Prevalence of COVID Associated Mucormycosis with Antifungal Susceptibility Profiles of Isolates in a Tertiary Care Hospital

Mucormycosis is an angioinvasive opportunistic fungal infection, but these have become emerging pathogens, especially in conditions with underlying predisposing risk factors in a favourable setting. With the exponential rise in COVID-19 cases, there was an increase in the number of mucormycosis case...
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Autor*in:	V. Dillirani [verfasserIn] R. Menaka [verfasserIn] V. Indumathi [verfasserIn] P. Balaji [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2023

Schlagwörter:	covid-19 mucormycosis antifungal susceptibility rhizopus sp

Übergeordnetes Werk:	In: Journal of Pure and Applied Microbiology - Journal of Pure and Applied Microbiology, 2019, 17(2023), 1, Seite 266-272
Übergeordnetes Werk:	volume:17 ; year:2023 ; number:1 ; pages:266-272

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc Journal toc

Katalog-ID:	DOAJ088475468

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520			\|a Mucormycosis is an angioinvasive opportunistic fungal infection, but these have become emerging pathogens, especially in conditions with underlying predisposing risk factors in a favourable setting. With the exponential rise in COVID-19 cases, there was an increase in the number of mucormycosis cases among them. The global prevalence rate of mucormycosis in COVID-19 globally varies from 0.005 to 1.7 per million population and in India, it is approximately 0.14 cases/1000. The objective of this study is to detect the prevalence of mucormycosis with the antifungal susceptibility pattern among COVID-19 patients admitted in our hospital. A total of 347 COVID-19 and post-COVID-19 patients with symptoms suggestive of mucormycosis were included in this study. Nasal scrapings, debrided necrotic tissue, unhealthy tissue bits and biopsy tissues taken through FESS were processed for mycological examination under sterile conditions. Among the total 347 samples processed, 87(25%) were positive for fungal culture. Among the culture positves 7.8% (25) belong to mucorales. Among the total 87 fungal isolates, the majority of organism isolated was Aspergillus sp(68%), followed by Rhizopus sp (18%). Rhizopus/Aspergillus sp (5%), Mucor species (5%), Rhizomucor sp (2%), Mucor/Aspergillus sp(1%), Curvularia sp (1%) were the other fungi isolated. All the strains of Mucorales were sensitive to Posaconazole and one strain showed resistance to amphotericin B with MIC 8 µg/ml by microbroth dilution method based on CLSI M27 guidelines for Amphotericin B, and Posaconazole.
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allfields	(DE-627)DOAJ088475468 (DE-599)DOAJ6b618913d2ca42c4b65c0270840af01c DE-627 ger DE-627 rakwb eng QR1-502 V. Dillirani verfasserin aut Prevalence of COVID Associated Mucormycosis with Antifungal Susceptibility Profiles of Isolates in a Tertiary Care Hospital 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Mucormycosis is an angioinvasive opportunistic fungal infection, but these have become emerging pathogens, especially in conditions with underlying predisposing risk factors in a favourable setting. With the exponential rise in COVID-19 cases, there was an increase in the number of mucormycosis cases among them. The global prevalence rate of mucormycosis in COVID-19 globally varies from 0.005 to 1.7 per million population and in India, it is approximately 0.14 cases/1000. The objective of this study is to detect the prevalence of mucormycosis with the antifungal susceptibility pattern among COVID-19 patients admitted in our hospital. A total of 347 COVID-19 and post-COVID-19 patients with symptoms suggestive of mucormycosis were included in this study. Nasal scrapings, debrided necrotic tissue, unhealthy tissue bits and biopsy tissues taken through FESS were processed for mycological examination under sterile conditions. Among the total 347 samples processed, 87(25%) were positive for fungal culture. Among the culture positves 7.8% (25) belong to mucorales. Among the total 87 fungal isolates, the majority of organism isolated was Aspergillus sp(68%), followed by Rhizopus sp (18%). Rhizopus/Aspergillus sp (5%), Mucor species (5%), Rhizomucor sp (2%), Mucor/Aspergillus sp(1%), Curvularia sp (1%) were the other fungi isolated. All the strains of Mucorales were sensitive to Posaconazole and one strain showed resistance to amphotericin B with MIC 8 µg/ml by microbroth dilution method based on CLSI M27 guidelines for Amphotericin B, and Posaconazole. covid-19 mucormycosis antifungal susceptibility rhizopus sp Microbiology R. Menaka verfasserin aut V. Indumathi verfasserin aut P. Balaji verfasserin aut In Journal of Pure and Applied Microbiology Journal of Pure and Applied Microbiology, 2019 17(2023), 1, Seite 266-272 (DE-627)857236156 (DE-600)2853403-7 2581690X nnns volume:17 year:2023 number:1 pages:266-272 https://doi.org/10.22207/JPAM.17.1.16 kostenfrei https://doaj.org/article/6b618913d2ca42c4b65c0270840af01c kostenfrei https://microbiologyjournal.org/prevalence-of-covid-associated-mucormycosis-with-antifungal-susceptibility-profiles-of-isolates-in-a-tertiary-care-hospital/ kostenfrei https://doaj.org/toc/0973-7510 Journal toc kostenfrei https://doaj.org/toc/2581-690X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 17 2023 1 266-272
spelling	(DE-627)DOAJ088475468 (DE-599)DOAJ6b618913d2ca42c4b65c0270840af01c DE-627 ger DE-627 rakwb eng QR1-502 V. Dillirani verfasserin aut Prevalence of COVID Associated Mucormycosis with Antifungal Susceptibility Profiles of Isolates in a Tertiary Care Hospital 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Mucormycosis is an angioinvasive opportunistic fungal infection, but these have become emerging pathogens, especially in conditions with underlying predisposing risk factors in a favourable setting. With the exponential rise in COVID-19 cases, there was an increase in the number of mucormycosis cases among them. The global prevalence rate of mucormycosis in COVID-19 globally varies from 0.005 to 1.7 per million population and in India, it is approximately 0.14 cases/1000. The objective of this study is to detect the prevalence of mucormycosis with the antifungal susceptibility pattern among COVID-19 patients admitted in our hospital. A total of 347 COVID-19 and post-COVID-19 patients with symptoms suggestive of mucormycosis were included in this study. Nasal scrapings, debrided necrotic tissue, unhealthy tissue bits and biopsy tissues taken through FESS were processed for mycological examination under sterile conditions. Among the total 347 samples processed, 87(25%) were positive for fungal culture. Among the culture positves 7.8% (25) belong to mucorales. Among the total 87 fungal isolates, the majority of organism isolated was Aspergillus sp(68%), followed by Rhizopus sp (18%). Rhizopus/Aspergillus sp (5%), Mucor species (5%), Rhizomucor sp (2%), Mucor/Aspergillus sp(1%), Curvularia sp (1%) were the other fungi isolated. All the strains of Mucorales were sensitive to Posaconazole and one strain showed resistance to amphotericin B with MIC 8 µg/ml by microbroth dilution method based on CLSI M27 guidelines for Amphotericin B, and Posaconazole. covid-19 mucormycosis antifungal susceptibility rhizopus sp Microbiology R. Menaka verfasserin aut V. Indumathi verfasserin aut P. Balaji verfasserin aut In Journal of Pure and Applied Microbiology Journal of Pure and Applied Microbiology, 2019 17(2023), 1, Seite 266-272 (DE-627)857236156 (DE-600)2853403-7 2581690X nnns volume:17 year:2023 number:1 pages:266-272 https://doi.org/10.22207/JPAM.17.1.16 kostenfrei https://doaj.org/article/6b618913d2ca42c4b65c0270840af01c kostenfrei https://microbiologyjournal.org/prevalence-of-covid-associated-mucormycosis-with-antifungal-susceptibility-profiles-of-isolates-in-a-tertiary-care-hospital/ kostenfrei https://doaj.org/toc/0973-7510 Journal toc kostenfrei https://doaj.org/toc/2581-690X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 17 2023 1 266-272
allfields_unstemmed	(DE-627)DOAJ088475468 (DE-599)DOAJ6b618913d2ca42c4b65c0270840af01c DE-627 ger DE-627 rakwb eng QR1-502 V. Dillirani verfasserin aut Prevalence of COVID Associated Mucormycosis with Antifungal Susceptibility Profiles of Isolates in a Tertiary Care Hospital 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Mucormycosis is an angioinvasive opportunistic fungal infection, but these have become emerging pathogens, especially in conditions with underlying predisposing risk factors in a favourable setting. With the exponential rise in COVID-19 cases, there was an increase in the number of mucormycosis cases among them. The global prevalence rate of mucormycosis in COVID-19 globally varies from 0.005 to 1.7 per million population and in India, it is approximately 0.14 cases/1000. The objective of this study is to detect the prevalence of mucormycosis with the antifungal susceptibility pattern among COVID-19 patients admitted in our hospital. A total of 347 COVID-19 and post-COVID-19 patients with symptoms suggestive of mucormycosis were included in this study. Nasal scrapings, debrided necrotic tissue, unhealthy tissue bits and biopsy tissues taken through FESS were processed for mycological examination under sterile conditions. Among the total 347 samples processed, 87(25%) were positive for fungal culture. Among the culture positves 7.8% (25) belong to mucorales. Among the total 87 fungal isolates, the majority of organism isolated was Aspergillus sp(68%), followed by Rhizopus sp (18%). Rhizopus/Aspergillus sp (5%), Mucor species (5%), Rhizomucor sp (2%), Mucor/Aspergillus sp(1%), Curvularia sp (1%) were the other fungi isolated. All the strains of Mucorales were sensitive to Posaconazole and one strain showed resistance to amphotericin B with MIC 8 µg/ml by microbroth dilution method based on CLSI M27 guidelines for Amphotericin B, and Posaconazole. covid-19 mucormycosis antifungal susceptibility rhizopus sp Microbiology R. Menaka verfasserin aut V. Indumathi verfasserin aut P. Balaji verfasserin aut In Journal of Pure and Applied Microbiology Journal of Pure and Applied Microbiology, 2019 17(2023), 1, Seite 266-272 (DE-627)857236156 (DE-600)2853403-7 2581690X nnns volume:17 year:2023 number:1 pages:266-272 https://doi.org/10.22207/JPAM.17.1.16 kostenfrei https://doaj.org/article/6b618913d2ca42c4b65c0270840af01c kostenfrei https://microbiologyjournal.org/prevalence-of-covid-associated-mucormycosis-with-antifungal-susceptibility-profiles-of-isolates-in-a-tertiary-care-hospital/ kostenfrei https://doaj.org/toc/0973-7510 Journal toc kostenfrei https://doaj.org/toc/2581-690X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 17 2023 1 266-272
allfieldsGer	(DE-627)DOAJ088475468 (DE-599)DOAJ6b618913d2ca42c4b65c0270840af01c DE-627 ger DE-627 rakwb eng QR1-502 V. Dillirani verfasserin aut Prevalence of COVID Associated Mucormycosis with Antifungal Susceptibility Profiles of Isolates in a Tertiary Care Hospital 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Mucormycosis is an angioinvasive opportunistic fungal infection, but these have become emerging pathogens, especially in conditions with underlying predisposing risk factors in a favourable setting. With the exponential rise in COVID-19 cases, there was an increase in the number of mucormycosis cases among them. The global prevalence rate of mucormycosis in COVID-19 globally varies from 0.005 to 1.7 per million population and in India, it is approximately 0.14 cases/1000. The objective of this study is to detect the prevalence of mucormycosis with the antifungal susceptibility pattern among COVID-19 patients admitted in our hospital. A total of 347 COVID-19 and post-COVID-19 patients with symptoms suggestive of mucormycosis were included in this study. Nasal scrapings, debrided necrotic tissue, unhealthy tissue bits and biopsy tissues taken through FESS were processed for mycological examination under sterile conditions. Among the total 347 samples processed, 87(25%) were positive for fungal culture. Among the culture positves 7.8% (25) belong to mucorales. Among the total 87 fungal isolates, the majority of organism isolated was Aspergillus sp(68%), followed by Rhizopus sp (18%). Rhizopus/Aspergillus sp (5%), Mucor species (5%), Rhizomucor sp (2%), Mucor/Aspergillus sp(1%), Curvularia sp (1%) were the other fungi isolated. All the strains of Mucorales were sensitive to Posaconazole and one strain showed resistance to amphotericin B with MIC 8 µg/ml by microbroth dilution method based on CLSI M27 guidelines for Amphotericin B, and Posaconazole. covid-19 mucormycosis antifungal susceptibility rhizopus sp Microbiology R. Menaka verfasserin aut V. Indumathi verfasserin aut P. Balaji verfasserin aut In Journal of Pure and Applied Microbiology Journal of Pure and Applied Microbiology, 2019 17(2023), 1, Seite 266-272 (DE-627)857236156 (DE-600)2853403-7 2581690X nnns volume:17 year:2023 number:1 pages:266-272 https://doi.org/10.22207/JPAM.17.1.16 kostenfrei https://doaj.org/article/6b618913d2ca42c4b65c0270840af01c kostenfrei https://microbiologyjournal.org/prevalence-of-covid-associated-mucormycosis-with-antifungal-susceptibility-profiles-of-isolates-in-a-tertiary-care-hospital/ kostenfrei https://doaj.org/toc/0973-7510 Journal toc kostenfrei https://doaj.org/toc/2581-690X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 17 2023 1 266-272
allfieldsSound	(DE-627)DOAJ088475468 (DE-599)DOAJ6b618913d2ca42c4b65c0270840af01c DE-627 ger DE-627 rakwb eng QR1-502 V. Dillirani verfasserin aut Prevalence of COVID Associated Mucormycosis with Antifungal Susceptibility Profiles of Isolates in a Tertiary Care Hospital 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Mucormycosis is an angioinvasive opportunistic fungal infection, but these have become emerging pathogens, especially in conditions with underlying predisposing risk factors in a favourable setting. With the exponential rise in COVID-19 cases, there was an increase in the number of mucormycosis cases among them. The global prevalence rate of mucormycosis in COVID-19 globally varies from 0.005 to 1.7 per million population and in India, it is approximately 0.14 cases/1000. The objective of this study is to detect the prevalence of mucormycosis with the antifungal susceptibility pattern among COVID-19 patients admitted in our hospital. A total of 347 COVID-19 and post-COVID-19 patients with symptoms suggestive of mucormycosis were included in this study. Nasal scrapings, debrided necrotic tissue, unhealthy tissue bits and biopsy tissues taken through FESS were processed for mycological examination under sterile conditions. Among the total 347 samples processed, 87(25%) were positive for fungal culture. Among the culture positves 7.8% (25) belong to mucorales. Among the total 87 fungal isolates, the majority of organism isolated was Aspergillus sp(68%), followed by Rhizopus sp (18%). Rhizopus/Aspergillus sp (5%), Mucor species (5%), Rhizomucor sp (2%), Mucor/Aspergillus sp(1%), Curvularia sp (1%) were the other fungi isolated. All the strains of Mucorales were sensitive to Posaconazole and one strain showed resistance to amphotericin B with MIC 8 µg/ml by microbroth dilution method based on CLSI M27 guidelines for Amphotericin B, and Posaconazole. covid-19 mucormycosis antifungal susceptibility rhizopus sp Microbiology R. Menaka verfasserin aut V. Indumathi verfasserin aut P. Balaji verfasserin aut In Journal of Pure and Applied Microbiology Journal of Pure and Applied Microbiology, 2019 17(2023), 1, Seite 266-272 (DE-627)857236156 (DE-600)2853403-7 2581690X nnns volume:17 year:2023 number:1 pages:266-272 https://doi.org/10.22207/JPAM.17.1.16 kostenfrei https://doaj.org/article/6b618913d2ca42c4b65c0270840af01c kostenfrei https://microbiologyjournal.org/prevalence-of-covid-associated-mucormycosis-with-antifungal-susceptibility-profiles-of-isolates-in-a-tertiary-care-hospital/ kostenfrei https://doaj.org/toc/0973-7510 Journal toc kostenfrei https://doaj.org/toc/2581-690X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 17 2023 1 266-272
language	English
source	In Journal of Pure and Applied Microbiology 17(2023), 1, Seite 266-272 volume:17 year:2023 number:1 pages:266-272
sourceStr	In Journal of Pure and Applied Microbiology 17(2023), 1, Seite 266-272 volume:17 year:2023 number:1 pages:266-272
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	covid-19 mucormycosis antifungal susceptibility rhizopus sp Microbiology
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container_title	Journal of Pure and Applied Microbiology
authorswithroles_txt_mv	V. Dillirani @@aut@@ R. Menaka @@aut@@ V. Indumathi @@aut@@ P. Balaji @@aut@@
publishDateDaySort_date	2023-01-01T00:00:00Z
hierarchy_top_id	857236156
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language_de	englisch
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callnumber-first	Q - Science
author	V. Dillirani
spellingShingle	V. Dillirani misc QR1-502 misc covid-19 misc mucormycosis misc antifungal susceptibility misc rhizopus sp misc Microbiology Prevalence of COVID Associated Mucormycosis with Antifungal Susceptibility Profiles of Isolates in a Tertiary Care Hospital
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topic_title	QR1-502 Prevalence of COVID Associated Mucormycosis with Antifungal Susceptibility Profiles of Isolates in a Tertiary Care Hospital covid-19 mucormycosis antifungal susceptibility rhizopus sp
topic	misc QR1-502 misc covid-19 misc mucormycosis misc antifungal susceptibility misc rhizopus sp misc Microbiology
topic_unstemmed	misc QR1-502 misc covid-19 misc mucormycosis misc antifungal susceptibility misc rhizopus sp misc Microbiology
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title	Prevalence of COVID Associated Mucormycosis with Antifungal Susceptibility Profiles of Isolates in a Tertiary Care Hospital
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title_full	Prevalence of COVID Associated Mucormycosis with Antifungal Susceptibility Profiles of Isolates in a Tertiary Care Hospital
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author_browse	V. Dillirani R. Menaka V. Indumathi P. Balaji
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title_sort	prevalence of covid associated mucormycosis with antifungal susceptibility profiles of isolates in a tertiary care hospital
callnumber	QR1-502
title_auth	Prevalence of COVID Associated Mucormycosis with Antifungal Susceptibility Profiles of Isolates in a Tertiary Care Hospital
abstract	Mucormycosis is an angioinvasive opportunistic fungal infection, but these have become emerging pathogens, especially in conditions with underlying predisposing risk factors in a favourable setting. With the exponential rise in COVID-19 cases, there was an increase in the number of mucormycosis cases among them. The global prevalence rate of mucormycosis in COVID-19 globally varies from 0.005 to 1.7 per million population and in India, it is approximately 0.14 cases/1000. The objective of this study is to detect the prevalence of mucormycosis with the antifungal susceptibility pattern among COVID-19 patients admitted in our hospital. A total of 347 COVID-19 and post-COVID-19 patients with symptoms suggestive of mucormycosis were included in this study. Nasal scrapings, debrided necrotic tissue, unhealthy tissue bits and biopsy tissues taken through FESS were processed for mycological examination under sterile conditions. Among the total 347 samples processed, 87(25%) were positive for fungal culture. Among the culture positves 7.8% (25) belong to mucorales. Among the total 87 fungal isolates, the majority of organism isolated was Aspergillus sp(68%), followed by Rhizopus sp (18%). Rhizopus/Aspergillus sp (5%), Mucor species (5%), Rhizomucor sp (2%), Mucor/Aspergillus sp(1%), Curvularia sp (1%) were the other fungi isolated. All the strains of Mucorales were sensitive to Posaconazole and one strain showed resistance to amphotericin B with MIC 8 µg/ml by microbroth dilution method based on CLSI M27 guidelines for Amphotericin B, and Posaconazole.
abstractGer	Mucormycosis is an angioinvasive opportunistic fungal infection, but these have become emerging pathogens, especially in conditions with underlying predisposing risk factors in a favourable setting. With the exponential rise in COVID-19 cases, there was an increase in the number of mucormycosis cases among them. The global prevalence rate of mucormycosis in COVID-19 globally varies from 0.005 to 1.7 per million population and in India, it is approximately 0.14 cases/1000. The objective of this study is to detect the prevalence of mucormycosis with the antifungal susceptibility pattern among COVID-19 patients admitted in our hospital. A total of 347 COVID-19 and post-COVID-19 patients with symptoms suggestive of mucormycosis were included in this study. Nasal scrapings, debrided necrotic tissue, unhealthy tissue bits and biopsy tissues taken through FESS were processed for mycological examination under sterile conditions. Among the total 347 samples processed, 87(25%) were positive for fungal culture. Among the culture positves 7.8% (25) belong to mucorales. Among the total 87 fungal isolates, the majority of organism isolated was Aspergillus sp(68%), followed by Rhizopus sp (18%). Rhizopus/Aspergillus sp (5%), Mucor species (5%), Rhizomucor sp (2%), Mucor/Aspergillus sp(1%), Curvularia sp (1%) were the other fungi isolated. All the strains of Mucorales were sensitive to Posaconazole and one strain showed resistance to amphotericin B with MIC 8 µg/ml by microbroth dilution method based on CLSI M27 guidelines for Amphotericin B, and Posaconazole.
abstract_unstemmed	Mucormycosis is an angioinvasive opportunistic fungal infection, but these have become emerging pathogens, especially in conditions with underlying predisposing risk factors in a favourable setting. With the exponential rise in COVID-19 cases, there was an increase in the number of mucormycosis cases among them. The global prevalence rate of mucormycosis in COVID-19 globally varies from 0.005 to 1.7 per million population and in India, it is approximately 0.14 cases/1000. The objective of this study is to detect the prevalence of mucormycosis with the antifungal susceptibility pattern among COVID-19 patients admitted in our hospital. A total of 347 COVID-19 and post-COVID-19 patients with symptoms suggestive of mucormycosis were included in this study. Nasal scrapings, debrided necrotic tissue, unhealthy tissue bits and biopsy tissues taken through FESS were processed for mycological examination under sterile conditions. Among the total 347 samples processed, 87(25%) were positive for fungal culture. Among the culture positves 7.8% (25) belong to mucorales. Among the total 87 fungal isolates, the majority of organism isolated was Aspergillus sp(68%), followed by Rhizopus sp (18%). Rhizopus/Aspergillus sp (5%), Mucor species (5%), Rhizomucor sp (2%), Mucor/Aspergillus sp(1%), Curvularia sp (1%) were the other fungi isolated. All the strains of Mucorales were sensitive to Posaconazole and one strain showed resistance to amphotericin B with MIC 8 µg/ml by microbroth dilution method based on CLSI M27 guidelines for Amphotericin B, and Posaconazole.
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container_issue	1
title_short	Prevalence of COVID Associated Mucormycosis with Antifungal Susceptibility Profiles of Isolates in a Tertiary Care Hospital
url	https://doi.org/10.22207/JPAM.17.1.16 https://doaj.org/article/6b618913d2ca42c4b65c0270840af01c https://microbiologyjournal.org/prevalence-of-covid-associated-mucormycosis-with-antifungal-susceptibility-profiles-of-isolates-in-a-tertiary-care-hospital/ https://doaj.org/toc/0973-7510 https://doaj.org/toc/2581-690X
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Prevalence of COVID Associated Mucormycosis with Antifungal Susceptibility Profiles of Isolates in a Tertiary Care Hospital

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