An Innovative Drug Repurposing Approach to Restrain Endometrial Cancer Metastatization

Background: Endometrial cancer (EC) is the most common gynecologic tumor and the world’s fourth most common cancer in women. Most patients respond to first-line treatments and have a low risk of recurrence, but refractory patients, and those with metastatic cancer at diagnosis, remain with no treatm...
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Gespeichert in:

Autor*in:	Federica Torricelli [verfasserIn] Elisabetta Sauta [verfasserIn] Veronica Manicardi [verfasserIn] Vincenzo Dario Mandato [verfasserIn] Andrea Palicelli [verfasserIn] Alessia Ciarrocchi [verfasserIn] Gloria Manzotti [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2023

Schlagwörter:	drug repurposing endometrial cancer gene expression metastasis PI3K pathway

Übergeordnetes Werk:	In: Cells - MDPI AG, 2012, 12(2023), 5, p 794
Übergeordnetes Werk:	volume:12 ; year:2023 ; number:5, p 794

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3390/cells12050794

Katalog-ID:	DOAJ088029204

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520			\|a Background: Endometrial cancer (EC) is the most common gynecologic tumor and the world’s fourth most common cancer in women. Most patients respond to first-line treatments and have a low risk of recurrence, but refractory patients, and those with metastatic cancer at diagnosis, remain with no treatment options. Drug repurposing aims to discover new clinical indications for existing drugs with known safety profiles. It provides ready-to-use new therapeutic options for highly aggressive tumors for which standard protocols are ineffective, such as high-risk EC. Methods: Here, we aimed at defining new therapeutic opportunities for high-risk EC using an innovative and integrated computational drug repurposing approach. Results: We compared gene-expression profiles, from publicly available databases, of metastatic and non-metastatic EC patients being metastatization the most severe feature of EC aggressiveness. A comprehensive analysis of transcriptomic data through a two-arm approach was applied to obtain a robust prediction of drug candidates. Conclusions: Some of the identified therapeutic agents are already successfully used in clinical practice to treat other types of tumors. This highlights the potential to repurpose them for EC and, therefore, the reliability of the proposed approach.
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language	English
source	In Cells 12(2023), 5, p 794 volume:12 year:2023 number:5, p 794
sourceStr	In Cells 12(2023), 5, p 794 volume:12 year:2023 number:5, p 794
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	drug repurposing endometrial cancer gene expression metastasis PI3K pathway Cytology
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container_title	Cells
authorswithroles_txt_mv	Federica Torricelli @@aut@@ Elisabetta Sauta @@aut@@ Veronica Manicardi @@aut@@ Vincenzo Dario Mandato @@aut@@ Andrea Palicelli @@aut@@ Alessia Ciarrocchi @@aut@@ Gloria Manzotti @@aut@@
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callnumber-first	Q - Science
author	Federica Torricelli
spellingShingle	Federica Torricelli misc QH573-671 misc drug repurposing misc endometrial cancer misc gene expression misc metastasis misc PI3K pathway misc Cytology An Innovative Drug Repurposing Approach to Restrain Endometrial Cancer Metastatization
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topic_title	QH573-671 An Innovative Drug Repurposing Approach to Restrain Endometrial Cancer Metastatization drug repurposing endometrial cancer gene expression metastasis PI3K pathway
topic	misc QH573-671 misc drug repurposing misc endometrial cancer misc gene expression misc metastasis misc PI3K pathway misc Cytology
topic_unstemmed	misc QH573-671 misc drug repurposing misc endometrial cancer misc gene expression misc metastasis misc PI3K pathway misc Cytology
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title	An Innovative Drug Repurposing Approach to Restrain Endometrial Cancer Metastatization
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title_sort	innovative drug repurposing approach to restrain endometrial cancer metastatization
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title_auth	An Innovative Drug Repurposing Approach to Restrain Endometrial Cancer Metastatization
abstract	Background: Endometrial cancer (EC) is the most common gynecologic tumor and the world’s fourth most common cancer in women. Most patients respond to first-line treatments and have a low risk of recurrence, but refractory patients, and those with metastatic cancer at diagnosis, remain with no treatment options. Drug repurposing aims to discover new clinical indications for existing drugs with known safety profiles. It provides ready-to-use new therapeutic options for highly aggressive tumors for which standard protocols are ineffective, such as high-risk EC. Methods: Here, we aimed at defining new therapeutic opportunities for high-risk EC using an innovative and integrated computational drug repurposing approach. Results: We compared gene-expression profiles, from publicly available databases, of metastatic and non-metastatic EC patients being metastatization the most severe feature of EC aggressiveness. A comprehensive analysis of transcriptomic data through a two-arm approach was applied to obtain a robust prediction of drug candidates. Conclusions: Some of the identified therapeutic agents are already successfully used in clinical practice to treat other types of tumors. This highlights the potential to repurpose them for EC and, therefore, the reliability of the proposed approach.
abstractGer	Background: Endometrial cancer (EC) is the most common gynecologic tumor and the world’s fourth most common cancer in women. Most patients respond to first-line treatments and have a low risk of recurrence, but refractory patients, and those with metastatic cancer at diagnosis, remain with no treatment options. Drug repurposing aims to discover new clinical indications for existing drugs with known safety profiles. It provides ready-to-use new therapeutic options for highly aggressive tumors for which standard protocols are ineffective, such as high-risk EC. Methods: Here, we aimed at defining new therapeutic opportunities for high-risk EC using an innovative and integrated computational drug repurposing approach. Results: We compared gene-expression profiles, from publicly available databases, of metastatic and non-metastatic EC patients being metastatization the most severe feature of EC aggressiveness. A comprehensive analysis of transcriptomic data through a two-arm approach was applied to obtain a robust prediction of drug candidates. Conclusions: Some of the identified therapeutic agents are already successfully used in clinical practice to treat other types of tumors. This highlights the potential to repurpose them for EC and, therefore, the reliability of the proposed approach.
abstract_unstemmed	Background: Endometrial cancer (EC) is the most common gynecologic tumor and the world’s fourth most common cancer in women. Most patients respond to first-line treatments and have a low risk of recurrence, but refractory patients, and those with metastatic cancer at diagnosis, remain with no treatment options. Drug repurposing aims to discover new clinical indications for existing drugs with known safety profiles. It provides ready-to-use new therapeutic options for highly aggressive tumors for which standard protocols are ineffective, such as high-risk EC. Methods: Here, we aimed at defining new therapeutic opportunities for high-risk EC using an innovative and integrated computational drug repurposing approach. Results: We compared gene-expression profiles, from publicly available databases, of metastatic and non-metastatic EC patients being metastatization the most severe feature of EC aggressiveness. A comprehensive analysis of transcriptomic data through a two-arm approach was applied to obtain a robust prediction of drug candidates. Conclusions: Some of the identified therapeutic agents are already successfully used in clinical practice to treat other types of tumors. This highlights the potential to repurpose them for EC and, therefore, the reliability of the proposed approach.
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title_short	An Innovative Drug Repurposing Approach to Restrain Endometrial Cancer Metastatization
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