Genetic assortative mating for schizophrenia and bipolar disorder

Abstract Background Psychiatric disorders are highly polygenic and show patterns of partner resemblance. Partner resemblance has direct population-level genetic implications if it is caused by assortative mating, but not if it is caused by convergence or social homogamy. Using genetics may help dis...
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Autor*in:	Oskar Hougaard Jefsen [verfasserIn] Ron Nudel [verfasserIn] Yunpeng Wang [verfasserIn] Jonas Bybjerg-Grauholm [verfasserIn] Nicoline Hemager [verfasserIn] Camilla A. J. Christiani [verfasserIn] Birgitte K. Burton [verfasserIn] Katrine S. Spang [verfasserIn] Ditte Ellersgaard [verfasserIn] Ditte L. Gantriis [verfasserIn] Kerstin Jessica Plessen [verfasserIn] Jens Richardt M. Jepsen [verfasserIn] Anne A. E. Thorup [verfasserIn] Thomas Werge [verfasserIn] Merete Nordentoft [verfasserIn] Ole Mors [verfasserIn] Aja Neergaard Greve [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2022

Schlagwörter:	Assortative mating bipolar disorder educational attainment polygenic scores schizophrenia

Übergeordnetes Werk:	In: European Psychiatry - Cambridge University Press, 2020, 65(2022)
Übergeordnetes Werk:	volume:65 ; year:2022

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc Journal toc

DOI / URN:	10.1192/j.eurpsy.2022.2304

Katalog-ID:	DOAJ088114635

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520			\|a Abstract Background Psychiatric disorders are highly polygenic and show patterns of partner resemblance. Partner resemblance has direct population-level genetic implications if it is caused by assortative mating, but not if it is caused by convergence or social homogamy. Using genetics may help distinguish these different mechanisms. Here, we investigated whether partner resemblance for schizophrenia and bipolar disorder is influenced by assortative mating using polygenic risk scores (PRSs). Methods PRSs from The Danish High-Risk and Resilience Study—VIA 7 were compared between parents in three subsamples: population-based control parent pairs (N=198), parent pairs where at least one parent had schizophrenia (N=193), and parent pairs where at least one parent had bipolar disorder (N=115). Results The PRS for schizophrenia was predictive of schizophrenia in the full sample and showed a significant correlation between parent pairs (r=0.121, p=0.0440), indicative of assortative mating. The PRS for bipolar disorder was also correlated between parent pairs (r=0.162, p=0.0067), but it was not predictive of bipolar disorder in the full sample, limiting the interpretation. Conclusions Our study provides genetic evidence for assortative mating for schizophrenia, with important implications for our understanding of the genetics of schizophrenia.
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allfields	10.1192/j.eurpsy.2022.2304 doi (DE-627)DOAJ088114635 (DE-599)DOAJ2b5fed5622f34e66b33420d897e3a3f9 DE-627 ger DE-627 rakwb eng RC435-571 Oskar Hougaard Jefsen verfasserin aut Genetic assortative mating for schizophrenia and bipolar disorder 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Background Psychiatric disorders are highly polygenic and show patterns of partner resemblance. Partner resemblance has direct population-level genetic implications if it is caused by assortative mating, but not if it is caused by convergence or social homogamy. Using genetics may help distinguish these different mechanisms. Here, we investigated whether partner resemblance for schizophrenia and bipolar disorder is influenced by assortative mating using polygenic risk scores (PRSs). Methods PRSs from The Danish High-Risk and Resilience Study—VIA 7 were compared between parents in three subsamples: population-based control parent pairs (N=198), parent pairs where at least one parent had schizophrenia (N=193), and parent pairs where at least one parent had bipolar disorder (N=115). Results The PRS for schizophrenia was predictive of schizophrenia in the full sample and showed a significant correlation between parent pairs (r=0.121, p=0.0440), indicative of assortative mating. The PRS for bipolar disorder was also correlated between parent pairs (r=0.162, p=0.0067), but it was not predictive of bipolar disorder in the full sample, limiting the interpretation. Conclusions Our study provides genetic evidence for assortative mating for schizophrenia, with important implications for our understanding of the genetics of schizophrenia. Assortative mating bipolar disorder educational attainment polygenic scores schizophrenia Psychiatry Ron Nudel verfasserin aut Yunpeng Wang verfasserin aut Jonas Bybjerg-Grauholm verfasserin aut Nicoline Hemager verfasserin aut Camilla A. J. Christiani verfasserin aut Birgitte K. Burton verfasserin aut Katrine S. Spang verfasserin aut Ditte Ellersgaard verfasserin aut Ditte L. Gantriis verfasserin aut Kerstin Jessica Plessen verfasserin aut Jens Richardt M. Jepsen verfasserin aut Anne A. E. Thorup verfasserin aut Thomas Werge verfasserin aut Merete Nordentoft verfasserin aut Ole Mors verfasserin aut Aja Neergaard Greve verfasserin aut In European Psychiatry Cambridge University Press, 2020 65(2022) (DE-627)320445070 (DE-600)2005377-0 17783585 nnns volume:65 year:2022 https://doi.org/10.1192/j.eurpsy.2022.2304 kostenfrei https://doaj.org/article/2b5fed5622f34e66b33420d897e3a3f9 kostenfrei https://www.cambridge.org/core/product/identifier/S0924933822023045/type/journal_article kostenfrei https://doaj.org/toc/0924-9338 Journal toc kostenfrei https://doaj.org/toc/1778-3585 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_217 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_374 GBV_ILN_602 GBV_ILN_636 GBV_ILN_2004 GBV_ILN_2014 GBV_ILN_2110 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 65 2022
spelling	10.1192/j.eurpsy.2022.2304 doi (DE-627)DOAJ088114635 (DE-599)DOAJ2b5fed5622f34e66b33420d897e3a3f9 DE-627 ger DE-627 rakwb eng RC435-571 Oskar Hougaard Jefsen verfasserin aut Genetic assortative mating for schizophrenia and bipolar disorder 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Background Psychiatric disorders are highly polygenic and show patterns of partner resemblance. Partner resemblance has direct population-level genetic implications if it is caused by assortative mating, but not if it is caused by convergence or social homogamy. Using genetics may help distinguish these different mechanisms. Here, we investigated whether partner resemblance for schizophrenia and bipolar disorder is influenced by assortative mating using polygenic risk scores (PRSs). Methods PRSs from The Danish High-Risk and Resilience Study—VIA 7 were compared between parents in three subsamples: population-based control parent pairs (N=198), parent pairs where at least one parent had schizophrenia (N=193), and parent pairs where at least one parent had bipolar disorder (N=115). Results The PRS for schizophrenia was predictive of schizophrenia in the full sample and showed a significant correlation between parent pairs (r=0.121, p=0.0440), indicative of assortative mating. The PRS for bipolar disorder was also correlated between parent pairs (r=0.162, p=0.0067), but it was not predictive of bipolar disorder in the full sample, limiting the interpretation. Conclusions Our study provides genetic evidence for assortative mating for schizophrenia, with important implications for our understanding of the genetics of schizophrenia. Assortative mating bipolar disorder educational attainment polygenic scores schizophrenia Psychiatry Ron Nudel verfasserin aut Yunpeng Wang verfasserin aut Jonas Bybjerg-Grauholm verfasserin aut Nicoline Hemager verfasserin aut Camilla A. J. Christiani verfasserin aut Birgitte K. Burton verfasserin aut Katrine S. Spang verfasserin aut Ditte Ellersgaard verfasserin aut Ditte L. Gantriis verfasserin aut Kerstin Jessica Plessen verfasserin aut Jens Richardt M. Jepsen verfasserin aut Anne A. E. Thorup verfasserin aut Thomas Werge verfasserin aut Merete Nordentoft verfasserin aut Ole Mors verfasserin aut Aja Neergaard Greve verfasserin aut In European Psychiatry Cambridge University Press, 2020 65(2022) (DE-627)320445070 (DE-600)2005377-0 17783585 nnns volume:65 year:2022 https://doi.org/10.1192/j.eurpsy.2022.2304 kostenfrei https://doaj.org/article/2b5fed5622f34e66b33420d897e3a3f9 kostenfrei https://www.cambridge.org/core/product/identifier/S0924933822023045/type/journal_article kostenfrei https://doaj.org/toc/0924-9338 Journal toc kostenfrei https://doaj.org/toc/1778-3585 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_217 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_374 GBV_ILN_602 GBV_ILN_636 GBV_ILN_2004 GBV_ILN_2014 GBV_ILN_2110 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 65 2022
allfields_unstemmed	10.1192/j.eurpsy.2022.2304 doi (DE-627)DOAJ088114635 (DE-599)DOAJ2b5fed5622f34e66b33420d897e3a3f9 DE-627 ger DE-627 rakwb eng RC435-571 Oskar Hougaard Jefsen verfasserin aut Genetic assortative mating for schizophrenia and bipolar disorder 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Background Psychiatric disorders are highly polygenic and show patterns of partner resemblance. Partner resemblance has direct population-level genetic implications if it is caused by assortative mating, but not if it is caused by convergence or social homogamy. Using genetics may help distinguish these different mechanisms. Here, we investigated whether partner resemblance for schizophrenia and bipolar disorder is influenced by assortative mating using polygenic risk scores (PRSs). Methods PRSs from The Danish High-Risk and Resilience Study—VIA 7 were compared between parents in three subsamples: population-based control parent pairs (N=198), parent pairs where at least one parent had schizophrenia (N=193), and parent pairs where at least one parent had bipolar disorder (N=115). Results The PRS for schizophrenia was predictive of schizophrenia in the full sample and showed a significant correlation between parent pairs (r=0.121, p=0.0440), indicative of assortative mating. The PRS for bipolar disorder was also correlated between parent pairs (r=0.162, p=0.0067), but it was not predictive of bipolar disorder in the full sample, limiting the interpretation. Conclusions Our study provides genetic evidence for assortative mating for schizophrenia, with important implications for our understanding of the genetics of schizophrenia. Assortative mating bipolar disorder educational attainment polygenic scores schizophrenia Psychiatry Ron Nudel verfasserin aut Yunpeng Wang verfasserin aut Jonas Bybjerg-Grauholm verfasserin aut Nicoline Hemager verfasserin aut Camilla A. J. Christiani verfasserin aut Birgitte K. Burton verfasserin aut Katrine S. Spang verfasserin aut Ditte Ellersgaard verfasserin aut Ditte L. Gantriis verfasserin aut Kerstin Jessica Plessen verfasserin aut Jens Richardt M. Jepsen verfasserin aut Anne A. E. Thorup verfasserin aut Thomas Werge verfasserin aut Merete Nordentoft verfasserin aut Ole Mors verfasserin aut Aja Neergaard Greve verfasserin aut In European Psychiatry Cambridge University Press, 2020 65(2022) (DE-627)320445070 (DE-600)2005377-0 17783585 nnns volume:65 year:2022 https://doi.org/10.1192/j.eurpsy.2022.2304 kostenfrei https://doaj.org/article/2b5fed5622f34e66b33420d897e3a3f9 kostenfrei https://www.cambridge.org/core/product/identifier/S0924933822023045/type/journal_article kostenfrei https://doaj.org/toc/0924-9338 Journal toc kostenfrei https://doaj.org/toc/1778-3585 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_217 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_374 GBV_ILN_602 GBV_ILN_636 GBV_ILN_2004 GBV_ILN_2014 GBV_ILN_2110 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 65 2022
allfieldsGer	10.1192/j.eurpsy.2022.2304 doi (DE-627)DOAJ088114635 (DE-599)DOAJ2b5fed5622f34e66b33420d897e3a3f9 DE-627 ger DE-627 rakwb eng RC435-571 Oskar Hougaard Jefsen verfasserin aut Genetic assortative mating for schizophrenia and bipolar disorder 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Background Psychiatric disorders are highly polygenic and show patterns of partner resemblance. Partner resemblance has direct population-level genetic implications if it is caused by assortative mating, but not if it is caused by convergence or social homogamy. Using genetics may help distinguish these different mechanisms. Here, we investigated whether partner resemblance for schizophrenia and bipolar disorder is influenced by assortative mating using polygenic risk scores (PRSs). Methods PRSs from The Danish High-Risk and Resilience Study—VIA 7 were compared between parents in three subsamples: population-based control parent pairs (N=198), parent pairs where at least one parent had schizophrenia (N=193), and parent pairs where at least one parent had bipolar disorder (N=115). Results The PRS for schizophrenia was predictive of schizophrenia in the full sample and showed a significant correlation between parent pairs (r=0.121, p=0.0440), indicative of assortative mating. The PRS for bipolar disorder was also correlated between parent pairs (r=0.162, p=0.0067), but it was not predictive of bipolar disorder in the full sample, limiting the interpretation. Conclusions Our study provides genetic evidence for assortative mating for schizophrenia, with important implications for our understanding of the genetics of schizophrenia. Assortative mating bipolar disorder educational attainment polygenic scores schizophrenia Psychiatry Ron Nudel verfasserin aut Yunpeng Wang verfasserin aut Jonas Bybjerg-Grauholm verfasserin aut Nicoline Hemager verfasserin aut Camilla A. J. Christiani verfasserin aut Birgitte K. Burton verfasserin aut Katrine S. Spang verfasserin aut Ditte Ellersgaard verfasserin aut Ditte L. Gantriis verfasserin aut Kerstin Jessica Plessen verfasserin aut Jens Richardt M. Jepsen verfasserin aut Anne A. E. Thorup verfasserin aut Thomas Werge verfasserin aut Merete Nordentoft verfasserin aut Ole Mors verfasserin aut Aja Neergaard Greve verfasserin aut In European Psychiatry Cambridge University Press, 2020 65(2022) (DE-627)320445070 (DE-600)2005377-0 17783585 nnns volume:65 year:2022 https://doi.org/10.1192/j.eurpsy.2022.2304 kostenfrei https://doaj.org/article/2b5fed5622f34e66b33420d897e3a3f9 kostenfrei https://www.cambridge.org/core/product/identifier/S0924933822023045/type/journal_article kostenfrei https://doaj.org/toc/0924-9338 Journal toc kostenfrei https://doaj.org/toc/1778-3585 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_217 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_374 GBV_ILN_602 GBV_ILN_636 GBV_ILN_2004 GBV_ILN_2014 GBV_ILN_2110 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 65 2022
allfieldsSound	10.1192/j.eurpsy.2022.2304 doi (DE-627)DOAJ088114635 (DE-599)DOAJ2b5fed5622f34e66b33420d897e3a3f9 DE-627 ger DE-627 rakwb eng RC435-571 Oskar Hougaard Jefsen verfasserin aut Genetic assortative mating for schizophrenia and bipolar disorder 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Background Psychiatric disorders are highly polygenic and show patterns of partner resemblance. Partner resemblance has direct population-level genetic implications if it is caused by assortative mating, but not if it is caused by convergence or social homogamy. Using genetics may help distinguish these different mechanisms. Here, we investigated whether partner resemblance for schizophrenia and bipolar disorder is influenced by assortative mating using polygenic risk scores (PRSs). Methods PRSs from The Danish High-Risk and Resilience Study—VIA 7 were compared between parents in three subsamples: population-based control parent pairs (N=198), parent pairs where at least one parent had schizophrenia (N=193), and parent pairs where at least one parent had bipolar disorder (N=115). Results The PRS for schizophrenia was predictive of schizophrenia in the full sample and showed a significant correlation between parent pairs (r=0.121, p=0.0440), indicative of assortative mating. The PRS for bipolar disorder was also correlated between parent pairs (r=0.162, p=0.0067), but it was not predictive of bipolar disorder in the full sample, limiting the interpretation. Conclusions Our study provides genetic evidence for assortative mating for schizophrenia, with important implications for our understanding of the genetics of schizophrenia. Assortative mating bipolar disorder educational attainment polygenic scores schizophrenia Psychiatry Ron Nudel verfasserin aut Yunpeng Wang verfasserin aut Jonas Bybjerg-Grauholm verfasserin aut Nicoline Hemager verfasserin aut Camilla A. J. Christiani verfasserin aut Birgitte K. Burton verfasserin aut Katrine S. Spang verfasserin aut Ditte Ellersgaard verfasserin aut Ditte L. Gantriis verfasserin aut Kerstin Jessica Plessen verfasserin aut Jens Richardt M. Jepsen verfasserin aut Anne A. E. Thorup verfasserin aut Thomas Werge verfasserin aut Merete Nordentoft verfasserin aut Ole Mors verfasserin aut Aja Neergaard Greve verfasserin aut In European Psychiatry Cambridge University Press, 2020 65(2022) (DE-627)320445070 (DE-600)2005377-0 17783585 nnns volume:65 year:2022 https://doi.org/10.1192/j.eurpsy.2022.2304 kostenfrei https://doaj.org/article/2b5fed5622f34e66b33420d897e3a3f9 kostenfrei https://www.cambridge.org/core/product/identifier/S0924933822023045/type/journal_article kostenfrei https://doaj.org/toc/0924-9338 Journal toc kostenfrei https://doaj.org/toc/1778-3585 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_217 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_374 GBV_ILN_602 GBV_ILN_636 GBV_ILN_2004 GBV_ILN_2014 GBV_ILN_2110 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 65 2022
language	English
source	In European Psychiatry 65(2022) volume:65 year:2022
sourceStr	In European Psychiatry 65(2022) volume:65 year:2022
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	Assortative mating bipolar disorder educational attainment polygenic scores schizophrenia Psychiatry
isfreeaccess_bool	true
container_title	European Psychiatry
authorswithroles_txt_mv	Oskar Hougaard Jefsen @@aut@@ Ron Nudel @@aut@@ Yunpeng Wang @@aut@@ Jonas Bybjerg-Grauholm @@aut@@ Nicoline Hemager @@aut@@ Camilla A. J. Christiani @@aut@@ Birgitte K. Burton @@aut@@ Katrine S. Spang @@aut@@ Ditte Ellersgaard @@aut@@ Ditte L. Gantriis @@aut@@ Kerstin Jessica Plessen @@aut@@ Jens Richardt M. Jepsen @@aut@@ Anne A. E. Thorup @@aut@@ Thomas Werge @@aut@@ Merete Nordentoft @@aut@@ Ole Mors @@aut@@ Aja Neergaard Greve @@aut@@
publishDateDaySort_date	2022-01-01T00:00:00Z
hierarchy_top_id	320445070
id	DOAJ088114635
language_de	englisch
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callnumber-first	R - Medicine
author	Oskar Hougaard Jefsen
spellingShingle	Oskar Hougaard Jefsen misc RC435-571 misc Assortative mating misc bipolar disorder misc educational attainment misc polygenic scores misc schizophrenia misc Psychiatry Genetic assortative mating for schizophrenia and bipolar disorder
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topic_title	RC435-571 Genetic assortative mating for schizophrenia and bipolar disorder Assortative mating bipolar disorder educational attainment polygenic scores schizophrenia
topic	misc RC435-571 misc Assortative mating misc bipolar disorder misc educational attainment misc polygenic scores misc schizophrenia misc Psychiatry
topic_unstemmed	misc RC435-571 misc Assortative mating misc bipolar disorder misc educational attainment misc polygenic scores misc schizophrenia misc Psychiatry
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title	Genetic assortative mating for schizophrenia and bipolar disorder
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title_full	Genetic assortative mating for schizophrenia and bipolar disorder
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author_browse	Oskar Hougaard Jefsen Ron Nudel Yunpeng Wang Jonas Bybjerg-Grauholm Nicoline Hemager Camilla A. J. Christiani Birgitte K. Burton Katrine S. Spang Ditte Ellersgaard Ditte L. Gantriis Kerstin Jessica Plessen Jens Richardt M. Jepsen Anne A. E. Thorup Thomas Werge Merete Nordentoft Ole Mors Aja Neergaard Greve
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author-letter	Oskar Hougaard Jefsen
doi_str_mv	10.1192/j.eurpsy.2022.2304
author2-role	verfasserin
title_sort	genetic assortative mating for schizophrenia and bipolar disorder
callnumber	RC435-571
title_auth	Genetic assortative mating for schizophrenia and bipolar disorder
abstract	Abstract Background Psychiatric disorders are highly polygenic and show patterns of partner resemblance. Partner resemblance has direct population-level genetic implications if it is caused by assortative mating, but not if it is caused by convergence or social homogamy. Using genetics may help distinguish these different mechanisms. Here, we investigated whether partner resemblance for schizophrenia and bipolar disorder is influenced by assortative mating using polygenic risk scores (PRSs). Methods PRSs from The Danish High-Risk and Resilience Study—VIA 7 were compared between parents in three subsamples: population-based control parent pairs (N=198), parent pairs where at least one parent had schizophrenia (N=193), and parent pairs where at least one parent had bipolar disorder (N=115). Results The PRS for schizophrenia was predictive of schizophrenia in the full sample and showed a significant correlation between parent pairs (r=0.121, p=0.0440), indicative of assortative mating. The PRS for bipolar disorder was also correlated between parent pairs (r=0.162, p=0.0067), but it was not predictive of bipolar disorder in the full sample, limiting the interpretation. Conclusions Our study provides genetic evidence for assortative mating for schizophrenia, with important implications for our understanding of the genetics of schizophrenia.
abstractGer	Abstract Background Psychiatric disorders are highly polygenic and show patterns of partner resemblance. Partner resemblance has direct population-level genetic implications if it is caused by assortative mating, but not if it is caused by convergence or social homogamy. Using genetics may help distinguish these different mechanisms. Here, we investigated whether partner resemblance for schizophrenia and bipolar disorder is influenced by assortative mating using polygenic risk scores (PRSs). Methods PRSs from The Danish High-Risk and Resilience Study—VIA 7 were compared between parents in three subsamples: population-based control parent pairs (N=198), parent pairs where at least one parent had schizophrenia (N=193), and parent pairs where at least one parent had bipolar disorder (N=115). Results The PRS for schizophrenia was predictive of schizophrenia in the full sample and showed a significant correlation between parent pairs (r=0.121, p=0.0440), indicative of assortative mating. The PRS for bipolar disorder was also correlated between parent pairs (r=0.162, p=0.0067), but it was not predictive of bipolar disorder in the full sample, limiting the interpretation. Conclusions Our study provides genetic evidence for assortative mating for schizophrenia, with important implications for our understanding of the genetics of schizophrenia.
abstract_unstemmed	Abstract Background Psychiatric disorders are highly polygenic and show patterns of partner resemblance. Partner resemblance has direct population-level genetic implications if it is caused by assortative mating, but not if it is caused by convergence or social homogamy. Using genetics may help distinguish these different mechanisms. Here, we investigated whether partner resemblance for schizophrenia and bipolar disorder is influenced by assortative mating using polygenic risk scores (PRSs). Methods PRSs from The Danish High-Risk and Resilience Study—VIA 7 were compared between parents in three subsamples: population-based control parent pairs (N=198), parent pairs where at least one parent had schizophrenia (N=193), and parent pairs where at least one parent had bipolar disorder (N=115). Results The PRS for schizophrenia was predictive of schizophrenia in the full sample and showed a significant correlation between parent pairs (r=0.121, p=0.0440), indicative of assortative mating. The PRS for bipolar disorder was also correlated between parent pairs (r=0.162, p=0.0067), but it was not predictive of bipolar disorder in the full sample, limiting the interpretation. Conclusions Our study provides genetic evidence for assortative mating for schizophrenia, with important implications for our understanding of the genetics of schizophrenia.
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title_short	Genetic assortative mating for schizophrenia and bipolar disorder
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author2	Ron Nudel Yunpeng Wang Jonas Bybjerg-Grauholm Nicoline Hemager Camilla A. J. Christiani Birgitte K. Burton Katrine S. Spang Ditte Ellersgaard Ditte L. Gantriis Kerstin Jessica Plessen Jens Richardt M. Jepsen Anne A. E. Thorup Thomas Werge Merete Nordentoft Ole Mors Aja Neergaard Greve
author2Str	Ron Nudel Yunpeng Wang Jonas Bybjerg-Grauholm Nicoline Hemager Camilla A. J. Christiani Birgitte K. Burton Katrine S. Spang Ditte Ellersgaard Ditte L. Gantriis Kerstin Jessica Plessen Jens Richardt M. Jepsen Anne A. E. Thorup Thomas Werge Merete Nordentoft Ole Mors Aja Neergaard Greve
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Genetic assortative mating for schizophrenia and bipolar disorder

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