The role of inflammation in personalised treatment of omega-3 fatty acids in depression

The increasing global burden calls for the development of novel approaches to tackle unmet needs in prevention and treatment of depression underlying biological, psychological and social dysregulations. Depressed patients with chronic low-grade inflammation might be classified as a subgroup of major...
Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Kuan-Pin Su, MD, PhD [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2023

Übergeordnetes Werk:	In: Journal of Affective Disorders Reports - Elsevier, 2021, 12(2023), Seite 100569-
Übergeordnetes Werk:	volume:12 ; year:2023 ; pages:100569-

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.1016/j.jadr.2023.100569

Katalog-ID:	DOAJ088823024

Internformat


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spelling	10.1016/j.jadr.2023.100569 doi (DE-627)DOAJ088823024 (DE-599)DOAJ0dd308289db648cfb235b583f84e8607 DE-627 ger DE-627 rakwb eng RZ400-408 Kuan-Pin Su, MD, PhD verfasserin aut The role of inflammation in personalised treatment of omega-3 fatty acids in depression 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The increasing global burden calls for the development of novel approaches to tackle unmet needs in prevention and treatment of depression underlying biological, psychological and social dysregulations. Depressed patients with chronic low-grade inflammation might be classified as a subgroup of major depressive disorder (MDD); therefore, looking for antidepressant therapies from anti-inflammatory pathways could improve treatment effectiveness for this subgroup of patients. Omega-3 (or n-3) polyunsaturated fatty acids (PUFAs) are anti-inflammatory both in peripheral organs and central nervous systems and have clinically applied in the treatment and prevention of depression, cardiovascular diseases, dyslipidaemia, diabetes and arthritis. Anthropological studies suggest that human beings evolved to a modern diet with less than one-tenth of omega-3 to omega-6 PUFAs intake ratio, which leads to a constitutional bias toward chronic systemic inflammatory status to explain dramatically increasing of depression and chronic medical illnesses in modern world. The presentation is to provide our recent clinical and pre-clinical studies and an overview about the role of inflammation in “mind-body” comorbidity and present anti-inflammatory mechanisms by which n-3 PUFAs may orchestrate the molecular and cellular functions and facilitate the therapeutic pathways in chronic medical illnesses and depression. Mental healing In Journal of Affective Disorders Reports Elsevier, 2021 12(2023), Seite 100569- (DE-627)1747967335 26669153 nnns volume:12 year:2023 pages:100569- https://doi.org/10.1016/j.jadr.2023.100569 kostenfrei https://doaj.org/article/0dd308289db648cfb235b583f84e8607 kostenfrei http://www.sciencedirect.com/science/article/pii/S2666915323001087 kostenfrei https://doaj.org/toc/2666-9153 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 12 2023 100569-
allfields_unstemmed	10.1016/j.jadr.2023.100569 doi (DE-627)DOAJ088823024 (DE-599)DOAJ0dd308289db648cfb235b583f84e8607 DE-627 ger DE-627 rakwb eng RZ400-408 Kuan-Pin Su, MD, PhD verfasserin aut The role of inflammation in personalised treatment of omega-3 fatty acids in depression 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The increasing global burden calls for the development of novel approaches to tackle unmet needs in prevention and treatment of depression underlying biological, psychological and social dysregulations. Depressed patients with chronic low-grade inflammation might be classified as a subgroup of major depressive disorder (MDD); therefore, looking for antidepressant therapies from anti-inflammatory pathways could improve treatment effectiveness for this subgroup of patients. Omega-3 (or n-3) polyunsaturated fatty acids (PUFAs) are anti-inflammatory both in peripheral organs and central nervous systems and have clinically applied in the treatment and prevention of depression, cardiovascular diseases, dyslipidaemia, diabetes and arthritis. Anthropological studies suggest that human beings evolved to a modern diet with less than one-tenth of omega-3 to omega-6 PUFAs intake ratio, which leads to a constitutional bias toward chronic systemic inflammatory status to explain dramatically increasing of depression and chronic medical illnesses in modern world. The presentation is to provide our recent clinical and pre-clinical studies and an overview about the role of inflammation in “mind-body” comorbidity and present anti-inflammatory mechanisms by which n-3 PUFAs may orchestrate the molecular and cellular functions and facilitate the therapeutic pathways in chronic medical illnesses and depression. Mental healing In Journal of Affective Disorders Reports Elsevier, 2021 12(2023), Seite 100569- (DE-627)1747967335 26669153 nnns volume:12 year:2023 pages:100569- https://doi.org/10.1016/j.jadr.2023.100569 kostenfrei https://doaj.org/article/0dd308289db648cfb235b583f84e8607 kostenfrei http://www.sciencedirect.com/science/article/pii/S2666915323001087 kostenfrei https://doaj.org/toc/2666-9153 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 12 2023 100569-
allfieldsGer	10.1016/j.jadr.2023.100569 doi (DE-627)DOAJ088823024 (DE-599)DOAJ0dd308289db648cfb235b583f84e8607 DE-627 ger DE-627 rakwb eng RZ400-408 Kuan-Pin Su, MD, PhD verfasserin aut The role of inflammation in personalised treatment of omega-3 fatty acids in depression 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The increasing global burden calls for the development of novel approaches to tackle unmet needs in prevention and treatment of depression underlying biological, psychological and social dysregulations. Depressed patients with chronic low-grade inflammation might be classified as a subgroup of major depressive disorder (MDD); therefore, looking for antidepressant therapies from anti-inflammatory pathways could improve treatment effectiveness for this subgroup of patients. Omega-3 (or n-3) polyunsaturated fatty acids (PUFAs) are anti-inflammatory both in peripheral organs and central nervous systems and have clinically applied in the treatment and prevention of depression, cardiovascular diseases, dyslipidaemia, diabetes and arthritis. Anthropological studies suggest that human beings evolved to a modern diet with less than one-tenth of omega-3 to omega-6 PUFAs intake ratio, which leads to a constitutional bias toward chronic systemic inflammatory status to explain dramatically increasing of depression and chronic medical illnesses in modern world. The presentation is to provide our recent clinical and pre-clinical studies and an overview about the role of inflammation in “mind-body” comorbidity and present anti-inflammatory mechanisms by which n-3 PUFAs may orchestrate the molecular and cellular functions and facilitate the therapeutic pathways in chronic medical illnesses and depression. Mental healing In Journal of Affective Disorders Reports Elsevier, 2021 12(2023), Seite 100569- (DE-627)1747967335 26669153 nnns volume:12 year:2023 pages:100569- https://doi.org/10.1016/j.jadr.2023.100569 kostenfrei https://doaj.org/article/0dd308289db648cfb235b583f84e8607 kostenfrei http://www.sciencedirect.com/science/article/pii/S2666915323001087 kostenfrei https://doaj.org/toc/2666-9153 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 12 2023 100569-
allfieldsSound	10.1016/j.jadr.2023.100569 doi (DE-627)DOAJ088823024 (DE-599)DOAJ0dd308289db648cfb235b583f84e8607 DE-627 ger DE-627 rakwb eng RZ400-408 Kuan-Pin Su, MD, PhD verfasserin aut The role of inflammation in personalised treatment of omega-3 fatty acids in depression 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The increasing global burden calls for the development of novel approaches to tackle unmet needs in prevention and treatment of depression underlying biological, psychological and social dysregulations. Depressed patients with chronic low-grade inflammation might be classified as a subgroup of major depressive disorder (MDD); therefore, looking for antidepressant therapies from anti-inflammatory pathways could improve treatment effectiveness for this subgroup of patients. Omega-3 (or n-3) polyunsaturated fatty acids (PUFAs) are anti-inflammatory both in peripheral organs and central nervous systems and have clinically applied in the treatment and prevention of depression, cardiovascular diseases, dyslipidaemia, diabetes and arthritis. Anthropological studies suggest that human beings evolved to a modern diet with less than one-tenth of omega-3 to omega-6 PUFAs intake ratio, which leads to a constitutional bias toward chronic systemic inflammatory status to explain dramatically increasing of depression and chronic medical illnesses in modern world. The presentation is to provide our recent clinical and pre-clinical studies and an overview about the role of inflammation in “mind-body” comorbidity and present anti-inflammatory mechanisms by which n-3 PUFAs may orchestrate the molecular and cellular functions and facilitate the therapeutic pathways in chronic medical illnesses and depression. Mental healing In Journal of Affective Disorders Reports Elsevier, 2021 12(2023), Seite 100569- (DE-627)1747967335 26669153 nnns volume:12 year:2023 pages:100569- https://doi.org/10.1016/j.jadr.2023.100569 kostenfrei https://doaj.org/article/0dd308289db648cfb235b583f84e8607 kostenfrei http://www.sciencedirect.com/science/article/pii/S2666915323001087 kostenfrei https://doaj.org/toc/2666-9153 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 12 2023 100569-
language	English
source	In Journal of Affective Disorders Reports 12(2023), Seite 100569- volume:12 year:2023 pages:100569-
sourceStr	In Journal of Affective Disorders Reports 12(2023), Seite 100569- volume:12 year:2023 pages:100569-
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	Mental healing
isfreeaccess_bool	true
container_title	Journal of Affective Disorders Reports
authorswithroles_txt_mv	Kuan-Pin Su, MD, PhD @@aut@@
publishDateDaySort_date	2023-01-01T00:00:00Z
hierarchy_top_id	1747967335
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language_de	englisch
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author	Kuan-Pin Su, MD, PhD
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title	The role of inflammation in personalised treatment of omega-3 fatty acids in depression
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title_full	The role of inflammation in personalised treatment of omega-3 fatty acids in depression
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title_sort	role of inflammation in personalised treatment of omega-3 fatty acids in depression
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title_auth	The role of inflammation in personalised treatment of omega-3 fatty acids in depression
abstract	The increasing global burden calls for the development of novel approaches to tackle unmet needs in prevention and treatment of depression underlying biological, psychological and social dysregulations. Depressed patients with chronic low-grade inflammation might be classified as a subgroup of major depressive disorder (MDD); therefore, looking for antidepressant therapies from anti-inflammatory pathways could improve treatment effectiveness for this subgroup of patients. Omega-3 (or n-3) polyunsaturated fatty acids (PUFAs) are anti-inflammatory both in peripheral organs and central nervous systems and have clinically applied in the treatment and prevention of depression, cardiovascular diseases, dyslipidaemia, diabetes and arthritis. Anthropological studies suggest that human beings evolved to a modern diet with less than one-tenth of omega-3 to omega-6 PUFAs intake ratio, which leads to a constitutional bias toward chronic systemic inflammatory status to explain dramatically increasing of depression and chronic medical illnesses in modern world. The presentation is to provide our recent clinical and pre-clinical studies and an overview about the role of inflammation in “mind-body” comorbidity and present anti-inflammatory mechanisms by which n-3 PUFAs may orchestrate the molecular and cellular functions and facilitate the therapeutic pathways in chronic medical illnesses and depression.
abstractGer	The increasing global burden calls for the development of novel approaches to tackle unmet needs in prevention and treatment of depression underlying biological, psychological and social dysregulations. Depressed patients with chronic low-grade inflammation might be classified as a subgroup of major depressive disorder (MDD); therefore, looking for antidepressant therapies from anti-inflammatory pathways could improve treatment effectiveness for this subgroup of patients. Omega-3 (or n-3) polyunsaturated fatty acids (PUFAs) are anti-inflammatory both in peripheral organs and central nervous systems and have clinically applied in the treatment and prevention of depression, cardiovascular diseases, dyslipidaemia, diabetes and arthritis. Anthropological studies suggest that human beings evolved to a modern diet with less than one-tenth of omega-3 to omega-6 PUFAs intake ratio, which leads to a constitutional bias toward chronic systemic inflammatory status to explain dramatically increasing of depression and chronic medical illnesses in modern world. The presentation is to provide our recent clinical and pre-clinical studies and an overview about the role of inflammation in “mind-body” comorbidity and present anti-inflammatory mechanisms by which n-3 PUFAs may orchestrate the molecular and cellular functions and facilitate the therapeutic pathways in chronic medical illnesses and depression.
abstract_unstemmed	The increasing global burden calls for the development of novel approaches to tackle unmet needs in prevention and treatment of depression underlying biological, psychological and social dysregulations. Depressed patients with chronic low-grade inflammation might be classified as a subgroup of major depressive disorder (MDD); therefore, looking for antidepressant therapies from anti-inflammatory pathways could improve treatment effectiveness for this subgroup of patients. Omega-3 (or n-3) polyunsaturated fatty acids (PUFAs) are anti-inflammatory both in peripheral organs and central nervous systems and have clinically applied in the treatment and prevention of depression, cardiovascular diseases, dyslipidaemia, diabetes and arthritis. Anthropological studies suggest that human beings evolved to a modern diet with less than one-tenth of omega-3 to omega-6 PUFAs intake ratio, which leads to a constitutional bias toward chronic systemic inflammatory status to explain dramatically increasing of depression and chronic medical illnesses in modern world. The presentation is to provide our recent clinical and pre-clinical studies and an overview about the role of inflammation in “mind-body” comorbidity and present anti-inflammatory mechanisms by which n-3 PUFAs may orchestrate the molecular and cellular functions and facilitate the therapeutic pathways in chronic medical illnesses and depression.
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title_short	The role of inflammation in personalised treatment of omega-3 fatty acids in depression
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