T peripheral helper cells in autoimmune diseases: What do we know?

The interactions between T cells and B cells are essential for antibody responses and the development of autoimmune diseases. Recently, a distinct subset of T cells capable of helping B cells was established in synovial fluid, and they were termed peripheral helper T (Tph) cells. PD-1hiCXCR5−CD4+ Tp...
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Autor*in:	Yao Huang [verfasserIn] Xin Ba [verfasserIn] Liang Han [verfasserIn] Hui Wang [verfasserIn] Weiji Lin [verfasserIn] Zhe Chen [verfasserIn] Shenghao Tu [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2023

Schlagwörter:	T peripheral helper cells autoimmune diseases CXCL13 tertiary lymphoid structures (TLSs) T follicular helper cells

Übergeordnetes Werk:	In: Frontiers in Immunology - Frontiers Media S.A., 2011, 14(2023)
Übergeordnetes Werk:	volume:14 ; year:2023

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3389/fimmu.2023.1145573

Katalog-ID:	DOAJ088770850

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allfields	10.3389/fimmu.2023.1145573 doi (DE-627)DOAJ088770850 (DE-599)DOAJ9d4856edf2e842d1a8dec0377c285170 DE-627 ger DE-627 rakwb eng RC581-607 Yao Huang verfasserin aut T peripheral helper cells in autoimmune diseases: What do we know? 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The interactions between T cells and B cells are essential for antibody responses and the development of autoimmune diseases. Recently, a distinct subset of T cells capable of helping B cells was established in synovial fluid, and they were termed peripheral helper T (Tph) cells. PD-1hiCXCR5−CD4+ Tph cells express high levels of CXCL13, which drives the formation of lymphoid aggregates and tertiary lymphoid structures, ultimately facilitating the local production of pathogenic autoantibodies. Tph and T follicular helper cells share some key features but can be distinguished by their surface markers, transcriptional regulation, and migration capability. We summarize recent findings on Tph cells in this review and provide a perspective on their potential roles in a range of autoimmune diseases. More clinical and in-depth mechanistic investigations of Tph cells may help to improve the understanding of pathogenesis and further provide novel therapeutic targets in autoimmune diseases. T peripheral helper cells autoimmune diseases CXCL13 tertiary lymphoid structures (TLSs) T follicular helper cells Immunologic diseases. Allergy Xin Ba verfasserin aut Liang Han verfasserin aut Hui Wang verfasserin aut Weiji Lin verfasserin aut Zhe Chen verfasserin aut Shenghao Tu verfasserin aut In Frontiers in Immunology Frontiers Media S.A., 2011 14(2023) (DE-627)657998354 (DE-600)2606827-8 16643224 nnns volume:14 year:2023 https://doi.org/10.3389/fimmu.2023.1145573 kostenfrei https://doaj.org/article/9d4856edf2e842d1a8dec0377c285170 kostenfrei https://www.frontiersin.org/articles/10.3389/fimmu.2023.1145573/full kostenfrei https://doaj.org/toc/1664-3224 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 14 2023
spelling	10.3389/fimmu.2023.1145573 doi (DE-627)DOAJ088770850 (DE-599)DOAJ9d4856edf2e842d1a8dec0377c285170 DE-627 ger DE-627 rakwb eng RC581-607 Yao Huang verfasserin aut T peripheral helper cells in autoimmune diseases: What do we know? 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The interactions between T cells and B cells are essential for antibody responses and the development of autoimmune diseases. Recently, a distinct subset of T cells capable of helping B cells was established in synovial fluid, and they were termed peripheral helper T (Tph) cells. PD-1hiCXCR5−CD4+ Tph cells express high levels of CXCL13, which drives the formation of lymphoid aggregates and tertiary lymphoid structures, ultimately facilitating the local production of pathogenic autoantibodies. Tph and T follicular helper cells share some key features but can be distinguished by their surface markers, transcriptional regulation, and migration capability. We summarize recent findings on Tph cells in this review and provide a perspective on their potential roles in a range of autoimmune diseases. More clinical and in-depth mechanistic investigations of Tph cells may help to improve the understanding of pathogenesis and further provide novel therapeutic targets in autoimmune diseases. T peripheral helper cells autoimmune diseases CXCL13 tertiary lymphoid structures (TLSs) T follicular helper cells Immunologic diseases. Allergy Xin Ba verfasserin aut Liang Han verfasserin aut Hui Wang verfasserin aut Weiji Lin verfasserin aut Zhe Chen verfasserin aut Shenghao Tu verfasserin aut In Frontiers in Immunology Frontiers Media S.A., 2011 14(2023) (DE-627)657998354 (DE-600)2606827-8 16643224 nnns volume:14 year:2023 https://doi.org/10.3389/fimmu.2023.1145573 kostenfrei https://doaj.org/article/9d4856edf2e842d1a8dec0377c285170 kostenfrei https://www.frontiersin.org/articles/10.3389/fimmu.2023.1145573/full kostenfrei https://doaj.org/toc/1664-3224 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 14 2023
allfields_unstemmed	10.3389/fimmu.2023.1145573 doi (DE-627)DOAJ088770850 (DE-599)DOAJ9d4856edf2e842d1a8dec0377c285170 DE-627 ger DE-627 rakwb eng RC581-607 Yao Huang verfasserin aut T peripheral helper cells in autoimmune diseases: What do we know? 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The interactions between T cells and B cells are essential for antibody responses and the development of autoimmune diseases. Recently, a distinct subset of T cells capable of helping B cells was established in synovial fluid, and they were termed peripheral helper T (Tph) cells. PD-1hiCXCR5−CD4+ Tph cells express high levels of CXCL13, which drives the formation of lymphoid aggregates and tertiary lymphoid structures, ultimately facilitating the local production of pathogenic autoantibodies. Tph and T follicular helper cells share some key features but can be distinguished by their surface markers, transcriptional regulation, and migration capability. We summarize recent findings on Tph cells in this review and provide a perspective on their potential roles in a range of autoimmune diseases. More clinical and in-depth mechanistic investigations of Tph cells may help to improve the understanding of pathogenesis and further provide novel therapeutic targets in autoimmune diseases. T peripheral helper cells autoimmune diseases CXCL13 tertiary lymphoid structures (TLSs) T follicular helper cells Immunologic diseases. Allergy Xin Ba verfasserin aut Liang Han verfasserin aut Hui Wang verfasserin aut Weiji Lin verfasserin aut Zhe Chen verfasserin aut Shenghao Tu verfasserin aut In Frontiers in Immunology Frontiers Media S.A., 2011 14(2023) (DE-627)657998354 (DE-600)2606827-8 16643224 nnns volume:14 year:2023 https://doi.org/10.3389/fimmu.2023.1145573 kostenfrei https://doaj.org/article/9d4856edf2e842d1a8dec0377c285170 kostenfrei https://www.frontiersin.org/articles/10.3389/fimmu.2023.1145573/full kostenfrei https://doaj.org/toc/1664-3224 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 14 2023
allfieldsGer	10.3389/fimmu.2023.1145573 doi (DE-627)DOAJ088770850 (DE-599)DOAJ9d4856edf2e842d1a8dec0377c285170 DE-627 ger DE-627 rakwb eng RC581-607 Yao Huang verfasserin aut T peripheral helper cells in autoimmune diseases: What do we know? 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The interactions between T cells and B cells are essential for antibody responses and the development of autoimmune diseases. Recently, a distinct subset of T cells capable of helping B cells was established in synovial fluid, and they were termed peripheral helper T (Tph) cells. PD-1hiCXCR5−CD4+ Tph cells express high levels of CXCL13, which drives the formation of lymphoid aggregates and tertiary lymphoid structures, ultimately facilitating the local production of pathogenic autoantibodies. Tph and T follicular helper cells share some key features but can be distinguished by their surface markers, transcriptional regulation, and migration capability. We summarize recent findings on Tph cells in this review and provide a perspective on their potential roles in a range of autoimmune diseases. More clinical and in-depth mechanistic investigations of Tph cells may help to improve the understanding of pathogenesis and further provide novel therapeutic targets in autoimmune diseases. T peripheral helper cells autoimmune diseases CXCL13 tertiary lymphoid structures (TLSs) T follicular helper cells Immunologic diseases. Allergy Xin Ba verfasserin aut Liang Han verfasserin aut Hui Wang verfasserin aut Weiji Lin verfasserin aut Zhe Chen verfasserin aut Shenghao Tu verfasserin aut In Frontiers in Immunology Frontiers Media S.A., 2011 14(2023) (DE-627)657998354 (DE-600)2606827-8 16643224 nnns volume:14 year:2023 https://doi.org/10.3389/fimmu.2023.1145573 kostenfrei https://doaj.org/article/9d4856edf2e842d1a8dec0377c285170 kostenfrei https://www.frontiersin.org/articles/10.3389/fimmu.2023.1145573/full kostenfrei https://doaj.org/toc/1664-3224 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 14 2023
allfieldsSound	10.3389/fimmu.2023.1145573 doi (DE-627)DOAJ088770850 (DE-599)DOAJ9d4856edf2e842d1a8dec0377c285170 DE-627 ger DE-627 rakwb eng RC581-607 Yao Huang verfasserin aut T peripheral helper cells in autoimmune diseases: What do we know? 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The interactions between T cells and B cells are essential for antibody responses and the development of autoimmune diseases. Recently, a distinct subset of T cells capable of helping B cells was established in synovial fluid, and they were termed peripheral helper T (Tph) cells. PD-1hiCXCR5−CD4+ Tph cells express high levels of CXCL13, which drives the formation of lymphoid aggregates and tertiary lymphoid structures, ultimately facilitating the local production of pathogenic autoantibodies. Tph and T follicular helper cells share some key features but can be distinguished by their surface markers, transcriptional regulation, and migration capability. We summarize recent findings on Tph cells in this review and provide a perspective on their potential roles in a range of autoimmune diseases. More clinical and in-depth mechanistic investigations of Tph cells may help to improve the understanding of pathogenesis and further provide novel therapeutic targets in autoimmune diseases. T peripheral helper cells autoimmune diseases CXCL13 tertiary lymphoid structures (TLSs) T follicular helper cells Immunologic diseases. Allergy Xin Ba verfasserin aut Liang Han verfasserin aut Hui Wang verfasserin aut Weiji Lin verfasserin aut Zhe Chen verfasserin aut Shenghao Tu verfasserin aut In Frontiers in Immunology Frontiers Media S.A., 2011 14(2023) (DE-627)657998354 (DE-600)2606827-8 16643224 nnns volume:14 year:2023 https://doi.org/10.3389/fimmu.2023.1145573 kostenfrei https://doaj.org/article/9d4856edf2e842d1a8dec0377c285170 kostenfrei https://www.frontiersin.org/articles/10.3389/fimmu.2023.1145573/full kostenfrei https://doaj.org/toc/1664-3224 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 14 2023
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authorswithroles_txt_mv	Yao Huang @@aut@@ Xin Ba @@aut@@ Liang Han @@aut@@ Hui Wang @@aut@@ Weiji Lin @@aut@@ Zhe Chen @@aut@@ Shenghao Tu @@aut@@
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callnumber-first	R - Medicine
author	Yao Huang
spellingShingle	Yao Huang misc RC581-607 misc T peripheral helper cells misc autoimmune diseases misc CXCL13 misc tertiary lymphoid structures (TLSs) misc T follicular helper cells misc Immunologic diseases. Allergy T peripheral helper cells in autoimmune diseases: What do we know?
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topic_title	RC581-607 T peripheral helper cells in autoimmune diseases: What do we know? T peripheral helper cells autoimmune diseases CXCL13 tertiary lymphoid structures (TLSs) T follicular helper cells
topic	misc RC581-607 misc T peripheral helper cells misc autoimmune diseases misc CXCL13 misc tertiary lymphoid structures (TLSs) misc T follicular helper cells misc Immunologic diseases. Allergy
topic_unstemmed	misc RC581-607 misc T peripheral helper cells misc autoimmune diseases misc CXCL13 misc tertiary lymphoid structures (TLSs) misc T follicular helper cells misc Immunologic diseases. Allergy
topic_browse	misc RC581-607 misc T peripheral helper cells misc autoimmune diseases misc CXCL13 misc tertiary lymphoid structures (TLSs) misc T follicular helper cells misc Immunologic diseases. Allergy
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title	T peripheral helper cells in autoimmune diseases: What do we know?
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title_full	T peripheral helper cells in autoimmune diseases: What do we know?
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title_sort	peripheral helper cells in autoimmune diseases: what do we know?
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title_auth	T peripheral helper cells in autoimmune diseases: What do we know?
abstract	The interactions between T cells and B cells are essential for antibody responses and the development of autoimmune diseases. Recently, a distinct subset of T cells capable of helping B cells was established in synovial fluid, and they were termed peripheral helper T (Tph) cells. PD-1hiCXCR5−CD4+ Tph cells express high levels of CXCL13, which drives the formation of lymphoid aggregates and tertiary lymphoid structures, ultimately facilitating the local production of pathogenic autoantibodies. Tph and T follicular helper cells share some key features but can be distinguished by their surface markers, transcriptional regulation, and migration capability. We summarize recent findings on Tph cells in this review and provide a perspective on their potential roles in a range of autoimmune diseases. More clinical and in-depth mechanistic investigations of Tph cells may help to improve the understanding of pathogenesis and further provide novel therapeutic targets in autoimmune diseases.
abstractGer	The interactions between T cells and B cells are essential for antibody responses and the development of autoimmune diseases. Recently, a distinct subset of T cells capable of helping B cells was established in synovial fluid, and they were termed peripheral helper T (Tph) cells. PD-1hiCXCR5−CD4+ Tph cells express high levels of CXCL13, which drives the formation of lymphoid aggregates and tertiary lymphoid structures, ultimately facilitating the local production of pathogenic autoantibodies. Tph and T follicular helper cells share some key features but can be distinguished by their surface markers, transcriptional regulation, and migration capability. We summarize recent findings on Tph cells in this review and provide a perspective on their potential roles in a range of autoimmune diseases. More clinical and in-depth mechanistic investigations of Tph cells may help to improve the understanding of pathogenesis and further provide novel therapeutic targets in autoimmune diseases.
abstract_unstemmed	The interactions between T cells and B cells are essential for antibody responses and the development of autoimmune diseases. Recently, a distinct subset of T cells capable of helping B cells was established in synovial fluid, and they were termed peripheral helper T (Tph) cells. PD-1hiCXCR5−CD4+ Tph cells express high levels of CXCL13, which drives the formation of lymphoid aggregates and tertiary lymphoid structures, ultimately facilitating the local production of pathogenic autoantibodies. Tph and T follicular helper cells share some key features but can be distinguished by their surface markers, transcriptional regulation, and migration capability. We summarize recent findings on Tph cells in this review and provide a perspective on their potential roles in a range of autoimmune diseases. More clinical and in-depth mechanistic investigations of Tph cells may help to improve the understanding of pathogenesis and further provide novel therapeutic targets in autoimmune diseases.
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title_short	T peripheral helper cells in autoimmune diseases: What do we know?
url	https://doi.org/10.3389/fimmu.2023.1145573 https://doaj.org/article/9d4856edf2e842d1a8dec0377c285170 https://www.frontiersin.org/articles/10.3389/fimmu.2023.1145573/full https://doaj.org/toc/1664-3224
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