Association of coronary artery calcium with heart rate variability in the Brazilian Longitudinal Study of Adult Health - ELSA-Brasil

Current data shows that the autonomic and vascular systems can influence each other. However, only a few studies have addressed this association in the general population. We aimed to investigate whether heart rate variability (HRV) was associated with coronary artery calcium (CAC) in a cross-sectio...
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Autor*in:	R.A. Hoshi [verfasserIn] I.S. Santos [verfasserIn] M.S. Bittencourt [verfasserIn] E.M. Dantas [verfasserIn] R.V. Andreão [verfasserIn] J.G. Mill [verfasserIn] P.A. Lotufo [verfasserIn] I.M. Benseñor [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2023

Schlagwörter:	Autonomic nervous system Atherosclerosis Heart rate control Vascular stiffness Vascular calcification

Übergeordnetes Werk:	In: Brazilian Journal of Medical and Biological Research - Associação Brasileira de Divulgação Científica, 2004, 56(2023)
Übergeordnetes Werk:	volume:56 ; year:2023

Links:	Link aufrufen Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.1590/1414-431x2023e12364

Katalog-ID:	DOAJ088457842

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allfields	10.1590/1414-431x2023e12364 doi (DE-627)DOAJ088457842 (DE-599)DOAJ9f047247c1de4d31b3e7b55cf738379e DE-627 ger DE-627 rakwb eng R5-920 QH301-705.5 R.A. Hoshi verfasserin aut Association of coronary artery calcium with heart rate variability in the Brazilian Longitudinal Study of Adult Health - ELSA-Brasil 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Current data shows that the autonomic and vascular systems can influence each other. However, only a few studies have addressed this association in the general population. We aimed to investigate whether heart rate variability (HRV) was associated with coronary artery calcium (CAC) in a cross-sectional analysis of the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil). We examined baseline data from 3138 participants (aged 35 to 74 years) without previous cardiovascular disease who underwent CAC score assessment and had validated HRV recordings. Prevalent CAC was defined as a CAC score<0, and HRV analyses were performed over 5-min segments. We detected CAC score<0 in 765 (24.4%) participants. Subgroup analyses in older participants (≥49 years) adjusted for sociodemographic and clinical variables revealed that CAC score<0 was associated with lower values of standard deviation of NN intervals (SDNN) (odds ratio [OR]=1.32; 95%CI: 1.05,1.65), root mean square of successive differences between adjacent NN intervals (RMSSD) (OR=1.28; 95%CI: 1.02,1.61), and low frequency (LF) (OR=1.53, 95%CI: 1.21,1.92). Interaction analysis between HRV indices and sex in age-stratified groups revealed significant effect modification: women showed increased OR for prevalent CAC in the younger group, while for men, the associations were in the older group. In conclusion, participants aged ≥49 years with low SDNN, RMSSD, and LF values were more likely to present prevalent CAC, suggesting a complex interaction between these markers in the pathogenesis of atherosclerosis. Furthermore, our results suggested that the relationship between CAC and HRV might be sex- and age-related. Autonomic nervous system Atherosclerosis Heart rate control Vascular stiffness Vascular calcification Medicine (General) Biology (General) I.S. Santos verfasserin aut M.S. Bittencourt verfasserin aut E.M. Dantas verfasserin aut R.V. Andreão verfasserin aut J.G. Mill verfasserin aut P.A. Lotufo verfasserin aut I.M. Benseñor verfasserin aut In Brazilian Journal of Medical and Biological Research Associação Brasileira de Divulgação Científica, 2004 56(2023) (DE-627)324613407 (DE-600)2028749-5 1414431X nnns volume:56 year:2023 https://doi.org/10.1590/1414-431x2023e12364 kostenfrei https://doaj.org/article/9f047247c1de4d31b3e7b55cf738379e kostenfrei http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2023000100611&lng=en&tlng=en kostenfrei http://www.scielo.br/pdf/bjmbr/v56/1414-431X-bjmbr-56-e12364.pdf kostenfrei https://doaj.org/toc/1414-431X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 56 2023
spelling	10.1590/1414-431x2023e12364 doi (DE-627)DOAJ088457842 (DE-599)DOAJ9f047247c1de4d31b3e7b55cf738379e DE-627 ger DE-627 rakwb eng R5-920 QH301-705.5 R.A. Hoshi verfasserin aut Association of coronary artery calcium with heart rate variability in the Brazilian Longitudinal Study of Adult Health - ELSA-Brasil 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Current data shows that the autonomic and vascular systems can influence each other. However, only a few studies have addressed this association in the general population. We aimed to investigate whether heart rate variability (HRV) was associated with coronary artery calcium (CAC) in a cross-sectional analysis of the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil). We examined baseline data from 3138 participants (aged 35 to 74 years) without previous cardiovascular disease who underwent CAC score assessment and had validated HRV recordings. Prevalent CAC was defined as a CAC score<0, and HRV analyses were performed over 5-min segments. We detected CAC score<0 in 765 (24.4%) participants. Subgroup analyses in older participants (≥49 years) adjusted for sociodemographic and clinical variables revealed that CAC score<0 was associated with lower values of standard deviation of NN intervals (SDNN) (odds ratio [OR]=1.32; 95%CI: 1.05,1.65), root mean square of successive differences between adjacent NN intervals (RMSSD) (OR=1.28; 95%CI: 1.02,1.61), and low frequency (LF) (OR=1.53, 95%CI: 1.21,1.92). Interaction analysis between HRV indices and sex in age-stratified groups revealed significant effect modification: women showed increased OR for prevalent CAC in the younger group, while for men, the associations were in the older group. In conclusion, participants aged ≥49 years with low SDNN, RMSSD, and LF values were more likely to present prevalent CAC, suggesting a complex interaction between these markers in the pathogenesis of atherosclerosis. Furthermore, our results suggested that the relationship between CAC and HRV might be sex- and age-related. Autonomic nervous system Atherosclerosis Heart rate control Vascular stiffness Vascular calcification Medicine (General) Biology (General) I.S. Santos verfasserin aut M.S. Bittencourt verfasserin aut E.M. Dantas verfasserin aut R.V. Andreão verfasserin aut J.G. Mill verfasserin aut P.A. Lotufo verfasserin aut I.M. Benseñor verfasserin aut In Brazilian Journal of Medical and Biological Research Associação Brasileira de Divulgação Científica, 2004 56(2023) (DE-627)324613407 (DE-600)2028749-5 1414431X nnns volume:56 year:2023 https://doi.org/10.1590/1414-431x2023e12364 kostenfrei https://doaj.org/article/9f047247c1de4d31b3e7b55cf738379e kostenfrei http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2023000100611&lng=en&tlng=en kostenfrei http://www.scielo.br/pdf/bjmbr/v56/1414-431X-bjmbr-56-e12364.pdf kostenfrei https://doaj.org/toc/1414-431X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 56 2023
allfields_unstemmed	10.1590/1414-431x2023e12364 doi (DE-627)DOAJ088457842 (DE-599)DOAJ9f047247c1de4d31b3e7b55cf738379e DE-627 ger DE-627 rakwb eng R5-920 QH301-705.5 R.A. Hoshi verfasserin aut Association of coronary artery calcium with heart rate variability in the Brazilian Longitudinal Study of Adult Health - ELSA-Brasil 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Current data shows that the autonomic and vascular systems can influence each other. However, only a few studies have addressed this association in the general population. We aimed to investigate whether heart rate variability (HRV) was associated with coronary artery calcium (CAC) in a cross-sectional analysis of the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil). We examined baseline data from 3138 participants (aged 35 to 74 years) without previous cardiovascular disease who underwent CAC score assessment and had validated HRV recordings. Prevalent CAC was defined as a CAC score<0, and HRV analyses were performed over 5-min segments. We detected CAC score<0 in 765 (24.4%) participants. Subgroup analyses in older participants (≥49 years) adjusted for sociodemographic and clinical variables revealed that CAC score<0 was associated with lower values of standard deviation of NN intervals (SDNN) (odds ratio [OR]=1.32; 95%CI: 1.05,1.65), root mean square of successive differences between adjacent NN intervals (RMSSD) (OR=1.28; 95%CI: 1.02,1.61), and low frequency (LF) (OR=1.53, 95%CI: 1.21,1.92). Interaction analysis between HRV indices and sex in age-stratified groups revealed significant effect modification: women showed increased OR for prevalent CAC in the younger group, while for men, the associations were in the older group. In conclusion, participants aged ≥49 years with low SDNN, RMSSD, and LF values were more likely to present prevalent CAC, suggesting a complex interaction between these markers in the pathogenesis of atherosclerosis. Furthermore, our results suggested that the relationship between CAC and HRV might be sex- and age-related. Autonomic nervous system Atherosclerosis Heart rate control Vascular stiffness Vascular calcification Medicine (General) Biology (General) I.S. Santos verfasserin aut M.S. Bittencourt verfasserin aut E.M. Dantas verfasserin aut R.V. Andreão verfasserin aut J.G. Mill verfasserin aut P.A. Lotufo verfasserin aut I.M. Benseñor verfasserin aut In Brazilian Journal of Medical and Biological Research Associação Brasileira de Divulgação Científica, 2004 56(2023) (DE-627)324613407 (DE-600)2028749-5 1414431X nnns volume:56 year:2023 https://doi.org/10.1590/1414-431x2023e12364 kostenfrei https://doaj.org/article/9f047247c1de4d31b3e7b55cf738379e kostenfrei http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2023000100611&lng=en&tlng=en kostenfrei http://www.scielo.br/pdf/bjmbr/v56/1414-431X-bjmbr-56-e12364.pdf kostenfrei https://doaj.org/toc/1414-431X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 56 2023
allfieldsGer	10.1590/1414-431x2023e12364 doi (DE-627)DOAJ088457842 (DE-599)DOAJ9f047247c1de4d31b3e7b55cf738379e DE-627 ger DE-627 rakwb eng R5-920 QH301-705.5 R.A. Hoshi verfasserin aut Association of coronary artery calcium with heart rate variability in the Brazilian Longitudinal Study of Adult Health - ELSA-Brasil 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Current data shows that the autonomic and vascular systems can influence each other. However, only a few studies have addressed this association in the general population. We aimed to investigate whether heart rate variability (HRV) was associated with coronary artery calcium (CAC) in a cross-sectional analysis of the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil). We examined baseline data from 3138 participants (aged 35 to 74 years) without previous cardiovascular disease who underwent CAC score assessment and had validated HRV recordings. Prevalent CAC was defined as a CAC score<0, and HRV analyses were performed over 5-min segments. We detected CAC score<0 in 765 (24.4%) participants. Subgroup analyses in older participants (≥49 years) adjusted for sociodemographic and clinical variables revealed that CAC score<0 was associated with lower values of standard deviation of NN intervals (SDNN) (odds ratio [OR]=1.32; 95%CI: 1.05,1.65), root mean square of successive differences between adjacent NN intervals (RMSSD) (OR=1.28; 95%CI: 1.02,1.61), and low frequency (LF) (OR=1.53, 95%CI: 1.21,1.92). Interaction analysis between HRV indices and sex in age-stratified groups revealed significant effect modification: women showed increased OR for prevalent CAC in the younger group, while for men, the associations were in the older group. In conclusion, participants aged ≥49 years with low SDNN, RMSSD, and LF values were more likely to present prevalent CAC, suggesting a complex interaction between these markers in the pathogenesis of atherosclerosis. Furthermore, our results suggested that the relationship between CAC and HRV might be sex- and age-related. Autonomic nervous system Atherosclerosis Heart rate control Vascular stiffness Vascular calcification Medicine (General) Biology (General) I.S. Santos verfasserin aut M.S. Bittencourt verfasserin aut E.M. Dantas verfasserin aut R.V. Andreão verfasserin aut J.G. Mill verfasserin aut P.A. Lotufo verfasserin aut I.M. Benseñor verfasserin aut In Brazilian Journal of Medical and Biological Research Associação Brasileira de Divulgação Científica, 2004 56(2023) (DE-627)324613407 (DE-600)2028749-5 1414431X nnns volume:56 year:2023 https://doi.org/10.1590/1414-431x2023e12364 kostenfrei https://doaj.org/article/9f047247c1de4d31b3e7b55cf738379e kostenfrei http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2023000100611&lng=en&tlng=en kostenfrei http://www.scielo.br/pdf/bjmbr/v56/1414-431X-bjmbr-56-e12364.pdf kostenfrei https://doaj.org/toc/1414-431X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 56 2023
allfieldsSound	10.1590/1414-431x2023e12364 doi (DE-627)DOAJ088457842 (DE-599)DOAJ9f047247c1de4d31b3e7b55cf738379e DE-627 ger DE-627 rakwb eng R5-920 QH301-705.5 R.A. Hoshi verfasserin aut Association of coronary artery calcium with heart rate variability in the Brazilian Longitudinal Study of Adult Health - ELSA-Brasil 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Current data shows that the autonomic and vascular systems can influence each other. However, only a few studies have addressed this association in the general population. We aimed to investigate whether heart rate variability (HRV) was associated with coronary artery calcium (CAC) in a cross-sectional analysis of the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil). We examined baseline data from 3138 participants (aged 35 to 74 years) without previous cardiovascular disease who underwent CAC score assessment and had validated HRV recordings. Prevalent CAC was defined as a CAC score<0, and HRV analyses were performed over 5-min segments. We detected CAC score<0 in 765 (24.4%) participants. Subgroup analyses in older participants (≥49 years) adjusted for sociodemographic and clinical variables revealed that CAC score<0 was associated with lower values of standard deviation of NN intervals (SDNN) (odds ratio [OR]=1.32; 95%CI: 1.05,1.65), root mean square of successive differences between adjacent NN intervals (RMSSD) (OR=1.28; 95%CI: 1.02,1.61), and low frequency (LF) (OR=1.53, 95%CI: 1.21,1.92). Interaction analysis between HRV indices and sex in age-stratified groups revealed significant effect modification: women showed increased OR for prevalent CAC in the younger group, while for men, the associations were in the older group. In conclusion, participants aged ≥49 years with low SDNN, RMSSD, and LF values were more likely to present prevalent CAC, suggesting a complex interaction between these markers in the pathogenesis of atherosclerosis. Furthermore, our results suggested that the relationship between CAC and HRV might be sex- and age-related. Autonomic nervous system Atherosclerosis Heart rate control Vascular stiffness Vascular calcification Medicine (General) Biology (General) I.S. Santos verfasserin aut M.S. Bittencourt verfasserin aut E.M. Dantas verfasserin aut R.V. Andreão verfasserin aut J.G. Mill verfasserin aut P.A. Lotufo verfasserin aut I.M. Benseñor verfasserin aut In Brazilian Journal of Medical and Biological Research Associação Brasileira de Divulgação Científica, 2004 56(2023) (DE-627)324613407 (DE-600)2028749-5 1414431X nnns volume:56 year:2023 https://doi.org/10.1590/1414-431x2023e12364 kostenfrei https://doaj.org/article/9f047247c1de4d31b3e7b55cf738379e kostenfrei http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2023000100611&lng=en&tlng=en kostenfrei http://www.scielo.br/pdf/bjmbr/v56/1414-431X-bjmbr-56-e12364.pdf kostenfrei https://doaj.org/toc/1414-431X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 56 2023
language	English
source	In Brazilian Journal of Medical and Biological Research 56(2023) volume:56 year:2023
sourceStr	In Brazilian Journal of Medical and Biological Research 56(2023) volume:56 year:2023
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	Autonomic nervous system Atherosclerosis Heart rate control Vascular stiffness Vascular calcification Medicine (General) Biology (General)
isfreeaccess_bool	true
container_title	Brazilian Journal of Medical and Biological Research
authorswithroles_txt_mv	R.A. Hoshi @@aut@@ I.S. Santos @@aut@@ M.S. Bittencourt @@aut@@ E.M. Dantas @@aut@@ R.V. Andreão @@aut@@ J.G. Mill @@aut@@ P.A. Lotufo @@aut@@ I.M. Benseñor @@aut@@
publishDateDaySort_date	2023-01-01T00:00:00Z
hierarchy_top_id	324613407
id	DOAJ088457842
language_de	englisch
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callnumber-first	R - Medicine
author	R.A. Hoshi
spellingShingle	R.A. Hoshi misc R5-920 misc QH301-705.5 misc Autonomic nervous system misc Atherosclerosis misc Heart rate control misc Vascular stiffness misc Vascular calcification misc Medicine (General) misc Biology (General) Association of coronary artery calcium with heart rate variability in the Brazilian Longitudinal Study of Adult Health - ELSA-Brasil
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topic_title	R5-920 QH301-705.5 Association of coronary artery calcium with heart rate variability in the Brazilian Longitudinal Study of Adult Health - ELSA-Brasil Autonomic nervous system Atherosclerosis Heart rate control Vascular stiffness Vascular calcification
topic	misc R5-920 misc QH301-705.5 misc Autonomic nervous system misc Atherosclerosis misc Heart rate control misc Vascular stiffness misc Vascular calcification misc Medicine (General) misc Biology (General)
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title	Association of coronary artery calcium with heart rate variability in the Brazilian Longitudinal Study of Adult Health - ELSA-Brasil
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title_full	Association of coronary artery calcium with heart rate variability in the Brazilian Longitudinal Study of Adult Health - ELSA-Brasil
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author_browse	R.A. Hoshi I.S. Santos M.S. Bittencourt E.M. Dantas R.V. Andreão J.G. Mill P.A. Lotufo I.M. Benseñor
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title_sort	association of coronary artery calcium with heart rate variability in the brazilian longitudinal study of adult health - elsa-brasil
callnumber	R5-920
title_auth	Association of coronary artery calcium with heart rate variability in the Brazilian Longitudinal Study of Adult Health - ELSA-Brasil
abstract	Current data shows that the autonomic and vascular systems can influence each other. However, only a few studies have addressed this association in the general population. We aimed to investigate whether heart rate variability (HRV) was associated with coronary artery calcium (CAC) in a cross-sectional analysis of the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil). We examined baseline data from 3138 participants (aged 35 to 74 years) without previous cardiovascular disease who underwent CAC score assessment and had validated HRV recordings. Prevalent CAC was defined as a CAC score<0, and HRV analyses were performed over 5-min segments. We detected CAC score<0 in 765 (24.4%) participants. Subgroup analyses in older participants (≥49 years) adjusted for sociodemographic and clinical variables revealed that CAC score<0 was associated with lower values of standard deviation of NN intervals (SDNN) (odds ratio [OR]=1.32; 95%CI: 1.05,1.65), root mean square of successive differences between adjacent NN intervals (RMSSD) (OR=1.28; 95%CI: 1.02,1.61), and low frequency (LF) (OR=1.53, 95%CI: 1.21,1.92). Interaction analysis between HRV indices and sex in age-stratified groups revealed significant effect modification: women showed increased OR for prevalent CAC in the younger group, while for men, the associations were in the older group. In conclusion, participants aged ≥49 years with low SDNN, RMSSD, and LF values were more likely to present prevalent CAC, suggesting a complex interaction between these markers in the pathogenesis of atherosclerosis. Furthermore, our results suggested that the relationship between CAC and HRV might be sex- and age-related.
abstractGer	Current data shows that the autonomic and vascular systems can influence each other. However, only a few studies have addressed this association in the general population. We aimed to investigate whether heart rate variability (HRV) was associated with coronary artery calcium (CAC) in a cross-sectional analysis of the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil). We examined baseline data from 3138 participants (aged 35 to 74 years) without previous cardiovascular disease who underwent CAC score assessment and had validated HRV recordings. Prevalent CAC was defined as a CAC score<0, and HRV analyses were performed over 5-min segments. We detected CAC score<0 in 765 (24.4%) participants. Subgroup analyses in older participants (≥49 years) adjusted for sociodemographic and clinical variables revealed that CAC score<0 was associated with lower values of standard deviation of NN intervals (SDNN) (odds ratio [OR]=1.32; 95%CI: 1.05,1.65), root mean square of successive differences between adjacent NN intervals (RMSSD) (OR=1.28; 95%CI: 1.02,1.61), and low frequency (LF) (OR=1.53, 95%CI: 1.21,1.92). Interaction analysis between HRV indices and sex in age-stratified groups revealed significant effect modification: women showed increased OR for prevalent CAC in the younger group, while for men, the associations were in the older group. In conclusion, participants aged ≥49 years with low SDNN, RMSSD, and LF values were more likely to present prevalent CAC, suggesting a complex interaction between these markers in the pathogenesis of atherosclerosis. Furthermore, our results suggested that the relationship between CAC and HRV might be sex- and age-related.
abstract_unstemmed	Current data shows that the autonomic and vascular systems can influence each other. However, only a few studies have addressed this association in the general population. We aimed to investigate whether heart rate variability (HRV) was associated with coronary artery calcium (CAC) in a cross-sectional analysis of the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil). We examined baseline data from 3138 participants (aged 35 to 74 years) without previous cardiovascular disease who underwent CAC score assessment and had validated HRV recordings. Prevalent CAC was defined as a CAC score<0, and HRV analyses were performed over 5-min segments. We detected CAC score<0 in 765 (24.4%) participants. Subgroup analyses in older participants (≥49 years) adjusted for sociodemographic and clinical variables revealed that CAC score<0 was associated with lower values of standard deviation of NN intervals (SDNN) (odds ratio [OR]=1.32; 95%CI: 1.05,1.65), root mean square of successive differences between adjacent NN intervals (RMSSD) (OR=1.28; 95%CI: 1.02,1.61), and low frequency (LF) (OR=1.53, 95%CI: 1.21,1.92). Interaction analysis between HRV indices and sex in age-stratified groups revealed significant effect modification: women showed increased OR for prevalent CAC in the younger group, while for men, the associations were in the older group. In conclusion, participants aged ≥49 years with low SDNN, RMSSD, and LF values were more likely to present prevalent CAC, suggesting a complex interaction between these markers in the pathogenesis of atherosclerosis. Furthermore, our results suggested that the relationship between CAC and HRV might be sex- and age-related.
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title_short	Association of coronary artery calcium with heart rate variability in the Brazilian Longitudinal Study of Adult Health - ELSA-Brasil
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