Successful naltrexone-bupropion treatment after several treatment failures in a patient with severe monogenic obesity

Summary: We describe the therapeutic journey of a 33-year-old patient with early-onset obesity (BMI 56.7 kg/m2) and hyperphagia due to a likely pathogenic heterozygous melanocortin-4 receptor (MC4R) gene variant.She was unsuccessfully treated with several intensive lifestyle interventions, gastric b...
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Autor*in:	Mila S. Welling [verfasserIn] Mostafa Mohseni [verfasserIn] Eline S. van der Valk [verfasserIn] Johanna M. van Hagen [verfasserIn] Jan Steven Burgerhart [verfasserIn] Mieke M. van Haelst [verfasserIn] Elisabeth F.C. van Rossum [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2023

Schlagwörter:	Biological sciences Physiology Human Physiology Human metabolism

Übergeordnetes Werk:	In: iScience - Elsevier, 2019, 26(2023), 3, Seite 106199-
Übergeordnetes Werk:	volume:26 ; year:2023 ; number:3 ; pages:106199-

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.1016/j.isci.2023.106199

Katalog-ID:	DOAJ088362035

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allfields	10.1016/j.isci.2023.106199 doi (DE-627)DOAJ088362035 (DE-599)DOAJ6e57a4259cfa41699a86bab0b6874739 DE-627 ger DE-627 rakwb eng Mila S. Welling verfasserin aut Successful naltrexone-bupropion treatment after several treatment failures in a patient with severe monogenic obesity 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Summary: We describe the therapeutic journey of a 33-year-old patient with early-onset obesity (BMI 56.7 kg/m2) and hyperphagia due to a likely pathogenic heterozygous melanocortin-4 receptor (MC4R) gene variant.She was unsuccessfully treated with several intensive lifestyle interventions, gastric bypass surgery (−40 kg weight loss, followed by +39.8 kg weight regain), liraglutide 3 mg (−3.8% weight loss with sustained hyperphagia), and metformin treatment. However, naltrexone-bupropion treatment led to −48.9 kg (−26.7%) weight loss, of which −39.9 kg (−38.3%) was fat mass, in 17 months of treatment. Importantly, she reported improved hyperphagia and quality of life.We describe the potential beneficial effects of naltrexone-bupropion on weight, hyperphagia, and quality of life in a patient with genetic obesity. This extensive journey shows that various anti-obesity agents can be initiated, subsequently terminated when ineffective and substituted with other anti-obesity agents to identify the most efficient anti-obesity treatment. Biological sciences Physiology Human Physiology Human metabolism Science Q Mostafa Mohseni verfasserin aut Eline S. van der Valk verfasserin aut Johanna M. van Hagen verfasserin aut Jan Steven Burgerhart verfasserin aut Mieke M. van Haelst verfasserin aut Elisabeth F.C. van Rossum verfasserin aut In iScience Elsevier, 2019 26(2023), 3, Seite 106199- (DE-627)1019532106 25890042 nnns volume:26 year:2023 number:3 pages:106199- https://doi.org/10.1016/j.isci.2023.106199 kostenfrei https://doaj.org/article/6e57a4259cfa41699a86bab0b6874739 kostenfrei http://www.sciencedirect.com/science/article/pii/S2589004223002766 kostenfrei https://doaj.org/toc/2589-0042 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_171 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 26 2023 3 106199-
spelling	10.1016/j.isci.2023.106199 doi (DE-627)DOAJ088362035 (DE-599)DOAJ6e57a4259cfa41699a86bab0b6874739 DE-627 ger DE-627 rakwb eng Mila S. Welling verfasserin aut Successful naltrexone-bupropion treatment after several treatment failures in a patient with severe monogenic obesity 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Summary: We describe the therapeutic journey of a 33-year-old patient with early-onset obesity (BMI 56.7 kg/m2) and hyperphagia due to a likely pathogenic heterozygous melanocortin-4 receptor (MC4R) gene variant.She was unsuccessfully treated with several intensive lifestyle interventions, gastric bypass surgery (−40 kg weight loss, followed by +39.8 kg weight regain), liraglutide 3 mg (−3.8% weight loss with sustained hyperphagia), and metformin treatment. However, naltrexone-bupropion treatment led to −48.9 kg (−26.7%) weight loss, of which −39.9 kg (−38.3%) was fat mass, in 17 months of treatment. Importantly, she reported improved hyperphagia and quality of life.We describe the potential beneficial effects of naltrexone-bupropion on weight, hyperphagia, and quality of life in a patient with genetic obesity. This extensive journey shows that various anti-obesity agents can be initiated, subsequently terminated when ineffective and substituted with other anti-obesity agents to identify the most efficient anti-obesity treatment. Biological sciences Physiology Human Physiology Human metabolism Science Q Mostafa Mohseni verfasserin aut Eline S. van der Valk verfasserin aut Johanna M. van Hagen verfasserin aut Jan Steven Burgerhart verfasserin aut Mieke M. van Haelst verfasserin aut Elisabeth F.C. van Rossum verfasserin aut In iScience Elsevier, 2019 26(2023), 3, Seite 106199- (DE-627)1019532106 25890042 nnns volume:26 year:2023 number:3 pages:106199- https://doi.org/10.1016/j.isci.2023.106199 kostenfrei https://doaj.org/article/6e57a4259cfa41699a86bab0b6874739 kostenfrei http://www.sciencedirect.com/science/article/pii/S2589004223002766 kostenfrei https://doaj.org/toc/2589-0042 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_171 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 26 2023 3 106199-
allfields_unstemmed	10.1016/j.isci.2023.106199 doi (DE-627)DOAJ088362035 (DE-599)DOAJ6e57a4259cfa41699a86bab0b6874739 DE-627 ger DE-627 rakwb eng Mila S. Welling verfasserin aut Successful naltrexone-bupropion treatment after several treatment failures in a patient with severe monogenic obesity 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Summary: We describe the therapeutic journey of a 33-year-old patient with early-onset obesity (BMI 56.7 kg/m2) and hyperphagia due to a likely pathogenic heterozygous melanocortin-4 receptor (MC4R) gene variant.She was unsuccessfully treated with several intensive lifestyle interventions, gastric bypass surgery (−40 kg weight loss, followed by +39.8 kg weight regain), liraglutide 3 mg (−3.8% weight loss with sustained hyperphagia), and metformin treatment. However, naltrexone-bupropion treatment led to −48.9 kg (−26.7%) weight loss, of which −39.9 kg (−38.3%) was fat mass, in 17 months of treatment. Importantly, she reported improved hyperphagia and quality of life.We describe the potential beneficial effects of naltrexone-bupropion on weight, hyperphagia, and quality of life in a patient with genetic obesity. This extensive journey shows that various anti-obesity agents can be initiated, subsequently terminated when ineffective and substituted with other anti-obesity agents to identify the most efficient anti-obesity treatment. Biological sciences Physiology Human Physiology Human metabolism Science Q Mostafa Mohseni verfasserin aut Eline S. van der Valk verfasserin aut Johanna M. van Hagen verfasserin aut Jan Steven Burgerhart verfasserin aut Mieke M. van Haelst verfasserin aut Elisabeth F.C. van Rossum verfasserin aut In iScience Elsevier, 2019 26(2023), 3, Seite 106199- (DE-627)1019532106 25890042 nnns volume:26 year:2023 number:3 pages:106199- https://doi.org/10.1016/j.isci.2023.106199 kostenfrei https://doaj.org/article/6e57a4259cfa41699a86bab0b6874739 kostenfrei http://www.sciencedirect.com/science/article/pii/S2589004223002766 kostenfrei https://doaj.org/toc/2589-0042 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_171 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 26 2023 3 106199-
allfieldsGer	10.1016/j.isci.2023.106199 doi (DE-627)DOAJ088362035 (DE-599)DOAJ6e57a4259cfa41699a86bab0b6874739 DE-627 ger DE-627 rakwb eng Mila S. Welling verfasserin aut Successful naltrexone-bupropion treatment after several treatment failures in a patient with severe monogenic obesity 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Summary: We describe the therapeutic journey of a 33-year-old patient with early-onset obesity (BMI 56.7 kg/m2) and hyperphagia due to a likely pathogenic heterozygous melanocortin-4 receptor (MC4R) gene variant.She was unsuccessfully treated with several intensive lifestyle interventions, gastric bypass surgery (−40 kg weight loss, followed by +39.8 kg weight regain), liraglutide 3 mg (−3.8% weight loss with sustained hyperphagia), and metformin treatment. However, naltrexone-bupropion treatment led to −48.9 kg (−26.7%) weight loss, of which −39.9 kg (−38.3%) was fat mass, in 17 months of treatment. Importantly, she reported improved hyperphagia and quality of life.We describe the potential beneficial effects of naltrexone-bupropion on weight, hyperphagia, and quality of life in a patient with genetic obesity. This extensive journey shows that various anti-obesity agents can be initiated, subsequently terminated when ineffective and substituted with other anti-obesity agents to identify the most efficient anti-obesity treatment. Biological sciences Physiology Human Physiology Human metabolism Science Q Mostafa Mohseni verfasserin aut Eline S. van der Valk verfasserin aut Johanna M. van Hagen verfasserin aut Jan Steven Burgerhart verfasserin aut Mieke M. van Haelst verfasserin aut Elisabeth F.C. van Rossum verfasserin aut In iScience Elsevier, 2019 26(2023), 3, Seite 106199- (DE-627)1019532106 25890042 nnns volume:26 year:2023 number:3 pages:106199- https://doi.org/10.1016/j.isci.2023.106199 kostenfrei https://doaj.org/article/6e57a4259cfa41699a86bab0b6874739 kostenfrei http://www.sciencedirect.com/science/article/pii/S2589004223002766 kostenfrei https://doaj.org/toc/2589-0042 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_171 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 26 2023 3 106199-
allfieldsSound	10.1016/j.isci.2023.106199 doi (DE-627)DOAJ088362035 (DE-599)DOAJ6e57a4259cfa41699a86bab0b6874739 DE-627 ger DE-627 rakwb eng Mila S. Welling verfasserin aut Successful naltrexone-bupropion treatment after several treatment failures in a patient with severe monogenic obesity 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Summary: We describe the therapeutic journey of a 33-year-old patient with early-onset obesity (BMI 56.7 kg/m2) and hyperphagia due to a likely pathogenic heterozygous melanocortin-4 receptor (MC4R) gene variant.She was unsuccessfully treated with several intensive lifestyle interventions, gastric bypass surgery (−40 kg weight loss, followed by +39.8 kg weight regain), liraglutide 3 mg (−3.8% weight loss with sustained hyperphagia), and metformin treatment. However, naltrexone-bupropion treatment led to −48.9 kg (−26.7%) weight loss, of which −39.9 kg (−38.3%) was fat mass, in 17 months of treatment. Importantly, she reported improved hyperphagia and quality of life.We describe the potential beneficial effects of naltrexone-bupropion on weight, hyperphagia, and quality of life in a patient with genetic obesity. This extensive journey shows that various anti-obesity agents can be initiated, subsequently terminated when ineffective and substituted with other anti-obesity agents to identify the most efficient anti-obesity treatment. Biological sciences Physiology Human Physiology Human metabolism Science Q Mostafa Mohseni verfasserin aut Eline S. van der Valk verfasserin aut Johanna M. van Hagen verfasserin aut Jan Steven Burgerhart verfasserin aut Mieke M. van Haelst verfasserin aut Elisabeth F.C. van Rossum verfasserin aut In iScience Elsevier, 2019 26(2023), 3, Seite 106199- (DE-627)1019532106 25890042 nnns volume:26 year:2023 number:3 pages:106199- https://doi.org/10.1016/j.isci.2023.106199 kostenfrei https://doaj.org/article/6e57a4259cfa41699a86bab0b6874739 kostenfrei http://www.sciencedirect.com/science/article/pii/S2589004223002766 kostenfrei https://doaj.org/toc/2589-0042 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_171 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 26 2023 3 106199-
language	English
source	In iScience 26(2023), 3, Seite 106199- volume:26 year:2023 number:3 pages:106199-
sourceStr	In iScience 26(2023), 3, Seite 106199- volume:26 year:2023 number:3 pages:106199-
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	Biological sciences Physiology Human Physiology Human metabolism Science Q
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container_title	iScience
authorswithroles_txt_mv	Mila S. Welling @@aut@@ Mostafa Mohseni @@aut@@ Eline S. van der Valk @@aut@@ Johanna M. van Hagen @@aut@@ Jan Steven Burgerhart @@aut@@ Mieke M. van Haelst @@aut@@ Elisabeth F.C. van Rossum @@aut@@
publishDateDaySort_date	2023-01-01T00:00:00Z
hierarchy_top_id	1019532106
id	DOAJ088362035
language_de	englisch
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author	Mila S. Welling
spellingShingle	Mila S. Welling misc Biological sciences misc Physiology misc Human Physiology misc Human metabolism misc Science misc Q Successful naltrexone-bupropion treatment after several treatment failures in a patient with severe monogenic obesity
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topic_title	Successful naltrexone-bupropion treatment after several treatment failures in a patient with severe monogenic obesity Biological sciences Physiology Human Physiology Human metabolism
topic	misc Biological sciences misc Physiology misc Human Physiology misc Human metabolism misc Science misc Q
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title	Successful naltrexone-bupropion treatment after several treatment failures in a patient with severe monogenic obesity
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title_full	Successful naltrexone-bupropion treatment after several treatment failures in a patient with severe monogenic obesity
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author_browse	Mila S. Welling Mostafa Mohseni Eline S. van der Valk Johanna M. van Hagen Jan Steven Burgerhart Mieke M. van Haelst Elisabeth F.C. van Rossum
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title_sort	successful naltrexone-bupropion treatment after several treatment failures in a patient with severe monogenic obesity
title_auth	Successful naltrexone-bupropion treatment after several treatment failures in a patient with severe monogenic obesity
abstract	Summary: We describe the therapeutic journey of a 33-year-old patient with early-onset obesity (BMI 56.7 kg/m2) and hyperphagia due to a likely pathogenic heterozygous melanocortin-4 receptor (MC4R) gene variant.She was unsuccessfully treated with several intensive lifestyle interventions, gastric bypass surgery (−40 kg weight loss, followed by +39.8 kg weight regain), liraglutide 3 mg (−3.8% weight loss with sustained hyperphagia), and metformin treatment. However, naltrexone-bupropion treatment led to −48.9 kg (−26.7%) weight loss, of which −39.9 kg (−38.3%) was fat mass, in 17 months of treatment. Importantly, she reported improved hyperphagia and quality of life.We describe the potential beneficial effects of naltrexone-bupropion on weight, hyperphagia, and quality of life in a patient with genetic obesity. This extensive journey shows that various anti-obesity agents can be initiated, subsequently terminated when ineffective and substituted with other anti-obesity agents to identify the most efficient anti-obesity treatment.
abstractGer	Summary: We describe the therapeutic journey of a 33-year-old patient with early-onset obesity (BMI 56.7 kg/m2) and hyperphagia due to a likely pathogenic heterozygous melanocortin-4 receptor (MC4R) gene variant.She was unsuccessfully treated with several intensive lifestyle interventions, gastric bypass surgery (−40 kg weight loss, followed by +39.8 kg weight regain), liraglutide 3 mg (−3.8% weight loss with sustained hyperphagia), and metformin treatment. However, naltrexone-bupropion treatment led to −48.9 kg (−26.7%) weight loss, of which −39.9 kg (−38.3%) was fat mass, in 17 months of treatment. Importantly, she reported improved hyperphagia and quality of life.We describe the potential beneficial effects of naltrexone-bupropion on weight, hyperphagia, and quality of life in a patient with genetic obesity. This extensive journey shows that various anti-obesity agents can be initiated, subsequently terminated when ineffective and substituted with other anti-obesity agents to identify the most efficient anti-obesity treatment.
abstract_unstemmed	Summary: We describe the therapeutic journey of a 33-year-old patient with early-onset obesity (BMI 56.7 kg/m2) and hyperphagia due to a likely pathogenic heterozygous melanocortin-4 receptor (MC4R) gene variant.She was unsuccessfully treated with several intensive lifestyle interventions, gastric bypass surgery (−40 kg weight loss, followed by +39.8 kg weight regain), liraglutide 3 mg (−3.8% weight loss with sustained hyperphagia), and metformin treatment. However, naltrexone-bupropion treatment led to −48.9 kg (−26.7%) weight loss, of which −39.9 kg (−38.3%) was fat mass, in 17 months of treatment. Importantly, she reported improved hyperphagia and quality of life.We describe the potential beneficial effects of naltrexone-bupropion on weight, hyperphagia, and quality of life in a patient with genetic obesity. This extensive journey shows that various anti-obesity agents can be initiated, subsequently terminated when ineffective and substituted with other anti-obesity agents to identify the most efficient anti-obesity treatment.
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title_short	Successful naltrexone-bupropion treatment after several treatment failures in a patient with severe monogenic obesity
url	https://doi.org/10.1016/j.isci.2023.106199 https://doaj.org/article/6e57a4259cfa41699a86bab0b6874739 http://www.sciencedirect.com/science/article/pii/S2589004223002766 https://doaj.org/toc/2589-0042
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Successful naltrexone-bupropion treatment after several treatment failures in a patient with severe monogenic obesity

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