Synergistic Effect of Hyperbaric Oxygen and Decellularized Human Amniotic Membrane on Full-Thickness Diabetic Wound Healing in Rats

Background and purpose: One of the common complications of diabetes is impairment of wound healing. The aim of the present study was to investigate the synergistic effect of hyperbaric oxygen (HBO) therapy and decellularized human amniotic membrane (dHAM) in healing of full-thickness diabetic wounds...
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Gespeichert in:

Autor*in:	Mostafa Izanlu [verfasserIn] Alireza Khalatbary [verfasserIn] Amin Aliabadi [verfasserIn] Sima Davoodi [verfasserIn] Amir Raoofi [verfasserIn] Faezeh Modanloo [verfasserIn] Davood Nasiry [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch ; Persisch

Erschienen:	2022

Schlagwörter:	diabetic wound hyperbaric oxygen human amniotic membrane

Übergeordnetes Werk:	In: Journal of Mazandaran University of Medical Sciences - Mazandaran University of Medical Sciences, 2018, 32(2022), 208, Seite 15
Übergeordnetes Werk:	volume:32 ; year:2022 ; number:208 ; pages:15

Links:	Link aufrufen Link aufrufen Journal toc Journal toc

Katalog-ID:	DOAJ088439666

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520			\|a Background and purpose: One of the common complications of diabetes is impairment of wound healing. The aim of the present study was to investigate the synergistic effect of hyperbaric oxygen (HBO) therapy and decellularized human amniotic membrane (dHAM) in healing of full-thickness diabetic wounds in rats. Materials and methods: In this experimental study, 60 diabetic male rats were randomly divided into four groups (n=15) as follows: untreated diabetic wound, wound treated with HBO, wound treated with dHAM, and wound treated with HBO+dHAM. Sampling was performed after 7, 14, and 21 days following wounding. Assessments included wound closure rate, histological (collagen density) and stereological examinations, expression of genes involved in repair and angiogenesis (TGF-β and VEGF), inflammatory genes (TNF-α and IL-1β), and wound tissue biomechanical properties. Results: Combined use of dHAM and HBO significantly increased wound closure rate, new epidermis and dermis volume, fibroblast cell and blood vessel density, collagen density, repair and angiogenesis genes, and wound biomechanical properties compared with those in the diabetic group (P<0.05). Also, the expression level of inflammatory genes and neutrophil density significantly decreased in all treatment groups, especially in HBO+dHAM group compared with the diabetic group (P<0.05). Conclusion: dHAM and HBO had a greater effect on the healing process of diabetic wounds when taken together than when each was taken separately.
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allfields	(DE-627)DOAJ088439666 (DE-599)DOAJ820df8ea6fa9426fae0d61aacbe6d0be DE-627 ger DE-627 rakwb eng per R5-920 Mostafa Izanlu verfasserin aut Synergistic Effect of Hyperbaric Oxygen and Decellularized Human Amniotic Membrane on Full-Thickness Diabetic Wound Healing in Rats 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background and purpose: One of the common complications of diabetes is impairment of wound healing. The aim of the present study was to investigate the synergistic effect of hyperbaric oxygen (HBO) therapy and decellularized human amniotic membrane (dHAM) in healing of full-thickness diabetic wounds in rats. Materials and methods: In this experimental study, 60 diabetic male rats were randomly divided into four groups (n=15) as follows: untreated diabetic wound, wound treated with HBO, wound treated with dHAM, and wound treated with HBO+dHAM. Sampling was performed after 7, 14, and 21 days following wounding. Assessments included wound closure rate, histological (collagen density) and stereological examinations, expression of genes involved in repair and angiogenesis (TGF-β and VEGF), inflammatory genes (TNF-α and IL-1β), and wound tissue biomechanical properties. Results: Combined use of dHAM and HBO significantly increased wound closure rate, new epidermis and dermis volume, fibroblast cell and blood vessel density, collagen density, repair and angiogenesis genes, and wound biomechanical properties compared with those in the diabetic group (P<0.05). Also, the expression level of inflammatory genes and neutrophil density significantly decreased in all treatment groups, especially in HBO+dHAM group compared with the diabetic group (P<0.05). Conclusion: dHAM and HBO had a greater effect on the healing process of diabetic wounds when taken together than when each was taken separately. diabetic wound hyperbaric oxygen human amniotic membrane Medicine R Medicine (General) Alireza Khalatbary verfasserin aut Amin Aliabadi verfasserin aut Sima Davoodi verfasserin aut Amir Raoofi verfasserin aut Faezeh Modanloo verfasserin aut Davood Nasiry verfasserin aut In Journal of Mazandaran University of Medical Sciences Mazandaran University of Medical Sciences, 2018 32(2022), 208, Seite 15 (DE-627)59095623X (DE-600)2476989-7 17359279 nnns volume:32 year:2022 number:208 pages:15 https://doaj.org/article/820df8ea6fa9426fae0d61aacbe6d0be kostenfrei http://jmums.mazums.ac.ir/article-1-17965-en.html kostenfrei https://doaj.org/toc/1735-9260 Journal toc kostenfrei https://doaj.org/toc/1735-9279 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 32 2022 208 15
spelling	(DE-627)DOAJ088439666 (DE-599)DOAJ820df8ea6fa9426fae0d61aacbe6d0be DE-627 ger DE-627 rakwb eng per R5-920 Mostafa Izanlu verfasserin aut Synergistic Effect of Hyperbaric Oxygen and Decellularized Human Amniotic Membrane on Full-Thickness Diabetic Wound Healing in Rats 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background and purpose: One of the common complications of diabetes is impairment of wound healing. The aim of the present study was to investigate the synergistic effect of hyperbaric oxygen (HBO) therapy and decellularized human amniotic membrane (dHAM) in healing of full-thickness diabetic wounds in rats. Materials and methods: In this experimental study, 60 diabetic male rats were randomly divided into four groups (n=15) as follows: untreated diabetic wound, wound treated with HBO, wound treated with dHAM, and wound treated with HBO+dHAM. Sampling was performed after 7, 14, and 21 days following wounding. Assessments included wound closure rate, histological (collagen density) and stereological examinations, expression of genes involved in repair and angiogenesis (TGF-β and VEGF), inflammatory genes (TNF-α and IL-1β), and wound tissue biomechanical properties. Results: Combined use of dHAM and HBO significantly increased wound closure rate, new epidermis and dermis volume, fibroblast cell and blood vessel density, collagen density, repair and angiogenesis genes, and wound biomechanical properties compared with those in the diabetic group (P<0.05). Also, the expression level of inflammatory genes and neutrophil density significantly decreased in all treatment groups, especially in HBO+dHAM group compared with the diabetic group (P<0.05). Conclusion: dHAM and HBO had a greater effect on the healing process of diabetic wounds when taken together than when each was taken separately. diabetic wound hyperbaric oxygen human amniotic membrane Medicine R Medicine (General) Alireza Khalatbary verfasserin aut Amin Aliabadi verfasserin aut Sima Davoodi verfasserin aut Amir Raoofi verfasserin aut Faezeh Modanloo verfasserin aut Davood Nasiry verfasserin aut In Journal of Mazandaran University of Medical Sciences Mazandaran University of Medical Sciences, 2018 32(2022), 208, Seite 15 (DE-627)59095623X (DE-600)2476989-7 17359279 nnns volume:32 year:2022 number:208 pages:15 https://doaj.org/article/820df8ea6fa9426fae0d61aacbe6d0be kostenfrei http://jmums.mazums.ac.ir/article-1-17965-en.html kostenfrei https://doaj.org/toc/1735-9260 Journal toc kostenfrei https://doaj.org/toc/1735-9279 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 32 2022 208 15
allfields_unstemmed	(DE-627)DOAJ088439666 (DE-599)DOAJ820df8ea6fa9426fae0d61aacbe6d0be DE-627 ger DE-627 rakwb eng per R5-920 Mostafa Izanlu verfasserin aut Synergistic Effect of Hyperbaric Oxygen and Decellularized Human Amniotic Membrane on Full-Thickness Diabetic Wound Healing in Rats 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background and purpose: One of the common complications of diabetes is impairment of wound healing. The aim of the present study was to investigate the synergistic effect of hyperbaric oxygen (HBO) therapy and decellularized human amniotic membrane (dHAM) in healing of full-thickness diabetic wounds in rats. Materials and methods: In this experimental study, 60 diabetic male rats were randomly divided into four groups (n=15) as follows: untreated diabetic wound, wound treated with HBO, wound treated with dHAM, and wound treated with HBO+dHAM. Sampling was performed after 7, 14, and 21 days following wounding. Assessments included wound closure rate, histological (collagen density) and stereological examinations, expression of genes involved in repair and angiogenesis (TGF-β and VEGF), inflammatory genes (TNF-α and IL-1β), and wound tissue biomechanical properties. Results: Combined use of dHAM and HBO significantly increased wound closure rate, new epidermis and dermis volume, fibroblast cell and blood vessel density, collagen density, repair and angiogenesis genes, and wound biomechanical properties compared with those in the diabetic group (P<0.05). Also, the expression level of inflammatory genes and neutrophil density significantly decreased in all treatment groups, especially in HBO+dHAM group compared with the diabetic group (P<0.05). Conclusion: dHAM and HBO had a greater effect on the healing process of diabetic wounds when taken together than when each was taken separately. diabetic wound hyperbaric oxygen human amniotic membrane Medicine R Medicine (General) Alireza Khalatbary verfasserin aut Amin Aliabadi verfasserin aut Sima Davoodi verfasserin aut Amir Raoofi verfasserin aut Faezeh Modanloo verfasserin aut Davood Nasiry verfasserin aut In Journal of Mazandaran University of Medical Sciences Mazandaran University of Medical Sciences, 2018 32(2022), 208, Seite 15 (DE-627)59095623X (DE-600)2476989-7 17359279 nnns volume:32 year:2022 number:208 pages:15 https://doaj.org/article/820df8ea6fa9426fae0d61aacbe6d0be kostenfrei http://jmums.mazums.ac.ir/article-1-17965-en.html kostenfrei https://doaj.org/toc/1735-9260 Journal toc kostenfrei https://doaj.org/toc/1735-9279 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 32 2022 208 15
allfieldsGer	(DE-627)DOAJ088439666 (DE-599)DOAJ820df8ea6fa9426fae0d61aacbe6d0be DE-627 ger DE-627 rakwb eng per R5-920 Mostafa Izanlu verfasserin aut Synergistic Effect of Hyperbaric Oxygen and Decellularized Human Amniotic Membrane on Full-Thickness Diabetic Wound Healing in Rats 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background and purpose: One of the common complications of diabetes is impairment of wound healing. The aim of the present study was to investigate the synergistic effect of hyperbaric oxygen (HBO) therapy and decellularized human amniotic membrane (dHAM) in healing of full-thickness diabetic wounds in rats. Materials and methods: In this experimental study, 60 diabetic male rats were randomly divided into four groups (n=15) as follows: untreated diabetic wound, wound treated with HBO, wound treated with dHAM, and wound treated with HBO+dHAM. Sampling was performed after 7, 14, and 21 days following wounding. Assessments included wound closure rate, histological (collagen density) and stereological examinations, expression of genes involved in repair and angiogenesis (TGF-β and VEGF), inflammatory genes (TNF-α and IL-1β), and wound tissue biomechanical properties. Results: Combined use of dHAM and HBO significantly increased wound closure rate, new epidermis and dermis volume, fibroblast cell and blood vessel density, collagen density, repair and angiogenesis genes, and wound biomechanical properties compared with those in the diabetic group (P<0.05). Also, the expression level of inflammatory genes and neutrophil density significantly decreased in all treatment groups, especially in HBO+dHAM group compared with the diabetic group (P<0.05). Conclusion: dHAM and HBO had a greater effect on the healing process of diabetic wounds when taken together than when each was taken separately. diabetic wound hyperbaric oxygen human amniotic membrane Medicine R Medicine (General) Alireza Khalatbary verfasserin aut Amin Aliabadi verfasserin aut Sima Davoodi verfasserin aut Amir Raoofi verfasserin aut Faezeh Modanloo verfasserin aut Davood Nasiry verfasserin aut In Journal of Mazandaran University of Medical Sciences Mazandaran University of Medical Sciences, 2018 32(2022), 208, Seite 15 (DE-627)59095623X (DE-600)2476989-7 17359279 nnns volume:32 year:2022 number:208 pages:15 https://doaj.org/article/820df8ea6fa9426fae0d61aacbe6d0be kostenfrei http://jmums.mazums.ac.ir/article-1-17965-en.html kostenfrei https://doaj.org/toc/1735-9260 Journal toc kostenfrei https://doaj.org/toc/1735-9279 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 32 2022 208 15
allfieldsSound	(DE-627)DOAJ088439666 (DE-599)DOAJ820df8ea6fa9426fae0d61aacbe6d0be DE-627 ger DE-627 rakwb eng per R5-920 Mostafa Izanlu verfasserin aut Synergistic Effect of Hyperbaric Oxygen and Decellularized Human Amniotic Membrane on Full-Thickness Diabetic Wound Healing in Rats 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background and purpose: One of the common complications of diabetes is impairment of wound healing. The aim of the present study was to investigate the synergistic effect of hyperbaric oxygen (HBO) therapy and decellularized human amniotic membrane (dHAM) in healing of full-thickness diabetic wounds in rats. Materials and methods: In this experimental study, 60 diabetic male rats were randomly divided into four groups (n=15) as follows: untreated diabetic wound, wound treated with HBO, wound treated with dHAM, and wound treated with HBO+dHAM. Sampling was performed after 7, 14, and 21 days following wounding. Assessments included wound closure rate, histological (collagen density) and stereological examinations, expression of genes involved in repair and angiogenesis (TGF-β and VEGF), inflammatory genes (TNF-α and IL-1β), and wound tissue biomechanical properties. Results: Combined use of dHAM and HBO significantly increased wound closure rate, new epidermis and dermis volume, fibroblast cell and blood vessel density, collagen density, repair and angiogenesis genes, and wound biomechanical properties compared with those in the diabetic group (P<0.05). Also, the expression level of inflammatory genes and neutrophil density significantly decreased in all treatment groups, especially in HBO+dHAM group compared with the diabetic group (P<0.05). Conclusion: dHAM and HBO had a greater effect on the healing process of diabetic wounds when taken together than when each was taken separately. diabetic wound hyperbaric oxygen human amniotic membrane Medicine R Medicine (General) Alireza Khalatbary verfasserin aut Amin Aliabadi verfasserin aut Sima Davoodi verfasserin aut Amir Raoofi verfasserin aut Faezeh Modanloo verfasserin aut Davood Nasiry verfasserin aut In Journal of Mazandaran University of Medical Sciences Mazandaran University of Medical Sciences, 2018 32(2022), 208, Seite 15 (DE-627)59095623X (DE-600)2476989-7 17359279 nnns volume:32 year:2022 number:208 pages:15 https://doaj.org/article/820df8ea6fa9426fae0d61aacbe6d0be kostenfrei http://jmums.mazums.ac.ir/article-1-17965-en.html kostenfrei https://doaj.org/toc/1735-9260 Journal toc kostenfrei https://doaj.org/toc/1735-9279 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 32 2022 208 15
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Results: Combined use of dHAM and HBO significantly increased wound closure rate, new epidermis and dermis volume, fibroblast cell and blood vessel density, collagen density, repair and angiogenesis genes, and wound biomechanical properties compared with those in the diabetic group (P<0.05). Also, the expression level of inflammatory genes and neutrophil density significantly decreased in all treatment groups, especially in HBO+dHAM group compared with the diabetic group (P<0.05). 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callnumber-first	R - Medicine
author	Mostafa Izanlu
spellingShingle	Mostafa Izanlu misc R5-920 misc diabetic wound misc hyperbaric oxygen misc human amniotic membrane misc Medicine misc R misc Medicine (General) Synergistic Effect of Hyperbaric Oxygen and Decellularized Human Amniotic Membrane on Full-Thickness Diabetic Wound Healing in Rats
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topic_title	R5-920 Synergistic Effect of Hyperbaric Oxygen and Decellularized Human Amniotic Membrane on Full-Thickness Diabetic Wound Healing in Rats diabetic wound hyperbaric oxygen human amniotic membrane
topic	misc R5-920 misc diabetic wound misc hyperbaric oxygen misc human amniotic membrane misc Medicine misc R misc Medicine (General)
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title	Synergistic Effect of Hyperbaric Oxygen and Decellularized Human Amniotic Membrane on Full-Thickness Diabetic Wound Healing in Rats
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title_full	Synergistic Effect of Hyperbaric Oxygen and Decellularized Human Amniotic Membrane on Full-Thickness Diabetic Wound Healing in Rats
author_sort	Mostafa Izanlu
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title_sort	synergistic effect of hyperbaric oxygen and decellularized human amniotic membrane on full-thickness diabetic wound healing in rats
callnumber	R5-920
title_auth	Synergistic Effect of Hyperbaric Oxygen and Decellularized Human Amniotic Membrane on Full-Thickness Diabetic Wound Healing in Rats
abstract	Background and purpose: One of the common complications of diabetes is impairment of wound healing. The aim of the present study was to investigate the synergistic effect of hyperbaric oxygen (HBO) therapy and decellularized human amniotic membrane (dHAM) in healing of full-thickness diabetic wounds in rats. Materials and methods: In this experimental study, 60 diabetic male rats were randomly divided into four groups (n=15) as follows: untreated diabetic wound, wound treated with HBO, wound treated with dHAM, and wound treated with HBO+dHAM. Sampling was performed after 7, 14, and 21 days following wounding. Assessments included wound closure rate, histological (collagen density) and stereological examinations, expression of genes involved in repair and angiogenesis (TGF-β and VEGF), inflammatory genes (TNF-α and IL-1β), and wound tissue biomechanical properties. Results: Combined use of dHAM and HBO significantly increased wound closure rate, new epidermis and dermis volume, fibroblast cell and blood vessel density, collagen density, repair and angiogenesis genes, and wound biomechanical properties compared with those in the diabetic group (P<0.05). Also, the expression level of inflammatory genes and neutrophil density significantly decreased in all treatment groups, especially in HBO+dHAM group compared with the diabetic group (P<0.05). Conclusion: dHAM and HBO had a greater effect on the healing process of diabetic wounds when taken together than when each was taken separately.
abstractGer	Background and purpose: One of the common complications of diabetes is impairment of wound healing. The aim of the present study was to investigate the synergistic effect of hyperbaric oxygen (HBO) therapy and decellularized human amniotic membrane (dHAM) in healing of full-thickness diabetic wounds in rats. Materials and methods: In this experimental study, 60 diabetic male rats were randomly divided into four groups (n=15) as follows: untreated diabetic wound, wound treated with HBO, wound treated with dHAM, and wound treated with HBO+dHAM. Sampling was performed after 7, 14, and 21 days following wounding. Assessments included wound closure rate, histological (collagen density) and stereological examinations, expression of genes involved in repair and angiogenesis (TGF-β and VEGF), inflammatory genes (TNF-α and IL-1β), and wound tissue biomechanical properties. Results: Combined use of dHAM and HBO significantly increased wound closure rate, new epidermis and dermis volume, fibroblast cell and blood vessel density, collagen density, repair and angiogenesis genes, and wound biomechanical properties compared with those in the diabetic group (P<0.05). Also, the expression level of inflammatory genes and neutrophil density significantly decreased in all treatment groups, especially in HBO+dHAM group compared with the diabetic group (P<0.05). Conclusion: dHAM and HBO had a greater effect on the healing process of diabetic wounds when taken together than when each was taken separately.
abstract_unstemmed	Background and purpose: One of the common complications of diabetes is impairment of wound healing. The aim of the present study was to investigate the synergistic effect of hyperbaric oxygen (HBO) therapy and decellularized human amniotic membrane (dHAM) in healing of full-thickness diabetic wounds in rats. Materials and methods: In this experimental study, 60 diabetic male rats were randomly divided into four groups (n=15) as follows: untreated diabetic wound, wound treated with HBO, wound treated with dHAM, and wound treated with HBO+dHAM. Sampling was performed after 7, 14, and 21 days following wounding. Assessments included wound closure rate, histological (collagen density) and stereological examinations, expression of genes involved in repair and angiogenesis (TGF-β and VEGF), inflammatory genes (TNF-α and IL-1β), and wound tissue biomechanical properties. Results: Combined use of dHAM and HBO significantly increased wound closure rate, new epidermis and dermis volume, fibroblast cell and blood vessel density, collagen density, repair and angiogenesis genes, and wound biomechanical properties compared with those in the diabetic group (P<0.05). Also, the expression level of inflammatory genes and neutrophil density significantly decreased in all treatment groups, especially in HBO+dHAM group compared with the diabetic group (P<0.05). Conclusion: dHAM and HBO had a greater effect on the healing process of diabetic wounds when taken together than when each was taken separately.
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title_short	Synergistic Effect of Hyperbaric Oxygen and Decellularized Human Amniotic Membrane on Full-Thickness Diabetic Wound Healing in Rats
url	https://doaj.org/article/820df8ea6fa9426fae0d61aacbe6d0be http://jmums.mazums.ac.ir/article-1-17965-en.html https://doaj.org/toc/1735-9260 https://doaj.org/toc/1735-9279
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author2	Alireza Khalatbary Amin Aliabadi Sima Davoodi Amir Raoofi Faezeh Modanloo Davood Nasiry
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up_date	2024-07-03T17:42:44.590Z
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Results: Combined use of dHAM and HBO significantly increased wound closure rate, new epidermis and dermis volume, fibroblast cell and blood vessel density, collagen density, repair and angiogenesis genes, and wound biomechanical properties compared with those in the diabetic group (P<0.05). Also, the expression level of inflammatory genes and neutrophil density significantly decreased in all treatment groups, especially in HBO+dHAM group compared with the diabetic group (P<0.05). 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Synergistic Effect of Hyperbaric Oxygen and Decellularized Human Amniotic Membrane on Full-Thickness Diabetic Wound Healing in Rats

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