Combining Fat-to-Muscle Ratio and Alanine Aminotransferase/Aspartate Aminotransferase Ratio in the Prediction of Cardiometabolic Risk: A Cross-Sectional Study
Fengqin Yan, Guqiao Nie, Nianli Zhou, Meng Zhang, Wen Peng Department of General Practice, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People’s Republic of ChinaCorrespondence: Wen Peng, Department of General Practice, Union Hospital, Tongji Medical...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Yan F [verfasserIn] Nie G [verfasserIn] Zhou N [verfasserIn] Zhang M [verfasserIn] Peng W [verfasserIn] |
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E-Artikel |
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Englisch |
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2023 |
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In: Diabetes, Metabolic Syndrome and Obesity - Dove Medical Press, 2009, (2023), Seite 795-806 |
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| Übergeordnetes Werk: |
year:2023 ; pages:795-806 |
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DOAJ088524698 |
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| 520 | |a Fengqin Yan, Guqiao Nie, Nianli Zhou, Meng Zhang, Wen Peng Department of General Practice, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People’s Republic of ChinaCorrespondence: Wen Peng, Department of General Practice, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1277 Jiefang Avenue, Jianghan District, Wuhan, People’s Republic of China, Tel +86 13986074846, Email pengwen666sina.comPurpose: Altered body composition and liver enzymes are known to be related to cardiometabolic risk. Our study aimed to evaluate the association between fat-to-muscle ratio (FMR), alanine aminotransferase/aspartate aminotransferase (ALT/AST) ratio and cardiometabolic risk.Methods: In total, 1557 participants aged ≥ 40 years were included. A bioelectrical impedance analyzer (BIA) was used to measure fat mass and muscle mass. We created a cardiometabolic risk score with one point for each cardiometabolic risk factor, including elevated triglycerides (TGs), decreased high-density lipoprotein cholesterol (HDL-C), elevated blood pressure (BP), and abnormal blood glucose, yielding a score of 0– 4 for each participant (≥ 2 for high-risk and < 2 for low-risk). Logistic regression analyses were used to analyze the relationship between FMR, ALT/AST ratio and cardiometabolic risk.Results: FMR and ALT/AST ratio were significantly higher in the high-risk group than in the low-risk group (P< 0.001). FMR and ALT/AST ratio were both positively correlated with a higher cardiometabolic risk score and the presence of each cardiometabolic risk factor. In subgroup analyses categorized according to FMR and ALT/AST ratio cutoffs, the high-FMR/high-ALT/AST group had the highest cardiometabolic risk (OR=8.51; 95% CI 4.46– 16.25 in women and OR=5.09; 95% CI 3.39– 7.65 in men) after adjusting for confounders.Conclusion: FMR and ALT/AST ratio were positively associated with cardiometabolic risk. Combining these two indicators improved the prediction of cardiometabolic risk.Keywords: body composition, liver enzymes, cardiometabolic disease | ||
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(DE-627)DOAJ088524698 (DE-599)DOAJf6fbe29e9583448bb4cd46e8c906437a DE-627 ger DE-627 rakwb eng RC581-951 Yan F verfasserin aut Combining Fat-to-Muscle Ratio and Alanine Aminotransferase/Aspartate Aminotransferase Ratio in the Prediction of Cardiometabolic Risk: A Cross-Sectional Study 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Fengqin Yan, Guqiao Nie, Nianli Zhou, Meng Zhang, Wen Peng Department of General Practice, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People’s Republic of ChinaCorrespondence: Wen Peng, Department of General Practice, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1277 Jiefang Avenue, Jianghan District, Wuhan, People’s Republic of China, Tel +86 13986074846, Email pengwen666sina.comPurpose: Altered body composition and liver enzymes are known to be related to cardiometabolic risk. Our study aimed to evaluate the association between fat-to-muscle ratio (FMR), alanine aminotransferase/aspartate aminotransferase (ALT/AST) ratio and cardiometabolic risk.Methods: In total, 1557 participants aged ≥ 40 years were included. A bioelectrical impedance analyzer (BIA) was used to measure fat mass and muscle mass. We created a cardiometabolic risk score with one point for each cardiometabolic risk factor, including elevated triglycerides (TGs), decreased high-density lipoprotein cholesterol (HDL-C), elevated blood pressure (BP), and abnormal blood glucose, yielding a score of 0– 4 for each participant (≥ 2 for high-risk and < 2 for low-risk). Logistic regression analyses were used to analyze the relationship between FMR, ALT/AST ratio and cardiometabolic risk.Results: FMR and ALT/AST ratio were significantly higher in the high-risk group than in the low-risk group (P< 0.001). FMR and ALT/AST ratio were both positively correlated with a higher cardiometabolic risk score and the presence of each cardiometabolic risk factor. In subgroup analyses categorized according to FMR and ALT/AST ratio cutoffs, the high-FMR/high-ALT/AST group had the highest cardiometabolic risk (OR=8.51; 95% CI 4.46– 16.25 in women and OR=5.09; 95% CI 3.39– 7.65 in men) after adjusting for confounders.Conclusion: FMR and ALT/AST ratio were positively associated with cardiometabolic risk. Combining these two indicators improved the prediction of cardiometabolic risk.Keywords: body composition, liver enzymes, cardiometabolic disease body composition liver enzymes cardiometabolic diseases Specialties of internal medicine Nie G verfasserin aut Zhou N verfasserin aut Zhang M verfasserin aut Peng W verfasserin aut In Diabetes, Metabolic Syndrome and Obesity Dove Medical Press, 2009 (2023), Seite 795-806 (DE-627)60030597X (DE-600)2494854-8 11787007 nnns year:2023 pages:795-806 https://doaj.org/article/f6fbe29e9583448bb4cd46e8c906437a kostenfrei https://www.dovepress.com/combining-fat-to-muscle-ratio-and-alanine-aminotransferaseaspartate-am-peer-reviewed-fulltext-article-DMSO kostenfrei https://doaj.org/toc/1178-7007 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 2023 795-806 |
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(DE-627)DOAJ088524698 (DE-599)DOAJf6fbe29e9583448bb4cd46e8c906437a DE-627 ger DE-627 rakwb eng RC581-951 Yan F verfasserin aut Combining Fat-to-Muscle Ratio and Alanine Aminotransferase/Aspartate Aminotransferase Ratio in the Prediction of Cardiometabolic Risk: A Cross-Sectional Study 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Fengqin Yan, Guqiao Nie, Nianli Zhou, Meng Zhang, Wen Peng Department of General Practice, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People’s Republic of ChinaCorrespondence: Wen Peng, Department of General Practice, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1277 Jiefang Avenue, Jianghan District, Wuhan, People’s Republic of China, Tel +86 13986074846, Email pengwen666sina.comPurpose: Altered body composition and liver enzymes are known to be related to cardiometabolic risk. Our study aimed to evaluate the association between fat-to-muscle ratio (FMR), alanine aminotransferase/aspartate aminotransferase (ALT/AST) ratio and cardiometabolic risk.Methods: In total, 1557 participants aged ≥ 40 years were included. A bioelectrical impedance analyzer (BIA) was used to measure fat mass and muscle mass. We created a cardiometabolic risk score with one point for each cardiometabolic risk factor, including elevated triglycerides (TGs), decreased high-density lipoprotein cholesterol (HDL-C), elevated blood pressure (BP), and abnormal blood glucose, yielding a score of 0– 4 for each participant (≥ 2 for high-risk and < 2 for low-risk). Logistic regression analyses were used to analyze the relationship between FMR, ALT/AST ratio and cardiometabolic risk.Results: FMR and ALT/AST ratio were significantly higher in the high-risk group than in the low-risk group (P< 0.001). FMR and ALT/AST ratio were both positively correlated with a higher cardiometabolic risk score and the presence of each cardiometabolic risk factor. In subgroup analyses categorized according to FMR and ALT/AST ratio cutoffs, the high-FMR/high-ALT/AST group had the highest cardiometabolic risk (OR=8.51; 95% CI 4.46– 16.25 in women and OR=5.09; 95% CI 3.39– 7.65 in men) after adjusting for confounders.Conclusion: FMR and ALT/AST ratio were positively associated with cardiometabolic risk. Combining these two indicators improved the prediction of cardiometabolic risk.Keywords: body composition, liver enzymes, cardiometabolic disease body composition liver enzymes cardiometabolic diseases Specialties of internal medicine Nie G verfasserin aut Zhou N verfasserin aut Zhang M verfasserin aut Peng W verfasserin aut In Diabetes, Metabolic Syndrome and Obesity Dove Medical Press, 2009 (2023), Seite 795-806 (DE-627)60030597X (DE-600)2494854-8 11787007 nnns year:2023 pages:795-806 https://doaj.org/article/f6fbe29e9583448bb4cd46e8c906437a kostenfrei https://www.dovepress.com/combining-fat-to-muscle-ratio-and-alanine-aminotransferaseaspartate-am-peer-reviewed-fulltext-article-DMSO kostenfrei https://doaj.org/toc/1178-7007 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 2023 795-806 |
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(DE-627)DOAJ088524698 (DE-599)DOAJf6fbe29e9583448bb4cd46e8c906437a DE-627 ger DE-627 rakwb eng RC581-951 Yan F verfasserin aut Combining Fat-to-Muscle Ratio and Alanine Aminotransferase/Aspartate Aminotransferase Ratio in the Prediction of Cardiometabolic Risk: A Cross-Sectional Study 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Fengqin Yan, Guqiao Nie, Nianli Zhou, Meng Zhang, Wen Peng Department of General Practice, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People’s Republic of ChinaCorrespondence: Wen Peng, Department of General Practice, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1277 Jiefang Avenue, Jianghan District, Wuhan, People’s Republic of China, Tel +86 13986074846, Email pengwen666sina.comPurpose: Altered body composition and liver enzymes are known to be related to cardiometabolic risk. Our study aimed to evaluate the association between fat-to-muscle ratio (FMR), alanine aminotransferase/aspartate aminotransferase (ALT/AST) ratio and cardiometabolic risk.Methods: In total, 1557 participants aged ≥ 40 years were included. A bioelectrical impedance analyzer (BIA) was used to measure fat mass and muscle mass. We created a cardiometabolic risk score with one point for each cardiometabolic risk factor, including elevated triglycerides (TGs), decreased high-density lipoprotein cholesterol (HDL-C), elevated blood pressure (BP), and abnormal blood glucose, yielding a score of 0– 4 for each participant (≥ 2 for high-risk and < 2 for low-risk). Logistic regression analyses were used to analyze the relationship between FMR, ALT/AST ratio and cardiometabolic risk.Results: FMR and ALT/AST ratio were significantly higher in the high-risk group than in the low-risk group (P< 0.001). FMR and ALT/AST ratio were both positively correlated with a higher cardiometabolic risk score and the presence of each cardiometabolic risk factor. In subgroup analyses categorized according to FMR and ALT/AST ratio cutoffs, the high-FMR/high-ALT/AST group had the highest cardiometabolic risk (OR=8.51; 95% CI 4.46– 16.25 in women and OR=5.09; 95% CI 3.39– 7.65 in men) after adjusting for confounders.Conclusion: FMR and ALT/AST ratio were positively associated with cardiometabolic risk. Combining these two indicators improved the prediction of cardiometabolic risk.Keywords: body composition, liver enzymes, cardiometabolic disease body composition liver enzymes cardiometabolic diseases Specialties of internal medicine Nie G verfasserin aut Zhou N verfasserin aut Zhang M verfasserin aut Peng W verfasserin aut In Diabetes, Metabolic Syndrome and Obesity Dove Medical Press, 2009 (2023), Seite 795-806 (DE-627)60030597X (DE-600)2494854-8 11787007 nnns year:2023 pages:795-806 https://doaj.org/article/f6fbe29e9583448bb4cd46e8c906437a kostenfrei https://www.dovepress.com/combining-fat-to-muscle-ratio-and-alanine-aminotransferaseaspartate-am-peer-reviewed-fulltext-article-DMSO kostenfrei https://doaj.org/toc/1178-7007 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 2023 795-806 |
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(DE-627)DOAJ088524698 (DE-599)DOAJf6fbe29e9583448bb4cd46e8c906437a DE-627 ger DE-627 rakwb eng RC581-951 Yan F verfasserin aut Combining Fat-to-Muscle Ratio and Alanine Aminotransferase/Aspartate Aminotransferase Ratio in the Prediction of Cardiometabolic Risk: A Cross-Sectional Study 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Fengqin Yan, Guqiao Nie, Nianli Zhou, Meng Zhang, Wen Peng Department of General Practice, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People’s Republic of ChinaCorrespondence: Wen Peng, Department of General Practice, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1277 Jiefang Avenue, Jianghan District, Wuhan, People’s Republic of China, Tel +86 13986074846, Email pengwen666sina.comPurpose: Altered body composition and liver enzymes are known to be related to cardiometabolic risk. Our study aimed to evaluate the association between fat-to-muscle ratio (FMR), alanine aminotransferase/aspartate aminotransferase (ALT/AST) ratio and cardiometabolic risk.Methods: In total, 1557 participants aged ≥ 40 years were included. A bioelectrical impedance analyzer (BIA) was used to measure fat mass and muscle mass. We created a cardiometabolic risk score with one point for each cardiometabolic risk factor, including elevated triglycerides (TGs), decreased high-density lipoprotein cholesterol (HDL-C), elevated blood pressure (BP), and abnormal blood glucose, yielding a score of 0– 4 for each participant (≥ 2 for high-risk and < 2 for low-risk). Logistic regression analyses were used to analyze the relationship between FMR, ALT/AST ratio and cardiometabolic risk.Results: FMR and ALT/AST ratio were significantly higher in the high-risk group than in the low-risk group (P< 0.001). FMR and ALT/AST ratio were both positively correlated with a higher cardiometabolic risk score and the presence of each cardiometabolic risk factor. In subgroup analyses categorized according to FMR and ALT/AST ratio cutoffs, the high-FMR/high-ALT/AST group had the highest cardiometabolic risk (OR=8.51; 95% CI 4.46– 16.25 in women and OR=5.09; 95% CI 3.39– 7.65 in men) after adjusting for confounders.Conclusion: FMR and ALT/AST ratio were positively associated with cardiometabolic risk. Combining these two indicators improved the prediction of cardiometabolic risk.Keywords: body composition, liver enzymes, cardiometabolic disease body composition liver enzymes cardiometabolic diseases Specialties of internal medicine Nie G verfasserin aut Zhou N verfasserin aut Zhang M verfasserin aut Peng W verfasserin aut In Diabetes, Metabolic Syndrome and Obesity Dove Medical Press, 2009 (2023), Seite 795-806 (DE-627)60030597X (DE-600)2494854-8 11787007 nnns year:2023 pages:795-806 https://doaj.org/article/f6fbe29e9583448bb4cd46e8c906437a kostenfrei https://www.dovepress.com/combining-fat-to-muscle-ratio-and-alanine-aminotransferaseaspartate-am-peer-reviewed-fulltext-article-DMSO kostenfrei https://doaj.org/toc/1178-7007 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 2023 795-806 |
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(DE-627)DOAJ088524698 (DE-599)DOAJf6fbe29e9583448bb4cd46e8c906437a DE-627 ger DE-627 rakwb eng RC581-951 Yan F verfasserin aut Combining Fat-to-Muscle Ratio and Alanine Aminotransferase/Aspartate Aminotransferase Ratio in the Prediction of Cardiometabolic Risk: A Cross-Sectional Study 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Fengqin Yan, Guqiao Nie, Nianli Zhou, Meng Zhang, Wen Peng Department of General Practice, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People’s Republic of ChinaCorrespondence: Wen Peng, Department of General Practice, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1277 Jiefang Avenue, Jianghan District, Wuhan, People’s Republic of China, Tel +86 13986074846, Email pengwen666sina.comPurpose: Altered body composition and liver enzymes are known to be related to cardiometabolic risk. Our study aimed to evaluate the association between fat-to-muscle ratio (FMR), alanine aminotransferase/aspartate aminotransferase (ALT/AST) ratio and cardiometabolic risk.Methods: In total, 1557 participants aged ≥ 40 years were included. A bioelectrical impedance analyzer (BIA) was used to measure fat mass and muscle mass. We created a cardiometabolic risk score with one point for each cardiometabolic risk factor, including elevated triglycerides (TGs), decreased high-density lipoprotein cholesterol (HDL-C), elevated blood pressure (BP), and abnormal blood glucose, yielding a score of 0– 4 for each participant (≥ 2 for high-risk and < 2 for low-risk). Logistic regression analyses were used to analyze the relationship between FMR, ALT/AST ratio and cardiometabolic risk.Results: FMR and ALT/AST ratio were significantly higher in the high-risk group than in the low-risk group (P< 0.001). FMR and ALT/AST ratio were both positively correlated with a higher cardiometabolic risk score and the presence of each cardiometabolic risk factor. In subgroup analyses categorized according to FMR and ALT/AST ratio cutoffs, the high-FMR/high-ALT/AST group had the highest cardiometabolic risk (OR=8.51; 95% CI 4.46– 16.25 in women and OR=5.09; 95% CI 3.39– 7.65 in men) after adjusting for confounders.Conclusion: FMR and ALT/AST ratio were positively associated with cardiometabolic risk. Combining these two indicators improved the prediction of cardiometabolic risk.Keywords: body composition, liver enzymes, cardiometabolic disease body composition liver enzymes cardiometabolic diseases Specialties of internal medicine Nie G verfasserin aut Zhou N verfasserin aut Zhang M verfasserin aut Peng W verfasserin aut In Diabetes, Metabolic Syndrome and Obesity Dove Medical Press, 2009 (2023), Seite 795-806 (DE-627)60030597X (DE-600)2494854-8 11787007 nnns year:2023 pages:795-806 https://doaj.org/article/f6fbe29e9583448bb4cd46e8c906437a kostenfrei https://www.dovepress.com/combining-fat-to-muscle-ratio-and-alanine-aminotransferaseaspartate-am-peer-reviewed-fulltext-article-DMSO kostenfrei https://doaj.org/toc/1178-7007 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 2023 795-806 |
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Combining Fat-to-Muscle Ratio and Alanine Aminotransferase/Aspartate Aminotransferase Ratio in the Prediction of Cardiometabolic Risk: A Cross-Sectional Study |
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Fengqin Yan, Guqiao Nie, Nianli Zhou, Meng Zhang, Wen Peng Department of General Practice, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People’s Republic of ChinaCorrespondence: Wen Peng, Department of General Practice, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1277 Jiefang Avenue, Jianghan District, Wuhan, People’s Republic of China, Tel +86 13986074846, Email pengwen666sina.comPurpose: Altered body composition and liver enzymes are known to be related to cardiometabolic risk. Our study aimed to evaluate the association between fat-to-muscle ratio (FMR), alanine aminotransferase/aspartate aminotransferase (ALT/AST) ratio and cardiometabolic risk.Methods: In total, 1557 participants aged ≥ 40 years were included. A bioelectrical impedance analyzer (BIA) was used to measure fat mass and muscle mass. We created a cardiometabolic risk score with one point for each cardiometabolic risk factor, including elevated triglycerides (TGs), decreased high-density lipoprotein cholesterol (HDL-C), elevated blood pressure (BP), and abnormal blood glucose, yielding a score of 0– 4 for each participant (≥ 2 for high-risk and < 2 for low-risk). Logistic regression analyses were used to analyze the relationship between FMR, ALT/AST ratio and cardiometabolic risk.Results: FMR and ALT/AST ratio were significantly higher in the high-risk group than in the low-risk group (P< 0.001). FMR and ALT/AST ratio were both positively correlated with a higher cardiometabolic risk score and the presence of each cardiometabolic risk factor. In subgroup analyses categorized according to FMR and ALT/AST ratio cutoffs, the high-FMR/high-ALT/AST group had the highest cardiometabolic risk (OR=8.51; 95% CI 4.46– 16.25 in women and OR=5.09; 95% CI 3.39– 7.65 in men) after adjusting for confounders.Conclusion: FMR and ALT/AST ratio were positively associated with cardiometabolic risk. Combining these two indicators improved the prediction of cardiometabolic risk.Keywords: body composition, liver enzymes, cardiometabolic disease |
| abstractGer |
Fengqin Yan, Guqiao Nie, Nianli Zhou, Meng Zhang, Wen Peng Department of General Practice, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People’s Republic of ChinaCorrespondence: Wen Peng, Department of General Practice, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1277 Jiefang Avenue, Jianghan District, Wuhan, People’s Republic of China, Tel +86 13986074846, Email pengwen666sina.comPurpose: Altered body composition and liver enzymes are known to be related to cardiometabolic risk. Our study aimed to evaluate the association between fat-to-muscle ratio (FMR), alanine aminotransferase/aspartate aminotransferase (ALT/AST) ratio and cardiometabolic risk.Methods: In total, 1557 participants aged ≥ 40 years were included. A bioelectrical impedance analyzer (BIA) was used to measure fat mass and muscle mass. We created a cardiometabolic risk score with one point for each cardiometabolic risk factor, including elevated triglycerides (TGs), decreased high-density lipoprotein cholesterol (HDL-C), elevated blood pressure (BP), and abnormal blood glucose, yielding a score of 0– 4 for each participant (≥ 2 for high-risk and < 2 for low-risk). Logistic regression analyses were used to analyze the relationship between FMR, ALT/AST ratio and cardiometabolic risk.Results: FMR and ALT/AST ratio were significantly higher in the high-risk group than in the low-risk group (P< 0.001). FMR and ALT/AST ratio were both positively correlated with a higher cardiometabolic risk score and the presence of each cardiometabolic risk factor. In subgroup analyses categorized according to FMR and ALT/AST ratio cutoffs, the high-FMR/high-ALT/AST group had the highest cardiometabolic risk (OR=8.51; 95% CI 4.46– 16.25 in women and OR=5.09; 95% CI 3.39– 7.65 in men) after adjusting for confounders.Conclusion: FMR and ALT/AST ratio were positively associated with cardiometabolic risk. Combining these two indicators improved the prediction of cardiometabolic risk.Keywords: body composition, liver enzymes, cardiometabolic disease |
| abstract_unstemmed |
Fengqin Yan, Guqiao Nie, Nianli Zhou, Meng Zhang, Wen Peng Department of General Practice, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People’s Republic of ChinaCorrespondence: Wen Peng, Department of General Practice, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1277 Jiefang Avenue, Jianghan District, Wuhan, People’s Republic of China, Tel +86 13986074846, Email pengwen666sina.comPurpose: Altered body composition and liver enzymes are known to be related to cardiometabolic risk. Our study aimed to evaluate the association between fat-to-muscle ratio (FMR), alanine aminotransferase/aspartate aminotransferase (ALT/AST) ratio and cardiometabolic risk.Methods: In total, 1557 participants aged ≥ 40 years were included. A bioelectrical impedance analyzer (BIA) was used to measure fat mass and muscle mass. We created a cardiometabolic risk score with one point for each cardiometabolic risk factor, including elevated triglycerides (TGs), decreased high-density lipoprotein cholesterol (HDL-C), elevated blood pressure (BP), and abnormal blood glucose, yielding a score of 0– 4 for each participant (≥ 2 for high-risk and < 2 for low-risk). Logistic regression analyses were used to analyze the relationship between FMR, ALT/AST ratio and cardiometabolic risk.Results: FMR and ALT/AST ratio were significantly higher in the high-risk group than in the low-risk group (P< 0.001). FMR and ALT/AST ratio were both positively correlated with a higher cardiometabolic risk score and the presence of each cardiometabolic risk factor. In subgroup analyses categorized according to FMR and ALT/AST ratio cutoffs, the high-FMR/high-ALT/AST group had the highest cardiometabolic risk (OR=8.51; 95% CI 4.46– 16.25 in women and OR=5.09; 95% CI 3.39– 7.65 in men) after adjusting for confounders.Conclusion: FMR and ALT/AST ratio were positively associated with cardiometabolic risk. Combining these two indicators improved the prediction of cardiometabolic risk.Keywords: body composition, liver enzymes, cardiometabolic disease |
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Combining Fat-to-Muscle Ratio and Alanine Aminotransferase/Aspartate Aminotransferase Ratio in the Prediction of Cardiometabolic Risk: A Cross-Sectional Study |
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https://doaj.org/article/f6fbe29e9583448bb4cd46e8c906437a https://www.dovepress.com/combining-fat-to-muscle-ratio-and-alanine-aminotransferaseaspartate-am-peer-reviewed-fulltext-article-DMSO https://doaj.org/toc/1178-7007 |
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2024-07-03T18:07:10.363Z |
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Our study aimed to evaluate the association between fat-to-muscle ratio (FMR), alanine aminotransferase/aspartate aminotransferase (ALT/AST) ratio and cardiometabolic risk.Methods: In total, 1557 participants aged ≥ 40 years were included. A bioelectrical impedance analyzer (BIA) was used to measure fat mass and muscle mass. We created a cardiometabolic risk score with one point for each cardiometabolic risk factor, including elevated triglycerides (TGs), decreased high-density lipoprotein cholesterol (HDL-C), elevated blood pressure (BP), and abnormal blood glucose, yielding a score of 0– 4 for each participant (≥ 2 for high-risk and < 2 for low-risk). Logistic regression analyses were used to analyze the relationship between FMR, ALT/AST ratio and cardiometabolic risk.Results: FMR and ALT/AST ratio were significantly higher in the high-risk group than in the low-risk group (P< 0.001). 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