MicroRNA-200c-5p Regulates Migration and Differentiation of Myoblasts via Targeting <i<Adamts5</i< in Skeletal Muscle Regeneration and Myogenesis
Skeletal muscle, as a regenerative organization, plays a vital role in physiological characteristics and homeostasis. However, the regulation mechanism of skeletal muscle regeneration is not entirely clear. miRNAs, as one of the regulatory factors, exert profound effects on regulating skeletal muscl...
Ausführliche Beschreibung
Autor*in: |
Yanwen Liu [verfasserIn] Yilong Yao [verfasserIn] Yongsheng Zhang [verfasserIn] Chao Yan [verfasserIn] Mingsha Yang [verfasserIn] Zishuai Wang [verfasserIn] Wangzhang Li [verfasserIn] Fanqinyu Li [verfasserIn] Wei Wang [verfasserIn] Yalan Yang [verfasserIn] Xinyun Li [verfasserIn] Zhonglin Tang [verfasserIn] |
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E-Artikel |
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Sprache: |
Englisch |
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2023 |
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In: International Journal of Molecular Sciences - MDPI AG, 2003, 24(2023), 5, p 4995 |
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Übergeordnetes Werk: |
volume:24 ; year:2023 ; number:5, p 4995 |
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Link aufrufen |
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DOI / URN: |
10.3390/ijms24054995 |
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Katalog-ID: |
DOAJ088000281 |
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520 | |a Skeletal muscle, as a regenerative organization, plays a vital role in physiological characteristics and homeostasis. However, the regulation mechanism of skeletal muscle regeneration is not entirely clear. miRNAs, as one of the regulatory factors, exert profound effects on regulating skeletal muscle regeneration and myogenesis. This study aimed to discover the regulatory function of important miRNA miR-200c-5p in skeletal muscle regeneration. In our study, miR-200c-5p increased at the early stage and peaked at first day during mouse skeletal muscle regeneration, which was also highly expressed in skeletal muscle of mouse tissue profile. Further, overexpression of miR-200c-5p promoted migration and inhibited differentiation of C2C12 myoblast, whereas inhibition of miR-200c-5p had the opposite effect. Bioinformatic analysis predicted that <i<Adamts5</i< has potential binding sites for miR-200c-5p at 3’UTR region. Dual-luciferase and RIP assays further proved that <i<Adamts5</i< is a target gene of miR-200c-5p. The expression patterns of miR-200c-5p and <i<Adamts5</i< were opposite during the skeletal muscle regeneration. Moreover, miR-200c-5p can rescue the effects of <i<Adamts5</i< in the C2C12 myoblast. In conclusion, miR-200c-5p might play a considerable function during skeletal muscle regeneration and myogenesis. These findings will provide a promising gene for promoting muscle health and candidate therapeutic target for skeletal muscle repair. | ||
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10.3390/ijms24054995 doi (DE-627)DOAJ088000281 (DE-599)DOAJaae4c51c37714749a7ef315e81cdcc45 DE-627 ger DE-627 rakwb eng QH301-705.5 QD1-999 Yanwen Liu verfasserin aut MicroRNA-200c-5p Regulates Migration and Differentiation of Myoblasts via Targeting <i<Adamts5</i< in Skeletal Muscle Regeneration and Myogenesis 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Skeletal muscle, as a regenerative organization, plays a vital role in physiological characteristics and homeostasis. However, the regulation mechanism of skeletal muscle regeneration is not entirely clear. miRNAs, as one of the regulatory factors, exert profound effects on regulating skeletal muscle regeneration and myogenesis. This study aimed to discover the regulatory function of important miRNA miR-200c-5p in skeletal muscle regeneration. In our study, miR-200c-5p increased at the early stage and peaked at first day during mouse skeletal muscle regeneration, which was also highly expressed in skeletal muscle of mouse tissue profile. Further, overexpression of miR-200c-5p promoted migration and inhibited differentiation of C2C12 myoblast, whereas inhibition of miR-200c-5p had the opposite effect. Bioinformatic analysis predicted that <i<Adamts5</i< has potential binding sites for miR-200c-5p at 3’UTR region. Dual-luciferase and RIP assays further proved that <i<Adamts5</i< is a target gene of miR-200c-5p. The expression patterns of miR-200c-5p and <i<Adamts5</i< were opposite during the skeletal muscle regeneration. Moreover, miR-200c-5p can rescue the effects of <i<Adamts5</i< in the C2C12 myoblast. In conclusion, miR-200c-5p might play a considerable function during skeletal muscle regeneration and myogenesis. These findings will provide a promising gene for promoting muscle health and candidate therapeutic target for skeletal muscle repair. miR-200c-5p <i<Adamts5</i< skeletal muscle regeneration migration differentiation Biology (General) Chemistry Yilong Yao verfasserin aut Yongsheng Zhang verfasserin aut Chao Yan verfasserin aut Mingsha Yang verfasserin aut Zishuai Wang verfasserin aut Wangzhang Li verfasserin aut Fanqinyu Li verfasserin aut Wei Wang verfasserin aut Yalan Yang verfasserin aut Xinyun Li verfasserin aut Zhonglin Tang verfasserin aut In International Journal of Molecular Sciences MDPI AG, 2003 24(2023), 5, p 4995 (DE-627)316340715 (DE-600)2019364-6 14220067 nnns volume:24 year:2023 number:5, p 4995 https://doi.org/10.3390/ijms24054995 kostenfrei https://doaj.org/article/aae4c51c37714749a7ef315e81cdcc45 kostenfrei https://www.mdpi.com/1422-0067/24/5/4995 kostenfrei https://doaj.org/toc/1661-6596 Journal toc kostenfrei https://doaj.org/toc/1422-0067 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 24 2023 5, p 4995 |
spelling |
10.3390/ijms24054995 doi (DE-627)DOAJ088000281 (DE-599)DOAJaae4c51c37714749a7ef315e81cdcc45 DE-627 ger DE-627 rakwb eng QH301-705.5 QD1-999 Yanwen Liu verfasserin aut MicroRNA-200c-5p Regulates Migration and Differentiation of Myoblasts via Targeting <i<Adamts5</i< in Skeletal Muscle Regeneration and Myogenesis 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Skeletal muscle, as a regenerative organization, plays a vital role in physiological characteristics and homeostasis. However, the regulation mechanism of skeletal muscle regeneration is not entirely clear. miRNAs, as one of the regulatory factors, exert profound effects on regulating skeletal muscle regeneration and myogenesis. This study aimed to discover the regulatory function of important miRNA miR-200c-5p in skeletal muscle regeneration. In our study, miR-200c-5p increased at the early stage and peaked at first day during mouse skeletal muscle regeneration, which was also highly expressed in skeletal muscle of mouse tissue profile. Further, overexpression of miR-200c-5p promoted migration and inhibited differentiation of C2C12 myoblast, whereas inhibition of miR-200c-5p had the opposite effect. Bioinformatic analysis predicted that <i<Adamts5</i< has potential binding sites for miR-200c-5p at 3’UTR region. Dual-luciferase and RIP assays further proved that <i<Adamts5</i< is a target gene of miR-200c-5p. The expression patterns of miR-200c-5p and <i<Adamts5</i< were opposite during the skeletal muscle regeneration. Moreover, miR-200c-5p can rescue the effects of <i<Adamts5</i< in the C2C12 myoblast. In conclusion, miR-200c-5p might play a considerable function during skeletal muscle regeneration and myogenesis. These findings will provide a promising gene for promoting muscle health and candidate therapeutic target for skeletal muscle repair. miR-200c-5p <i<Adamts5</i< skeletal muscle regeneration migration differentiation Biology (General) Chemistry Yilong Yao verfasserin aut Yongsheng Zhang verfasserin aut Chao Yan verfasserin aut Mingsha Yang verfasserin aut Zishuai Wang verfasserin aut Wangzhang Li verfasserin aut Fanqinyu Li verfasserin aut Wei Wang verfasserin aut Yalan Yang verfasserin aut Xinyun Li verfasserin aut Zhonglin Tang verfasserin aut In International Journal of Molecular Sciences MDPI AG, 2003 24(2023), 5, p 4995 (DE-627)316340715 (DE-600)2019364-6 14220067 nnns volume:24 year:2023 number:5, p 4995 https://doi.org/10.3390/ijms24054995 kostenfrei https://doaj.org/article/aae4c51c37714749a7ef315e81cdcc45 kostenfrei https://www.mdpi.com/1422-0067/24/5/4995 kostenfrei https://doaj.org/toc/1661-6596 Journal toc kostenfrei https://doaj.org/toc/1422-0067 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 24 2023 5, p 4995 |
allfields_unstemmed |
10.3390/ijms24054995 doi (DE-627)DOAJ088000281 (DE-599)DOAJaae4c51c37714749a7ef315e81cdcc45 DE-627 ger DE-627 rakwb eng QH301-705.5 QD1-999 Yanwen Liu verfasserin aut MicroRNA-200c-5p Regulates Migration and Differentiation of Myoblasts via Targeting <i<Adamts5</i< in Skeletal Muscle Regeneration and Myogenesis 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Skeletal muscle, as a regenerative organization, plays a vital role in physiological characteristics and homeostasis. However, the regulation mechanism of skeletal muscle regeneration is not entirely clear. miRNAs, as one of the regulatory factors, exert profound effects on regulating skeletal muscle regeneration and myogenesis. This study aimed to discover the regulatory function of important miRNA miR-200c-5p in skeletal muscle regeneration. In our study, miR-200c-5p increased at the early stage and peaked at first day during mouse skeletal muscle regeneration, which was also highly expressed in skeletal muscle of mouse tissue profile. Further, overexpression of miR-200c-5p promoted migration and inhibited differentiation of C2C12 myoblast, whereas inhibition of miR-200c-5p had the opposite effect. Bioinformatic analysis predicted that <i<Adamts5</i< has potential binding sites for miR-200c-5p at 3’UTR region. Dual-luciferase and RIP assays further proved that <i<Adamts5</i< is a target gene of miR-200c-5p. The expression patterns of miR-200c-5p and <i<Adamts5</i< were opposite during the skeletal muscle regeneration. Moreover, miR-200c-5p can rescue the effects of <i<Adamts5</i< in the C2C12 myoblast. In conclusion, miR-200c-5p might play a considerable function during skeletal muscle regeneration and myogenesis. These findings will provide a promising gene for promoting muscle health and candidate therapeutic target for skeletal muscle repair. miR-200c-5p <i<Adamts5</i< skeletal muscle regeneration migration differentiation Biology (General) Chemistry Yilong Yao verfasserin aut Yongsheng Zhang verfasserin aut Chao Yan verfasserin aut Mingsha Yang verfasserin aut Zishuai Wang verfasserin aut Wangzhang Li verfasserin aut Fanqinyu Li verfasserin aut Wei Wang verfasserin aut Yalan Yang verfasserin aut Xinyun Li verfasserin aut Zhonglin Tang verfasserin aut In International Journal of Molecular Sciences MDPI AG, 2003 24(2023), 5, p 4995 (DE-627)316340715 (DE-600)2019364-6 14220067 nnns volume:24 year:2023 number:5, p 4995 https://doi.org/10.3390/ijms24054995 kostenfrei https://doaj.org/article/aae4c51c37714749a7ef315e81cdcc45 kostenfrei https://www.mdpi.com/1422-0067/24/5/4995 kostenfrei https://doaj.org/toc/1661-6596 Journal toc kostenfrei https://doaj.org/toc/1422-0067 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 24 2023 5, p 4995 |
allfieldsGer |
10.3390/ijms24054995 doi (DE-627)DOAJ088000281 (DE-599)DOAJaae4c51c37714749a7ef315e81cdcc45 DE-627 ger DE-627 rakwb eng QH301-705.5 QD1-999 Yanwen Liu verfasserin aut MicroRNA-200c-5p Regulates Migration and Differentiation of Myoblasts via Targeting <i<Adamts5</i< in Skeletal Muscle Regeneration and Myogenesis 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Skeletal muscle, as a regenerative organization, plays a vital role in physiological characteristics and homeostasis. However, the regulation mechanism of skeletal muscle regeneration is not entirely clear. miRNAs, as one of the regulatory factors, exert profound effects on regulating skeletal muscle regeneration and myogenesis. This study aimed to discover the regulatory function of important miRNA miR-200c-5p in skeletal muscle regeneration. In our study, miR-200c-5p increased at the early stage and peaked at first day during mouse skeletal muscle regeneration, which was also highly expressed in skeletal muscle of mouse tissue profile. Further, overexpression of miR-200c-5p promoted migration and inhibited differentiation of C2C12 myoblast, whereas inhibition of miR-200c-5p had the opposite effect. Bioinformatic analysis predicted that <i<Adamts5</i< has potential binding sites for miR-200c-5p at 3’UTR region. Dual-luciferase and RIP assays further proved that <i<Adamts5</i< is a target gene of miR-200c-5p. The expression patterns of miR-200c-5p and <i<Adamts5</i< were opposite during the skeletal muscle regeneration. Moreover, miR-200c-5p can rescue the effects of <i<Adamts5</i< in the C2C12 myoblast. In conclusion, miR-200c-5p might play a considerable function during skeletal muscle regeneration and myogenesis. These findings will provide a promising gene for promoting muscle health and candidate therapeutic target for skeletal muscle repair. miR-200c-5p <i<Adamts5</i< skeletal muscle regeneration migration differentiation Biology (General) Chemistry Yilong Yao verfasserin aut Yongsheng Zhang verfasserin aut Chao Yan verfasserin aut Mingsha Yang verfasserin aut Zishuai Wang verfasserin aut Wangzhang Li verfasserin aut Fanqinyu Li verfasserin aut Wei Wang verfasserin aut Yalan Yang verfasserin aut Xinyun Li verfasserin aut Zhonglin Tang verfasserin aut In International Journal of Molecular Sciences MDPI AG, 2003 24(2023), 5, p 4995 (DE-627)316340715 (DE-600)2019364-6 14220067 nnns volume:24 year:2023 number:5, p 4995 https://doi.org/10.3390/ijms24054995 kostenfrei https://doaj.org/article/aae4c51c37714749a7ef315e81cdcc45 kostenfrei https://www.mdpi.com/1422-0067/24/5/4995 kostenfrei https://doaj.org/toc/1661-6596 Journal toc kostenfrei https://doaj.org/toc/1422-0067 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 24 2023 5, p 4995 |
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10.3390/ijms24054995 doi (DE-627)DOAJ088000281 (DE-599)DOAJaae4c51c37714749a7ef315e81cdcc45 DE-627 ger DE-627 rakwb eng QH301-705.5 QD1-999 Yanwen Liu verfasserin aut MicroRNA-200c-5p Regulates Migration and Differentiation of Myoblasts via Targeting <i<Adamts5</i< in Skeletal Muscle Regeneration and Myogenesis 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Skeletal muscle, as a regenerative organization, plays a vital role in physiological characteristics and homeostasis. However, the regulation mechanism of skeletal muscle regeneration is not entirely clear. miRNAs, as one of the regulatory factors, exert profound effects on regulating skeletal muscle regeneration and myogenesis. This study aimed to discover the regulatory function of important miRNA miR-200c-5p in skeletal muscle regeneration. In our study, miR-200c-5p increased at the early stage and peaked at first day during mouse skeletal muscle regeneration, which was also highly expressed in skeletal muscle of mouse tissue profile. Further, overexpression of miR-200c-5p promoted migration and inhibited differentiation of C2C12 myoblast, whereas inhibition of miR-200c-5p had the opposite effect. Bioinformatic analysis predicted that <i<Adamts5</i< has potential binding sites for miR-200c-5p at 3’UTR region. Dual-luciferase and RIP assays further proved that <i<Adamts5</i< is a target gene of miR-200c-5p. The expression patterns of miR-200c-5p and <i<Adamts5</i< were opposite during the skeletal muscle regeneration. Moreover, miR-200c-5p can rescue the effects of <i<Adamts5</i< in the C2C12 myoblast. In conclusion, miR-200c-5p might play a considerable function during skeletal muscle regeneration and myogenesis. These findings will provide a promising gene for promoting muscle health and candidate therapeutic target for skeletal muscle repair. miR-200c-5p <i<Adamts5</i< skeletal muscle regeneration migration differentiation Biology (General) Chemistry Yilong Yao verfasserin aut Yongsheng Zhang verfasserin aut Chao Yan verfasserin aut Mingsha Yang verfasserin aut Zishuai Wang verfasserin aut Wangzhang Li verfasserin aut Fanqinyu Li verfasserin aut Wei Wang verfasserin aut Yalan Yang verfasserin aut Xinyun Li verfasserin aut Zhonglin Tang verfasserin aut In International Journal of Molecular Sciences MDPI AG, 2003 24(2023), 5, p 4995 (DE-627)316340715 (DE-600)2019364-6 14220067 nnns volume:24 year:2023 number:5, p 4995 https://doi.org/10.3390/ijms24054995 kostenfrei https://doaj.org/article/aae4c51c37714749a7ef315e81cdcc45 kostenfrei https://www.mdpi.com/1422-0067/24/5/4995 kostenfrei https://doaj.org/toc/1661-6596 Journal toc kostenfrei https://doaj.org/toc/1422-0067 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 24 2023 5, p 4995 |
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microrna-200c-5p regulates migration and differentiation of myoblasts via targeting <i<adamts5</i< in skeletal muscle regeneration and myogenesis |
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MicroRNA-200c-5p Regulates Migration and Differentiation of Myoblasts via Targeting <i<Adamts5</i< in Skeletal Muscle Regeneration and Myogenesis |
abstract |
Skeletal muscle, as a regenerative organization, plays a vital role in physiological characteristics and homeostasis. However, the regulation mechanism of skeletal muscle regeneration is not entirely clear. miRNAs, as one of the regulatory factors, exert profound effects on regulating skeletal muscle regeneration and myogenesis. This study aimed to discover the regulatory function of important miRNA miR-200c-5p in skeletal muscle regeneration. In our study, miR-200c-5p increased at the early stage and peaked at first day during mouse skeletal muscle regeneration, which was also highly expressed in skeletal muscle of mouse tissue profile. Further, overexpression of miR-200c-5p promoted migration and inhibited differentiation of C2C12 myoblast, whereas inhibition of miR-200c-5p had the opposite effect. Bioinformatic analysis predicted that <i<Adamts5</i< has potential binding sites for miR-200c-5p at 3’UTR region. Dual-luciferase and RIP assays further proved that <i<Adamts5</i< is a target gene of miR-200c-5p. The expression patterns of miR-200c-5p and <i<Adamts5</i< were opposite during the skeletal muscle regeneration. Moreover, miR-200c-5p can rescue the effects of <i<Adamts5</i< in the C2C12 myoblast. In conclusion, miR-200c-5p might play a considerable function during skeletal muscle regeneration and myogenesis. These findings will provide a promising gene for promoting muscle health and candidate therapeutic target for skeletal muscle repair. |
abstractGer |
Skeletal muscle, as a regenerative organization, plays a vital role in physiological characteristics and homeostasis. However, the regulation mechanism of skeletal muscle regeneration is not entirely clear. miRNAs, as one of the regulatory factors, exert profound effects on regulating skeletal muscle regeneration and myogenesis. This study aimed to discover the regulatory function of important miRNA miR-200c-5p in skeletal muscle regeneration. In our study, miR-200c-5p increased at the early stage and peaked at first day during mouse skeletal muscle regeneration, which was also highly expressed in skeletal muscle of mouse tissue profile. Further, overexpression of miR-200c-5p promoted migration and inhibited differentiation of C2C12 myoblast, whereas inhibition of miR-200c-5p had the opposite effect. Bioinformatic analysis predicted that <i<Adamts5</i< has potential binding sites for miR-200c-5p at 3’UTR region. Dual-luciferase and RIP assays further proved that <i<Adamts5</i< is a target gene of miR-200c-5p. The expression patterns of miR-200c-5p and <i<Adamts5</i< were opposite during the skeletal muscle regeneration. Moreover, miR-200c-5p can rescue the effects of <i<Adamts5</i< in the C2C12 myoblast. In conclusion, miR-200c-5p might play a considerable function during skeletal muscle regeneration and myogenesis. These findings will provide a promising gene for promoting muscle health and candidate therapeutic target for skeletal muscle repair. |
abstract_unstemmed |
Skeletal muscle, as a regenerative organization, plays a vital role in physiological characteristics and homeostasis. However, the regulation mechanism of skeletal muscle regeneration is not entirely clear. miRNAs, as one of the regulatory factors, exert profound effects on regulating skeletal muscle regeneration and myogenesis. This study aimed to discover the regulatory function of important miRNA miR-200c-5p in skeletal muscle regeneration. In our study, miR-200c-5p increased at the early stage and peaked at first day during mouse skeletal muscle regeneration, which was also highly expressed in skeletal muscle of mouse tissue profile. Further, overexpression of miR-200c-5p promoted migration and inhibited differentiation of C2C12 myoblast, whereas inhibition of miR-200c-5p had the opposite effect. Bioinformatic analysis predicted that <i<Adamts5</i< has potential binding sites for miR-200c-5p at 3’UTR region. Dual-luciferase and RIP assays further proved that <i<Adamts5</i< is a target gene of miR-200c-5p. The expression patterns of miR-200c-5p and <i<Adamts5</i< were opposite during the skeletal muscle regeneration. Moreover, miR-200c-5p can rescue the effects of <i<Adamts5</i< in the C2C12 myoblast. In conclusion, miR-200c-5p might play a considerable function during skeletal muscle regeneration and myogenesis. These findings will provide a promising gene for promoting muscle health and candidate therapeutic target for skeletal muscle repair. |
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5, p 4995 |
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MicroRNA-200c-5p Regulates Migration and Differentiation of Myoblasts via Targeting <i<Adamts5</i< in Skeletal Muscle Regeneration and Myogenesis |
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https://doi.org/10.3390/ijms24054995 https://doaj.org/article/aae4c51c37714749a7ef315e81cdcc45 https://www.mdpi.com/1422-0067/24/5/4995 https://doaj.org/toc/1661-6596 https://doaj.org/toc/1422-0067 |
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