Structural basis of the substrate recognition and inhibition mechanism of Plasmodium falciparum nucleoside transporter PfENT1

PfENT1 is a promising antimalarial drug target. Here, authors report cryo-EM structures of PfENT1 that, together with biochemical work, suggests PfENT1 is an inosine transporter and describe the inhibitory mechanism of the endofacial inhibitor, GSK4.

Gespeichert in:

Autor*in:	Chen Wang [verfasserIn] Leiye Yu [verfasserIn] Jiying Zhang [verfasserIn] Yanxia Zhou [verfasserIn] Bo Sun [verfasserIn] Qingjie Xiao [verfasserIn] Minhua Zhang [verfasserIn] Huayi Liu [verfasserIn] Jinhong Li [verfasserIn] Jialu Li [verfasserIn] Yunzi Luo [verfasserIn] Jie Xu [verfasserIn] Zhong Lian [verfasserIn] Jingwen Lin [verfasserIn] Xiang Wang [verfasserIn] Peng Zhang [verfasserIn] Li Guo [verfasserIn] Ruobing Ren [verfasserIn] Dong Deng [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2023

Übergeordnetes Werk:	In: Nature Communications - Nature Portfolio, 2016, 14(2023), 1, Seite 11
Übergeordnetes Werk:	volume:14 ; year:2023 ; number:1 ; pages:11

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.1038/s41467-023-37411-1

Katalog-ID:	DOAJ088753271

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allfields	10.1038/s41467-023-37411-1 doi (DE-627)DOAJ088753271 (DE-599)DOAJ09dc3993856a4849af7df41b65a76f74 DE-627 ger DE-627 rakwb eng Chen Wang verfasserin aut Structural basis of the substrate recognition and inhibition mechanism of Plasmodium falciparum nucleoside transporter PfENT1 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier PfENT1 is a promising antimalarial drug target. Here, authors report cryo-EM structures of PfENT1 that, together with biochemical work, suggests PfENT1 is an inosine transporter and describe the inhibitory mechanism of the endofacial inhibitor, GSK4. Science Q Leiye Yu verfasserin aut Jiying Zhang verfasserin aut Yanxia Zhou verfasserin aut Bo Sun verfasserin aut Qingjie Xiao verfasserin aut Minhua Zhang verfasserin aut Huayi Liu verfasserin aut Jinhong Li verfasserin aut Jialu Li verfasserin aut Yunzi Luo verfasserin aut Jie Xu verfasserin aut Zhong Lian verfasserin aut Jingwen Lin verfasserin aut Xiang Wang verfasserin aut Peng Zhang verfasserin aut Li Guo verfasserin aut Ruobing Ren verfasserin aut Dong Deng verfasserin aut In Nature Communications Nature Portfolio, 2016 14(2023), 1, Seite 11 (DE-627)626457688 (DE-600)2553671-0 20411723 nnns volume:14 year:2023 number:1 pages:11 https://doi.org/10.1038/s41467-023-37411-1 kostenfrei https://doaj.org/article/09dc3993856a4849af7df41b65a76f74 kostenfrei https://doi.org/10.1038/s41467-023-37411-1 kostenfrei https://doaj.org/toc/2041-1723 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_211 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_2110 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 14 2023 1 11
spelling	10.1038/s41467-023-37411-1 doi (DE-627)DOAJ088753271 (DE-599)DOAJ09dc3993856a4849af7df41b65a76f74 DE-627 ger DE-627 rakwb eng Chen Wang verfasserin aut Structural basis of the substrate recognition and inhibition mechanism of Plasmodium falciparum nucleoside transporter PfENT1 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier PfENT1 is a promising antimalarial drug target. Here, authors report cryo-EM structures of PfENT1 that, together with biochemical work, suggests PfENT1 is an inosine transporter and describe the inhibitory mechanism of the endofacial inhibitor, GSK4. Science Q Leiye Yu verfasserin aut Jiying Zhang verfasserin aut Yanxia Zhou verfasserin aut Bo Sun verfasserin aut Qingjie Xiao verfasserin aut Minhua Zhang verfasserin aut Huayi Liu verfasserin aut Jinhong Li verfasserin aut Jialu Li verfasserin aut Yunzi Luo verfasserin aut Jie Xu verfasserin aut Zhong Lian verfasserin aut Jingwen Lin verfasserin aut Xiang Wang verfasserin aut Peng Zhang verfasserin aut Li Guo verfasserin aut Ruobing Ren verfasserin aut Dong Deng verfasserin aut In Nature Communications Nature Portfolio, 2016 14(2023), 1, Seite 11 (DE-627)626457688 (DE-600)2553671-0 20411723 nnns volume:14 year:2023 number:1 pages:11 https://doi.org/10.1038/s41467-023-37411-1 kostenfrei https://doaj.org/article/09dc3993856a4849af7df41b65a76f74 kostenfrei https://doi.org/10.1038/s41467-023-37411-1 kostenfrei https://doaj.org/toc/2041-1723 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_211 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_2110 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 14 2023 1 11
allfields_unstemmed	10.1038/s41467-023-37411-1 doi (DE-627)DOAJ088753271 (DE-599)DOAJ09dc3993856a4849af7df41b65a76f74 DE-627 ger DE-627 rakwb eng Chen Wang verfasserin aut Structural basis of the substrate recognition and inhibition mechanism of Plasmodium falciparum nucleoside transporter PfENT1 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier PfENT1 is a promising antimalarial drug target. Here, authors report cryo-EM structures of PfENT1 that, together with biochemical work, suggests PfENT1 is an inosine transporter and describe the inhibitory mechanism of the endofacial inhibitor, GSK4. Science Q Leiye Yu verfasserin aut Jiying Zhang verfasserin aut Yanxia Zhou verfasserin aut Bo Sun verfasserin aut Qingjie Xiao verfasserin aut Minhua Zhang verfasserin aut Huayi Liu verfasserin aut Jinhong Li verfasserin aut Jialu Li verfasserin aut Yunzi Luo verfasserin aut Jie Xu verfasserin aut Zhong Lian verfasserin aut Jingwen Lin verfasserin aut Xiang Wang verfasserin aut Peng Zhang verfasserin aut Li Guo verfasserin aut Ruobing Ren verfasserin aut Dong Deng verfasserin aut In Nature Communications Nature Portfolio, 2016 14(2023), 1, Seite 11 (DE-627)626457688 (DE-600)2553671-0 20411723 nnns volume:14 year:2023 number:1 pages:11 https://doi.org/10.1038/s41467-023-37411-1 kostenfrei https://doaj.org/article/09dc3993856a4849af7df41b65a76f74 kostenfrei https://doi.org/10.1038/s41467-023-37411-1 kostenfrei https://doaj.org/toc/2041-1723 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_211 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_2110 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 14 2023 1 11
allfieldsGer	10.1038/s41467-023-37411-1 doi (DE-627)DOAJ088753271 (DE-599)DOAJ09dc3993856a4849af7df41b65a76f74 DE-627 ger DE-627 rakwb eng Chen Wang verfasserin aut Structural basis of the substrate recognition and inhibition mechanism of Plasmodium falciparum nucleoside transporter PfENT1 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier PfENT1 is a promising antimalarial drug target. Here, authors report cryo-EM structures of PfENT1 that, together with biochemical work, suggests PfENT1 is an inosine transporter and describe the inhibitory mechanism of the endofacial inhibitor, GSK4. Science Q Leiye Yu verfasserin aut Jiying Zhang verfasserin aut Yanxia Zhou verfasserin aut Bo Sun verfasserin aut Qingjie Xiao verfasserin aut Minhua Zhang verfasserin aut Huayi Liu verfasserin aut Jinhong Li verfasserin aut Jialu Li verfasserin aut Yunzi Luo verfasserin aut Jie Xu verfasserin aut Zhong Lian verfasserin aut Jingwen Lin verfasserin aut Xiang Wang verfasserin aut Peng Zhang verfasserin aut Li Guo verfasserin aut Ruobing Ren verfasserin aut Dong Deng verfasserin aut In Nature Communications Nature Portfolio, 2016 14(2023), 1, Seite 11 (DE-627)626457688 (DE-600)2553671-0 20411723 nnns volume:14 year:2023 number:1 pages:11 https://doi.org/10.1038/s41467-023-37411-1 kostenfrei https://doaj.org/article/09dc3993856a4849af7df41b65a76f74 kostenfrei https://doi.org/10.1038/s41467-023-37411-1 kostenfrei https://doaj.org/toc/2041-1723 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_211 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_2110 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 14 2023 1 11
allfieldsSound	10.1038/s41467-023-37411-1 doi (DE-627)DOAJ088753271 (DE-599)DOAJ09dc3993856a4849af7df41b65a76f74 DE-627 ger DE-627 rakwb eng Chen Wang verfasserin aut Structural basis of the substrate recognition and inhibition mechanism of Plasmodium falciparum nucleoside transporter PfENT1 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier PfENT1 is a promising antimalarial drug target. Here, authors report cryo-EM structures of PfENT1 that, together with biochemical work, suggests PfENT1 is an inosine transporter and describe the inhibitory mechanism of the endofacial inhibitor, GSK4. Science Q Leiye Yu verfasserin aut Jiying Zhang verfasserin aut Yanxia Zhou verfasserin aut Bo Sun verfasserin aut Qingjie Xiao verfasserin aut Minhua Zhang verfasserin aut Huayi Liu verfasserin aut Jinhong Li verfasserin aut Jialu Li verfasserin aut Yunzi Luo verfasserin aut Jie Xu verfasserin aut Zhong Lian verfasserin aut Jingwen Lin verfasserin aut Xiang Wang verfasserin aut Peng Zhang verfasserin aut Li Guo verfasserin aut Ruobing Ren verfasserin aut Dong Deng verfasserin aut In Nature Communications Nature Portfolio, 2016 14(2023), 1, Seite 11 (DE-627)626457688 (DE-600)2553671-0 20411723 nnns volume:14 year:2023 number:1 pages:11 https://doi.org/10.1038/s41467-023-37411-1 kostenfrei https://doaj.org/article/09dc3993856a4849af7df41b65a76f74 kostenfrei https://doi.org/10.1038/s41467-023-37411-1 kostenfrei https://doaj.org/toc/2041-1723 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_211 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_2110 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 14 2023 1 11
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author	Chen Wang
spellingShingle	Chen Wang misc Science misc Q Structural basis of the substrate recognition and inhibition mechanism of Plasmodium falciparum nucleoside transporter PfENT1
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topic_title	Structural basis of the substrate recognition and inhibition mechanism of Plasmodium falciparum nucleoside transporter PfENT1
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title	Structural basis of the substrate recognition and inhibition mechanism of Plasmodium falciparum nucleoside transporter PfENT1
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title_full	Structural basis of the substrate recognition and inhibition mechanism of Plasmodium falciparum nucleoside transporter PfENT1
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author_browse	Chen Wang Leiye Yu Jiying Zhang Yanxia Zhou Bo Sun Qingjie Xiao Minhua Zhang Huayi Liu Jinhong Li Jialu Li Yunzi Luo Jie Xu Zhong Lian Jingwen Lin Xiang Wang Peng Zhang Li Guo Ruobing Ren Dong Deng
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title_sort	structural basis of the substrate recognition and inhibition mechanism of plasmodium falciparum nucleoside transporter pfent1
title_auth	Structural basis of the substrate recognition and inhibition mechanism of Plasmodium falciparum nucleoside transporter PfENT1
abstract	PfENT1 is a promising antimalarial drug target. Here, authors report cryo-EM structures of PfENT1 that, together with biochemical work, suggests PfENT1 is an inosine transporter and describe the inhibitory mechanism of the endofacial inhibitor, GSK4.
abstractGer	PfENT1 is a promising antimalarial drug target. Here, authors report cryo-EM structures of PfENT1 that, together with biochemical work, suggests PfENT1 is an inosine transporter and describe the inhibitory mechanism of the endofacial inhibitor, GSK4.
abstract_unstemmed	PfENT1 is a promising antimalarial drug target. Here, authors report cryo-EM structures of PfENT1 that, together with biochemical work, suggests PfENT1 is an inosine transporter and describe the inhibitory mechanism of the endofacial inhibitor, GSK4.
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title_short	Structural basis of the substrate recognition and inhibition mechanism of Plasmodium falciparum nucleoside transporter PfENT1
url	https://doi.org/10.1038/s41467-023-37411-1 https://doaj.org/article/09dc3993856a4849af7df41b65a76f74 https://doaj.org/toc/2041-1723
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author2	Leiye Yu Jiying Zhang Yanxia Zhou Bo Sun Qingjie Xiao Minhua Zhang Huayi Liu Jinhong Li Jialu Li Yunzi Luo Jie Xu Zhong Lian Jingwen Lin Xiang Wang Peng Zhang Li Guo Ruobing Ren Dong Deng
author2Str	Leiye Yu Jiying Zhang Yanxia Zhou Bo Sun Qingjie Xiao Minhua Zhang Huayi Liu Jinhong Li Jialu Li Yunzi Luo Jie Xu Zhong Lian Jingwen Lin Xiang Wang Peng Zhang Li Guo Ruobing Ren Dong Deng
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up_date	2024-07-03T19:22:42.091Z
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Structural basis of the substrate recognition and inhibition mechanism of Plasmodium falciparum nucleoside transporter PfENT1

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