Assessment of information as regards the toxicity of deoxynivalenol for horses and poultry
Abstract In 2017, the EFSA Panel on Contaminants in the Food Chain (CONTAM) adopted a Scientific Opinion on the risks for animal health related to the presence of deoxynivalenol (DON) and its acetylated and modified forms in food and feed. No observed adverse effect levels (NOAELs) and lowest observ...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
EFSA Panel on Contaminants in the Food Chain (CONTAM) [verfasserIn] Dieter Schrenk [verfasserIn] Margherita Bignami [verfasserIn] Laurent Bodin [verfasserIn] James Kevin Chipman Jesús delMazo [verfasserIn] Bettina Grasl‐Kraupp [verfasserIn] Christer Hogstrand [verfasserIn] Jean‐Charles Leblanc [verfasserIn] Elsa Nielsen [verfasserIn] Evangelia Ntzani [verfasserIn] Annette Petersen [verfasserIn] Salomon Sand [verfasserIn] Tanja Schwerdtle [verfasserIn] Christiane Vleminckx [verfasserIn] Heather Wallace [verfasserIn] Sven Dänicke [verfasserIn] Carlo Stefano Nebbia [verfasserIn] Isabelle P Oswald [verfasserIn] Elena Rovesti [verfasserIn] Hans Steinkellner [verfasserIn] Laurentius (Ron) Hoogenboom [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2023 |
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| Schlagwörter: |
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| Übergeordnetes Werk: |
In: EFSA Journal - Wiley, 2018, 21(2023), 2, Seite n/a-n/a |
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| Übergeordnetes Werk: |
volume:21 ; year:2023 ; number:2 ; pages:n/a-n/a |
| Links: |
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| DOI / URN: |
10.2903/j.efsa.2023.7806 |
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| Katalog-ID: |
DOAJ08842779X |
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| 520 | |a Abstract In 2017, the EFSA Panel on Contaminants in the Food Chain (CONTAM) adopted a Scientific Opinion on the risks for animal health related to the presence of deoxynivalenol (DON) and its acetylated and modified forms in food and feed. No observed adverse effect levels (NOAELs) and lowest observed adverse effect levels (LOAELs) were derived for different animal species. For horses, an NOAEL of 36 mg DON/kg feed was established, the highest concentration tested and not showing adverse effects. For poultry, an NOAEL of 5 mg DON/kg feed for broiler chickens and laying hens, and an NOAEL of 7 mg DON/kg feed for ducks and turkeys was derived. The European Commission requested EFSA to review the information regarding the toxicity of DON for horses and poultry and to revise, if necessary, the established reference points (RPs). Adverse effect levels of 1.9 and 1.7 mg DON/kg feed for, respectively, broiler chickens and turkeys were derived from reassessment of existing studies and newly available literature, showing that DON causes effects on the intestines, in particular the jejunum, with a decreased villus height but also histological damage. An RP for adverse animal health effects of 0.6 mg/kg feed for broiler chickens and turkeys, respectively, was established. For horses, an adverse effect level of 5.6 mg DON/kg feed was established from studies showing reduced feed intake, with an RP for adverse animal health effects of 3.5 mg/kg feed. For ducks and laying hens, RPs remain unchanged. Based on mean and P95 (UB) exposure estimates performed in the previous Opinion, the risk of adverse health effects of feeds containing DON was considered a potential concern for broiler chickens and turkeys. For horses, the risk for adverse health effects from feed containing DON is low. | ||
| 650 | 4 | |a deoxynivalenol | |
| 650 | 4 | |a DON | |
| 650 | 4 | |a exposure | |
| 650 | 4 | |a toxicity | |
| 650 | 4 | |a animal health risk assessment | |
| 650 | 4 | |a horses | |
| 653 | 0 | |a Nutrition. Foods and food supply | |
| 653 | 0 | |a Chemical technology | |
| 700 | 0 | |a Dieter Schrenk |e verfasserin |4 aut | |
| 700 | 0 | |a Margherita Bignami |e verfasserin |4 aut | |
| 700 | 0 | |a Laurent Bodin |e verfasserin |4 aut | |
| 700 | 0 | |a James Kevin Chipman Jesús delMazo |e verfasserin |4 aut | |
| 700 | 0 | |a Bettina Grasl‐Kraupp |e verfasserin |4 aut | |
| 700 | 0 | |a Christer Hogstrand |e verfasserin |4 aut | |
| 700 | 0 | |a Jean‐Charles Leblanc |e verfasserin |4 aut | |
| 700 | 0 | |a Elsa Nielsen |e verfasserin |4 aut | |
| 700 | 0 | |a Evangelia Ntzani |e verfasserin |4 aut | |
| 700 | 0 | |a Annette Petersen |e verfasserin |4 aut | |
| 700 | 0 | |a Salomon Sand |e verfasserin |4 aut | |
| 700 | 0 | |a Tanja Schwerdtle |e verfasserin |4 aut | |
| 700 | 0 | |a Christiane Vleminckx |e verfasserin |4 aut | |
| 700 | 0 | |a Heather Wallace |e verfasserin |4 aut | |
| 700 | 0 | |a Sven Dänicke |e verfasserin |4 aut | |
| 700 | 0 | |a Carlo Stefano Nebbia |e verfasserin |4 aut | |
| 700 | 0 | |a Isabelle P Oswald |e verfasserin |4 aut | |
| 700 | 0 | |a Elena Rovesti |e verfasserin |4 aut | |
| 700 | 0 | |a Hans Steinkellner |e verfasserin |4 aut | |
| 700 | 0 | |a Laurentius (Ron) Hoogenboom |e verfasserin |4 aut | |
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10.2903/j.efsa.2023.7806 doi (DE-627)DOAJ08842779X (DE-599)DOAJ58a53dafe6cc4c4aa8fc03378617fa41 DE-627 ger DE-627 rakwb eng TX341-641 TP1-1185 EFSA Panel on Contaminants in the Food Chain (CONTAM) verfasserin aut Assessment of information as regards the toxicity of deoxynivalenol for horses and poultry 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract In 2017, the EFSA Panel on Contaminants in the Food Chain (CONTAM) adopted a Scientific Opinion on the risks for animal health related to the presence of deoxynivalenol (DON) and its acetylated and modified forms in food and feed. No observed adverse effect levels (NOAELs) and lowest observed adverse effect levels (LOAELs) were derived for different animal species. For horses, an NOAEL of 36 mg DON/kg feed was established, the highest concentration tested and not showing adverse effects. For poultry, an NOAEL of 5 mg DON/kg feed for broiler chickens and laying hens, and an NOAEL of 7 mg DON/kg feed for ducks and turkeys was derived. The European Commission requested EFSA to review the information regarding the toxicity of DON for horses and poultry and to revise, if necessary, the established reference points (RPs). Adverse effect levels of 1.9 and 1.7 mg DON/kg feed for, respectively, broiler chickens and turkeys were derived from reassessment of existing studies and newly available literature, showing that DON causes effects on the intestines, in particular the jejunum, with a decreased villus height but also histological damage. An RP for adverse animal health effects of 0.6 mg/kg feed for broiler chickens and turkeys, respectively, was established. For horses, an adverse effect level of 5.6 mg DON/kg feed was established from studies showing reduced feed intake, with an RP for adverse animal health effects of 3.5 mg/kg feed. For ducks and laying hens, RPs remain unchanged. Based on mean and P95 (UB) exposure estimates performed in the previous Opinion, the risk of adverse health effects of feeds containing DON was considered a potential concern for broiler chickens and turkeys. For horses, the risk for adverse health effects from feed containing DON is low. deoxynivalenol DON exposure toxicity animal health risk assessment horses Nutrition. Foods and food supply Chemical technology Dieter Schrenk verfasserin aut Margherita Bignami verfasserin aut Laurent Bodin verfasserin aut James Kevin Chipman Jesús delMazo verfasserin aut Bettina Grasl‐Kraupp verfasserin aut Christer Hogstrand verfasserin aut Jean‐Charles Leblanc verfasserin aut Elsa Nielsen verfasserin aut Evangelia Ntzani verfasserin aut Annette Petersen verfasserin aut Salomon Sand verfasserin aut Tanja Schwerdtle verfasserin aut Christiane Vleminckx verfasserin aut Heather Wallace verfasserin aut Sven Dänicke verfasserin aut Carlo Stefano Nebbia verfasserin aut Isabelle P Oswald verfasserin aut Elena Rovesti verfasserin aut Hans Steinkellner verfasserin aut Laurentius (Ron) Hoogenboom verfasserin aut In EFSA Journal Wiley, 2018 21(2023), 2, Seite n/a-n/a (DE-627)618834982 (DE-600)2540248-1 18314732 nnns volume:21 year:2023 number:2 pages:n/a-n/a https://doi.org/10.2903/j.efsa.2023.7806 kostenfrei https://doaj.org/article/58a53dafe6cc4c4aa8fc03378617fa41 kostenfrei https://doi.org/10.2903/j.efsa.2023.7806 kostenfrei https://doaj.org/toc/1831-4732 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_235 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_636 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 21 2023 2 n/a-n/a |
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10.2903/j.efsa.2023.7806 doi (DE-627)DOAJ08842779X (DE-599)DOAJ58a53dafe6cc4c4aa8fc03378617fa41 DE-627 ger DE-627 rakwb eng TX341-641 TP1-1185 EFSA Panel on Contaminants in the Food Chain (CONTAM) verfasserin aut Assessment of information as regards the toxicity of deoxynivalenol for horses and poultry 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract In 2017, the EFSA Panel on Contaminants in the Food Chain (CONTAM) adopted a Scientific Opinion on the risks for animal health related to the presence of deoxynivalenol (DON) and its acetylated and modified forms in food and feed. No observed adverse effect levels (NOAELs) and lowest observed adverse effect levels (LOAELs) were derived for different animal species. For horses, an NOAEL of 36 mg DON/kg feed was established, the highest concentration tested and not showing adverse effects. For poultry, an NOAEL of 5 mg DON/kg feed for broiler chickens and laying hens, and an NOAEL of 7 mg DON/kg feed for ducks and turkeys was derived. The European Commission requested EFSA to review the information regarding the toxicity of DON for horses and poultry and to revise, if necessary, the established reference points (RPs). Adverse effect levels of 1.9 and 1.7 mg DON/kg feed for, respectively, broiler chickens and turkeys were derived from reassessment of existing studies and newly available literature, showing that DON causes effects on the intestines, in particular the jejunum, with a decreased villus height but also histological damage. An RP for adverse animal health effects of 0.6 mg/kg feed for broiler chickens and turkeys, respectively, was established. For horses, an adverse effect level of 5.6 mg DON/kg feed was established from studies showing reduced feed intake, with an RP for adverse animal health effects of 3.5 mg/kg feed. For ducks and laying hens, RPs remain unchanged. Based on mean and P95 (UB) exposure estimates performed in the previous Opinion, the risk of adverse health effects of feeds containing DON was considered a potential concern for broiler chickens and turkeys. For horses, the risk for adverse health effects from feed containing DON is low. deoxynivalenol DON exposure toxicity animal health risk assessment horses Nutrition. Foods and food supply Chemical technology Dieter Schrenk verfasserin aut Margherita Bignami verfasserin aut Laurent Bodin verfasserin aut James Kevin Chipman Jesús delMazo verfasserin aut Bettina Grasl‐Kraupp verfasserin aut Christer Hogstrand verfasserin aut Jean‐Charles Leblanc verfasserin aut Elsa Nielsen verfasserin aut Evangelia Ntzani verfasserin aut Annette Petersen verfasserin aut Salomon Sand verfasserin aut Tanja Schwerdtle verfasserin aut Christiane Vleminckx verfasserin aut Heather Wallace verfasserin aut Sven Dänicke verfasserin aut Carlo Stefano Nebbia verfasserin aut Isabelle P Oswald verfasserin aut Elena Rovesti verfasserin aut Hans Steinkellner verfasserin aut Laurentius (Ron) Hoogenboom verfasserin aut In EFSA Journal Wiley, 2018 21(2023), 2, Seite n/a-n/a (DE-627)618834982 (DE-600)2540248-1 18314732 nnns volume:21 year:2023 number:2 pages:n/a-n/a https://doi.org/10.2903/j.efsa.2023.7806 kostenfrei https://doaj.org/article/58a53dafe6cc4c4aa8fc03378617fa41 kostenfrei https://doi.org/10.2903/j.efsa.2023.7806 kostenfrei https://doaj.org/toc/1831-4732 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_235 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_636 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 21 2023 2 n/a-n/a |
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10.2903/j.efsa.2023.7806 doi (DE-627)DOAJ08842779X (DE-599)DOAJ58a53dafe6cc4c4aa8fc03378617fa41 DE-627 ger DE-627 rakwb eng TX341-641 TP1-1185 EFSA Panel on Contaminants in the Food Chain (CONTAM) verfasserin aut Assessment of information as regards the toxicity of deoxynivalenol for horses and poultry 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract In 2017, the EFSA Panel on Contaminants in the Food Chain (CONTAM) adopted a Scientific Opinion on the risks for animal health related to the presence of deoxynivalenol (DON) and its acetylated and modified forms in food and feed. No observed adverse effect levels (NOAELs) and lowest observed adverse effect levels (LOAELs) were derived for different animal species. For horses, an NOAEL of 36 mg DON/kg feed was established, the highest concentration tested and not showing adverse effects. For poultry, an NOAEL of 5 mg DON/kg feed for broiler chickens and laying hens, and an NOAEL of 7 mg DON/kg feed for ducks and turkeys was derived. The European Commission requested EFSA to review the information regarding the toxicity of DON for horses and poultry and to revise, if necessary, the established reference points (RPs). Adverse effect levels of 1.9 and 1.7 mg DON/kg feed for, respectively, broiler chickens and turkeys were derived from reassessment of existing studies and newly available literature, showing that DON causes effects on the intestines, in particular the jejunum, with a decreased villus height but also histological damage. An RP for adverse animal health effects of 0.6 mg/kg feed for broiler chickens and turkeys, respectively, was established. For horses, an adverse effect level of 5.6 mg DON/kg feed was established from studies showing reduced feed intake, with an RP for adverse animal health effects of 3.5 mg/kg feed. For ducks and laying hens, RPs remain unchanged. Based on mean and P95 (UB) exposure estimates performed in the previous Opinion, the risk of adverse health effects of feeds containing DON was considered a potential concern for broiler chickens and turkeys. For horses, the risk for adverse health effects from feed containing DON is low. deoxynivalenol DON exposure toxicity animal health risk assessment horses Nutrition. Foods and food supply Chemical technology Dieter Schrenk verfasserin aut Margherita Bignami verfasserin aut Laurent Bodin verfasserin aut James Kevin Chipman Jesús delMazo verfasserin aut Bettina Grasl‐Kraupp verfasserin aut Christer Hogstrand verfasserin aut Jean‐Charles Leblanc verfasserin aut Elsa Nielsen verfasserin aut Evangelia Ntzani verfasserin aut Annette Petersen verfasserin aut Salomon Sand verfasserin aut Tanja Schwerdtle verfasserin aut Christiane Vleminckx verfasserin aut Heather Wallace verfasserin aut Sven Dänicke verfasserin aut Carlo Stefano Nebbia verfasserin aut Isabelle P Oswald verfasserin aut Elena Rovesti verfasserin aut Hans Steinkellner verfasserin aut Laurentius (Ron) Hoogenboom verfasserin aut In EFSA Journal Wiley, 2018 21(2023), 2, Seite n/a-n/a (DE-627)618834982 (DE-600)2540248-1 18314732 nnns volume:21 year:2023 number:2 pages:n/a-n/a https://doi.org/10.2903/j.efsa.2023.7806 kostenfrei https://doaj.org/article/58a53dafe6cc4c4aa8fc03378617fa41 kostenfrei https://doi.org/10.2903/j.efsa.2023.7806 kostenfrei https://doaj.org/toc/1831-4732 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_235 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_636 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 21 2023 2 n/a-n/a |
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10.2903/j.efsa.2023.7806 doi (DE-627)DOAJ08842779X (DE-599)DOAJ58a53dafe6cc4c4aa8fc03378617fa41 DE-627 ger DE-627 rakwb eng TX341-641 TP1-1185 EFSA Panel on Contaminants in the Food Chain (CONTAM) verfasserin aut Assessment of information as regards the toxicity of deoxynivalenol for horses and poultry 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract In 2017, the EFSA Panel on Contaminants in the Food Chain (CONTAM) adopted a Scientific Opinion on the risks for animal health related to the presence of deoxynivalenol (DON) and its acetylated and modified forms in food and feed. No observed adverse effect levels (NOAELs) and lowest observed adverse effect levels (LOAELs) were derived for different animal species. For horses, an NOAEL of 36 mg DON/kg feed was established, the highest concentration tested and not showing adverse effects. For poultry, an NOAEL of 5 mg DON/kg feed for broiler chickens and laying hens, and an NOAEL of 7 mg DON/kg feed for ducks and turkeys was derived. The European Commission requested EFSA to review the information regarding the toxicity of DON for horses and poultry and to revise, if necessary, the established reference points (RPs). Adverse effect levels of 1.9 and 1.7 mg DON/kg feed for, respectively, broiler chickens and turkeys were derived from reassessment of existing studies and newly available literature, showing that DON causes effects on the intestines, in particular the jejunum, with a decreased villus height but also histological damage. An RP for adverse animal health effects of 0.6 mg/kg feed for broiler chickens and turkeys, respectively, was established. For horses, an adverse effect level of 5.6 mg DON/kg feed was established from studies showing reduced feed intake, with an RP for adverse animal health effects of 3.5 mg/kg feed. For ducks and laying hens, RPs remain unchanged. Based on mean and P95 (UB) exposure estimates performed in the previous Opinion, the risk of adverse health effects of feeds containing DON was considered a potential concern for broiler chickens and turkeys. For horses, the risk for adverse health effects from feed containing DON is low. deoxynivalenol DON exposure toxicity animal health risk assessment horses Nutrition. Foods and food supply Chemical technology Dieter Schrenk verfasserin aut Margherita Bignami verfasserin aut Laurent Bodin verfasserin aut James Kevin Chipman Jesús delMazo verfasserin aut Bettina Grasl‐Kraupp verfasserin aut Christer Hogstrand verfasserin aut Jean‐Charles Leblanc verfasserin aut Elsa Nielsen verfasserin aut Evangelia Ntzani verfasserin aut Annette Petersen verfasserin aut Salomon Sand verfasserin aut Tanja Schwerdtle verfasserin aut Christiane Vleminckx verfasserin aut Heather Wallace verfasserin aut Sven Dänicke verfasserin aut Carlo Stefano Nebbia verfasserin aut Isabelle P Oswald verfasserin aut Elena Rovesti verfasserin aut Hans Steinkellner verfasserin aut Laurentius (Ron) Hoogenboom verfasserin aut In EFSA Journal Wiley, 2018 21(2023), 2, Seite n/a-n/a (DE-627)618834982 (DE-600)2540248-1 18314732 nnns volume:21 year:2023 number:2 pages:n/a-n/a https://doi.org/10.2903/j.efsa.2023.7806 kostenfrei https://doaj.org/article/58a53dafe6cc4c4aa8fc03378617fa41 kostenfrei https://doi.org/10.2903/j.efsa.2023.7806 kostenfrei https://doaj.org/toc/1831-4732 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_235 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_636 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 21 2023 2 n/a-n/a |
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10.2903/j.efsa.2023.7806 doi (DE-627)DOAJ08842779X (DE-599)DOAJ58a53dafe6cc4c4aa8fc03378617fa41 DE-627 ger DE-627 rakwb eng TX341-641 TP1-1185 EFSA Panel on Contaminants in the Food Chain (CONTAM) verfasserin aut Assessment of information as regards the toxicity of deoxynivalenol for horses and poultry 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract In 2017, the EFSA Panel on Contaminants in the Food Chain (CONTAM) adopted a Scientific Opinion on the risks for animal health related to the presence of deoxynivalenol (DON) and its acetylated and modified forms in food and feed. No observed adverse effect levels (NOAELs) and lowest observed adverse effect levels (LOAELs) were derived for different animal species. For horses, an NOAEL of 36 mg DON/kg feed was established, the highest concentration tested and not showing adverse effects. For poultry, an NOAEL of 5 mg DON/kg feed for broiler chickens and laying hens, and an NOAEL of 7 mg DON/kg feed for ducks and turkeys was derived. The European Commission requested EFSA to review the information regarding the toxicity of DON for horses and poultry and to revise, if necessary, the established reference points (RPs). Adverse effect levels of 1.9 and 1.7 mg DON/kg feed for, respectively, broiler chickens and turkeys were derived from reassessment of existing studies and newly available literature, showing that DON causes effects on the intestines, in particular the jejunum, with a decreased villus height but also histological damage. An RP for adverse animal health effects of 0.6 mg/kg feed for broiler chickens and turkeys, respectively, was established. For horses, an adverse effect level of 5.6 mg DON/kg feed was established from studies showing reduced feed intake, with an RP for adverse animal health effects of 3.5 mg/kg feed. For ducks and laying hens, RPs remain unchanged. Based on mean and P95 (UB) exposure estimates performed in the previous Opinion, the risk of adverse health effects of feeds containing DON was considered a potential concern for broiler chickens and turkeys. For horses, the risk for adverse health effects from feed containing DON is low. deoxynivalenol DON exposure toxicity animal health risk assessment horses Nutrition. Foods and food supply Chemical technology Dieter Schrenk verfasserin aut Margherita Bignami verfasserin aut Laurent Bodin verfasserin aut James Kevin Chipman Jesús delMazo verfasserin aut Bettina Grasl‐Kraupp verfasserin aut Christer Hogstrand verfasserin aut Jean‐Charles Leblanc verfasserin aut Elsa Nielsen verfasserin aut Evangelia Ntzani verfasserin aut Annette Petersen verfasserin aut Salomon Sand verfasserin aut Tanja Schwerdtle verfasserin aut Christiane Vleminckx verfasserin aut Heather Wallace verfasserin aut Sven Dänicke verfasserin aut Carlo Stefano Nebbia verfasserin aut Isabelle P Oswald verfasserin aut Elena Rovesti verfasserin aut Hans Steinkellner verfasserin aut Laurentius (Ron) Hoogenboom verfasserin aut In EFSA Journal Wiley, 2018 21(2023), 2, Seite n/a-n/a (DE-627)618834982 (DE-600)2540248-1 18314732 nnns volume:21 year:2023 number:2 pages:n/a-n/a https://doi.org/10.2903/j.efsa.2023.7806 kostenfrei https://doaj.org/article/58a53dafe6cc4c4aa8fc03378617fa41 kostenfrei https://doi.org/10.2903/j.efsa.2023.7806 kostenfrei https://doaj.org/toc/1831-4732 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_235 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_636 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 21 2023 2 n/a-n/a |
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EFSA Panel on Contaminants in the Food Chain (CONTAM) @@aut@@ Dieter Schrenk @@aut@@ Margherita Bignami @@aut@@ Laurent Bodin @@aut@@ James Kevin Chipman Jesús delMazo @@aut@@ Bettina Grasl‐Kraupp @@aut@@ Christer Hogstrand @@aut@@ Jean‐Charles Leblanc @@aut@@ Elsa Nielsen @@aut@@ Evangelia Ntzani @@aut@@ Annette Petersen @@aut@@ Salomon Sand @@aut@@ Tanja Schwerdtle @@aut@@ Christiane Vleminckx @@aut@@ Heather Wallace @@aut@@ Sven Dänicke @@aut@@ Carlo Stefano Nebbia @@aut@@ Isabelle P Oswald @@aut@@ Elena Rovesti @@aut@@ Hans Steinkellner @@aut@@ Laurentius (Ron) Hoogenboom @@aut@@ |
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No observed adverse effect levels (NOAELs) and lowest observed adverse effect levels (LOAELs) were derived for different animal species. For horses, an NOAEL of 36 mg DON/kg feed was established, the highest concentration tested and not showing adverse effects. For poultry, an NOAEL of 5 mg DON/kg feed for broiler chickens and laying hens, and an NOAEL of 7 mg DON/kg feed for ducks and turkeys was derived. The European Commission requested EFSA to review the information regarding the toxicity of DON for horses and poultry and to revise, if necessary, the established reference points (RPs). Adverse effect levels of 1.9 and 1.7 mg DON/kg feed for, respectively, broiler chickens and turkeys were derived from reassessment of existing studies and newly available literature, showing that DON causes effects on the intestines, in particular the jejunum, with a decreased villus height but also histological damage. An RP for adverse animal health effects of 0.6 mg/kg feed for broiler chickens and turkeys, respectively, was established. For horses, an adverse effect level of 5.6 mg DON/kg feed was established from studies showing reduced feed intake, with an RP for adverse animal health effects of 3.5 mg/kg feed. For ducks and laying hens, RPs remain unchanged. Based on mean and P95 (UB) exposure estimates performed in the previous Opinion, the risk of adverse health effects of feeds containing DON was considered a potential concern for broiler chickens and turkeys. 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TX341-641 TP1-1185 Assessment of information as regards the toxicity of deoxynivalenol for horses and poultry deoxynivalenol DON exposure toxicity animal health risk assessment horses |
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EFSA Panel on Contaminants in the Food Chain (CONTAM) Dieter Schrenk Margherita Bignami Laurent Bodin James Kevin Chipman Jesús delMazo Bettina Grasl‐Kraupp Christer Hogstrand Jean‐Charles Leblanc Elsa Nielsen Evangelia Ntzani Annette Petersen Salomon Sand Tanja Schwerdtle Christiane Vleminckx Heather Wallace Sven Dänicke Carlo Stefano Nebbia Isabelle P Oswald Elena Rovesti Hans Steinkellner Laurentius (Ron) Hoogenboom |
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assessment of information as regards the toxicity of deoxynivalenol for horses and poultry |
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Assessment of information as regards the toxicity of deoxynivalenol for horses and poultry |
| abstract |
Abstract In 2017, the EFSA Panel on Contaminants in the Food Chain (CONTAM) adopted a Scientific Opinion on the risks for animal health related to the presence of deoxynivalenol (DON) and its acetylated and modified forms in food and feed. No observed adverse effect levels (NOAELs) and lowest observed adverse effect levels (LOAELs) were derived for different animal species. For horses, an NOAEL of 36 mg DON/kg feed was established, the highest concentration tested and not showing adverse effects. For poultry, an NOAEL of 5 mg DON/kg feed for broiler chickens and laying hens, and an NOAEL of 7 mg DON/kg feed for ducks and turkeys was derived. The European Commission requested EFSA to review the information regarding the toxicity of DON for horses and poultry and to revise, if necessary, the established reference points (RPs). Adverse effect levels of 1.9 and 1.7 mg DON/kg feed for, respectively, broiler chickens and turkeys were derived from reassessment of existing studies and newly available literature, showing that DON causes effects on the intestines, in particular the jejunum, with a decreased villus height but also histological damage. An RP for adverse animal health effects of 0.6 mg/kg feed for broiler chickens and turkeys, respectively, was established. For horses, an adverse effect level of 5.6 mg DON/kg feed was established from studies showing reduced feed intake, with an RP for adverse animal health effects of 3.5 mg/kg feed. For ducks and laying hens, RPs remain unchanged. Based on mean and P95 (UB) exposure estimates performed in the previous Opinion, the risk of adverse health effects of feeds containing DON was considered a potential concern for broiler chickens and turkeys. For horses, the risk for adverse health effects from feed containing DON is low. |
| abstractGer |
Abstract In 2017, the EFSA Panel on Contaminants in the Food Chain (CONTAM) adopted a Scientific Opinion on the risks for animal health related to the presence of deoxynivalenol (DON) and its acetylated and modified forms in food and feed. No observed adverse effect levels (NOAELs) and lowest observed adverse effect levels (LOAELs) were derived for different animal species. For horses, an NOAEL of 36 mg DON/kg feed was established, the highest concentration tested and not showing adverse effects. For poultry, an NOAEL of 5 mg DON/kg feed for broiler chickens and laying hens, and an NOAEL of 7 mg DON/kg feed for ducks and turkeys was derived. The European Commission requested EFSA to review the information regarding the toxicity of DON for horses and poultry and to revise, if necessary, the established reference points (RPs). Adverse effect levels of 1.9 and 1.7 mg DON/kg feed for, respectively, broiler chickens and turkeys were derived from reassessment of existing studies and newly available literature, showing that DON causes effects on the intestines, in particular the jejunum, with a decreased villus height but also histological damage. An RP for adverse animal health effects of 0.6 mg/kg feed for broiler chickens and turkeys, respectively, was established. For horses, an adverse effect level of 5.6 mg DON/kg feed was established from studies showing reduced feed intake, with an RP for adverse animal health effects of 3.5 mg/kg feed. For ducks and laying hens, RPs remain unchanged. Based on mean and P95 (UB) exposure estimates performed in the previous Opinion, the risk of adverse health effects of feeds containing DON was considered a potential concern for broiler chickens and turkeys. For horses, the risk for adverse health effects from feed containing DON is low. |
| abstract_unstemmed |
Abstract In 2017, the EFSA Panel on Contaminants in the Food Chain (CONTAM) adopted a Scientific Opinion on the risks for animal health related to the presence of deoxynivalenol (DON) and its acetylated and modified forms in food and feed. No observed adverse effect levels (NOAELs) and lowest observed adverse effect levels (LOAELs) were derived for different animal species. For horses, an NOAEL of 36 mg DON/kg feed was established, the highest concentration tested and not showing adverse effects. For poultry, an NOAEL of 5 mg DON/kg feed for broiler chickens and laying hens, and an NOAEL of 7 mg DON/kg feed for ducks and turkeys was derived. The European Commission requested EFSA to review the information regarding the toxicity of DON for horses and poultry and to revise, if necessary, the established reference points (RPs). Adverse effect levels of 1.9 and 1.7 mg DON/kg feed for, respectively, broiler chickens and turkeys were derived from reassessment of existing studies and newly available literature, showing that DON causes effects on the intestines, in particular the jejunum, with a decreased villus height but also histological damage. An RP for adverse animal health effects of 0.6 mg/kg feed for broiler chickens and turkeys, respectively, was established. For horses, an adverse effect level of 5.6 mg DON/kg feed was established from studies showing reduced feed intake, with an RP for adverse animal health effects of 3.5 mg/kg feed. For ducks and laying hens, RPs remain unchanged. Based on mean and P95 (UB) exposure estimates performed in the previous Opinion, the risk of adverse health effects of feeds containing DON was considered a potential concern for broiler chickens and turkeys. For horses, the risk for adverse health effects from feed containing DON is low. |
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| container_issue |
2 |
| title_short |
Assessment of information as regards the toxicity of deoxynivalenol for horses and poultry |
| url |
https://doi.org/10.2903/j.efsa.2023.7806 https://doaj.org/article/58a53dafe6cc4c4aa8fc03378617fa41 https://doaj.org/toc/1831-4732 |
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Dieter Schrenk Margherita Bignami Laurent Bodin James Kevin Chipman Jesús delMazo Bettina Grasl‐Kraupp Christer Hogstrand Jean‐Charles Leblanc Elsa Nielsen Evangelia Ntzani Annette Petersen Salomon Sand Tanja Schwerdtle Christiane Vleminckx Heather Wallace Sven Dänicke Carlo Stefano Nebbia Isabelle P Oswald Elena Rovesti Hans Steinkellner Laurentius (Ron) Hoogenboom |
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Dieter Schrenk Margherita Bignami Laurent Bodin James Kevin Chipman Jesús delMazo Bettina Grasl‐Kraupp Christer Hogstrand Jean‐Charles Leblanc Elsa Nielsen Evangelia Ntzani Annette Petersen Salomon Sand Tanja Schwerdtle Christiane Vleminckx Heather Wallace Sven Dänicke Carlo Stefano Nebbia Isabelle P Oswald Elena Rovesti Hans Steinkellner Laurentius (Ron) Hoogenboom |
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10.2903/j.efsa.2023.7806 |
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| up_date |
2024-07-03T17:38:42.318Z |
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|
| score |
7.399088 |