identify biological pathways of relevance to multiple diseases.
650		4	\|a Cross‐disease analysis
650		4	\|a endometrial cancer
650		4	\|a endometriosis
650		4	\|a genome‐wide association study
650		4	\|a genetic correlation
653		0	\|a Neoplasms. Tumors. Oncology. Including cancer and carcinogens
700	0		\|a Tracy A. O'Mara \|e verfasserin \|4 aut
700	0		\|a Andrew P. Morris \|e verfasserin \|4 aut
700	0		\|a Timothy H. T. Cheng \|e verfasserin \|4 aut
700	0		\|a Maggie Gorman \|e verfasserin \|4 aut
700	0		\|a Lynn Martin \|e verfasserin \|4 aut
700	0		\|a Shirley Hodson \|e verfasserin \|4 aut
700	0		\|a Angela Jones \|e verfasserin \|4 aut
700	0		\|a Nicholas G. Martin \|e verfasserin \|4 aut
700	0		\|a Scott Gordon \|e verfasserin \|4 aut
700	0		\|a Anjali K. Henders \|e verfasserin \|4 aut
700	0		\|a John Attia \|e verfasserin \|4 aut
700	0		\|a Mark McEvoy \|e verfasserin \|4 aut
700	0		\|a Elizabeth G. Holliday \|e verfasserin \|4 aut
700	0		\|a Rodney J. Scott \|e verfasserin \|4 aut
700	0		\|a Penelope M. Webb \|e verfasserin \|4 aut
700	0		\|a Peter A. Fasching \|e verfasserin \|4 aut
700	0		\|a Matthias W. Beckmann \|e verfasserin \|4 aut
700	0		\|a Arif B. Ekici \|e verfasserin \|4 aut
700	0		\|a Alexander Hein \|e verfasserin \|4 aut
700	0		\|a Matthias Rübner \|e verfasserin \|4 aut
700	0		\|a Per Hall \|e verfasserin \|4 aut
700	0		\|a Kamila Czene \|e verfasserin \|4 aut
700	0		\|a Thilo Dörk \|e verfasserin \|4 aut
700	0		\|a Matthias Dürst \|e verfasserin \|4 aut
700	0		\|a Peter Hillemanns \|e verfasserin \|4 aut
700	0		\|a Ingo Runnebaum \|e verfasserin \|4 aut
700	0		\|a Diether Lambrechts \|e verfasserin \|4 aut
700	0		\|a Frederic Amant \|e verfasserin \|4 aut
700	0		\|a Daniela Annibali \|e verfasserin \|4 aut
700	0		\|a Jeroen Depreeuw \|e verfasserin \|4 aut
700	0		\|a Adriaan Vanderstichele \|e verfasserin \|4 aut
700	0		\|a Ellen L. Goode \|e verfasserin \|4 aut
700	0		\|a Julie M. Cunningham \|e verfasserin \|4 aut
700	0		\|a Sean C. Dowdy \|e verfasserin \|4 aut
700	0		\|a Stacey J. Winham \|e verfasserin \|4 aut
700	0		\|a Jone Trovik \|e verfasserin \|4 aut
700	0		\|a Erling Hoivik \|e verfasserin \|4 aut
700	0		\|a Henrica M. J. Werner \|e verfasserin \|4 aut
700	0		\|a Camilla Krakstad \|e verfasserin \|4 aut
700	0		\|a Katie Ashton \|e verfasserin \|4 aut
700	0		\|a Geoffrey Otton \|e verfasserin \|4 aut
700	0		\|a Tony Proietto \|e verfasserin \|4 aut
700	0		\|a Emma Tham \|e verfasserin \|4 aut
700	0		\|a Miriam Mints \|e verfasserin \|4 aut
700	0		\|a Shahana Ahmed \|e verfasserin \|4 aut
700	0		\|a Catherine S. Healey \|e verfasserin \|4 aut
700	0		\|a Mitul Shah \|e verfasserin \|4 aut
700	0		\|a Paul D. P. Pharoah \|e verfasserin \|4 aut
700	0		\|a Alison M. Dunning \|e verfasserin \|4 aut
700	0		\|a Joe Dennis \|e verfasserin \|4 aut
700	0		\|a Manjeet K. Bolla \|e verfasserin \|4 aut
700	0		\|a Kyriaki Michailidou \|e verfasserin \|4 aut
700	0		\|a Qin Wang \|e verfasserin \|4 aut
700	0		\|a Jonathan P. Tyrer \|e verfasserin \|4 aut
700	0		\|a John L. Hopper \|e verfasserin \|4 aut
700	0		\|a Julian Peto \|e verfasserin \|4 aut
700	0		\|a Anthony J. Swerdlow \|e verfasserin \|4 aut
700	0		\|a Barbara Burwinkel \|e verfasserin \|4 aut
700	0		\|a Hermann Brenner \|e verfasserin \|4 aut
700	0		\|a Alfons Meindl \|e verfasserin \|4 aut
700	0		\|a Hiltrud Brauch \|e verfasserin \|4 aut
700	0		\|a Annika Lindblom \|e verfasserin \|4 aut
700	0		\|a Jenny Chang‐Claude \|e verfasserin \|4 aut
700	0		\|a Fergus J. Couch \|e verfasserin \|4 aut
700	0		\|a Graham G. Giles \|e verfasserin \|4 aut
700	0		\|a Vessela N. Kristensen \|e verfasserin \|4 aut
700	0		\|a Angela Cox \|e verfasserin \|4 aut
700	0		\|a Krina T. Zondervan \|e verfasserin \|4 aut
700	0		\|a Dale R. Nyholt \|e verfasserin \|4 aut
700	0		\|a Stuart MacGregor \|e verfasserin \|4 aut
700	0		\|a Grant W. Montgomery \|e verfasserin \|4 aut
700	0		\|a Ian Tomlinson \|e verfasserin \|4 aut
700	0		\|a Douglas F. Easton \|e verfasserin \|4 aut
700	0		\|a Deborah J. Thompson \|e verfasserin \|4 aut
700	0		\|a Amanda B. Spurdle \|e verfasserin \|4 aut
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allfields	10.1002/cam4.1445 doi (DE-627)DOAJ087956071 (DE-599)DOAJ463fb4a945b24c1c8ee3d74f75c3da32 DE-627 ger DE-627 rakwb eng RC254-282 Jodie N. Painter verfasserin aut Genetic overlap between endometriosis and endometrial cancer: evidence from cross‐disease genetic correlation and GWAS meta‐analyses 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Epidemiological, biological, and molecular data suggest links between endometriosis and endometrial cancer, with recent epidemiological studies providing evidence for an association between a previous diagnosis of endometriosis and risk of endometrial cancer. We used genetic data as an alternative approach to investigate shared biological etiology of these two diseases. Genetic correlation analysis of summary level statistics from genomewide association studies (GWAS) using LD Score regression revealed moderate but significant genetic correlation (rg = 0.23, P = 9.3 × 10−3), and SNP effect concordance analysis provided evidence for significant SNP pleiotropy (P = 6.0 × 10−3) and concordance in effect direction (P = 2.0 × 10−3) between the two diseases. Cross‐disease GWAS meta‐analysis highlighted 13 distinct loci associated at P ≤ 10−5 with both endometriosis and endometrial cancer, with one locus (SNP rs2475335) located within PTPRD associated at a genomewide significant level (P = 4.9 × 10−8, OR = 1.11, 95% CI = 1.07–1.15). PTPRD acts in the STAT3 pathway, which has been implicated in both endometriosis and endometrial cancer. This study demonstrates the value of cross‐disease genetic analysis to support epidemiological observations and to identify biological pathways of relevance to multiple diseases. Cross‐disease analysis endometrial cancer endometriosis genome‐wide association study genetic correlation Neoplasms. Tumors. Oncology. Including cancer and carcinogens Tracy A. O'Mara verfasserin aut Andrew P. Morris verfasserin aut Timothy H. T. Cheng verfasserin aut Maggie Gorman verfasserin aut Lynn Martin verfasserin aut Shirley Hodson verfasserin aut Angela Jones verfasserin aut Nicholas G. Martin verfasserin aut Scott Gordon verfasserin aut Anjali K. Henders verfasserin aut John Attia verfasserin aut Mark McEvoy verfasserin aut Elizabeth G. Holliday verfasserin aut Rodney J. Scott verfasserin aut Penelope M. Webb verfasserin aut Peter A. Fasching verfasserin aut Matthias W. Beckmann verfasserin aut Arif B. Ekici verfasserin aut Alexander Hein verfasserin aut Matthias Rübner verfasserin aut Per Hall verfasserin aut Kamila Czene verfasserin aut Thilo Dörk verfasserin aut Matthias Dürst verfasserin aut Peter Hillemanns verfasserin aut Ingo Runnebaum verfasserin aut Diether Lambrechts verfasserin aut Frederic Amant verfasserin aut Daniela Annibali verfasserin aut Jeroen Depreeuw verfasserin aut Adriaan Vanderstichele verfasserin aut Ellen L. Goode verfasserin aut Julie M. Cunningham verfasserin aut Sean C. Dowdy verfasserin aut Stacey J. Winham verfasserin aut Jone Trovik verfasserin aut Erling Hoivik verfasserin aut Henrica M. J. Werner verfasserin aut Camilla Krakstad verfasserin aut Katie Ashton verfasserin aut Geoffrey Otton verfasserin aut Tony Proietto verfasserin aut Emma Tham verfasserin aut Miriam Mints verfasserin aut Shahana Ahmed verfasserin aut Catherine S. Healey verfasserin aut Mitul Shah verfasserin aut Paul D. P. Pharoah verfasserin aut Alison M. Dunning verfasserin aut Joe Dennis verfasserin aut Manjeet K. Bolla verfasserin aut Kyriaki Michailidou verfasserin aut Qin Wang verfasserin aut Jonathan P. Tyrer verfasserin aut John L. Hopper verfasserin aut Julian Peto verfasserin aut Anthony J. Swerdlow verfasserin aut Barbara Burwinkel verfasserin aut Hermann Brenner verfasserin aut Alfons Meindl verfasserin aut Hiltrud Brauch verfasserin aut Annika Lindblom verfasserin aut Jenny Chang‐Claude verfasserin aut Fergus J. Couch verfasserin aut Graham G. Giles verfasserin aut Vessela N. Kristensen verfasserin aut Angela Cox verfasserin aut Krina T. Zondervan verfasserin aut Dale R. Nyholt verfasserin aut Stuart MacGregor verfasserin aut Grant W. Montgomery verfasserin aut Ian Tomlinson verfasserin aut Douglas F. Easton verfasserin aut Deborah J. Thompson verfasserin aut Amanda B. Spurdle verfasserin aut In Cancer Medicine Wiley, 2012 7(2018), 5, Seite 1978-1987 (DE-627)71860153X (DE-600)2659751-2 20457634 nnns volume:7 year:2018 number:5 pages:1978-1987 https://doi.org/10.1002/cam4.1445 kostenfrei https://doaj.org/article/463fb4a945b24c1c8ee3d74f75c3da32 kostenfrei https://doi.org/10.1002/cam4.1445 kostenfrei https://doaj.org/toc/2045-7634 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_636 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 7 2018 5 1978-1987
spelling	10.1002/cam4.1445 doi (DE-627)DOAJ087956071 (DE-599)DOAJ463fb4a945b24c1c8ee3d74f75c3da32 DE-627 ger DE-627 rakwb eng RC254-282 Jodie N. Painter verfasserin aut Genetic overlap between endometriosis and endometrial cancer: evidence from cross‐disease genetic correlation and GWAS meta‐analyses 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Epidemiological, biological, and molecular data suggest links between endometriosis and endometrial cancer, with recent epidemiological studies providing evidence for an association between a previous diagnosis of endometriosis and risk of endometrial cancer. We used genetic data as an alternative approach to investigate shared biological etiology of these two diseases. Genetic correlation analysis of summary level statistics from genomewide association studies (GWAS) using LD Score regression revealed moderate but significant genetic correlation (rg = 0.23, P = 9.3 × 10−3), and SNP effect concordance analysis provided evidence for significant SNP pleiotropy (P = 6.0 × 10−3) and concordance in effect direction (P = 2.0 × 10−3) between the two diseases. Cross‐disease GWAS meta‐analysis highlighted 13 distinct loci associated at P ≤ 10−5 with both endometriosis and endometrial cancer, with one locus (SNP rs2475335) located within PTPRD associated at a genomewide significant level (P = 4.9 × 10−8, OR = 1.11, 95% CI = 1.07–1.15). PTPRD acts in the STAT3 pathway, which has been implicated in both endometriosis and endometrial cancer. This study demonstrates the value of cross‐disease genetic analysis to support epidemiological observations and to identify biological pathways of relevance to multiple diseases. Cross‐disease analysis endometrial cancer endometriosis genome‐wide association study genetic correlation Neoplasms. Tumors. Oncology. Including cancer and carcinogens Tracy A. O'Mara verfasserin aut Andrew P. Morris verfasserin aut Timothy H. T. Cheng verfasserin aut Maggie Gorman verfasserin aut Lynn Martin verfasserin aut Shirley Hodson verfasserin aut Angela Jones verfasserin aut Nicholas G. Martin verfasserin aut Scott Gordon verfasserin aut Anjali K. Henders verfasserin aut John Attia verfasserin aut Mark McEvoy verfasserin aut Elizabeth G. Holliday verfasserin aut Rodney J. Scott verfasserin aut Penelope M. Webb verfasserin aut Peter A. Fasching verfasserin aut Matthias W. Beckmann verfasserin aut Arif B. Ekici verfasserin aut Alexander Hein verfasserin aut Matthias Rübner verfasserin aut Per Hall verfasserin aut Kamila Czene verfasserin aut Thilo Dörk verfasserin aut Matthias Dürst verfasserin aut Peter Hillemanns verfasserin aut Ingo Runnebaum verfasserin aut Diether Lambrechts verfasserin aut Frederic Amant verfasserin aut Daniela Annibali verfasserin aut Jeroen Depreeuw verfasserin aut Adriaan Vanderstichele verfasserin aut Ellen L. Goode verfasserin aut Julie M. Cunningham verfasserin aut Sean C. Dowdy verfasserin aut Stacey J. Winham verfasserin aut Jone Trovik verfasserin aut Erling Hoivik verfasserin aut Henrica M. J. Werner verfasserin aut Camilla Krakstad verfasserin aut Katie Ashton verfasserin aut Geoffrey Otton verfasserin aut Tony Proietto verfasserin aut Emma Tham verfasserin aut Miriam Mints verfasserin aut Shahana Ahmed verfasserin aut Catherine S. Healey verfasserin aut Mitul Shah verfasserin aut Paul D. P. Pharoah verfasserin aut Alison M. Dunning verfasserin aut Joe Dennis verfasserin aut Manjeet K. Bolla verfasserin aut Kyriaki Michailidou verfasserin aut Qin Wang verfasserin aut Jonathan P. Tyrer verfasserin aut John L. Hopper verfasserin aut Julian Peto verfasserin aut Anthony J. Swerdlow verfasserin aut Barbara Burwinkel verfasserin aut Hermann Brenner verfasserin aut Alfons Meindl verfasserin aut Hiltrud Brauch verfasserin aut Annika Lindblom verfasserin aut Jenny Chang‐Claude verfasserin aut Fergus J. Couch verfasserin aut Graham G. Giles verfasserin aut Vessela N. Kristensen verfasserin aut Angela Cox verfasserin aut Krina T. Zondervan verfasserin aut Dale R. Nyholt verfasserin aut Stuart MacGregor verfasserin aut Grant W. Montgomery verfasserin aut Ian Tomlinson verfasserin aut Douglas F. Easton verfasserin aut Deborah J. Thompson verfasserin aut Amanda B. Spurdle verfasserin aut In Cancer Medicine Wiley, 2012 7(2018), 5, Seite 1978-1987 (DE-627)71860153X (DE-600)2659751-2 20457634 nnns volume:7 year:2018 number:5 pages:1978-1987 https://doi.org/10.1002/cam4.1445 kostenfrei https://doaj.org/article/463fb4a945b24c1c8ee3d74f75c3da32 kostenfrei https://doi.org/10.1002/cam4.1445 kostenfrei https://doaj.org/toc/2045-7634 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_636 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 7 2018 5 1978-1987
allfields_unstemmed	10.1002/cam4.1445 doi (DE-627)DOAJ087956071 (DE-599)DOAJ463fb4a945b24c1c8ee3d74f75c3da32 DE-627 ger DE-627 rakwb eng RC254-282 Jodie N. Painter verfasserin aut Genetic overlap between endometriosis and endometrial cancer: evidence from cross‐disease genetic correlation and GWAS meta‐analyses 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Epidemiological, biological, and molecular data suggest links between endometriosis and endometrial cancer, with recent epidemiological studies providing evidence for an association between a previous diagnosis of endometriosis and risk of endometrial cancer. We used genetic data as an alternative approach to investigate shared biological etiology of these two diseases. Genetic correlation analysis of summary level statistics from genomewide association studies (GWAS) using LD Score regression revealed moderate but significant genetic correlation (rg = 0.23, P = 9.3 × 10−3), and SNP effect concordance analysis provided evidence for significant SNP pleiotropy (P = 6.0 × 10−3) and concordance in effect direction (P = 2.0 × 10−3) between the two diseases. Cross‐disease GWAS meta‐analysis highlighted 13 distinct loci associated at P ≤ 10−5 with both endometriosis and endometrial cancer, with one locus (SNP rs2475335) located within PTPRD associated at a genomewide significant level (P = 4.9 × 10−8, OR = 1.11, 95% CI = 1.07–1.15). PTPRD acts in the STAT3 pathway, which has been implicated in both endometriosis and endometrial cancer. This study demonstrates the value of cross‐disease genetic analysis to support epidemiological observations and to identify biological pathways of relevance to multiple diseases. Cross‐disease analysis endometrial cancer endometriosis genome‐wide association study genetic correlation Neoplasms. Tumors. Oncology. Including cancer and carcinogens Tracy A. O'Mara verfasserin aut Andrew P. Morris verfasserin aut Timothy H. T. Cheng verfasserin aut Maggie Gorman verfasserin aut Lynn Martin verfasserin aut Shirley Hodson verfasserin aut Angela Jones verfasserin aut Nicholas G. Martin verfasserin aut Scott Gordon verfasserin aut Anjali K. Henders verfasserin aut John Attia verfasserin aut Mark McEvoy verfasserin aut Elizabeth G. Holliday verfasserin aut Rodney J. Scott verfasserin aut Penelope M. Webb verfasserin aut Peter A. Fasching verfasserin aut Matthias W. Beckmann verfasserin aut Arif B. Ekici verfasserin aut Alexander Hein verfasserin aut Matthias Rübner verfasserin aut Per Hall verfasserin aut Kamila Czene verfasserin aut Thilo Dörk verfasserin aut Matthias Dürst verfasserin aut Peter Hillemanns verfasserin aut Ingo Runnebaum verfasserin aut Diether Lambrechts verfasserin aut Frederic Amant verfasserin aut Daniela Annibali verfasserin aut Jeroen Depreeuw verfasserin aut Adriaan Vanderstichele verfasserin aut Ellen L. Goode verfasserin aut Julie M. Cunningham verfasserin aut Sean C. Dowdy verfasserin aut Stacey J. Winham verfasserin aut Jone Trovik verfasserin aut Erling Hoivik verfasserin aut Henrica M. J. Werner verfasserin aut Camilla Krakstad verfasserin aut Katie Ashton verfasserin aut Geoffrey Otton verfasserin aut Tony Proietto verfasserin aut Emma Tham verfasserin aut Miriam Mints verfasserin aut Shahana Ahmed verfasserin aut Catherine S. Healey verfasserin aut Mitul Shah verfasserin aut Paul D. P. Pharoah verfasserin aut Alison M. Dunning verfasserin aut Joe Dennis verfasserin aut Manjeet K. Bolla verfasserin aut Kyriaki Michailidou verfasserin aut Qin Wang verfasserin aut Jonathan P. Tyrer verfasserin aut John L. Hopper verfasserin aut Julian Peto verfasserin aut Anthony J. Swerdlow verfasserin aut Barbara Burwinkel verfasserin aut Hermann Brenner verfasserin aut Alfons Meindl verfasserin aut Hiltrud Brauch verfasserin aut Annika Lindblom verfasserin aut Jenny Chang‐Claude verfasserin aut Fergus J. Couch verfasserin aut Graham G. Giles verfasserin aut Vessela N. Kristensen verfasserin aut Angela Cox verfasserin aut Krina T. Zondervan verfasserin aut Dale R. Nyholt verfasserin aut Stuart MacGregor verfasserin aut Grant W. Montgomery verfasserin aut Ian Tomlinson verfasserin aut Douglas F. Easton verfasserin aut Deborah J. Thompson verfasserin aut Amanda B. Spurdle verfasserin aut In Cancer Medicine Wiley, 2012 7(2018), 5, Seite 1978-1987 (DE-627)71860153X (DE-600)2659751-2 20457634 nnns volume:7 year:2018 number:5 pages:1978-1987 https://doi.org/10.1002/cam4.1445 kostenfrei https://doaj.org/article/463fb4a945b24c1c8ee3d74f75c3da32 kostenfrei https://doi.org/10.1002/cam4.1445 kostenfrei https://doaj.org/toc/2045-7634 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_636 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 7 2018 5 1978-1987
allfieldsGer	10.1002/cam4.1445 doi (DE-627)DOAJ087956071 (DE-599)DOAJ463fb4a945b24c1c8ee3d74f75c3da32 DE-627 ger DE-627 rakwb eng RC254-282 Jodie N. Painter verfasserin aut Genetic overlap between endometriosis and endometrial cancer: evidence from cross‐disease genetic correlation and GWAS meta‐analyses 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Epidemiological, biological, and molecular data suggest links between endometriosis and endometrial cancer, with recent epidemiological studies providing evidence for an association between a previous diagnosis of endometriosis and risk of endometrial cancer. We used genetic data as an alternative approach to investigate shared biological etiology of these two diseases. Genetic correlation analysis of summary level statistics from genomewide association studies (GWAS) using LD Score regression revealed moderate but significant genetic correlation (rg = 0.23, P = 9.3 × 10−3), and SNP effect concordance analysis provided evidence for significant SNP pleiotropy (P = 6.0 × 10−3) and concordance in effect direction (P = 2.0 × 10−3) between the two diseases. Cross‐disease GWAS meta‐analysis highlighted 13 distinct loci associated at P ≤ 10−5 with both endometriosis and endometrial cancer, with one locus (SNP rs2475335) located within PTPRD associated at a genomewide significant level (P = 4.9 × 10−8, OR = 1.11, 95% CI = 1.07–1.15). PTPRD acts in the STAT3 pathway, which has been implicated in both endometriosis and endometrial cancer. This study demonstrates the value of cross‐disease genetic analysis to support epidemiological observations and to identify biological pathways of relevance to multiple diseases. Cross‐disease analysis endometrial cancer endometriosis genome‐wide association study genetic correlation Neoplasms. Tumors. Oncology. Including cancer and carcinogens Tracy A. O'Mara verfasserin aut Andrew P. Morris verfasserin aut Timothy H. T. Cheng verfasserin aut Maggie Gorman verfasserin aut Lynn Martin verfasserin aut Shirley Hodson verfasserin aut Angela Jones verfasserin aut Nicholas G. Martin verfasserin aut Scott Gordon verfasserin aut Anjali K. Henders verfasserin aut John Attia verfasserin aut Mark McEvoy verfasserin aut Elizabeth G. Holliday verfasserin aut Rodney J. Scott verfasserin aut Penelope M. Webb verfasserin aut Peter A. Fasching verfasserin aut Matthias W. Beckmann verfasserin aut Arif B. Ekici verfasserin aut Alexander Hein verfasserin aut Matthias Rübner verfasserin aut Per Hall verfasserin aut Kamila Czene verfasserin aut Thilo Dörk verfasserin aut Matthias Dürst verfasserin aut Peter Hillemanns verfasserin aut Ingo Runnebaum verfasserin aut Diether Lambrechts verfasserin aut Frederic Amant verfasserin aut Daniela Annibali verfasserin aut Jeroen Depreeuw verfasserin aut Adriaan Vanderstichele verfasserin aut Ellen L. Goode verfasserin aut Julie M. Cunningham verfasserin aut Sean C. Dowdy verfasserin aut Stacey J. Winham verfasserin aut Jone Trovik verfasserin aut Erling Hoivik verfasserin aut Henrica M. J. Werner verfasserin aut Camilla Krakstad verfasserin aut Katie Ashton verfasserin aut Geoffrey Otton verfasserin aut Tony Proietto verfasserin aut Emma Tham verfasserin aut Miriam Mints verfasserin aut Shahana Ahmed verfasserin aut Catherine S. Healey verfasserin aut Mitul Shah verfasserin aut Paul D. P. Pharoah verfasserin aut Alison M. Dunning verfasserin aut Joe Dennis verfasserin aut Manjeet K. Bolla verfasserin aut Kyriaki Michailidou verfasserin aut Qin Wang verfasserin aut Jonathan P. Tyrer verfasserin aut John L. Hopper verfasserin aut Julian Peto verfasserin aut Anthony J. Swerdlow verfasserin aut Barbara Burwinkel verfasserin aut Hermann Brenner verfasserin aut Alfons Meindl verfasserin aut Hiltrud Brauch verfasserin aut Annika Lindblom verfasserin aut Jenny Chang‐Claude verfasserin aut Fergus J. Couch verfasserin aut Graham G. Giles verfasserin aut Vessela N. Kristensen verfasserin aut Angela Cox verfasserin aut Krina T. Zondervan verfasserin aut Dale R. Nyholt verfasserin aut Stuart MacGregor verfasserin aut Grant W. Montgomery verfasserin aut Ian Tomlinson verfasserin aut Douglas F. Easton verfasserin aut Deborah J. Thompson verfasserin aut Amanda B. Spurdle verfasserin aut In Cancer Medicine Wiley, 2012 7(2018), 5, Seite 1978-1987 (DE-627)71860153X (DE-600)2659751-2 20457634 nnns volume:7 year:2018 number:5 pages:1978-1987 https://doi.org/10.1002/cam4.1445 kostenfrei https://doaj.org/article/463fb4a945b24c1c8ee3d74f75c3da32 kostenfrei https://doi.org/10.1002/cam4.1445 kostenfrei https://doaj.org/toc/2045-7634 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_636 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 7 2018 5 1978-1987
allfieldsSound	10.1002/cam4.1445 doi (DE-627)DOAJ087956071 (DE-599)DOAJ463fb4a945b24c1c8ee3d74f75c3da32 DE-627 ger DE-627 rakwb eng RC254-282 Jodie N. Painter verfasserin aut Genetic overlap between endometriosis and endometrial cancer: evidence from cross‐disease genetic correlation and GWAS meta‐analyses 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Epidemiological, biological, and molecular data suggest links between endometriosis and endometrial cancer, with recent epidemiological studies providing evidence for an association between a previous diagnosis of endometriosis and risk of endometrial cancer. We used genetic data as an alternative approach to investigate shared biological etiology of these two diseases. Genetic correlation analysis of summary level statistics from genomewide association studies (GWAS) using LD Score regression revealed moderate but significant genetic correlation (rg = 0.23, P = 9.3 × 10−3), and SNP effect concordance analysis provided evidence for significant SNP pleiotropy (P = 6.0 × 10−3) and concordance in effect direction (P = 2.0 × 10−3) between the two diseases. Cross‐disease GWAS meta‐analysis highlighted 13 distinct loci associated at P ≤ 10−5 with both endometriosis and endometrial cancer, with one locus (SNP rs2475335) located within PTPRD associated at a genomewide significant level (P = 4.9 × 10−8, OR = 1.11, 95% CI = 1.07–1.15). PTPRD acts in the STAT3 pathway, which has been implicated in both endometriosis and endometrial cancer. This study demonstrates the value of cross‐disease genetic analysis to support epidemiological observations and to identify biological pathways of relevance to multiple diseases. Cross‐disease analysis endometrial cancer endometriosis genome‐wide association study genetic correlation Neoplasms. Tumors. Oncology. Including cancer and carcinogens Tracy A. O'Mara verfasserin aut Andrew P. Morris verfasserin aut Timothy H. T. Cheng verfasserin aut Maggie Gorman verfasserin aut Lynn Martin verfasserin aut Shirley Hodson verfasserin aut Angela Jones verfasserin aut Nicholas G. Martin verfasserin aut Scott Gordon verfasserin aut Anjali K. Henders verfasserin aut John Attia verfasserin aut Mark McEvoy verfasserin aut Elizabeth G. Holliday verfasserin aut Rodney J. Scott verfasserin aut Penelope M. Webb verfasserin aut Peter A. Fasching verfasserin aut Matthias W. Beckmann verfasserin aut Arif B. Ekici verfasserin aut Alexander Hein verfasserin aut Matthias Rübner verfasserin aut Per Hall verfasserin aut Kamila Czene verfasserin aut Thilo Dörk verfasserin aut Matthias Dürst verfasserin aut Peter Hillemanns verfasserin aut Ingo Runnebaum verfasserin aut Diether Lambrechts verfasserin aut Frederic Amant verfasserin aut Daniela Annibali verfasserin aut Jeroen Depreeuw verfasserin aut Adriaan Vanderstichele verfasserin aut Ellen L. Goode verfasserin aut Julie M. Cunningham verfasserin aut Sean C. Dowdy verfasserin aut Stacey J. Winham verfasserin aut Jone Trovik verfasserin aut Erling Hoivik verfasserin aut Henrica M. J. Werner verfasserin aut Camilla Krakstad verfasserin aut Katie Ashton verfasserin aut Geoffrey Otton verfasserin aut Tony Proietto verfasserin aut Emma Tham verfasserin aut Miriam Mints verfasserin aut Shahana Ahmed verfasserin aut Catherine S. Healey verfasserin aut Mitul Shah verfasserin aut Paul D. P. Pharoah verfasserin aut Alison M. Dunning verfasserin aut Joe Dennis verfasserin aut Manjeet K. Bolla verfasserin aut Kyriaki Michailidou verfasserin aut Qin Wang verfasserin aut Jonathan P. Tyrer verfasserin aut John L. Hopper verfasserin aut Julian Peto verfasserin aut Anthony J. Swerdlow verfasserin aut Barbara Burwinkel verfasserin aut Hermann Brenner verfasserin aut Alfons Meindl verfasserin aut Hiltrud Brauch verfasserin aut Annika Lindblom verfasserin aut Jenny Chang‐Claude verfasserin aut Fergus J. Couch verfasserin aut Graham G. Giles verfasserin aut Vessela N. Kristensen verfasserin aut Angela Cox verfasserin aut Krina T. Zondervan verfasserin aut Dale R. Nyholt verfasserin aut Stuart MacGregor verfasserin aut Grant W. Montgomery verfasserin aut Ian Tomlinson verfasserin aut Douglas F. Easton verfasserin aut Deborah J. Thompson verfasserin aut Amanda B. Spurdle verfasserin aut In Cancer Medicine Wiley, 2012 7(2018), 5, Seite 1978-1987 (DE-627)71860153X (DE-600)2659751-2 20457634 nnns volume:7 year:2018 number:5 pages:1978-1987 https://doi.org/10.1002/cam4.1445 kostenfrei https://doaj.org/article/463fb4a945b24c1c8ee3d74f75c3da32 kostenfrei https://doi.org/10.1002/cam4.1445 kostenfrei https://doaj.org/toc/2045-7634 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_636 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 7 2018 5 1978-1987
language	English
source	In Cancer Medicine 7(2018), 5, Seite 1978-1987 volume:7 year:2018 number:5 pages:1978-1987
sourceStr	In Cancer Medicine 7(2018), 5, Seite 1978-1987 volume:7 year:2018 number:5 pages:1978-1987
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	Cross‐disease analysis endometrial cancer endometriosis genome‐wide association study genetic correlation Neoplasms. Tumors. Oncology. Including cancer and carcinogens
isfreeaccess_bool	true
container_title	Cancer Medicine
authorswithroles_txt_mv	Jodie N. Painter @@aut@@ Tracy A. O'Mara @@aut@@ Andrew P. Morris @@aut@@ Timothy H. T. Cheng @@aut@@ Maggie Gorman @@aut@@ Lynn Martin @@aut@@ Shirley Hodson @@aut@@ Angela Jones @@aut@@ Nicholas G. Martin @@aut@@ Scott Gordon @@aut@@ Anjali K. Henders @@aut@@ John Attia @@aut@@ Mark McEvoy @@aut@@ Elizabeth G. Holliday @@aut@@ Rodney J. Scott @@aut@@ Penelope M. Webb @@aut@@ Peter A. Fasching @@aut@@ Matthias W. Beckmann @@aut@@ Arif B. Ekici @@aut@@ Alexander Hein @@aut@@ Matthias Rübner @@aut@@ Per Hall @@aut@@ Kamila Czene @@aut@@ Thilo Dörk @@aut@@ Matthias Dürst @@aut@@ Peter Hillemanns @@aut@@ Ingo Runnebaum @@aut@@ Diether Lambrechts @@aut@@ Frederic Amant @@aut@@ Daniela Annibali @@aut@@ Jeroen Depreeuw @@aut@@ Adriaan Vanderstichele @@aut@@ Ellen L. Goode @@aut@@ Julie M. Cunningham @@aut@@ Sean C. Dowdy @@aut@@ Stacey J. Winham @@aut@@ Jone Trovik @@aut@@ Erling Hoivik @@aut@@ Henrica M. J. Werner @@aut@@ Camilla Krakstad @@aut@@ Katie Ashton @@aut@@ Geoffrey Otton @@aut@@ Tony Proietto @@aut@@ Emma Tham @@aut@@ Miriam Mints @@aut@@ Shahana Ahmed @@aut@@ Catherine S. Healey @@aut@@ Mitul Shah @@aut@@ Paul D. P. Pharoah @@aut@@ Alison M. Dunning @@aut@@ Joe Dennis @@aut@@ Manjeet K. Bolla @@aut@@ Kyriaki Michailidou @@aut@@ Qin Wang @@aut@@ Jonathan P. Tyrer @@aut@@ John L. Hopper @@aut@@ Julian Peto @@aut@@ Anthony J. Swerdlow @@aut@@ Barbara Burwinkel @@aut@@ Hermann Brenner @@aut@@ Alfons Meindl @@aut@@ Hiltrud Brauch @@aut@@ Annika Lindblom @@aut@@ Jenny Chang‐Claude @@aut@@ Fergus J. Couch @@aut@@ Graham G. Giles @@aut@@ Vessela N. Kristensen @@aut@@ Angela Cox @@aut@@ Krina T. Zondervan @@aut@@ Dale R. Nyholt @@aut@@ Stuart MacGregor @@aut@@ Grant W. Montgomery @@aut@@ Ian Tomlinson @@aut@@ Douglas F. Easton @@aut@@ Deborah J. Thompson @@aut@@ Amanda B. Spurdle @@aut@@
publishDateDaySort_date	2018-01-01T00:00:00Z
hierarchy_top_id	71860153X
id	DOAJ087956071
language_de	englisch
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Painter</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Genetic overlap between endometriosis and endometrial cancer: evidence from cross‐disease genetic correlation and GWAS meta‐analyses</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2018</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">Text</subfield><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">Computermedien</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Abstract Epidemiological, biological, and molecular data suggest links between endometriosis and endometrial cancer, with recent epidemiological studies providing evidence for an association between a previous diagnosis of endometriosis and risk of endometrial cancer. We used genetic data as an alternative approach to investigate shared biological etiology of these two diseases. Genetic correlation analysis of summary level statistics from genomewide association studies (GWAS) using LD Score regression revealed moderate but significant genetic correlation (rg = 0.23, P = 9.3 × 10−3), and SNP effect concordance analysis provided evidence for significant SNP pleiotropy (P = 6.0 × 10−3) and concordance in effect direction (P = 2.0 × 10−3) between the two diseases. Cross‐disease GWAS meta‐analysis highlighted 13 distinct loci associated at P ≤ 10−5 with both endometriosis and endometrial cancer, with one locus (SNP rs2475335) located within PTPRD associated at a genomewide significant level (P = 4.9 × 10−8, OR = 1.11, 95% CI = 1.07–1.15). PTPRD acts in the STAT3 pathway, which has been implicated in both endometriosis and endometrial cancer. 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callnumber-first	R - Medicine
author	Jodie N. Painter
spellingShingle	Jodie N. Painter misc RC254-282 misc Cross‐disease analysis misc endometrial cancer misc endometriosis misc genome‐wide association study misc genetic correlation misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens Genetic overlap between endometriosis and endometrial cancer: evidence from cross‐disease genetic correlation and GWAS meta‐analyses
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topic_title	RC254-282 Genetic overlap between endometriosis and endometrial cancer: evidence from cross‐disease genetic correlation and GWAS meta‐analyses Cross‐disease analysis endometrial cancer endometriosis genome‐wide association study genetic correlation
topic	misc RC254-282 misc Cross‐disease analysis misc endometrial cancer misc endometriosis misc genome‐wide association study misc genetic correlation misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens
topic_unstemmed	misc RC254-282 misc Cross‐disease analysis misc endometrial cancer misc endometriosis misc genome‐wide association study misc genetic correlation misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens
topic_browse	misc RC254-282 misc Cross‐disease analysis misc endometrial cancer misc endometriosis misc genome‐wide association study misc genetic correlation misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens
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title	Genetic overlap between endometriosis and endometrial cancer: evidence from cross‐disease genetic correlation and GWAS meta‐analyses
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title_full	Genetic overlap between endometriosis and endometrial cancer: evidence from cross‐disease genetic correlation and GWAS meta‐analyses
author_sort	Jodie N. Painter
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author_browse	Jodie N. Painter Tracy A. O'Mara Andrew P. Morris Timothy H. T. Cheng Maggie Gorman Lynn Martin Shirley Hodson Angela Jones Nicholas G. Martin Scott Gordon Anjali K. Henders John Attia Mark McEvoy Elizabeth G. Holliday Rodney J. Scott Penelope M. Webb Peter A. Fasching Matthias W. Beckmann Arif B. Ekici Alexander Hein Matthias Rübner Per Hall Kamila Czene Thilo Dörk Matthias Dürst Peter Hillemanns Ingo Runnebaum Diether Lambrechts Frederic Amant Daniela Annibali Jeroen Depreeuw Adriaan Vanderstichele Ellen L. Goode Julie M. Cunningham Sean C. Dowdy Stacey J. Winham Jone Trovik Erling Hoivik Henrica M. J. Werner Camilla Krakstad Katie Ashton Geoffrey Otton Tony Proietto Emma Tham Miriam Mints Shahana Ahmed Catherine S. Healey Mitul Shah Paul D. P. Pharoah Alison M. Dunning Joe Dennis Manjeet K. Bolla Kyriaki Michailidou Qin Wang Jonathan P. Tyrer John L. Hopper Julian Peto Anthony J. Swerdlow Barbara Burwinkel Hermann Brenner Alfons Meindl Hiltrud Brauch Annika Lindblom Jenny Chang‐Claude Fergus J. Couch Graham G. Giles Vessela N. Kristensen Angela Cox Krina T. Zondervan Dale R. Nyholt Stuart MacGregor Grant W. Montgomery Ian Tomlinson Douglas F. Easton Deborah J. Thompson Amanda B. Spurdle
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title_sort	genetic overlap between endometriosis and endometrial cancer: evidence from cross‐disease genetic correlation and gwas meta‐analyses
callnumber	RC254-282
title_auth	Genetic overlap between endometriosis and endometrial cancer: evidence from cross‐disease genetic correlation and GWAS meta‐analyses
abstract	Abstract Epidemiological, biological, and molecular data suggest links between endometriosis and endometrial cancer, with recent epidemiological studies providing evidence for an association between a previous diagnosis of endometriosis and risk of endometrial cancer. We used genetic data as an alternative approach to investigate shared biological etiology of these two diseases. Genetic correlation analysis of summary level statistics from genomewide association studies (GWAS) using LD Score regression revealed moderate but significant genetic correlation (rg = 0.23, P = 9.3 × 10−3), and SNP effect concordance analysis provided evidence for significant SNP pleiotropy (P = 6.0 × 10−3) and concordance in effect direction (P = 2.0 × 10−3) between the two diseases. Cross‐disease GWAS meta‐analysis highlighted 13 distinct loci associated at P ≤ 10−5 with both endometriosis and endometrial cancer, with one locus (SNP rs2475335) located within PTPRD associated at a genomewide significant level (P = 4.9 × 10−8, OR = 1.11, 95% CI = 1.07–1.15). PTPRD acts in the STAT3 pathway, which has been implicated in both endometriosis and endometrial cancer. This study demonstrates the value of cross‐disease genetic analysis to support epidemiological observations and to identify biological pathways of relevance to multiple diseases.
abstractGer	Abstract Epidemiological, biological, and molecular data suggest links between endometriosis and endometrial cancer, with recent epidemiological studies providing evidence for an association between a previous diagnosis of endometriosis and risk of endometrial cancer. We used genetic data as an alternative approach to investigate shared biological etiology of these two diseases. Genetic correlation analysis of summary level statistics from genomewide association studies (GWAS) using LD Score regression revealed moderate but significant genetic correlation (rg = 0.23, P = 9.3 × 10−3), and SNP effect concordance analysis provided evidence for significant SNP pleiotropy (P = 6.0 × 10−3) and concordance in effect direction (P = 2.0 × 10−3) between the two diseases. Cross‐disease GWAS meta‐analysis highlighted 13 distinct loci associated at P ≤ 10−5 with both endometriosis and endometrial cancer, with one locus (SNP rs2475335) located within PTPRD associated at a genomewide significant level (P = 4.9 × 10−8, OR = 1.11, 95% CI = 1.07–1.15). PTPRD acts in the STAT3 pathway, which has been implicated in both endometriosis and endometrial cancer. This study demonstrates the value of cross‐disease genetic analysis to support epidemiological observations and to identify biological pathways of relevance to multiple diseases.
abstract_unstemmed	Abstract Epidemiological, biological, and molecular data suggest links between endometriosis and endometrial cancer, with recent epidemiological studies providing evidence for an association between a previous diagnosis of endometriosis and risk of endometrial cancer. We used genetic data as an alternative approach to investigate shared biological etiology of these two diseases. Genetic correlation analysis of summary level statistics from genomewide association studies (GWAS) using LD Score regression revealed moderate but significant genetic correlation (rg = 0.23, P = 9.3 × 10−3), and SNP effect concordance analysis provided evidence for significant SNP pleiotropy (P = 6.0 × 10−3) and concordance in effect direction (P = 2.0 × 10−3) between the two diseases. Cross‐disease GWAS meta‐analysis highlighted 13 distinct loci associated at P ≤ 10−5 with both endometriosis and endometrial cancer, with one locus (SNP rs2475335) located within PTPRD associated at a genomewide significant level (P = 4.9 × 10−8, OR = 1.11, 95% CI = 1.07–1.15). PTPRD acts in the STAT3 pathway, which has been implicated in both endometriosis and endometrial cancer. This study demonstrates the value of cross‐disease genetic analysis to support epidemiological observations and to identify biological pathways of relevance to multiple diseases.
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title_short	Genetic overlap between endometriosis and endometrial cancer: evidence from cross‐disease genetic correlation and GWAS meta‐analyses
url	https://doi.org/10.1002/cam4.1445 https://doaj.org/article/463fb4a945b24c1c8ee3d74f75c3da32 https://doaj.org/toc/2045-7634
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author2Str	Tracy A. O'Mara Andrew P. Morris Timothy H. T. Cheng Maggie Gorman Lynn Martin Shirley Hodson Angela Jones Nicholas G. Martin Scott Gordon Anjali K. Henders John Attia Mark McEvoy Elizabeth G. Holliday Rodney J. Scott Penelope M. Webb Peter A. Fasching Matthias W. Beckmann Arif B. Ekici Alexander Hein Matthias Rübner Per Hall Kamila Czene Thilo Dörk Matthias Dürst Peter Hillemanns Ingo Runnebaum Diether Lambrechts Frederic Amant Daniela Annibali Jeroen Depreeuw Adriaan Vanderstichele Ellen L. Goode Julie M. Cunningham Sean C. Dowdy Stacey J. Winham Jone Trovik Erling Hoivik Henrica M. J. Werner Camilla Krakstad Katie Ashton Geoffrey Otton Tony Proietto Emma Tham Miriam Mints Shahana Ahmed Catherine S. Healey Mitul Shah Paul D. P. Pharoah Alison M. Dunning Joe Dennis Manjeet K. Bolla Kyriaki Michailidou Qin Wang Jonathan P. Tyrer John L. Hopper Julian Peto Anthony J. Swerdlow Barbara Burwinkel Hermann Brenner Alfons Meindl Hiltrud Brauch Annika Lindblom Jenny Chang‐Claude Fergus J. Couch Graham G. Giles Vessela N. Kristensen Angela Cox Krina T. Zondervan Dale R. Nyholt Stuart MacGregor Grant W. Montgomery Ian Tomlinson Douglas F. Easton Deborah J. Thompson Amanda B. Spurdle
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doi_str	10.1002/cam4.1445
callnumber-a	RC254-282
up_date	2024-07-03T14:56:34.539Z
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Painter</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Genetic overlap between endometriosis and endometrial cancer: evidence from cross‐disease genetic correlation and GWAS meta‐analyses</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2018</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">Text</subfield><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">Computermedien</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Abstract Epidemiological, biological, and molecular data suggest links between endometriosis and endometrial cancer, with recent epidemiological studies providing evidence for an association between a previous diagnosis of endometriosis and risk of endometrial cancer. We used genetic data as an alternative approach to investigate shared biological etiology of these two diseases. Genetic correlation analysis of summary level statistics from genomewide association studies (GWAS) using LD Score regression revealed moderate but significant genetic correlation (rg = 0.23, P = 9.3 × 10−3), and SNP effect concordance analysis provided evidence for significant SNP pleiotropy (P = 6.0 × 10−3) and concordance in effect direction (P = 2.0 × 10−3) between the two diseases. Cross‐disease GWAS meta‐analysis highlighted 13 distinct loci associated at P ≤ 10−5 with both endometriosis and endometrial cancer, with one locus (SNP rs2475335) located within PTPRD associated at a genomewide significant level (P = 4.9 × 10−8, OR = 1.11, 95% CI = 1.07–1.15). PTPRD acts in the STAT3 pathway, which has been implicated in both endometriosis and endometrial cancer. 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Genetic overlap between endometriosis and endometrial cancer: evidence from cross‐disease genetic correlation and GWAS meta‐analyses

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