Prioritizing studies of COVID-19 and lessons learned

Abstract Introduction: COVID-19 altered research in Clinical and Translational Science Award (CTSA) hubs in an unprecedented manner, leading to adjustments for COVID-19 research. Methods: CTSA members volunteered to conduct a review on the impact of CTSA network on COVID-19 pandemic with the assi...
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Autor*in:	Dushyantha Jayaweera [verfasserIn] Patrick A. Flume [verfasserIn] Nora G. Singer [verfasserIn] Myron S. Cohen [verfasserIn] Anne M. Lachiewicz [verfasserIn] Amanda Cameron [verfasserIn] Naresh Kumar [verfasserIn] Joel Thompson [verfasserIn] Alyssa Cabrera [verfasserIn] Denise Daudelin [verfasserIn] Reza Shaker [verfasserIn] Philippe R Bauer [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2021

Schlagwörter:	Clinical translational research COVID-19 lessons learned CTSA leadership

Übergeordnetes Werk:	In: Journal of Clinical and Translational Science - Cambridge University Press, 2019, 5(2021)
Übergeordnetes Werk:	volume:5 ; year:2021

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.1017/cts.2021.784

Katalog-ID:	DOAJ088125734

Internformat


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allfields	10.1017/cts.2021.784 doi (DE-627)DOAJ088125734 (DE-599)DOAJb9c73b40e1384a26ba720f1a8cce1011 DE-627 ger DE-627 rakwb eng Dushyantha Jayaweera verfasserin aut Prioritizing studies of COVID-19 and lessons learned 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Introduction: COVID-19 altered research in Clinical and Translational Science Award (CTSA) hubs in an unprecedented manner, leading to adjustments for COVID-19 research. Methods: CTSA members volunteered to conduct a review on the impact of CTSA network on COVID-19 pandemic with the assistance from NIH survey team in October 2020. The survey questions included the involvement of CTSAs in decision-making concerning the prioritization of COVID-19 studies. Descriptive and statistical analyses were conducted to analyze the survey data. Results: 60 of the 64 CTSAs completed the survey. Most CTSAs lacked preparedness but promptly responded to the pandemic. Early disruption of research triggered, enhanced CTSA engagement, creation of dedicated research areas and triage for prioritization of COVID-19 studies. CTSAs involvement in decision-making were 16.75 times more likely to create dedicated diagnostic laboratories (95% confidence interval [CI] = 2.17–129.39; P < 0.01). Likewise, institutions with internal funding were 3.88 times more likely to establish COVID-19 dedicated research (95% CI = 1.12–13.40; P < 0.05). CTSAs were instrumental in securing funds and facilitating establishment of laboratory/clinical spaces for COVID-19 research. Workflow was modified to support contracting and IRB review at most institutions with CTSAs. To mitigate chaos generated by competing clinical trials, central feasibility committees were often formed for orderly review/prioritization. Conclusions: The lessons learned from the COVID-19 pandemic emphasize the pivotal role of CTSAs in prioritizing studies and establishing the necessary research infrastructure, and the importance of prompt and flexible research leadership with decision-making capacity to manage future pandemics. Clinical translational research COVID-19 lessons learned CTSA leadership Medicine R Patrick A. Flume verfasserin aut Nora G. Singer verfasserin aut Myron S. Cohen verfasserin aut Anne M. Lachiewicz verfasserin aut Amanda Cameron verfasserin aut Naresh Kumar verfasserin aut Joel Thompson verfasserin aut Alyssa Cabrera verfasserin aut Denise Daudelin verfasserin aut Reza Shaker verfasserin aut Philippe R Bauer verfasserin aut In Journal of Clinical and Translational Science Cambridge University Press, 2019 5(2021) (DE-627)891016082 (DE-600)2898186-8 20598661 nnns volume:5 year:2021 https://doi.org/10.1017/cts.2021.784 kostenfrei https://doaj.org/article/b9c73b40e1384a26ba720f1a8cce1011 kostenfrei https://www.cambridge.org/core/product/identifier/S2059866121007846/type/journal_article kostenfrei https://doaj.org/toc/2059-8661 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_374 GBV_ILN_602 GBV_ILN_636 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2110 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2924 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 5 2021
spelling	10.1017/cts.2021.784 doi (DE-627)DOAJ088125734 (DE-599)DOAJb9c73b40e1384a26ba720f1a8cce1011 DE-627 ger DE-627 rakwb eng Dushyantha Jayaweera verfasserin aut Prioritizing studies of COVID-19 and lessons learned 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Introduction: COVID-19 altered research in Clinical and Translational Science Award (CTSA) hubs in an unprecedented manner, leading to adjustments for COVID-19 research. Methods: CTSA members volunteered to conduct a review on the impact of CTSA network on COVID-19 pandemic with the assistance from NIH survey team in October 2020. The survey questions included the involvement of CTSAs in decision-making concerning the prioritization of COVID-19 studies. Descriptive and statistical analyses were conducted to analyze the survey data. Results: 60 of the 64 CTSAs completed the survey. Most CTSAs lacked preparedness but promptly responded to the pandemic. Early disruption of research triggered, enhanced CTSA engagement, creation of dedicated research areas and triage for prioritization of COVID-19 studies. CTSAs involvement in decision-making were 16.75 times more likely to create dedicated diagnostic laboratories (95% confidence interval [CI] = 2.17–129.39; P < 0.01). Likewise, institutions with internal funding were 3.88 times more likely to establish COVID-19 dedicated research (95% CI = 1.12–13.40; P < 0.05). CTSAs were instrumental in securing funds and facilitating establishment of laboratory/clinical spaces for COVID-19 research. Workflow was modified to support contracting and IRB review at most institutions with CTSAs. To mitigate chaos generated by competing clinical trials, central feasibility committees were often formed for orderly review/prioritization. Conclusions: The lessons learned from the COVID-19 pandemic emphasize the pivotal role of CTSAs in prioritizing studies and establishing the necessary research infrastructure, and the importance of prompt and flexible research leadership with decision-making capacity to manage future pandemics. Clinical translational research COVID-19 lessons learned CTSA leadership Medicine R Patrick A. Flume verfasserin aut Nora G. Singer verfasserin aut Myron S. Cohen verfasserin aut Anne M. Lachiewicz verfasserin aut Amanda Cameron verfasserin aut Naresh Kumar verfasserin aut Joel Thompson verfasserin aut Alyssa Cabrera verfasserin aut Denise Daudelin verfasserin aut Reza Shaker verfasserin aut Philippe R Bauer verfasserin aut In Journal of Clinical and Translational Science Cambridge University Press, 2019 5(2021) (DE-627)891016082 (DE-600)2898186-8 20598661 nnns volume:5 year:2021 https://doi.org/10.1017/cts.2021.784 kostenfrei https://doaj.org/article/b9c73b40e1384a26ba720f1a8cce1011 kostenfrei https://www.cambridge.org/core/product/identifier/S2059866121007846/type/journal_article kostenfrei https://doaj.org/toc/2059-8661 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_374 GBV_ILN_602 GBV_ILN_636 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2110 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2924 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 5 2021
allfields_unstemmed	10.1017/cts.2021.784 doi (DE-627)DOAJ088125734 (DE-599)DOAJb9c73b40e1384a26ba720f1a8cce1011 DE-627 ger DE-627 rakwb eng Dushyantha Jayaweera verfasserin aut Prioritizing studies of COVID-19 and lessons learned 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Introduction: COVID-19 altered research in Clinical and Translational Science Award (CTSA) hubs in an unprecedented manner, leading to adjustments for COVID-19 research. Methods: CTSA members volunteered to conduct a review on the impact of CTSA network on COVID-19 pandemic with the assistance from NIH survey team in October 2020. The survey questions included the involvement of CTSAs in decision-making concerning the prioritization of COVID-19 studies. Descriptive and statistical analyses were conducted to analyze the survey data. Results: 60 of the 64 CTSAs completed the survey. Most CTSAs lacked preparedness but promptly responded to the pandemic. Early disruption of research triggered, enhanced CTSA engagement, creation of dedicated research areas and triage for prioritization of COVID-19 studies. CTSAs involvement in decision-making were 16.75 times more likely to create dedicated diagnostic laboratories (95% confidence interval [CI] = 2.17–129.39; P < 0.01). Likewise, institutions with internal funding were 3.88 times more likely to establish COVID-19 dedicated research (95% CI = 1.12–13.40; P < 0.05). CTSAs were instrumental in securing funds and facilitating establishment of laboratory/clinical spaces for COVID-19 research. Workflow was modified to support contracting and IRB review at most institutions with CTSAs. To mitigate chaos generated by competing clinical trials, central feasibility committees were often formed for orderly review/prioritization. Conclusions: The lessons learned from the COVID-19 pandemic emphasize the pivotal role of CTSAs in prioritizing studies and establishing the necessary research infrastructure, and the importance of prompt and flexible research leadership with decision-making capacity to manage future pandemics. Clinical translational research COVID-19 lessons learned CTSA leadership Medicine R Patrick A. Flume verfasserin aut Nora G. Singer verfasserin aut Myron S. Cohen verfasserin aut Anne M. Lachiewicz verfasserin aut Amanda Cameron verfasserin aut Naresh Kumar verfasserin aut Joel Thompson verfasserin aut Alyssa Cabrera verfasserin aut Denise Daudelin verfasserin aut Reza Shaker verfasserin aut Philippe R Bauer verfasserin aut In Journal of Clinical and Translational Science Cambridge University Press, 2019 5(2021) (DE-627)891016082 (DE-600)2898186-8 20598661 nnns volume:5 year:2021 https://doi.org/10.1017/cts.2021.784 kostenfrei https://doaj.org/article/b9c73b40e1384a26ba720f1a8cce1011 kostenfrei https://www.cambridge.org/core/product/identifier/S2059866121007846/type/journal_article kostenfrei https://doaj.org/toc/2059-8661 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_374 GBV_ILN_602 GBV_ILN_636 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2110 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2924 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 5 2021
allfieldsGer	10.1017/cts.2021.784 doi (DE-627)DOAJ088125734 (DE-599)DOAJb9c73b40e1384a26ba720f1a8cce1011 DE-627 ger DE-627 rakwb eng Dushyantha Jayaweera verfasserin aut Prioritizing studies of COVID-19 and lessons learned 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Introduction: COVID-19 altered research in Clinical and Translational Science Award (CTSA) hubs in an unprecedented manner, leading to adjustments for COVID-19 research. Methods: CTSA members volunteered to conduct a review on the impact of CTSA network on COVID-19 pandemic with the assistance from NIH survey team in October 2020. The survey questions included the involvement of CTSAs in decision-making concerning the prioritization of COVID-19 studies. Descriptive and statistical analyses were conducted to analyze the survey data. Results: 60 of the 64 CTSAs completed the survey. Most CTSAs lacked preparedness but promptly responded to the pandemic. Early disruption of research triggered, enhanced CTSA engagement, creation of dedicated research areas and triage for prioritization of COVID-19 studies. CTSAs involvement in decision-making were 16.75 times more likely to create dedicated diagnostic laboratories (95% confidence interval [CI] = 2.17–129.39; P < 0.01). Likewise, institutions with internal funding were 3.88 times more likely to establish COVID-19 dedicated research (95% CI = 1.12–13.40; P < 0.05). CTSAs were instrumental in securing funds and facilitating establishment of laboratory/clinical spaces for COVID-19 research. Workflow was modified to support contracting and IRB review at most institutions with CTSAs. To mitigate chaos generated by competing clinical trials, central feasibility committees were often formed for orderly review/prioritization. Conclusions: The lessons learned from the COVID-19 pandemic emphasize the pivotal role of CTSAs in prioritizing studies and establishing the necessary research infrastructure, and the importance of prompt and flexible research leadership with decision-making capacity to manage future pandemics. Clinical translational research COVID-19 lessons learned CTSA leadership Medicine R Patrick A. Flume verfasserin aut Nora G. Singer verfasserin aut Myron S. Cohen verfasserin aut Anne M. Lachiewicz verfasserin aut Amanda Cameron verfasserin aut Naresh Kumar verfasserin aut Joel Thompson verfasserin aut Alyssa Cabrera verfasserin aut Denise Daudelin verfasserin aut Reza Shaker verfasserin aut Philippe R Bauer verfasserin aut In Journal of Clinical and Translational Science Cambridge University Press, 2019 5(2021) (DE-627)891016082 (DE-600)2898186-8 20598661 nnns volume:5 year:2021 https://doi.org/10.1017/cts.2021.784 kostenfrei https://doaj.org/article/b9c73b40e1384a26ba720f1a8cce1011 kostenfrei https://www.cambridge.org/core/product/identifier/S2059866121007846/type/journal_article kostenfrei https://doaj.org/toc/2059-8661 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_374 GBV_ILN_602 GBV_ILN_636 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2110 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2924 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 5 2021
allfieldsSound	10.1017/cts.2021.784 doi (DE-627)DOAJ088125734 (DE-599)DOAJb9c73b40e1384a26ba720f1a8cce1011 DE-627 ger DE-627 rakwb eng Dushyantha Jayaweera verfasserin aut Prioritizing studies of COVID-19 and lessons learned 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Introduction: COVID-19 altered research in Clinical and Translational Science Award (CTSA) hubs in an unprecedented manner, leading to adjustments for COVID-19 research. Methods: CTSA members volunteered to conduct a review on the impact of CTSA network on COVID-19 pandemic with the assistance from NIH survey team in October 2020. The survey questions included the involvement of CTSAs in decision-making concerning the prioritization of COVID-19 studies. Descriptive and statistical analyses were conducted to analyze the survey data. Results: 60 of the 64 CTSAs completed the survey. Most CTSAs lacked preparedness but promptly responded to the pandemic. Early disruption of research triggered, enhanced CTSA engagement, creation of dedicated research areas and triage for prioritization of COVID-19 studies. CTSAs involvement in decision-making were 16.75 times more likely to create dedicated diagnostic laboratories (95% confidence interval [CI] = 2.17–129.39; P < 0.01). Likewise, institutions with internal funding were 3.88 times more likely to establish COVID-19 dedicated research (95% CI = 1.12–13.40; P < 0.05). CTSAs were instrumental in securing funds and facilitating establishment of laboratory/clinical spaces for COVID-19 research. Workflow was modified to support contracting and IRB review at most institutions with CTSAs. To mitigate chaos generated by competing clinical trials, central feasibility committees were often formed for orderly review/prioritization. Conclusions: The lessons learned from the COVID-19 pandemic emphasize the pivotal role of CTSAs in prioritizing studies and establishing the necessary research infrastructure, and the importance of prompt and flexible research leadership with decision-making capacity to manage future pandemics. Clinical translational research COVID-19 lessons learned CTSA leadership Medicine R Patrick A. Flume verfasserin aut Nora G. Singer verfasserin aut Myron S. Cohen verfasserin aut Anne M. Lachiewicz verfasserin aut Amanda Cameron verfasserin aut Naresh Kumar verfasserin aut Joel Thompson verfasserin aut Alyssa Cabrera verfasserin aut Denise Daudelin verfasserin aut Reza Shaker verfasserin aut Philippe R Bauer verfasserin aut In Journal of Clinical and Translational Science Cambridge University Press, 2019 5(2021) (DE-627)891016082 (DE-600)2898186-8 20598661 nnns volume:5 year:2021 https://doi.org/10.1017/cts.2021.784 kostenfrei https://doaj.org/article/b9c73b40e1384a26ba720f1a8cce1011 kostenfrei https://www.cambridge.org/core/product/identifier/S2059866121007846/type/journal_article kostenfrei https://doaj.org/toc/2059-8661 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_374 GBV_ILN_602 GBV_ILN_636 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2110 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2924 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 5 2021
language	English
source	In Journal of Clinical and Translational Science 5(2021) volume:5 year:2021
sourceStr	In Journal of Clinical and Translational Science 5(2021) volume:5 year:2021
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institution	findex.gbv.de
topic_facet	Clinical translational research COVID-19 lessons learned CTSA leadership Medicine R
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container_title	Journal of Clinical and Translational Science
authorswithroles_txt_mv	Dushyantha Jayaweera @@aut@@ Patrick A. Flume @@aut@@ Nora G. Singer @@aut@@ Myron S. Cohen @@aut@@ Anne M. Lachiewicz @@aut@@ Amanda Cameron @@aut@@ Naresh Kumar @@aut@@ Joel Thompson @@aut@@ Alyssa Cabrera @@aut@@ Denise Daudelin @@aut@@ Reza Shaker @@aut@@ Philippe R Bauer @@aut@@
publishDateDaySort_date	2021-01-01T00:00:00Z
hierarchy_top_id	891016082
id	DOAJ088125734
language_de	englisch
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author	Dushyantha Jayaweera
spellingShingle	Dushyantha Jayaweera misc Clinical translational research misc COVID-19 misc lessons learned misc CTSA misc leadership misc Medicine misc R Prioritizing studies of COVID-19 and lessons learned
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topic_title	Prioritizing studies of COVID-19 and lessons learned Clinical translational research COVID-19 lessons learned CTSA leadership
topic	misc Clinical translational research misc COVID-19 misc lessons learned misc CTSA misc leadership misc Medicine misc R
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title	Prioritizing studies of COVID-19 and lessons learned
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title_full	Prioritizing studies of COVID-19 and lessons learned
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author_browse	Dushyantha Jayaweera Patrick A. Flume Nora G. Singer Myron S. Cohen Anne M. Lachiewicz Amanda Cameron Naresh Kumar Joel Thompson Alyssa Cabrera Denise Daudelin Reza Shaker Philippe R Bauer
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title_sort	prioritizing studies of covid-19 and lessons learned
title_auth	Prioritizing studies of COVID-19 and lessons learned
abstract	Abstract Introduction: COVID-19 altered research in Clinical and Translational Science Award (CTSA) hubs in an unprecedented manner, leading to adjustments for COVID-19 research. Methods: CTSA members volunteered to conduct a review on the impact of CTSA network on COVID-19 pandemic with the assistance from NIH survey team in October 2020. The survey questions included the involvement of CTSAs in decision-making concerning the prioritization of COVID-19 studies. Descriptive and statistical analyses were conducted to analyze the survey data. Results: 60 of the 64 CTSAs completed the survey. Most CTSAs lacked preparedness but promptly responded to the pandemic. Early disruption of research triggered, enhanced CTSA engagement, creation of dedicated research areas and triage for prioritization of COVID-19 studies. CTSAs involvement in decision-making were 16.75 times more likely to create dedicated diagnostic laboratories (95% confidence interval [CI] = 2.17–129.39; P < 0.01). Likewise, institutions with internal funding were 3.88 times more likely to establish COVID-19 dedicated research (95% CI = 1.12–13.40; P < 0.05). CTSAs were instrumental in securing funds and facilitating establishment of laboratory/clinical spaces for COVID-19 research. Workflow was modified to support contracting and IRB review at most institutions with CTSAs. To mitigate chaos generated by competing clinical trials, central feasibility committees were often formed for orderly review/prioritization. Conclusions: The lessons learned from the COVID-19 pandemic emphasize the pivotal role of CTSAs in prioritizing studies and establishing the necessary research infrastructure, and the importance of prompt and flexible research leadership with decision-making capacity to manage future pandemics.
abstractGer	Abstract Introduction: COVID-19 altered research in Clinical and Translational Science Award (CTSA) hubs in an unprecedented manner, leading to adjustments for COVID-19 research. Methods: CTSA members volunteered to conduct a review on the impact of CTSA network on COVID-19 pandemic with the assistance from NIH survey team in October 2020. The survey questions included the involvement of CTSAs in decision-making concerning the prioritization of COVID-19 studies. Descriptive and statistical analyses were conducted to analyze the survey data. Results: 60 of the 64 CTSAs completed the survey. Most CTSAs lacked preparedness but promptly responded to the pandemic. Early disruption of research triggered, enhanced CTSA engagement, creation of dedicated research areas and triage for prioritization of COVID-19 studies. CTSAs involvement in decision-making were 16.75 times more likely to create dedicated diagnostic laboratories (95% confidence interval [CI] = 2.17–129.39; P < 0.01). Likewise, institutions with internal funding were 3.88 times more likely to establish COVID-19 dedicated research (95% CI = 1.12–13.40; P < 0.05). CTSAs were instrumental in securing funds and facilitating establishment of laboratory/clinical spaces for COVID-19 research. Workflow was modified to support contracting and IRB review at most institutions with CTSAs. To mitigate chaos generated by competing clinical trials, central feasibility committees were often formed for orderly review/prioritization. Conclusions: The lessons learned from the COVID-19 pandemic emphasize the pivotal role of CTSAs in prioritizing studies and establishing the necessary research infrastructure, and the importance of prompt and flexible research leadership with decision-making capacity to manage future pandemics.
abstract_unstemmed	Abstract Introduction: COVID-19 altered research in Clinical and Translational Science Award (CTSA) hubs in an unprecedented manner, leading to adjustments for COVID-19 research. Methods: CTSA members volunteered to conduct a review on the impact of CTSA network on COVID-19 pandemic with the assistance from NIH survey team in October 2020. The survey questions included the involvement of CTSAs in decision-making concerning the prioritization of COVID-19 studies. Descriptive and statistical analyses were conducted to analyze the survey data. Results: 60 of the 64 CTSAs completed the survey. Most CTSAs lacked preparedness but promptly responded to the pandemic. Early disruption of research triggered, enhanced CTSA engagement, creation of dedicated research areas and triage for prioritization of COVID-19 studies. CTSAs involvement in decision-making were 16.75 times more likely to create dedicated diagnostic laboratories (95% confidence interval [CI] = 2.17–129.39; P < 0.01). Likewise, institutions with internal funding were 3.88 times more likely to establish COVID-19 dedicated research (95% CI = 1.12–13.40; P < 0.05). CTSAs were instrumental in securing funds and facilitating establishment of laboratory/clinical spaces for COVID-19 research. Workflow was modified to support contracting and IRB review at most institutions with CTSAs. To mitigate chaos generated by competing clinical trials, central feasibility committees were often formed for orderly review/prioritization. Conclusions: The lessons learned from the COVID-19 pandemic emphasize the pivotal role of CTSAs in prioritizing studies and establishing the necessary research infrastructure, and the importance of prompt and flexible research leadership with decision-making capacity to manage future pandemics.
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title_short	Prioritizing studies of COVID-19 and lessons learned
url	https://doi.org/10.1017/cts.2021.784 https://doaj.org/article/b9c73b40e1384a26ba720f1a8cce1011 https://www.cambridge.org/core/product/identifier/S2059866121007846/type/journal_article https://doaj.org/toc/2059-8661
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author2	Patrick A. Flume Nora G. Singer Myron S. Cohen Anne M. Lachiewicz Amanda Cameron Naresh Kumar Joel Thompson Alyssa Cabrera Denise Daudelin Reza Shaker Philippe R Bauer
author2Str	Patrick A. Flume Nora G. Singer Myron S. Cohen Anne M. Lachiewicz Amanda Cameron Naresh Kumar Joel Thompson Alyssa Cabrera Denise Daudelin Reza Shaker Philippe R Bauer
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up_date	2024-07-03T15:57:33.171Z
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