Delayed hypersensitivity reaction to allopurinol: A case report

Allopurinol is the well-known first-line treatment option for symptomatic hyperuricaemia and gout. It is cost-effective particularly for the management of chronic gout. The common early side effects of allopurinol are skin rashes, diarrhoea and nausea. Meanwhile, a dangerous concerning complication...
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Autor*in:	Mohammad Che Man [verfasserIn] Shahidah Che Alhadi [verfasserIn] Wan Fatimah Suriyani Wan Mahmud [verfasserIn] Salman Amiruddin [verfasserIn] Mohd Zhafri Mohd Razib [verfasserIn] Rasimah Ismail [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2023

Schlagwörter:	delayed hypersensitivity allopurinol rashes xanthine oxidase inhibitor

Übergeordnetes Werk:	In: Malaysian Family Physician - Academy of Family Physicians of Malaysia, 2017, 18, p 11(2023)
Übergeordnetes Werk:	volume:18, p 11 ; year:2023

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc Journal toc

DOI / URN:	10.51866/cr.65

Katalog-ID:	DOAJ088643379

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allfields	10.51866/cr.65 doi (DE-627)DOAJ088643379 (DE-599)DOAJ852b3676e0ea458287bb85ba462bc0e4 DE-627 ger DE-627 rakwb eng Mohammad Che Man verfasserin aut Delayed hypersensitivity reaction to allopurinol: A case report 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Allopurinol is the well-known first-line treatment option for symptomatic hyperuricaemia and gout. It is cost-effective particularly for the management of chronic gout. The common early side effects of allopurinol are skin rashes, diarrhoea and nausea. Meanwhile, a dangerous concerning complication is Stevens–Johnson syndrome, which can cause severe morbidity and mortality. Delayed hypersensitivity to allopurinol is rare but should be one of the differential diagnoses if a patient with underlying gout on chronic allopurinol treatment presents with skin rashes. The present case highlights the importance of a high index of suspicion in at-risk patients with underlying gout along with skin rashes on long-term allopurinol treatment to avoid unnecessary patient management. delayed hypersensitivity allopurinol rashes xanthine oxidase inhibitor Medicine R Shahidah Che Alhadi verfasserin aut Wan Fatimah Suriyani Wan Mahmud verfasserin aut Salman Amiruddin verfasserin aut Mohd Zhafri Mohd Razib verfasserin aut Rasimah Ismail verfasserin aut In Malaysian Family Physician Academy of Family Physicians of Malaysia, 2017 18, p 11(2023) (DE-627)52289898X (DE-600)2265779-4 19852274 nnns volume:18, p 11 year:2023 https://doi.org/10.51866/cr.65 kostenfrei https://doaj.org/article/852b3676e0ea458287bb85ba462bc0e4 kostenfrei https://e-mfp.org/wp-content/uploads/18.11CRDelayedhypersensitivity.pdf kostenfrei https://doaj.org/toc/1985-207X Journal toc kostenfrei https://doaj.org/toc/1985-2274 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 18, p 11 2023
spelling	10.51866/cr.65 doi (DE-627)DOAJ088643379 (DE-599)DOAJ852b3676e0ea458287bb85ba462bc0e4 DE-627 ger DE-627 rakwb eng Mohammad Che Man verfasserin aut Delayed hypersensitivity reaction to allopurinol: A case report 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Allopurinol is the well-known first-line treatment option for symptomatic hyperuricaemia and gout. It is cost-effective particularly for the management of chronic gout. The common early side effects of allopurinol are skin rashes, diarrhoea and nausea. Meanwhile, a dangerous concerning complication is Stevens–Johnson syndrome, which can cause severe morbidity and mortality. Delayed hypersensitivity to allopurinol is rare but should be one of the differential diagnoses if a patient with underlying gout on chronic allopurinol treatment presents with skin rashes. The present case highlights the importance of a high index of suspicion in at-risk patients with underlying gout along with skin rashes on long-term allopurinol treatment to avoid unnecessary patient management. delayed hypersensitivity allopurinol rashes xanthine oxidase inhibitor Medicine R Shahidah Che Alhadi verfasserin aut Wan Fatimah Suriyani Wan Mahmud verfasserin aut Salman Amiruddin verfasserin aut Mohd Zhafri Mohd Razib verfasserin aut Rasimah Ismail verfasserin aut In Malaysian Family Physician Academy of Family Physicians of Malaysia, 2017 18, p 11(2023) (DE-627)52289898X (DE-600)2265779-4 19852274 nnns volume:18, p 11 year:2023 https://doi.org/10.51866/cr.65 kostenfrei https://doaj.org/article/852b3676e0ea458287bb85ba462bc0e4 kostenfrei https://e-mfp.org/wp-content/uploads/18.11CRDelayedhypersensitivity.pdf kostenfrei https://doaj.org/toc/1985-207X Journal toc kostenfrei https://doaj.org/toc/1985-2274 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 18, p 11 2023
allfields_unstemmed	10.51866/cr.65 doi (DE-627)DOAJ088643379 (DE-599)DOAJ852b3676e0ea458287bb85ba462bc0e4 DE-627 ger DE-627 rakwb eng Mohammad Che Man verfasserin aut Delayed hypersensitivity reaction to allopurinol: A case report 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Allopurinol is the well-known first-line treatment option for symptomatic hyperuricaemia and gout. It is cost-effective particularly for the management of chronic gout. The common early side effects of allopurinol are skin rashes, diarrhoea and nausea. Meanwhile, a dangerous concerning complication is Stevens–Johnson syndrome, which can cause severe morbidity and mortality. Delayed hypersensitivity to allopurinol is rare but should be one of the differential diagnoses if a patient with underlying gout on chronic allopurinol treatment presents with skin rashes. The present case highlights the importance of a high index of suspicion in at-risk patients with underlying gout along with skin rashes on long-term allopurinol treatment to avoid unnecessary patient management. delayed hypersensitivity allopurinol rashes xanthine oxidase inhibitor Medicine R Shahidah Che Alhadi verfasserin aut Wan Fatimah Suriyani Wan Mahmud verfasserin aut Salman Amiruddin verfasserin aut Mohd Zhafri Mohd Razib verfasserin aut Rasimah Ismail verfasserin aut In Malaysian Family Physician Academy of Family Physicians of Malaysia, 2017 18, p 11(2023) (DE-627)52289898X (DE-600)2265779-4 19852274 nnns volume:18, p 11 year:2023 https://doi.org/10.51866/cr.65 kostenfrei https://doaj.org/article/852b3676e0ea458287bb85ba462bc0e4 kostenfrei https://e-mfp.org/wp-content/uploads/18.11CRDelayedhypersensitivity.pdf kostenfrei https://doaj.org/toc/1985-207X Journal toc kostenfrei https://doaj.org/toc/1985-2274 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 18, p 11 2023
allfieldsGer	10.51866/cr.65 doi (DE-627)DOAJ088643379 (DE-599)DOAJ852b3676e0ea458287bb85ba462bc0e4 DE-627 ger DE-627 rakwb eng Mohammad Che Man verfasserin aut Delayed hypersensitivity reaction to allopurinol: A case report 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Allopurinol is the well-known first-line treatment option for symptomatic hyperuricaemia and gout. It is cost-effective particularly for the management of chronic gout. The common early side effects of allopurinol are skin rashes, diarrhoea and nausea. Meanwhile, a dangerous concerning complication is Stevens–Johnson syndrome, which can cause severe morbidity and mortality. Delayed hypersensitivity to allopurinol is rare but should be one of the differential diagnoses if a patient with underlying gout on chronic allopurinol treatment presents with skin rashes. The present case highlights the importance of a high index of suspicion in at-risk patients with underlying gout along with skin rashes on long-term allopurinol treatment to avoid unnecessary patient management. delayed hypersensitivity allopurinol rashes xanthine oxidase inhibitor Medicine R Shahidah Che Alhadi verfasserin aut Wan Fatimah Suriyani Wan Mahmud verfasserin aut Salman Amiruddin verfasserin aut Mohd Zhafri Mohd Razib verfasserin aut Rasimah Ismail verfasserin aut In Malaysian Family Physician Academy of Family Physicians of Malaysia, 2017 18, p 11(2023) (DE-627)52289898X (DE-600)2265779-4 19852274 nnns volume:18, p 11 year:2023 https://doi.org/10.51866/cr.65 kostenfrei https://doaj.org/article/852b3676e0ea458287bb85ba462bc0e4 kostenfrei https://e-mfp.org/wp-content/uploads/18.11CRDelayedhypersensitivity.pdf kostenfrei https://doaj.org/toc/1985-207X Journal toc kostenfrei https://doaj.org/toc/1985-2274 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 18, p 11 2023
allfieldsSound	10.51866/cr.65 doi (DE-627)DOAJ088643379 (DE-599)DOAJ852b3676e0ea458287bb85ba462bc0e4 DE-627 ger DE-627 rakwb eng Mohammad Che Man verfasserin aut Delayed hypersensitivity reaction to allopurinol: A case report 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Allopurinol is the well-known first-line treatment option for symptomatic hyperuricaemia and gout. It is cost-effective particularly for the management of chronic gout. The common early side effects of allopurinol are skin rashes, diarrhoea and nausea. Meanwhile, a dangerous concerning complication is Stevens–Johnson syndrome, which can cause severe morbidity and mortality. Delayed hypersensitivity to allopurinol is rare but should be one of the differential diagnoses if a patient with underlying gout on chronic allopurinol treatment presents with skin rashes. The present case highlights the importance of a high index of suspicion in at-risk patients with underlying gout along with skin rashes on long-term allopurinol treatment to avoid unnecessary patient management. delayed hypersensitivity allopurinol rashes xanthine oxidase inhibitor Medicine R Shahidah Che Alhadi verfasserin aut Wan Fatimah Suriyani Wan Mahmud verfasserin aut Salman Amiruddin verfasserin aut Mohd Zhafri Mohd Razib verfasserin aut Rasimah Ismail verfasserin aut In Malaysian Family Physician Academy of Family Physicians of Malaysia, 2017 18, p 11(2023) (DE-627)52289898X (DE-600)2265779-4 19852274 nnns volume:18, p 11 year:2023 https://doi.org/10.51866/cr.65 kostenfrei https://doaj.org/article/852b3676e0ea458287bb85ba462bc0e4 kostenfrei https://e-mfp.org/wp-content/uploads/18.11CRDelayedhypersensitivity.pdf kostenfrei https://doaj.org/toc/1985-207X Journal toc kostenfrei https://doaj.org/toc/1985-2274 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 18, p 11 2023
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author	Mohammad Che Man
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topic_title	Delayed hypersensitivity reaction to allopurinol: A case report delayed hypersensitivity allopurinol rashes xanthine oxidase inhibitor
topic	misc delayed hypersensitivity misc allopurinol misc rashes misc xanthine oxidase inhibitor misc Medicine misc R
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title	Delayed hypersensitivity reaction to allopurinol: A case report
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title_sort	delayed hypersensitivity reaction to allopurinol: a case report
title_auth	Delayed hypersensitivity reaction to allopurinol: A case report
abstract	Allopurinol is the well-known first-line treatment option for symptomatic hyperuricaemia and gout. It is cost-effective particularly for the management of chronic gout. The common early side effects of allopurinol are skin rashes, diarrhoea and nausea. Meanwhile, a dangerous concerning complication is Stevens–Johnson syndrome, which can cause severe morbidity and mortality. Delayed hypersensitivity to allopurinol is rare but should be one of the differential diagnoses if a patient with underlying gout on chronic allopurinol treatment presents with skin rashes. The present case highlights the importance of a high index of suspicion in at-risk patients with underlying gout along with skin rashes on long-term allopurinol treatment to avoid unnecessary patient management.
abstractGer	Allopurinol is the well-known first-line treatment option for symptomatic hyperuricaemia and gout. It is cost-effective particularly for the management of chronic gout. The common early side effects of allopurinol are skin rashes, diarrhoea and nausea. Meanwhile, a dangerous concerning complication is Stevens–Johnson syndrome, which can cause severe morbidity and mortality. Delayed hypersensitivity to allopurinol is rare but should be one of the differential diagnoses if a patient with underlying gout on chronic allopurinol treatment presents with skin rashes. The present case highlights the importance of a high index of suspicion in at-risk patients with underlying gout along with skin rashes on long-term allopurinol treatment to avoid unnecessary patient management.
abstract_unstemmed	Allopurinol is the well-known first-line treatment option for symptomatic hyperuricaemia and gout. It is cost-effective particularly for the management of chronic gout. The common early side effects of allopurinol are skin rashes, diarrhoea and nausea. Meanwhile, a dangerous concerning complication is Stevens–Johnson syndrome, which can cause severe morbidity and mortality. Delayed hypersensitivity to allopurinol is rare but should be one of the differential diagnoses if a patient with underlying gout on chronic allopurinol treatment presents with skin rashes. The present case highlights the importance of a high index of suspicion in at-risk patients with underlying gout along with skin rashes on long-term allopurinol treatment to avoid unnecessary patient management.
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title_short	Delayed hypersensitivity reaction to allopurinol: A case report
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Delayed hypersensitivity reaction to allopurinol: A case report

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